GREMLIN Database
RMLA2 - Glucose-1-phosphate thymidylyltransferase 2
UniProt: P61887 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11454
Length: 293 (239)
Sequences: 22261 (13880)
Seq/√Len: 897.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_E185_K3.6661.00
31_K39_S3.1211.00
147_E155_I2.9411.00
147_E156_S2.7781.00
35_Y64_L2.7331.00
136_Q167_N2.6521.00
128_E211_T2.5311.00
48_E74_Q2.4871.00
183_Y207_A2.4871.00
84_D88_Q2.4321.00
149_D153_R2.4291.00
48_E76_E2.3191.00
101_P177_D2.2711.00
183_Y203_M2.2611.00
136_Q214_L2.2371.00
134_G212_V2.2041.00
149_D155_I2.1851.00
3_G46_I2.1441.00
123_V131_T2.0721.00
58_K62_Q2.0691.00
38_L49_I2.0491.00
3_G41_L2.0391.00
91_I94_E1.9521.00
153_R211_T1.9481.00
202_Q206_E1.9431.00
203_M207_A1.9381.00
168_W214_L1.9151.00
53_T58_K1.8781.00
147_E166_S1.8471.00
122_H213_E1.8351.00
7_A51_I1.8091.00
222_L232_E1.8031.00
156_S202_Q1.7881.00
78_A92_I1.7591.00
59_G63_R1.7571.00
58_K79_E1.7501.00
41_L105_V1.7331.00
90_F104_L1.7271.00
160_K164_P1.7141.00
203_M206_E1.7131.00
154_A212_V1.7001.00
126_R211_T1.6771.00
35_Y39_S1.6681.00
129_G177_D1.6681.00
139_D142_R1.6611.00
21_V27_P1.6471.00
117_S121_R1.6441.00
15_H19_R1.6421.00
101_P124_A1.6411.00
148_F168_W1.6301.00
21_V60_Y1.6141.00
50_L96_F1.5741.00
4_I93_G1.5661.00
62_Q79_E1.5541.00
128_E209_N1.5121.00
32_P35_Y1.4881.00
60_Y63_R1.4731.00
199_S202_Q1.4661.00
122_H126_R1.4561.00
76_E96_F1.4541.00
118_P121_R1.4521.00
25_L60_Y1.4221.00
50_L78_A1.4091.00
88_Q92_I1.4091.00
146_V154_A1.4021.00
230_L234_S1.3791.00
215_L218_G1.3381.00
134_G146_V1.3201.00
179_K182_E1.3171.00
97_L102_S1.3171.00
130_A176_Y1.3061.00
115_G118_P1.3041.00
91_I185_K1.2921.00
121_R125_A1.2871.00
153_R209_N1.2821.00
226_T229_S1.2821.00
147_E158_E1.2711.00
102_S178_S1.2711.00
49_I73_I1.2651.00
119_K133_F1.2621.00
66_G77_Y1.2581.00
88_Q91_I1.2481.00
176_Y201_N1.2481.00
186_Q203_M1.2411.00
224_T233_A1.2361.00
101_P178_S1.2351.00
183_Y200_I1.2341.00
186_Q207_A1.2131.00
112_F240_V1.2111.00
118_P122_H1.1921.00
183_Y186_Q1.1861.00
129_G209_N1.1821.00
158_E165_K1.1801.00
103_C175_F1.1751.00
189_P195_L1.1641.00
231_I235_T1.1581.00
182_E186_Q1.1571.00
62_Q77_Y1.1351.00
134_G168_W1.1321.00
222_L236_F1.1281.00
119_K175_F1.1221.00
50_L93_G1.1211.00
100_E178_S1.1191.00
10_S83_P1.1101.00
31_K36_Y1.1031.00
34_I65_L1.0941.00
53_T62_Q1.0911.00
106_L172_G1.0871.00
25_L64_L1.0871.00
46_I103_C1.0841.00
182_E185_K1.0821.00
33_M224_T1.0721.00
229_S232_E1.0661.00
68_G71_F1.0661.00
14_L26_L1.0581.00
219_F236_F1.0541.00
53_T61_F1.0501.00
191_E194_E1.0431.00
