GREMLIN Database
SECM - Secretion monitor
UniProt: P62395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11087
Length: 170 (164)
Sequences: 108 (74)
Seq/√Len: 5.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_F157_S2.4620.61
133_S137_Y2.4060.59
4_I21_L2.2790.54
60_G66_E2.2350.53
31_L86_I2.1490.50
2_S97_M2.0650.47
9_R16_F2.0480.46
9_R17_W2.0480.46
153_P156_I2.0400.46
88_T118_L2.0320.46
79_D88_T1.8930.41
12_G17_W1.8910.41
9_R12_G1.8910.41
12_G16_F1.8910.41
133_S136_G1.8900.41
27_A125_L1.8860.41
120_D130_G1.8790.41
121_T158_Q1.7710.37
9_R14_R1.7700.37
14_R17_W1.7700.37
24_M127_T1.7350.36
96_A158_Q1.6690.34
45_K66_E1.6390.33
5_L11_F1.6310.33
43_P96_A1.6310.33
19_H23_G1.5700.31
109_L149_K1.5670.31
15_Y19_H1.5560.30
136_G140_D1.5500.30
8_W19_H1.5150.29
36_N160_Q1.5090.29
36_N113_A1.4950.29
8_W20_L1.4690.28
10_Q161_G1.4670.28
84_H95_F1.4550.27
66_E115_H1.4540.27
88_T92_H1.4480.27
16_F19_H1.4360.27
9_R19_H1.4360.27
34_L119_L1.4230.27
2_S6_T1.4150.26
73_N152_T1.4090.26
7_R18_P1.4080.26
12_G19_H1.3990.26
63_A121_T1.3700.25
14_R19_H1.3630.25
89_V95_F1.3440.24
110_P117_A1.3430.24
99_P132_P1.3370.24
79_D118_L1.3320.24
34_L156_I1.3240.24
121_T128_Q1.3230.24
6_T152_T1.2710.23
34_L37_A1.2700.23
4_I15_Y1.2570.22
73_N77_S1.2440.22
15_Y23_G1.2370.22
107_E111_L1.2370.22
107_E128_Q1.2250.22
135_K159_A1.2100.21
11_F15_Y1.2070.21
8_W23_G1.2060.21
60_G123_S1.2010.21
154_V157_S1.1920.21
8_W15_Y1.1910.21
129_E135_K1.1750.20
121_T129_E1.1740.20
79_D92_H1.1630.20
35_S46_A1.1580.20
132_P159_A1.1540.20
28_S144_F1.1390.20
58_N67_A1.1220.19
9_R23_G1.1180.19
16_F23_G1.1180.19
17_W23_G1.1180.19
18_P21_L1.1150.19
9_R15_Y1.1040.19
10_Q19_H1.0940.19
13_K17_W1.0850.18
13_K16_F1.0850.18
9_R13_K1.0850.18
84_H89_V1.0760.18
27_A118_L1.0750.18
12_G23_G1.0750.18
15_Y21_L1.0730.18
8_W17_W1.0700.18
8_W16_F1.0700.18
34_L112_Q1.0670.18
12_G15_Y1.0620.18
8_W21_L1.0510.18
50_N64_L1.0490.18
16_F22_L1.0410.17
9_R22_L1.0410.17
17_W22_L1.0410.17
3_G7_R1.0300.17
14_R23_G1.0290.17
53_P69_T1.0290.17
8_W12_G1.0170.17
98_A148_A1.0120.17
41_N68_N1.0090.17
48_T123_S0.9890.16
95_F124_A0.9860.16
28_S120_D0.9840.16
8_W14_R0.9800.16
43_P158_Q0.9770.16
60_G67_A0.9760.16
58_N66_E0.9700.16
97_M167_Q0.9610.16
9_R21_L0.9610.16
17_W21_L0.9610.16
16_F21_L0.9610.16
58_N73_N0.9610.16
47_T124_A0.9570.16
113_A153_P0.9510.16
89_V124_A0.9470.16
33_A49_R0.9460.16
51_H96_A0.9450.16
86_I115_H0.9420.16
115_H160_Q0.9360.15
77_S149_K0.9350.15
41_N147_Q0.9180.15
12_G21_L0.9170.15
29_L79_D0.9110.15
52_E59_F0.8920.15
71_R117_A0.8860.15
35_S40_P0.8840.15
41_N138_R0.8810.15
20_L23_G0.8800.14
57_V82_H0.8780.14
24_M94_S0.8720.14
15_Y20_L0.8720.14
