GREMLIN Database
RL5 - 50S ribosomal protein L5
UniProt: P62399 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10868
Length: 179 (176)
Sequences: 2683 (1138)
Seq/√Len: 85.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_K101_E4.6611.00
6_D10_D4.1011.00
36_L61_S3.4891.00
129_S155_T3.1661.00
19_E168_A3.0981.00
7_Y11_E3.0381.00
13_V28_V2.4061.00
34_I100_F2.3411.00
117_L175_F2.3231.00
35_T157_T2.3101.00
108_V111_I2.3021.00
22_Y165_E2.2421.00
15_K18_T2.1701.00
31_V156_I2.1701.00
168_A172_A2.1591.00
132_V137_I2.1371.00
68_T88_K2.1211.00
58_A64_K2.1061.00
98_E102_R1.9831.00
103_L130_M1.9571.00
100_F156_I1.9211.00
38_M53_A1.8891.00
124_G163_D1.8821.00
11_E15_K1.8731.00
7_Y12_V1.8721.00
5_H9_K1.8581.00
119_A167_R1.7961.00
142_D145_K1.7951.00
9_K13_V1.7911.00
168_A171_A1.7881.00
100_F104_I1.7731.00
97_W173_F1.7571.00
167_R171_A1.7241.00
58_A65_P1.6991.00
69_K84_P1.6771.00
22_Y162_S1.6741.00
17_M28_V1.6711.00
20_F168_A1.6411.00
101_E105_T1.6401.00
57_L87_C1.6231.00
15_K172_A1.6181.00
38_M57_L1.6031.00
12_V173_F1.5871.00
70_A73_S1.5701.00
27_Q161_K1.5371.00
40_V53_A1.5301.00
123_D127_N1.4690.99
79_I85_I1.4580.99
162_S165_E1.4570.99
54_A67_I1.4140.99
68_T86_G1.4110.99
36_L152_L1.3990.99
19_E172_A1.3890.99
67_I84_P1.3870.99
34_I104_I1.3760.99
164_E167_R1.3530.99
44_I85_I1.3510.99
70_A82_G1.3340.99
50_L87_C1.3320.99
108_V117_L1.3270.99
88_K153_D1.2850.98
32_E159_T1.2470.98
73_S81_Q1.2280.98
17_M25_V1.2130.98
14_K18_T1.1700.97
5_H94_E1.1670.97
54_A58_A1.1650.97
34_I173_F1.1550.97
52_N56_D1.1540.97
135_Q150_R1.1360.97
121_S153_D1.1010.96
19_E164_E1.0970.96
117_L130_M1.0960.96
56_D150_R1.0890.96
51_D55_A1.0710.95
147_D150_R1.0690.95
46_D49_L1.0600.95
55_A58_A1.0500.95
36_L57_L1.0490.95
32_E35_T1.0490.95
14_K17_M1.0350.94
44_I50_L1.0310.94
38_M87_C0.9970.93
91_L99_F0.9880.93
15_K19_E0.9770.92
134_E149_V0.9690.92
3_K105_T0.9660.92
38_M150_R0.9560.91
18_T21_N0.9560.91
104_I173_F0.9530.91
55_A59_A0.9470.91
37_N153_D0.9440.91
22_Y27_Q0.9420.91
52_N147_D0.9340.90
20_F165_E0.9320.90
42_E148_R0.9310.90
136_I143_Y0.9290.90
40_V50_L0.9170.90
19_E171_A0.9160.90
136_I149_V0.9150.90
44_I79_I0.9100.89
158_T166_G0.9020.89
119_A178_R0.9020.89
13_V17_M0.9010.89
54_A87_C0.8940.88
31_V34_I0.8930.88
9_K14_K0.8890.88
31_V100_F0.8880.88
52_N143_Y0.8870.88
121_S130_M0.8760.87
103_L108_V0.8760.87
73_S82_G0.8720.87
107_A132_V0.8570.86
7_Y173_F0.8560.86
132_V153_D0.8420.85
100_F173_F0.8400.85
143_Y150_R0.8380.85
10_D18_T0.8360.85
125_R163_D0.8330.85
57_L89_V0.8240.84
7_Y174_D0.8230.84
42_E150_R0.8200.84
44_I83_Y0.8160.83
33_K90_T0.8020.82
40_V49_L0.7980.82
131_G151_G0.7910.81
13_V25_V0.7870.81
7_Y15_K0.7860.81
33_K92_R0.7790.80
98_E101_E0.7750.80
74_V129_S0.7610.79
47_K84_P0.7520.78
66_L88_K0.7500.78
31_V96_M0.7460.77
58_A61_S0.7440.77
118_S121_S0.7410.77
54_A65_P0.7380.77
121_S128_Y0.7370.77
160_A165_E0.7350.76
