ISPG - ECOLI - GREMLIN Contacts

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ISPG - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

UniProt:	P62620	Sequences: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10370
Length:	372 (347)
Sequences:	1739 (757)
Seq/√Len:	40.6

ECOLI - ISPG
BACSU - ISPG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_R	230_E	4.906	1.00
76_K	103_D	3.857	1.00
144_D	163_R	3.538	1.00
14_R	26_A	3.309	1.00
347_Q	350_A	3.028	1.00
155_Q	194_L	3.025	1.00
58_I	84_V	2.998	1.00
279_D	282_G	2.787	1.00
14_R	21_P	2.650	1.00
16_Y	21_P	2.608	1.00
115_E	170_R	2.593	1.00
96_K	99_E	2.537	1.00
15_I	177_K	2.520	1.00
189_V	226_L	2.516	1.00
165_V	178_V	2.407	1.00
166_D	170_R	2.397	1.00
45_V	79_V	2.355	1.00
188_A	207_I	2.335	1.00
217_A	250_V	2.332	1.00
52_E	80_N	2.315	1.00
13_T	174_D	2.297	1.00
216_G	240_L	2.264	1.00
45_V	78_Q	2.253	1.00
10_R	196_A	2.243	1.00
326_K	338_R	2.242	1.00
74_L	77_Q	2.222	1.00
327_S	344_M	2.210	1.00
50_A	243_D	2.201	1.00
104_C	177_K	2.200	1.00
36_T	44_T	2.196	0.99
41_V	45_V	2.191	0.99
266_N	299_D	2.178	0.99
98_A	125_A	2.146	0.99
98_A	130_I	2.131	0.99
238_V	254_I	2.121	0.99
79_V	83_L	2.071	0.99
12_S	196_A	2.058	0.99
291_L	300_V	2.031	0.99
142_E	160_S	1.989	0.99
40_D	43_A	1.945	0.99
39_T	65_T	1.933	0.99
142_E	163_R	1.926	0.99
340_D	343_D	1.896	0.98
129_N	175_Q	1.878	0.98
32_S	51_L	1.876	0.98
49_K	80_N	1.875	0.98
178_V	195_L	1.846	0.98
290_R	349_E	1.820	0.98
178_V	199_I	1.818	0.98
283_T	345_I	1.809	0.98
13_T	200_D	1.771	0.98
120_M	123_D	1.771	0.98
52_E	79_V	1.769	0.98
30_V	252_F	1.768	0.98
222_I	254_I	1.766	0.98
14_R	25_G	1.758	0.98
73_K	100_Y	1.738	0.97
241_A	269_A	1.726	0.97
84_V	104_C	1.702	0.97
30_V	251_G	1.700	0.97
180_V	195_L	1.698	0.97
16_Y	19_N	1.675	0.97
169_D	201_Q	1.668	0.97
148_K	159_E	1.666	0.97
46_N	50_A	1.648	0.96
278_F	322_G	1.646	0.96
45_V	80_N	1.608	0.96
242_A	246_E	1.603	0.96
42_E	78_Q	1.600	0.96
277_E	324_N	1.598	0.96
34_T	44_T	1.593	0.96
57_D	261_R	1.579	0.95
50_A	245_V	1.570	0.95
351_R	354_A	1.564	0.95
145_L	156_A	1.554	0.95
282_G	286_A	1.553	0.95
167_H	171_L	1.551	0.95
122_V	171_L	1.542	0.95
343_D	347_Q	1.524	0.94
122_V	168_L	1.517	0.94
337_D	347_Q	1.509	0.94
246_E	249_K	1.506	0.94
325_K	341_N	1.491	0.94
29_A	58_I	1.461	0.93
61_V	79_V	1.458	0.93
72_F	102_V	1.443	0.92
38_T	44_T	1.442	0.92
138_A	182_A	1.428	0.92
195_L	199_I	1.424	0.92
221_A	225_G	1.421	0.92
290_R	346_D	1.421	0.92
162_M	199_I	1.416	0.92
29_A	57_D	1.415	0.92
205_L	236_L	1.410	0.92
76_K	83_L	1.406	0.91
212_G	284_V	1.398	0.91