35_Y68_G1.0381.00
101_P175_F1.0361.00
42_M73_I1.0361.00
50_L76_E1.0351.00
141_E160_K1.0311.00
53_T79_E1.0301.00
148_F152_F1.0231.00
8_G52_I1.0161.00
39_S42_M1.0161.00
104_L176_Y1.0051.00
56_E60_Y0.9891.00
228_D232_E0.9831.00
32_P64_L0.9771.00
189_P194_E0.9741.00
34_I51_I0.9721.00
59_G62_Q0.9571.00
152_F214_L0.9501.00
235_T238_Q0.9491.00
53_T77_Y0.9461.00
103_C120_L0.9381.00
231_I234_S0.9301.00
144_G159_E0.9271.00
34_I61_F0.9251.00
121_R124_A0.9231.00
91_I184_A0.9211.00
94_E181_V0.9161.00
38_L65_L0.9141.00
148_F212_V0.9081.00
200_I203_M0.8991.00
27_P32_P0.8961.00
24_Q107_G0.8911.00
222_L233_A0.8841.00
54_T57_D0.8811.00
44_A117_S0.8771.00
14_L18_T0.8771.00
29_Y234_S0.8721.00
156_S163_Q0.8651.00
170_V174_Y0.8611.00
145_V169_A0.8471.00
33_M37_P0.8421.00
127_T177_D0.8411.00
232_E235_T0.8391.00
123_V177_D0.8391.00
201_N210_L0.8381.00
4_I102_S0.8381.00
22_S60_Y0.8371.00
142_R229_S0.8311.00
40_V44_A0.8291.00
6_L106_L0.8251.00
236_F239_T0.8251.00
190_S193_G0.8221.00
109_N221_W0.8221.00
232_E236_F0.8181.00
122_H211_T0.8171.00
123_V175_F0.8161.00
164_P167_N0.8111.00
36_Y237_V0.8081.00
18_T26_L0.8081.00
62_Q66_G0.8081.00
78_A96_F0.8041.00
211_T214_L0.8031.00
42_M49_I0.7991.00
5_I107_G0.7981.00
234_S238_Q0.7951.00
51_I75_L0.7941.00
192_R195_L0.7941.00
81_P84_D0.7931.00
155_I158_E0.7911.00
43_L117_S0.7891.00
130_A210_L0.7871.00
65_L75_L0.7871.00
152_F155_I0.7851.00
63_R66_G0.7831.00
31_K35_Y0.7811.00
120_L124_A0.7771.00
17_I227_H0.7771.00
191_E195_L0.7771.00
42_M47_R0.7731.00
179_K183_Y0.7731.00
120_L175_F0.7721.00
69_S73_I0.7651.00
29_Y36_Y0.7641.00
39_S71_F0.7641.00
38_L75_L0.7641.00
47_R74_Q0.7631.00
56_E59_G0.7621.00
26_L230_L0.7621.00
237_V241_E0.7531.00
141_E162_K0.7531.00
96_F99_G0.7511.00
179_K209_N0.7431.00
98_N178_S0.7421.00
36_Y39_S0.7411.00
189_P192_R0.7391.00
51_I65_L0.7371.00
129_G179_K0.7341.00
130_A204_Y0.7321.00
142_R160_K0.7271.00
30_D36_Y0.7261.00
131_T135_Y0.7241.00
134_G137_V0.7231.00
238_Q242_K0.7201.00
194_E198_T0.7201.00
187_V203_M0.7201.00
128_E153_R0.7181.00
46_I120_L0.7161.00
209_N212_V0.7121.00
105_V116_F0.7111.00
86_L106_L0.7111.00
4_I52_I0.7071.00
130_A201_N0.6991.00
97_L181_V0.6981.00
180_V204_Y0.6961.00
198_T202_Q0.6951.00
183_Y209_N0.6921.00
4_I50_L0.6911.00
52_I89_A0.6911.00
119_K131_T0.6891.00
157_L170_V0.6881.00
13_R23_K0.6841.00
39_S68_G0.6821.00
11_G23_K0.6791.00
91_I195_L0.6761.00
78_A93_G0.6731.00
53_T57_D0.6731.00
142_R226_T0.6721.00
158_E161_P0.6691.00
17_I21_V0.6641.00
90_F180_V0.6631.00
110_I233_A0.6631.00
130_A134_G0.6621.00