8_W13_K0.8710.14
12_G22_L0.8540.14
14_R21_L0.8540.14
129_E133_S0.8510.14
54_S60_G0.8440.14
76_Y110_P0.8400.14
39_E97_M0.8330.14
35_S73_N0.8320.14
156_I160_Q0.8080.13
18_P92_H0.8040.13
61_Q123_S0.8040.13
49_R73_N0.8010.13
45_K60_G0.7990.13
13_K19_H0.7970.13
54_S59_F0.7880.13
131_T135_K0.7850.13
4_I19_H0.7760.13
38_A157_S0.7660.13
96_A115_H0.7630.13
78_V110_P0.7620.13
2_S121_T0.7610.13
124_A158_Q0.7610.13
11_F20_L0.7600.13
61_Q160_Q0.7600.13
22_L121_T0.7600.13
44_A97_M0.7570.12
138_R159_A0.7560.12
9_R20_L0.7500.12
17_W20_L0.7500.12
16_F20_L0.7500.12
51_H66_E0.7490.12
22_L120_D0.7420.12
71_R87_R0.7380.12
45_K67_A0.7380.12
65_L94_S0.7370.12
125_L128_Q0.7350.12
80_Y90_I0.7340.12
18_P27_A0.7330.12
119_L123_S0.7300.12
138_R154_V0.7280.12
10_Q23_G0.7250.12
33_A42_A0.7200.12
98_A138_R0.7060.12
52_E96_A0.7050.12
43_P159_A0.6930.12
10_Q15_Y0.6920.12
14_R22_L0.6880.11
113_A151_S0.6840.11
7_R10_Q0.6740.11
5_L19_H0.6730.11
116_L120_D0.6730.11
119_L160_Q0.6660.11
12_G20_L0.6640.11
7_R118_L0.6560.11
52_E121_T0.6550.11
123_S138_R0.6550.11
138_R142_A0.6510.11
7_R15_Y0.6510.11
98_A118_L0.6490.11
29_L136_G0.6450.11
104_V112_Q0.6400.11
54_S67_A0.6340.11
64_L72_P0.6270.11
114_Q127_T0.6250.11
5_L10_Q0.6250.11
61_Q66_E0.6230.11
34_L115_H0.6230.11
48_T136_G0.6230.11
41_N143_H0.6160.10
31_L115_H0.6150.10
90_I126_L0.6150.10
53_P96_A0.6120.10
118_L125_L0.6090.10
46_A140_D0.6070.10
19_H22_L0.6050.10
44_A77_S0.6030.10
14_R20_L0.6010.10
59_F72_P0.5940.10
7_R79_D0.5940.10
97_M116_L0.5890.10
10_Q17_W0.5890.10
10_Q16_F0.5890.10
48_T167_Q0.5800.10
139_I143_H0.5750.10
8_W11_F0.5720.10
82_H86_I0.5690.10
31_L37_A0.5670.10
61_Q106_E0.5660.10
2_S7_R0.5590.10
29_L88_T0.5530.10
104_V124_A0.5520.10
77_S145_T0.5460.10
51_H115_H0.5420.10
79_D86_I0.5410.10
140_D148_A0.5400.10
86_I103_P0.5380.10
51_H58_N0.5350.09
100_Q137_Y0.5340.09
86_I92_H0.5310.09
64_L69_T0.5300.09
27_A86_I0.5280.09
150_F167_Q0.5230.09
109_L141_Y0.5210.09
92_H111_L0.5210.09
11_F19_H0.5170.09
3_G9_R0.5170.09
3_G17_W0.5170.09
3_G16_F0.5170.09
10_Q21_L0.5160.09
7_R14_R0.5140.09
22_L124_A0.5080.09
153_P157_S0.5070.09
73_N144_F0.5060.09
142_A149_K0.5050.09
50_N67_A0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v0xA 2 0.2941 15.2 0.966 Contact Map
3j46n 1 0.5294 4.5 0.973 Contact Map
1w36C 1 0.3412 2.1 0.977 Contact Map
2m8fA 1 0.1118 2 0.978 Contact Map
2mv6A 1 0.1 1.8 0.978 Contact Map
3i5xA 1 0.3882 1.7 0.978 Contact Map
4jwhA 1 0.1471 1.6 0.979 Contact Map
2vofB 2 0.1353 1.5 0.979 Contact Map
2hfrA 1 0.1471 1.4 0.979 Contact Map
3kj0B 1 0.0706 1.4 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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