29_A	251_G	1.392	0.91
145_L	163_R	1.362	0.90
66_M	96_K	1.361	0.90
116_E	120_M	1.359	0.90
348_L	352_I	1.355	0.90
207_I	223_G	1.352	0.90
226_L	230_E	1.347	0.90
224_L	238_V	1.346	0.89
119_R	123_D	1.346	0.89
20_V	29_A	1.337	0.89
26_A	29_A	1.335	0.89
327_S	339_L	1.335	0.89
252_F	263_R	1.334	0.89
320_V	344_M	1.329	0.89
119_R	171_L	1.325	0.89
153_T	156_A	1.312	0.88
138_A	141_L	1.306	0.88
349_E	353_R	1.296	0.88
54_V	245_V	1.294	0.88
194_L	198_Q	1.291	0.87
118_I	164_H	1.282	0.87
214_R	253_D	1.264	0.86
329_L	339_L	1.264	0.86
350_A	354_A	1.263	0.86
14_R	24_D	1.263	0.86
329_L	348_L	1.262	0.86
49_K	52_E	1.260	0.86
21_P	25_G	1.255	0.86
62_S	274_S	1.238	0.85
99_E	124_C	1.237	0.85
105_L	125_A	1.237	0.85
70_E	96_K	1.232	0.85
182_A	187_L	1.231	0.85
226_L	229_S	1.231	0.85
337_D	351_R	1.224	0.84
157_L	180_V	1.220	0.84
95_L	102_V	1.197	0.83
343_D	346_D	1.186	0.83
21_P	26_A	1.175	0.82
35_N	276_Q	1.157	0.81
222_I	225_G	1.148	0.80
115_E	119_R	1.147	0.80
286_A	290_R	1.141	0.80
15_I	21_P	1.140	0.80
84_V	177_K	1.138	0.80
289_Q	292_E	1.135	0.80
11_K	200_D	1.135	0.80
134_I	164_H	1.124	0.79
249_K	292_E	1.123	0.79
285_N	289_Q	1.106	0.78
98_A	124_C	1.104	0.78
34_T	38_T	1.100	0.77
49_K	78_Q	1.091	0.77
242_A	281_I	1.090	0.77
41_V	75_I	1.087	0.77
190_E	193_R	1.084	0.76
126_R	172_N	1.081	0.76
39_T	68_A	1.079	0.76
168_L	173_F	1.079	0.76
319_G	330_Y	1.072	0.76
301_S	316_S	1.071	0.76
41_V	74_L	1.070	0.75
283_T	286_A	1.066	0.75
328_G	338_R	1.066	0.75
95_L	128_K	1.061	0.75
44_T	47_Q	1.057	0.75
222_I	226_L	1.054	0.74
213_A	242_A	1.053	0.74
205_L	227_L	1.052	0.74
146_Q	314_L	1.044	0.74
155_Q	198_Q	1.044	0.74
318_L	351_R	1.043	0.74
331_E	336_K	1.033	0.73
176_F	201_Q	1.024	0.72
212_G	288_E	1.022	0.72
95_L	124_C	1.019	0.72
52_E	81_V	1.012	0.71
21_P	29_A	1.009	0.71
117_R	120_M	1.007	0.71
124_C	127_D	1.006	0.71
69_A	100_Y	0.995	0.70
252_F	261_R	0.992	0.70
328_G	344_M	0.979	0.69
286_A	345_I	0.975	0.68
17_V	29_A	0.975	0.68
286_A	289_Q	0.967	0.68
45_V	76_K	0.966	0.68
25_G	318_L	0.966	0.68
164_H	168_L	0.965	0.68
97_V	100_Y	0.961	0.67
321_T	330_Y	0.961	0.67
76_K	79_V	0.960	0.67
41_V	71_A	0.959	0.67
222_I	257_S	0.959	0.67
124_C	128_K	0.958	0.67
96_K	100_Y	0.953	0.67
11_K	25_G	0.950	0.66
107_I	113_G	0.946	0.66
42_E	46_N	0.938	0.65
45_V	49_K	0.934	0.65
267_F	291_L	0.932	0.65
72_F	76_K	0.928	0.64
165_V	180_V	0.923	0.64
157_L	187_L	0.917	0.64
157_L	182_A	0.915	0.63
155_Q	190_E	0.914	0.63
56_A	81_V	0.911	0.63
221_A	254_I	0.906	0.63
146_Q	156_A	0.904	0.62
22_I	29_A	0.899	0.62
168_L	176_F	0.899	0.62
65_T	68_A	0.898	0.62
