GREMLIN Database
GPMA - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
UniProt: P62707 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11699
Length: 250 (192)
Sequences: 7922 (5352)
Seq/√Len: 386.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_V65_H2.9881.00
86_K167_E2.8491.00
13_E33_K2.8091.00
64_I83_K2.7341.00
5_K215_V2.6411.00
94_A150_L2.6171.00
59_V88_N2.6041.00
54_F82_E2.4151.00
5_K217_E2.3631.00
5_K178_R2.3331.00
9_V70_V2.3111.00
98_L106_K2.2591.00
86_K163_P2.1951.00
55_A71_L2.1221.00
29_D65_H2.0981.00
162_I194_Y2.0601.00
39_K69_N2.0341.00
35_V69_N2.0251.00
55_A67_L1.9911.00
13_E31_S1.9791.00
29_D61_K1.9661.00
53_D177_E1.9581.00
43_K73_E1.9351.00
86_K164_Y1.9001.00
65_H68_W1.8721.00
87_L164_Y1.8561.00
161_V187_S1.8441.00
9_V180_I1.8391.00
183_A187_S1.8231.00
15_Q19_E1.8171.00
32_E35_V1.8091.00
9_V41_A1.7921.00
15_Q31_S1.7791.00
153_S156_L1.7451.00
7_V52_F1.7041.00
36_S39_K1.7021.00
52_F180_I1.6951.00
25_W88_N1.6801.00
217_E226_K1.6121.00
57_T83_K1.5591.00
13_E18_K1.5491.00
152_E160_R1.5321.00
35_V39_K1.4941.00
84_S164_Y1.4891.00
188_L208_I1.4891.00
183_A188_L1.4681.00
84_S167_E1.4661.00
53_D178_R1.4651.00
25_W91_H1.4521.00
36_S40_A1.4251.00
33_K36_S1.4231.00
16_W28_V1.4041.00
70_V182_A1.3701.00
16_W21_R1.3471.00
7_V178_R1.3371.00
107_Y110_E1.2971.00
33_K37_E1.2961.00
17_N210_T1.2901.00
64_I68_W1.2761.00
39_K72_D1.2711.00
155_A159_D1.2711.00
8_L188_L1.2681.00
38_A66_T1.2631.00
99_N102_E1.2621.00
54_F177_E1.2541.00
113_K117_R1.2491.00
91_H96_Q1.2481.00
59_V85_W1.2401.00
156_L159_D1.2341.00
39_K73_E1.2301.00
68_W72_D1.2181.00
40_A43_K1.2121.00
58_S63_A1.2071.00
162_I166_N1.2021.00
16_W23_T1.1991.00
98_L102_E1.1981.00
27_D61_K1.1851.00
147_E156_L1.1851.00
32_E36_S1.1721.00
164_Y168_T1.1591.00
68_W81_V1.1551.00
43_K46_K1.1421.00
196_D216_Y1.1391.00
56_Y164_Y1.1261.00
161_V191_L1.1251.00
67_L81_V1.1251.00
199_S202_E1.1121.00
59_V83_K1.1081.00
192_V214_L1.0871.00
7_V215_V1.0741.00
208_I214_L1.0691.00
101_A104_A1.0641.00
98_L103_T1.0591.00
23_T28_V1.0521.00
42_G69_N1.0271.00
159_D163_P1.0241.00
198_M202_E1.0231.00
71_L81_V1.0141.00
58_S184_H1.0101.00
166_N170_L1.0101.00
37_E210_T1.0031.00
52_F178_R1.0001.00
174_K177_E0.9941.00
157_T187_S0.9921.00
67_L182_A0.9871.00
25_W59_V0.9841.00
101_A105_E0.9711.00
95_L103_T0.9611.00
202_E205_E0.9311.00
8_L191_L0.9281.00
171_P174_K0.9261.00
104_A112_V0.9261.00
219_D223_K0.9251.00
26_Y96_Q0.9241.00
69_N72_D0.9101.00
61_K64_I0.9081.00
57_T81_V0.9081.00
61_K65_H0.9071.00
57_T64_I0.9071.00
14_S31_S0.9041.00
102_E105_E0.9021.00
63_A184_H0.8921.00
193_K200_E0.8901.00
17_N23_T0.8871.00
4_T176_G0.8831.00
4_T174_K0.8821.00
30_L38_A0.8791.00
157_T161_V0.8701.00
4_T175_S0.8651.00
54_F179_V0.8611.00
219_D222_F0.8561.00
109_D113_K0.8551.00
65_H69_N0.8531.00
94_A149_P0.8521.00
56_Y82_E0.8521.00
158_I162_I0.8481.00
144_S147_E0.8451.00
12_G30_L0.8441.00
7_V50_Y0.8401.00
52_F74_L0.8371.00
56_Y174_K0.8341.00
38_A211_G0.8341.00
14_S23_T0.8321.00
28_V31_S0.8281.00
50_Y178_R0.8281.00
14_S17_N0.8241.00
56_Y168_T0.8191.00
15_Q18_K0.8161.00
192_V196_D0.8131.00
218_F223_K0.8071.00
57_T63_A0.8071.00