143_Y147_D0.7340.76
107_A137_I0.7270.76
5_H93_G0.7240.75
6_D9_K0.7230.75
53_A87_C0.7200.75
49_L150_R0.7150.74
25_V28_V0.7110.74
36_L103_L0.7100.74
160_A166_G0.7100.74
129_S153_D0.7070.74
99_F138_F0.6980.73
44_I129_S0.6930.72
34_I156_I0.6900.72
70_A79_I0.6830.71
46_D50_L0.6830.71
10_D14_K0.6820.71
38_M56_D0.6800.71
39_G86_G0.6780.70
19_E22_Y0.6750.70
17_M24_S0.6720.70
94_E98_E0.6710.70
4_L7_Y0.6600.68
5_H17_M0.6510.67
3_K98_E0.6480.67
145_K148_R0.6460.67
79_I83_Y0.6450.67
24_S132_V0.6420.66
161_K165_E0.6400.66
135_Q156_I0.6380.66
122_F127_N0.6380.66
56_D147_D0.6370.66
156_I173_F0.6350.65
68_T74_V0.6340.65
23_N27_Q0.6320.65
27_Q160_A0.6310.65
17_M20_F0.6300.65
40_V58_A0.6270.64
47_K178_R0.6260.64
13_V172_A0.6260.64
53_A57_L0.6260.64
12_V20_F0.6230.64
41_G80_R0.6170.63
93_G117_L0.6150.63
120_K164_E0.6120.63
124_G158_T0.6060.62
134_E144_D0.6050.62
132_V154_I0.6050.62
4_L104_I0.6040.62
33_K157_T0.6020.61
42_E46_D0.5970.61
76_G79_I0.5960.61
35_T88_K0.5940.60
9_K17_M0.5930.60
117_L128_Y0.5910.60
34_I99_F0.5910.60
65_P88_K0.5890.60
94_E97_W0.5860.59
61_S65_P0.5800.59
9_K30_R0.5800.59
34_I96_M0.5790.58
32_E157_T0.5780.58
20_F24_S0.5760.58
130_M139_P0.5760.58
20_F172_A0.5760.58
59_A145_K0.5750.58
115_R178_R0.5730.58
45_A132_V0.5730.58
40_V68_T0.5710.57
10_D21_N0.5710.57
7_Y10_D0.5700.57
46_D175_F0.5700.57
9_K12_V0.5680.57
45_A76_G0.5680.57
150_R153_D0.5670.57
5_H8_Y0.5650.57
61_S135_Q0.5640.56
26_M38_M0.5520.55
44_I47_K0.5500.55
36_L99_F0.5490.54
45_A178_R0.5490.54
106_I132_V0.5470.54
45_A175_F0.5460.54
156_I175_F0.5450.54
158_T169_L0.5440.54
16_L172_A0.5440.54
63_Q95_R0.5410.53
39_G77_F0.5380.53
56_D135_Q0.5380.53
17_M21_N0.5370.53
108_V130_M0.5370.53
29_P158_T0.5350.53
80_R144_D0.5350.53
102_R173_F0.5350.53
57_L61_S0.5350.53
16_L19_E0.5320.52
102_R140_E0.5310.52
103_L117_L0.5300.52
121_S157_T0.5280.52
9_K15_K0.5280.52
122_F170_L0.5280.52
11_E164_E0.5270.51
46_D147_D0.5250.51
143_Y148_R0.5240.51
31_V173_F0.5230.51
104_I175_F0.5180.50
39_G85_I0.5170.50
164_E171_A0.5150.50
47_K50_L0.5130.50
63_Q92_R0.5120.49
29_P140_E0.5110.49
38_M129_S0.5100.49
14_K132_V0.5080.49
63_Q77_F0.5080.49
35_T38_M0.5070.49
132_V152_L0.5060.49
56_D146_V0.5050.49
105_T174_D0.5050.49
129_S137_I0.5050.49
125_R146_V0.5030.48
164_E168_A0.5030.48
38_M153_D0.5030.48
52_N55_A0.5020.48
95_R98_E0.5010.48
133_R143_Y0.5000.48
73_S83_Y0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iq4A 1 1 100 0.014 Contact Map
3bboH 1 0.9777 100 0.014 Contact Map
4rb6G 1 1 100 0.021 Contact Map
4tp9F 1 0.9888 100 0.027 Contact Map
1vw4E 1 1 100 0.09 Contact Map
3j21E 1 0.9162 100 0.261 Contact Map
1vq8D 1 0.6648 100 0.268 Contact Map
3zf7L 1 0.8212 100 0.276 Contact Map
4ujqM 1 0.8212 100 0.283 Contact Map
1vx7G 1 0.6145 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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