64_P	68_A	0.893	0.61
159_E	163_R	0.887	0.61
188_A	224_L	0.886	0.61
13_T	175_Q	0.885	0.61
216_G	242_A	0.882	0.61
291_L	294_I	0.882	0.61
123_D	127_D	0.878	0.60
166_D	169_D	0.875	0.60
219_K	266_N	0.871	0.60
184_D	266_N	0.869	0.59
236_L	251_G	0.866	0.59
284_V	287_L	0.866	0.59
214_R	217_A	0.865	0.59
35_N	47_Q	0.863	0.59
38_T	71_A	0.861	0.59
306_V	328_G	0.860	0.59
331_E	351_R	0.859	0.58
339_L	347_Q	0.857	0.58
27_P	261_R	0.856	0.58
214_R	249_K	0.853	0.58
287_L	302_I	0.850	0.58
157_L	165_V	0.849	0.58
34_T	59_V	0.844	0.57
326_K	340_D	0.843	0.57
263_R	295_I	0.842	0.57
45_V	52_E	0.842	0.57
10_R	200_D	0.841	0.57
309_G	319_G	0.836	0.56
44_T	61_V	0.835	0.56
90_D	93_I	0.835	0.56
163_R	166_D	0.833	0.56
162_M	198_Q	0.831	0.56
169_D	174_D	0.830	0.56
146_Q	152_P	0.830	0.56
189_V	229_S	0.828	0.56
229_S	258_L	0.827	0.56
57_D	252_F	0.827	0.56
38_T	47_Q	0.825	0.55
49_K	79_V	0.824	0.55
165_V	199_I	0.824	0.55
207_I	227_L	0.819	0.55
28_I	236_L	0.817	0.55
17_V	104_C	0.813	0.54
115_E	167_H	0.810	0.54
184_D	187_L	0.810	0.54
272_T	276_Q	0.810	0.54
83_L	103_D	0.809	0.54
37_R	68_A	0.809	0.54
207_I	257_S	0.807	0.54
241_A	280_V	0.806	0.54
284_V	302_I	0.805	0.54
145_L	148_K	0.804	0.53
194_L	197_K	0.803	0.53
62_S	93_I	0.801	0.53
337_D	350_A	0.798	0.53
66_M	70_E	0.797	0.53
214_R	218_V	0.796	0.53
35_N	244_P	0.795	0.53
166_D	201_Q	0.792	0.52
36_T	47_Q	0.790	0.52
112_I	118_I	0.785	0.52
293_D	353_R	0.780	0.51
301_S	310_P	0.778	0.51
242_A	285_N	0.777	0.51
303_I	316_S	0.775	0.51
79_V	103_D	0.772	0.51
180_V	191_S	0.772	0.51
20_V	58_I	0.772	0.51
25_G	234_D	0.770	0.50
213_A	246_E	0.767	0.50
72_F	97_V	0.763	0.50
207_I	226_L	0.762	0.50
164_H	167_H	0.761	0.49
10_R	25_G	0.756	0.49
59_V	79_V	0.756	0.49
220_S	238_V	0.754	0.49
68_A	274_S	0.753	0.49
265_I	291_L	0.753	0.49
189_V	207_I	0.751	0.49
49_K	53_R	0.749	0.48
158_L	194_L	0.748	0.48
303_I	310_P	0.747	0.48
17_V	20_V	0.743	0.48
22_I	177_K	0.741	0.48
34_T	48_I	0.741	0.48
318_L	352_I	0.740	0.48
105_L	199_I	0.736	0.47
142_E	164_H	0.731	0.47
99_E	128_K	0.731	0.47
149_Y	153_T	0.730	0.47
349_E	352_I	0.729	0.47
287_L	300_V	0.725	0.46
16_Y	20_V	0.720	0.46
15_I	104_C	0.715	0.45
267_F	302_I	0.715	0.45
34_T	47_Q	0.715	0.45
88_H	274_S	0.713	0.45
141_L	154_P	0.712	0.45
39_T	277_E	0.710	0.45
213_A	218_V	0.707	0.45
115_E	171_L	0.706	0.44
14_R	29_A	0.705	0.44
300_V	318_L	0.702	0.44
193_R	226_L	0.702	0.44
95_L	99_E	0.701	0.44
263_R	297_P	0.701	0.44
195_L	263_R	0.700	0.44
287_L	345_I	0.700	0.44
258_L	261_R	0.698	0.44
22_I	104_C	0.698	0.44
193_R	229_S	0.698	0.44
