GREMLIN Database
FLAV - Flavodoxin-1
UniProt: P61949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10318
Length: 176 (138)
Sequences: 2927 (1971)
Seq/√Len: 167.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_G102_L3.9591.00
82_L115_T3.4061.00
106_R116_I3.2731.00
110_E116_I3.1811.00
103_G122_T2.9151.00
53_G86_F2.7911.00
108_I112_R2.6911.00
108_I111_P2.4151.00
100_D104_T2.4051.00
11_D64_C2.2891.00
49_I82_L2.2831.00
74_E108_I2.2601.00
6_I23_Q2.1321.00
23_Q33_V2.0831.00
4_T26_L2.0731.00
85_L102_L2.0191.00
7_F36_I1.9141.00
36_I69_F1.9071.00
83_V106_R1.9051.00
15_T53_G1.8681.00
32_D47_Y1.8311.00
6_I31_A1.8301.00
83_V116_I1.7621.00
100_D103_G1.7311.00
35_D38_K1.6361.00
39_S47_Y1.6351.00
16_E20_K1.6251.00
70_F105_I1.6221.00
40_S43_D1.6201.00
83_V114_A1.5701.00
58_Y61_E1.5511.00
54_I101_A1.5281.00
9_G54_I1.4671.00
109_I114_A1.4291.00
106_R110_E1.4251.00
9_G66_W1.4191.00
18_I88_C1.4181.00
59_Y97_Y1.4141.00
106_R120_W1.4101.00
86_F123_A1.3921.00
131_K134_A1.3571.00
109_I116_I1.3501.00
5_G47_Y1.3501.00
103_G120_W1.3131.00
61_E104_T1.3101.00
23_Q27_G1.2931.00
17_N21_M1.2681.00
52_L109_I1.2541.00
83_V110_E1.2511.00
7_F39_S1.2241.00
54_I105_I1.2211.00
50_L81_K1.2071.00
138_H142_L1.2021.00
52_L105_I1.1911.00
10_S15_T1.1721.00
43_D46_A1.1451.00
62_A101_A1.1191.00
51_L84_A1.1141.00
9_G65_D1.1141.00
139_F142_L1.1091.00
127_F133_L1.1071.00
34_H39_S1.0971.00
9_G63_Q1.0751.00
26_L31_A1.0570.99
99_C102_L1.0550.99
36_I66_W1.0230.99
70_F101_A1.0180.99
20_K33_V1.0130.99
107_D111_P1.0110.99
37_A65_D0.9880.99
49_I117_V0.9740.99
64_C67_D0.9540.99
62_A104_T0.9480.99
138_H143_A0.9260.99
89_G99_C0.9220.99
80_G115_T0.9190.99
5_G34_H0.9050.98
107_D110_E0.9020.98
59_Y96_E0.8810.98
4_T51_L0.8740.98
70_F104_T0.8740.98
106_R119_H0.8690.98
133_L137_D0.8670.98
99_C143_A0.8640.98
17_N20_K0.8520.98
4_T49_I0.8460.97
127_F131_K0.8450.97
22_I53_G0.8310.97
102_L143_A0.8180.97
87_G99_C0.8170.97
55_P63_Q0.8160.97
23_Q31_A0.8160.97
137_D141_G0.8010.96
78_F114_A0.7990.96
25_Q29_D0.7960.96
39_S69_F0.7930.96
19_A33_V0.7890.96
84_A118_G0.7890.96
14_N18_I0.7860.96
51_L139_F0.7820.96
3_I30_V0.7780.96
6_I33_V0.7730.96
123_A127_F0.7670.95
84_A117_V0.7520.95
22_I87_G0.7470.95
85_L116_I0.7470.95
6_I48_D0.7320.94
116_I119_H0.7260.94
85_L106_R0.7230.94
7_F47_Y0.7190.94
69_F105_I0.7150.93
130_S133_L0.7120.93
32_D43_D0.7110.93
89_G98_F0.7080.93
41_K72_T0.7070.93
67_D71_P0.7010.93
118_G138_H0.6950.92
34_H38_K0.6920.92
83_V109_I0.6900.92
16_E64_C0.6890.92
102_L120_W0.6840.92
6_I22_I0.6770.91
24_K29_D0.6720.91
9_G88_C0.6710.91
48_D80_G0.6690.91
22_I51_L0.6620.91
54_I58_Y0.6610.90
70_F74_E0.6580.90
18_I53_G0.6560.90
39_S43_D0.6520.90
15_T88_C0.6520.90
55_P124_G0.6510.90
78_F112_R0.6510.90
76_I112_R0.6490.90
10_S13_G0.6480.90
131_K135_D0.6430.89
27_G30_V0.6420.89
11_D63_Q0.6400.89
44_L50_L0.6400.89
52_L85_L0.6390.89
88_C94_Y0.6360.89
7_F34_H0.6340.89
13_G69_F0.6340.89
36_I105_I0.6330.88
31_A34_H0.6310.88
7_F52_L0.6260.88
140_V143_A0.6250.88
9_G101_A0.6220.88
57_W101_A0.6210.88
10_S63_Q0.6210.88
54_I102_L0.6200.87
106_R134_A0.6160.87
44_L99_C0.6100.87
25_Q135_D0.6060.86
13_G16_E0.6010.86
45_E76_I0.5960.85
121_P130_S0.5950.85
137_D140_V0.5940.85
73_L108_I0.5940.85
54_I62_A0.5840.84
5_G32_D0.5840.84
5_G50_L0.5830.84
5_G39_S0.5810.84
139_F143_A0.5800.84
52_L63_Q0.5790.84
21_M24_K0.5790.84
58_Y100_D0.5770.83
25_Q28_K0.5760.83
41_K69_F0.5700.83
27_G32_D0.5660.82
69_F72_T0.5630.82
34_H43_D0.5620.82
87_G123_A0.5550.81
60_G63_Q0.5540.81
104_T107_D0.5520.81
18_I21_M0.5520.81
73_L109_I0.5520.81
37_A63_Q0.5470.80
74_E107_D0.5470.80
54_I65_D0.5470.80
29_D118_G0.5460.80
96_E128_E0.5460.80
8_F20_K0.5450.80
19_A86_F0.5440.80
86_F131_K0.5400.79
88_C124_G0.5360.79
8_F65_D0.5350.79
16_E57_W0.5270.78
57_W65_D0.5270.78
70_F108_I0.5220.77
10_S65_D0.5210.77
13_G58_Y0.5200.77
55_P101_A0.5190.77
42_E47_Y0.5180.76
97_Y100_D0.5180.76
47_Y50_L0.5140.76
56_T102_L0.5130.76
10_S124_G0.5110.75
48_D81_K0.5110.75
128_E132_G0.5100.75
74_E112_R0.5100.75
12_T16_E0.5070.75
40_S72_T0.5050.75
26_L140_V0.5030.74
107_D134_A0.5020.74
46_A77_D0.5010.74
119_H138_H0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.9432 100 0.359 Contact Map
1ag9A 2 0.9943 100 0.376 Contact Map
2bpoA 1 0.983 100 0.381 Contact Map
3qe2A 1 0.9716 100 0.389 Contact Map
2wc1A 1 0.983 100 0.404 Contact Map
2bmvA 1 0.9261 100 0.405 Contact Map
1yobA 1 0.9659 100 0.406 Contact Map
2fcrA 1 0.9489 100 0.434 Contact Map
3hr4A 2 0.9034 100 0.435 Contact Map
1oboA 1 0.9545 100 0.444 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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