38_L51_I0.6591.00
95_T98_N0.6571.00
35_Y65_L0.6511.00
132_V146_V0.6501.00
235_T239_T0.6481.00
187_V200_I0.6461.00
32_P36_Y0.6461.00
179_K207_A0.6451.00
27_P30_D0.6431.00
147_E165_K0.6431.00
236_F240_V0.6421.00
122_H125_A0.6391.00
136_Q168_W0.6381.00
119_K213_E0.6381.00
188_K194_E0.6341.00
111_F171_T0.6341.00
186_Q210_L0.6331.00
106_L109_N0.6291.00
75_L79_E0.6261.00
75_L80_Q0.6261.00
131_T211_T0.6251.00
126_R131_T0.6251.00
17_I26_L0.6251.00
239_T243_R0.6221.00
41_L103_C0.6221.00
178_S181_V0.6181.00
3_G49_I0.6161.00
52_I78_A0.6141.00
53_T59_G0.6131.00
183_Y204_Y0.6131.00
111_F173_L0.6121.00
40_V173_L0.6111.00
228_D242_K0.6101.00
94_E102_S0.6081.00
6_L86_L0.6071.00
241_E244_Q0.6051.00
25_L61_F0.6051.00
83_P88_Q0.6021.00
154_A157_L0.6001.00
114_Q117_S0.5981.00
184_A187_V0.5971.00
52_I93_G0.5961.00
85_G199_S0.5941.00
187_V195_L0.5941.00
38_L42_M0.5811.00
190_S194_E0.5811.00
179_K208_G0.5811.00
232_E242_K0.5801.00
188_K195_L0.5791.00
227_H231_I0.5771.00
36_Y40_V0.5741.00
77_Y80_Q0.5731.00
231_I238_Q0.5731.00
135_Y171_T0.5731.00
28_I234_S0.5721.00
37_P40_V0.5721.00
80_Q83_P0.5701.00
187_V199_S0.5701.00
5_I105_V0.5701.00
39_S43_L0.5691.00
228_D243_R0.5691.00
171_T221_W0.5641.00
5_I37_P0.5631.00
137_V140_P0.5611.00
132_V136_Q0.5611.00
80_Q89_A0.5601.00
231_I236_F0.5601.00
105_V173_L0.5601.00
94_E98_N0.5591.00
76_E80_Q0.5591.00
17_I20_G0.5591.00
129_G133_F0.5591.00
192_R196_E0.5581.00
135_Y169_A0.5571.00
37_P105_V0.5561.00
195_L198_T0.5541.00
74_Q80_Q0.5521.00
76_E79_E0.5521.00
7_A34_I0.5511.00
116_F119_K0.5511.00
88_Q195_L0.5511.00
6_L89_A0.5461.00
23_K108_D0.5441.00
120_L123_V0.5441.00
42_M74_Q0.5401.00
182_E207_A0.5391.00
82_S88_Q0.5381.00
4_I90_F0.5331.00
133_F137_V0.5321.00
132_V137_V0.5301.00
103_C116_F0.5261.00
156_S206_E0.5261.00
143_F223_D0.5261.00
199_S203_M0.5231.00
163_Q166_S0.5221.00
94_E182_E0.5181.00
86_L170_V0.5171.00
90_F181_V0.5161.00
188_K191_E0.5161.00
149_D152_F0.5131.00
135_Y221_W0.5111.00
73_I76_E0.5111.00
24_Q61_F0.5091.00
41_L46_I0.5091.00
183_Y187_V0.5061.00
58_K61_F0.5061.00
54_T83_P0.5041.00
222_L229_S0.5041.00
184_A195_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mc3A 3 0.9898 100 0.32 Contact Map
1lvwA 3 0.9966 100 0.325 Contact Map
4ho4A 3 1 100 0.331 Contact Map
1iimA 3 0.9761 100 0.34 Contact Map
3jukA 3 0.8055 100 0.372 Contact Map
2e3dA 3 0.8601 100 0.379 Contact Map
3brkX 2 0.9454 100 0.385 Contact Map
2ux8A 4 0.8635 100 0.387 Contact Map
2ggoA 3 0.942 100 0.392 Contact Map
1yp2A 4 0.959 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.