GREMLIN Database
ISPE - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
UniProt: P62615 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11294
Length: 283 (246)
Sequences: 6048 (4380)
Seq/√Len: 279.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_E91_N3.3411.00
127_S130_E3.0671.00
140_A156_V3.0491.00
40_T95_D2.9581.00
52_R91_N2.8461.00
248_F257_V2.7081.00
115_L131_L2.6411.00
43_I117_A2.5801.00
212_E226_L2.5751.00
54_L93_S2.5681.00
29_Q152_F2.4581.00
63_E72_R2.4221.00
73_L137_T2.3501.00
132_A147_R2.2761.00
172_V243_C2.2501.00
216_R223_D2.1951.00
184_I211_C2.1621.00
46_R91_N2.0781.00
182_P186_K2.0591.00
42_S93_S2.0181.00
170_Y247_E1.9781.00
222_V244_V1.9661.00
29_Q154_E1.9301.00
73_L134_M1.9251.00
74_L124_C1.8971.00
77_T137_T1.8751.00
251_E255_R1.8711.00
30_T153_A1.8311.00
119_N126_L1.8291.00
250_T253_E1.8071.00
46_R49_G1.7761.00
223_D227_S1.7561.00
72_R76_K1.7551.00
42_S95_D1.7471.00
119_N125_G1.7431.00
68_V72_R1.7241.00
171_L248_F1.7221.00
19_G27_T1.7171.00
28_L185_F1.6761.00
187_D218_R1.6651.00
33_Q150_A1.6481.00
130_E133_E1.6181.00
74_L115_L1.6031.00
51_I68_V1.5991.00
77_T130_E1.5951.00
67_I114_V1.5551.00
44_E93_S1.5461.00
169_W251_E1.5381.00
77_T134_M1.5361.00
226_L244_V1.5271.00
73_L77_T1.5221.00
183_V186_K1.5221.00
179_I184_I1.5201.00
72_R75_M1.5191.00
74_L122_W1.5171.00
227_S231_E1.5141.00
40_T97_R1.5071.00
154_E161_T1.4961.00
179_I215_A1.4941.00
67_I94_I1.4911.00
43_I92_I1.4691.00
41_I114_V1.4391.00
78_A124_C1.3941.00
236_R245_F1.3911.00
52_R93_S1.3881.00
101_G178_S1.3751.00
45_L88_S1.3741.00
17_I188_P1.3661.00
221_E224_A1.3401.00
212_E216_R1.3391.00
222_V237_L1.3341.00
180_P183_V1.3231.00
32_F153_A1.3221.00
61_E64_D1.3061.00
174_H243_C1.3051.00
18_T27_T1.3041.00
187_D190_L1.3031.00
171_L254_A1.2911.00
54_L91_N1.2901.00
172_V245_F1.2841.00
228_W232_Y1.2701.00
78_A126_L1.2651.00
71_A75_M1.2551.00
153_A160_L1.2451.00
50_D91_N1.2311.00
118_L122_W1.2191.00
71_A92_I1.2181.00
21_R27_T1.2171.00
235_S246_A1.2171.00
34_F150_A1.1881.00
63_E68_V1.1821.00
229_L246_A1.1741.00
184_I215_A1.1721.00
136_L156_V1.1651.00
25_Y140_A1.1541.00
70_A138_L1.1481.00
173_A225_V1.1391.00
183_V218_R1.1361.00
39_D98_L1.1331.00
46_R89_G1.1301.00
41_I67_I1.1201.00
92_I114_V1.1131.00
177_V221_E1.1111.00
119_N124_C1.0981.00
234_P246_A1.0951.00
255_R258_L1.0951.00
128_M147_R1.0941.00
151_A160_L1.0901.00
119_N131_L1.0881.00
46_R50_D1.0871.00
249_D253_E1.0851.00
73_L76_K1.0851.00
41_I113_T1.0741.00
114_V118_L1.0711.00
258_L262_P1.0711.00
102_G174_H1.0661.00
216_R222_V1.0651.00
109_S145_F1.0611.00
66_L138_L1.0601.00
211_C215_A1.0591.00
229_L234_P1.0591.00
216_R226_L1.0541.00
224_A227_S1.0521.00
