GREMLIN Database
APAG - Protein ApaG
UniProt: P62672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10047
Length: 125 (117)
Sequences: 1242 (802)
Seq/√Len: 74.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G100_E3.7121.00
96_Q115_V3.1331.00
49_Y63_Q2.7031.00
34_T81_Q2.6161.00
44_Q73_L2.5321.00
8_C38_L2.3741.00
92_L119_A2.1991.00
7_V43_V2.1511.00
103_D107_V2.1171.00
100_E110_S2.0191.00
36_R79_E1.8771.00
52_I62_V1.8761.00
45_L101_M1.8741.00
49_Y61_E1.8541.00
10_Q36_R1.8461.00
73_L104_E1.8181.00
98_H110_S1.7781.00
32_T83_T1.7251.00
21_S24_N1.7101.00
94_T115_V1.7041.00
102_I108_P1.6631.00
28_V87_I1.6451.00
29_F92_L1.6401.00
100_E108_P1.6321.00
39_G43_V1.6080.99
34_T79_E1.5930.99
51_L96_Q1.5800.99
41_A103_D1.5400.99
9_I111_I1.5330.99
63_Q98_H1.4560.99
46_L102_I1.4340.99
15_Y22_P1.4290.99
88_I93_G1.4160.99
41_A104_E1.3990.99
42_P73_L1.3770.98
75_A78_E1.3750.98
51_L61_E1.3200.98
42_P75_A1.2720.97
14_V30_A1.2580.97
42_P74_I1.2290.97
49_Y98_H1.2240.97
46_L71_Q1.2230.97
13_S33_V1.2210.96
51_L59_E1.2150.96
11_V33_V1.1980.96
44_Q71_Q1.1880.96
52_I116_F1.1430.95
6_R86_A1.1420.95
29_F117_R1.1390.95
74_I78_E1.1000.94
19_Q85_G1.0950.94
29_F114_P1.0920.94
99_Y113_I1.0810.93
43_V109_F1.0660.93
8_C36_R1.0560.92
45_L67_V1.0130.91
66_G99_Y1.0070.90
16_I19_Q1.0070.90
70_V80_Y1.0060.90
14_V32_T1.0030.90
10_Q13_S0.9860.89
49_Y59_E0.9860.89
32_T81_Q0.9780.89
92_L117_R0.9620.88
17_E20_S0.9580.88
54_N85_G0.9570.88
7_V111_I0.9410.87
54_N58_R0.9400.87
58_R89_E0.9330.87
91_P120_V0.9250.86
47_G63_Q0.9220.86
12_Q81_Q0.9170.86
102_I106_G0.9140.86
16_I30_A0.9080.85
65_E71_Q0.8880.84
6_R39_G0.8850.84
96_Q112_D0.8810.83
57_G60_T0.8790.83
113_I118_L0.8710.83
6_R103_D0.8700.83
63_Q110_S0.8660.82
56_N90_T0.8400.80
35_I74_I0.8340.80
30_A83_T0.8230.79
13_S87_I0.8220.79
53_T90_T0.8200.79
26_R89_E0.8160.78
37_N43_V0.8130.78
7_V101_M0.8120.78
54_N88_I0.8020.77
14_V81_Q0.8020.77
80_Y122_T0.7940.77
62_V77_G0.7930.76
54_N90_T0.7870.76
115_V119_A0.7820.75
28_V86_A0.7810.75
60_T63_Q0.7810.75
18_A75_A0.7790.75
35_I71_Q0.7740.75
35_I80_Y0.7700.74
29_F119_A0.7650.74
9_I101_M0.7650.74
44_Q102_I0.7640.74
26_R87_I0.7620.74
15_Y27_Y0.7590.73
10_Q34_T0.7420.72
33_V109_F0.7170.69
29_F87_I0.7150.69
55_G90_T0.7080.68
9_I103_D0.6990.67
94_T120_V0.6980.67
47_G108_P0.6950.67
58_R73_L0.6870.66
85_G88_I0.6860.66
39_G42_P0.6790.65
19_Q22_P0.6790.65
33_V86_A0.6740.64
37_N71_Q0.6720.64
104_E107_V0.6700.64
46_L65_E0.6690.64
44_Q110_S0.6650.63
52_I95_M0.6640.63
51_L98_H0.6620.63
80_Y86_A0.6530.62
30_A85_G0.6480.61
22_P68_V0.6470.61
64_G95_M0.6370.60
16_I28_V0.6360.60
30_A77_G0.6310.59
43_V101_M0.6240.58
101_M111_I0.6230.58
68_V80_Y0.6200.58
10_Q114_P0.6170.57
67_V84_S0.6170.57
27_Y109_F0.6160.57
21_S26_R0.6100.57
19_Q26_R0.6090.56
45_L95_M0.6050.56
62_V98_H0.6000.55
76_P114_P0.5990.55
8_C12_Q0.5950.55
53_T58_R0.5870.54
29_F120_V0.5870.54
94_T117_R0.5830.53
57_G91_P0.5650.51
17_E111_I0.5630.51
86_A94_T0.5570.50
22_P27_Y0.5570.50
65_E87_I0.5550.50
72_P97_G0.5520.49
60_T89_E0.5480.49
66_G95_M0.5460.49
11_V116_F0.5450.48
50_W54_N0.5430.48
19_Q28_V0.5430.48
58_R96_Q0.5420.48
116_F121_P0.5420.48
13_S46_L0.5410.48
67_V95_M0.5370.47
12_Q79_E0.5310.47
63_Q91_P0.5290.46
12_Q24_N0.5290.46
51_L94_T0.5280.46
59_E96_Q0.5280.46
29_F94_T0.5280.46
86_A120_V0.5260.46
46_L74_I0.5210.45
38_L74_I0.5160.45
51_L63_Q0.5160.45
25_E89_E0.5130.45
16_I29_F0.5130.45
12_Q34_T0.5110.44
38_L41_A0.5020.43
19_Q32_T0.5020.43
33_V75_A0.5020.43
14_V77_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f1eA 1 0.928 100 0.044 Contact Map
1xvsA 2 0.984 100 0.049 Contact Map
1tzaA 2 0.992 100 0.054 Contact Map
1xq4A 3 0.976 100 0.065 Contact Map
3nrfA 3 0.832 90.8 0.893 Contact Map
3cfuA 1 0.896 80.1 0.908 Contact Map
4r4gA 1 0.896 67.2 0.917 Contact Map
1cuoA 1 0.784 42.5 0.928 Contact Map
3ay2A 1 0.776 38.3 0.93 Contact Map
2iaaC 1 0.768 37.4 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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