157_T186_N0.8061.00
208_I212_V0.8051.00
55_A79_L0.8051.00
41_A211_G0.8031.00
15_Q29_D0.8031.00
85_W88_N0.7981.00
56_Y84_S0.7951.00
192_V216_Y0.7861.00
21_R99_N0.7791.00
23_T210_T0.7761.00
13_E37_E0.7721.00
87_L168_T0.7711.00
167_E171_P0.7651.00
42_G73_E0.7651.00
168_T181_I0.7621.00
157_T190_A0.7581.00
82_E171_P0.7501.00
34_G38_A0.7461.00
8_L181_I0.7441.00
16_W26_Y0.7391.00
9_V213_P0.7351.00
22_F100_K0.7341.00
90_R157_T0.7341.00
114_Q118_G0.7321.00
196_D206_L0.7311.00
42_G70_V0.7291.00
57_T67_L0.7261.00
60_L88_N0.7241.00
170_L174_K0.7221.00
18_K33_K0.7141.00
8_L216_Y0.7141.00
4_T220_E0.7091.00
102_E106_K0.7031.00
55_A180_I0.6991.00
158_I190_A0.6981.00
46_K73_E0.6940.99
89_E185_G0.6930.99
69_N73_E0.6930.99
44_L213_P0.6920.99
31_S34_G0.6900.99
166_N194_Y0.6900.99
185_G207_N0.6830.99
165_W191_L0.6820.99
56_Y179_V0.6760.99
38_A69_N0.6660.99
41_A213_P0.6650.99
110_E149_P0.6630.99
93_G151_T0.6620.99
92_Y186_N0.6590.99
39_K43_K0.6580.99
71_L74_L0.6530.99
188_L214_L0.6510.99
87_L181_I0.6440.99
6_L169_I0.6430.99
167_E170_L0.6420.99
170_L222_F0.6370.99
55_A81_V0.6370.99
92_Y96_Q0.6360.99
220_E223_K0.6340.99
53_D180_I0.6170.99
103_T107_Y0.6130.99
28_V92_Y0.6120.99
20_N99_N0.6100.99
166_N169_I0.6100.99
29_D35_V0.6060.99
154_L190_A0.6040.99
6_L218_F0.6000.99
154_L189_R0.5970.98
56_Y171_P0.5950.98
185_G210_T0.5940.98
209_P212_V0.5940.98
60_L63_A0.5940.98
22_F92_Y0.5930.98
51_S178_R0.5910.98
158_I194_Y0.5910.98
103_T112_V0.5870.98
219_D224_P0.5870.98
112_V115_W0.5860.98
34_G37_E0.5790.98
18_K31_S0.5790.98
71_L79_L0.5770.98
24_G60_L0.5750.98
38_A42_G0.5750.98
14_S96_Q0.5720.98
143_L148_L0.5710.98
162_I191_L0.5710.98
154_L203_I0.5700.98
50_Y74_L0.5690.98
87_L187_S0.5670.98
193_K203_I0.5670.98
90_R95_L0.5650.98
183_A208_I0.5620.98
43_K47_E0.5600.98
45_L50_Y0.5570.98
24_G27_D0.5540.98
142_K145_E0.5520.97
52_F55_A0.5490.97
104_A109_D0.5440.97
164_Y181_I0.5440.97
42_G46_K0.5440.97
45_L74_L0.5430.97
10_R89_E0.5420.97
168_T179_V0.5410.97
15_Q28_V0.5370.97
13_E17_N0.5370.97
7_V45_L0.5360.97
164_Y167_E0.5350.97
193_K198_M0.5330.97
191_L195_L0.5320.97
4_T177_E0.5300.97
58_S62_R0.5280.97
143_L146_K0.5270.97
6_L165_W0.5250.97
159_D162_I0.5250.97
7_V213_P0.5220.96
165_W195_L0.5190.96
25_W60_L0.5190.96
159_D175_S0.5180.96
203_I206_L0.5180.96
161_V194_Y0.5160.96
20_N101_A0.5160.96
46_K75_D0.5150.96
21_R102_E0.5150.96
9_V182_A0.5150.96
11_H89_E0.5150.96
148_L151_T0.5140.96
93_G152_E0.5130.96
75_D79_L0.5130.96
54_F174_K0.5110.96
66_T211_G0.5100.96
23_T185_G0.5100.96
63_A67_L0.5070.96
82_E168_T0.5060.96
10_R17_N0.5060.96
90_R189_R0.5050.96
90_R154_L0.5000.95
30_L34_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4odiA 3 0.976 100 0.164 Contact Map
3kkkA 3 0.92 100 0.165 Contact Map
2hhjA 2 0.996 100 0.171 Contact Map
3gp3A 1 0.916 100 0.171 Contact Map
3d8hA 2 0.928 100 0.18 Contact Map
1e58A 2 0.988 100 0.19 Contact Map
1riiA 4 0.964 100 0.198 Contact Map
4gpzA 2 0.952 100 0.209 Contact Map
4embA 2 0.98 100 0.21 Contact Map
4pzaA 2 0.812 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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