34_F149_H1.0521.00
35_L38_G1.0491.00
183_V187_D1.0451.00
207_F236_R1.0251.00
238_T243_C1.0251.00
54_L95_D1.0211.00
66_L111_A1.0191.00
119_N127_S1.0171.00
78_A86_T1.0101.00
188_P192_R1.0091.00
117_A121_L0.9991.00
171_L258_L0.9971.00
43_I114_V0.9961.00
119_N128_M0.9961.00
98_L104_L0.9931.00
75_M122_W0.9921.00
197_R202_L0.9821.00
101_G242_A0.9801.00
115_L135_G0.9741.00
126_L134_M0.9701.00
48_D89_G0.9701.00
120_H124_C0.9641.00
38_G98_L0.9641.00
198_S201_T0.9621.00
154_E159_I0.9581.00
196_K210_D0.9561.00
159_I162_P0.9471.00
169_W254_A0.9461.00
74_L78_A0.9441.00
101_G243_C0.9401.00
135_G146_V0.9401.00
37_Y104_L0.9311.00
132_A146_V0.9301.00
49_G89_G0.9281.00
90_A122_W0.9271.00
71_A118_L0.9201.00
135_G142_V0.9191.00
228_W264_W0.9181.00
28_L32_F0.9161.00
197_R201_T0.9131.00
155_G158_E0.9111.00
16_Y208_S0.9061.00
199_I202_L0.9031.00
105_G145_F0.9031.00
53_L65_N0.8991.00
60_V100_M0.8911.00
70_A115_L0.8831.00
230_L235_S0.8821.00
34_F144_V0.8821.00
179_I219_F0.8721.00
73_L138_L0.8671.00
232_Y248_F0.8611.00
177_V219_F0.8601.00
109_S148_G0.8591.00
35_L172_V0.8591.00
203_L206_E0.8581.00
70_A73_L0.8531.00
203_L207_F0.8481.00
204_K207_F0.8471.00
246_A257_V0.8461.00
32_F144_V0.8431.00
259_E263_E0.8421.00
228_W231_E0.8371.00
129_D147_R0.8371.00
226_L230_L0.8361.00
187_D217_K0.8361.00
116_V146_V0.8351.00
39_D96_K0.8331.00
232_Y257_V0.8321.00
253_E256_Q0.8301.00
112_A146_V0.8291.00
104_L238_T0.8231.00
23_D27_T0.8231.00
126_L130_E0.8190.99
174_H178_S0.8160.99
198_S202_L0.8130.99
132_A135_G0.8120.99
71_A90_A0.8120.99
256_Q260_Q0.8110.99
98_L109_S0.8100.99
128_M132_A0.8090.99
79_A87_G0.8090.99
179_I240_T0.8080.99
34_F148_G0.8070.99
229_L235_S0.8040.99
211_C240_T0.8030.99
74_L118_L0.8000.99
16_Y210_D0.7820.99
235_S244_V0.7810.99
114_V117_A0.7780.99
221_E225_V0.7770.99
226_L235_S0.7580.99
232_Y260_Q0.7540.99
62_H65_N0.7530.99
179_I242_A0.7520.99
21_R33_Q0.7520.99
215_A222_V0.7500.99
126_L131_L0.7370.99
62_H68_V0.7370.99
46_R52_R0.7350.99
134_M137_T0.7320.99
71_A114_V0.7300.99
35_L245_F0.7290.99
129_D133_E0.7230.99
193_N196_K0.7210.99
25_Y156_V0.7170.99
144_V153_A0.7140.99
230_L234_P0.7140.99
169_W250_T0.7060.98
248_F254_A0.7060.98
246_A261_A0.7050.98
20_Q145_F0.7040.98
53_L60_V0.7040.98
90_A118_L0.6940.98
77_T133_E0.6930.98
255_R259_E0.6910.98
34_F145_F0.6900.98
65_N94_I0.6890.98
49_G75_M0.6880.98
224_A228_W0.6870.98
53_L56_P0.6860.98
228_W261_A0.6820.98
102_G243_C0.6790.98
260_Q264_W0.6760.98
75_M89_G0.6700.98
171_L257_V0.6690.98
190_L193_N0.6680.98
71_A89_G0.6670.98
136_L158_E0.6670.98
115_L134_M0.6620.98
35_L170_Y0.6600.98
147_R151_A0.6600.98
129_D132_A0.6600.98
29_Q32_F0.6590.98
147_R160_L0.6590.98
173_A265_L0.6580.98