278_F	283_T	0.697	0.44
37_R	277_E	0.697	0.44
212_G	302_I	0.694	0.43
38_T	75_I	0.693	0.43
75_I	81_V	0.692	0.43
154_P	187_L	0.691	0.43
162_M	178_V	0.689	0.43
215_S	253_D	0.689	0.43
221_A	224_L	0.686	0.43
91_Y	95_L	0.685	0.43
276_Q	303_I	0.682	0.42
217_A	221_A	0.680	0.42
121_V	124_C	0.679	0.42
48_I	71_A	0.679	0.42
280_V	341_N	0.678	0.42
56_A	248_I	0.677	0.42
57_D	79_V	0.676	0.42
294_I	297_P	0.675	0.42
80_N	83_L	0.671	0.41
341_N	348_L	0.671	0.41
45_V	103_D	0.668	0.41
143_K	332_D	0.666	0.41
317_T	332_D	0.665	0.41
142_E	183_S	0.664	0.41
320_V	328_G	0.661	0.40
331_E	347_Q	0.661	0.40
63_V	69_A	0.657	0.40
306_V	335_R	0.656	0.40
14_R	20_V	0.652	0.40
346_D	349_E	0.651	0.39
29_A	104_C	0.650	0.39
122_V	167_H	0.648	0.39
145_L	159_E	0.646	0.39
267_F	284_V	0.646	0.39
73_K	77_Q	0.643	0.39
329_L	347_Q	0.643	0.39
336_K	354_A	0.642	0.39
57_D	263_R	0.641	0.39
253_D	256_K	0.640	0.39
32_S	56_A	0.634	0.38
89_F	306_V	0.634	0.38
335_R	338_R	0.633	0.38
71_A	100_Y	0.632	0.38
196_A	203_L	0.632	0.38
69_A	96_K	0.631	0.38
327_S	341_N	0.630	0.38
329_L	345_I	0.627	0.37
44_T	48_I	0.625	0.37
50_A	53_R	0.625	0.37
154_P	194_L	0.624	0.37
8_Q	11_K	0.622	0.37
343_D	350_A	0.619	0.37
35_N	281_I	0.615	0.36
64_P	88_H	0.612	0.36
184_D	188_A	0.610	0.36
45_V	83_L	0.607	0.36
197_K	230_E	0.604	0.35
160_S	183_S	0.604	0.35
91_Y	121_V	0.603	0.35
16_Y	129_N	0.602	0.35
48_I	75_I	0.600	0.35
222_I	238_V	0.600	0.35
22_I	83_L	0.599	0.35
313_A	321_T	0.598	0.35
182_A	188_A	0.598	0.35
72_F	79_V	0.597	0.35
340_D	344_M	0.597	0.35
251_G	350_A	0.596	0.35
152_P	182_A	0.596	0.35
38_T	48_I	0.595	0.35
76_K	80_N	0.595	0.35
156_A	159_E	0.595	0.35
310_P	313_A	0.594	0.35
45_V	75_I	0.593	0.34
30_V	227_L	0.593	0.34
168_L	192_Y	0.592	0.34
182_A	186_F	0.590	0.34
93_I	241_A	0.588	0.34
73_K	96_K	0.588	0.34
290_R	353_R	0.588	0.34
289_Q	334_V	0.586	0.34
296_T	352_I	0.586	0.34
182_A	207_I	0.584	0.34
287_L	344_M	0.584	0.34
152_P	156_A	0.583	0.34
192_Y	203_L	0.583	0.34
329_L	340_D	0.582	0.34
329_L	337_D	0.582	0.34
113_G	118_I	0.581	0.33
276_Q	301_S	0.578	0.33
76_K	119_R	0.578	0.33
114_N	120_M	0.577	0.33
46_N	53_R	0.576	0.33
153_T	187_L	0.576	0.33
39_T	64_P	0.575	0.33
289_Q	346_D	0.574	0.33
45_V	81_V	0.574	0.33
134_I	192_Y	0.574	0.33
224_L	236_L	0.573	0.33
152_P	315_V	0.572	0.33
222_I	229_S	0.570	0.33
163_R	167_H	0.569	0.33
122_V	178_V	0.568	0.32
91_Y	113_G	0.568	0.32
262_S	297_P	0.566	0.32
123_D	126_R	0.565	0.32
232_I	299_D	0.565	0.32
253_D	267_F	0.564	0.32
44_T	75_I	0.564	0.32
180_V	188_A	0.562	0.32
28_I	57_D	0.559	0.32
177_K	252_F	0.555	0.31
183_S	219_K	0.555	0.31
36_T	75_I	0.553	0.31
259_R	267_F	0.551	0.31
70_E	346_D	0.551	0.31
122_V	126_R	0.551	0.31
152_P	159_E	0.550	0.31
272_T	321_T	0.549	0.31
122_V	299_D	0.549	0.31
92_R	117_R	0.549	0.31
99_E	127_D	0.548	0.31
54_V	249_K	0.546	0.31
90_D	243_D	0.545	0.31
214_R	250_V	0.545	0.31
61_V	72_F	0.545	0.31
177_K	263_R	0.545	0.31
186_F	229_S	0.545	0.31
22_I	58_I	0.544	0.31
131_P	176_F	0.544	0.31
180_V	192_Y	0.543	0.30
98_A	128_K	0.543	0.30
142_E	145_L	0.542	0.30
104_C	175_Q	0.542	0.30
283_T	341_N	0.540	0.30
189_V	230_E	0.540	0.30
9_R	12_S	0.539	0.30
113_G	121_V	0.539	0.30
131_P	175_Q	0.538	0.30
298_M	349_E	0.538	0.30
36_T	43_A	0.538	0.30
113_G	143_K	0.535	0.30
47_Q	244_P	0.533	0.30
238_V	269_A	0.533	0.30
22_I	26_A	0.533	0.30
63_V	102_V	0.533	0.30
36_T	40_D	0.533	0.30
331_E	334_V	0.532	0.30
195_L	203_L	0.532	0.30
318_L	331_E	0.532	0.30
83_L	147_E	0.532	0.30
17_V	175_Q	0.532	0.30
223_G	238_V	0.531	0.30
62_S	88_H	0.530	0.29
112_I	143_K	0.530	0.29
184_D	299_D	0.530	0.29
243_D	246_E	0.529	0.29
276_Q	281_I	0.529	0.29
241_A	303_I	0.527	0.29
167_H	170_R	0.527	0.29
40_D	47_Q	0.527	0.29
59_V	81_V	0.527	0.29
205_L	224_L	0.527	0.29
264_G	344_M	0.526	0.29
276_Q	283_T	0.525	0.29
138_A	191_S	0.525	0.29
306_V	326_K	0.524	0.29
34_T	125_A	0.523	0.29
146_Q	151_E	0.523	0.29
320_V	329_L	0.522	0.29
40_D	44_T	0.521	0.29
41_V	61_V	0.521	0.29
294_I	353_R	0.519	0.29
272_T	278_F	0.519	0.29
276_Q	280_V	0.517	0.28
196_A	232_I	0.517	0.28
52_E	103_D	0.517	0.28
238_V	251_G	0.514	0.28
25_G	42_E	0.511	0.28
93_I	269_A	0.511	0.28
203_L	232_I	0.510	0.28
149_Y	159_E	0.509	0.28
134_I	168_L	0.509	0.28
9_R	234_D	0.508	0.28
173_F	176_F	0.507	0.28
89_F	114_N	0.507	0.28
114_N	117_R	0.507	0.28
298_M	317_T	0.506	0.28
104_C	131_P	0.506	0.28
191_S	205_L	0.505	0.28
32_S	243_D	0.505	0.28
154_P	159_E	0.504	0.27
197_K	354_A	0.504	0.27
72_F	201_Q	0.503	0.27
325_K	339_L	0.503	0.27
309_G	322_G	0.502	0.27
57_D	81_V	0.501	0.27
11_K	119_R	0.501	0.27
28_I	56_A	0.501	0.27
323_G	341_N	0.501	0.27
120_M	124_C	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4s39A	2	0.9543	100	0.253	Contact Map
3noyA	2	0.9435	100	0.295	Contact Map
4mwaA	4	0.7016	100	0.502	Contact Map
2yr1A	2	0.6022	100	0.739	Contact Map
4g38A	1	0.914	99.8	0.871	Contact Map
1zj8A	1	0.9624	99.7	0.887	Contact Map
4nirA	3	0.6317	98.9	0.927	Contact Map
4djdD	1	0.6344	98.6	0.934	Contact Map
2yciX	2	0.6398	98.5	0.935	Contact Map
1eyeA	2	0.6075	98.4	0.937	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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