51_I55_T0.6560.98
43_I90_A0.6540.98
18_T189_E0.6530.97
74_L125_G0.6500.97
78_A119_N0.6490.97
133_E137_T0.6470.97
144_V151_A0.6460.97
218_R221_E0.6460.97
74_L134_M0.6450.97
104_L172_V0.6410.97
67_I92_I0.6410.97
179_I218_R0.6390.97
41_I110_N0.6380.97
111_A138_L0.6370.97
219_F237_L0.6360.97
70_A142_V0.6350.97
68_V92_I0.6350.97
259_E262_P0.6340.97
260_Q263_E0.6330.97
51_I71_A0.6320.97
101_G174_H0.6290.97
113_T145_F0.6290.97
79_A86_T0.6240.97
173_A261_A0.6240.97
132_A143_P0.6220.97
144_V185_F0.6210.97
201_T206_E0.6180.96
15_L28_L0.6170.96
69_R138_L0.6070.96
136_L143_P0.6030.96
88_S122_W0.6000.96
70_A114_V0.5970.96
204_K209_N0.5950.96
134_M138_L0.5930.96
74_L114_V0.5920.96
256_Q259_E0.5910.95
225_V265_L0.5860.95
41_I109_S0.5860.95
16_Y29_Q0.5840.95
74_L119_N0.5820.95
137_T140_A0.5820.95
69_R73_L0.5790.95
31_L163_V0.5770.95
132_A136_L0.5730.95
263_E266_N0.5680.94
27_T188_P0.5680.94
262_P265_L0.5670.94
138_L142_V0.5640.94
17_I211_C0.5620.94
23_D156_V0.5610.94
108_S144_V0.5600.94
100_M242_A0.5580.94
108_S145_F0.5570.94
216_R227_S0.5560.94
112_A135_G0.5560.94
174_H242_A0.5520.94
215_A218_R0.5520.94
184_I218_R0.5480.93
114_V121_L0.5480.93
43_I71_A0.5480.93
21_R158_E0.5470.93
227_S230_L0.5450.93
251_E254_A0.5440.93
116_V120_H0.5430.93
43_I121_L0.5430.93
51_I89_G0.5410.93
120_H123_Q0.5400.93
197_R210_D0.5400.93
122_W125_G0.5390.93
113_T116_V0.5390.93
19_G22_A0.5390.93
215_A219_F0.5370.93
139_G185_F0.5360.93
139_G142_V0.5340.92
150_A165_P0.5320.92
204_K230_L0.5310.92
220_R224_A0.5290.92
197_R200_E0.5290.92
211_C214_I0.5280.92
20_Q144_V0.5280.92
98_L106_G0.5270.92
261_A265_L0.5270.92
33_Q165_P0.5260.92
53_L94_I0.5260.92
41_I94_I0.5250.92
49_G90_A0.5250.92
17_I28_L0.5250.92
222_V226_L0.5250.92
74_L126_L0.5230.92
20_Q190_L0.5220.92
211_C237_L0.5220.92
189_E192_R0.5220.92
234_P248_F0.5220.92
31_L150_A0.5220.92
170_Y245_F0.5190.91
89_G121_L0.5180.91
51_I94_I0.5170.91
32_F185_F0.5160.91
261_A264_W0.5160.91
90_A117_A0.5150.91
225_V244_V0.5140.91
45_L49_G0.5100.91
67_I110_N0.5100.91
28_L188_P0.5090.91
212_E236_R0.5080.90
31_L202_L0.5050.90
143_P151_A0.5040.90
55_T58_E0.5040.90
111_A142_V0.5020.90
20_Q189_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ww4A 2 0.9823 100 0.302 Contact Map
2v8pA 1 0.9152 100 0.331 Contact Map
1uekA 1 0.9152 100 0.332 Contact Map
3pyfA 1 0.9753 100 0.361 Contact Map
3ltoA 2 0.9258 100 0.441 Contact Map
3hulA 4 0.8728 100 0.444 Contact Map
4rpfA 2 0.9399 100 0.459 Contact Map
1h72C 2 0.9152 100 0.461 Contact Map
2gs8A 1 0.9435 100 0.467 Contact Map
4p52A 2 0.9399 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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