GREMLIN Database
RISB - 6,7-dimethyl-8-ribityllumazine synthase
UniProt: P61714 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11322
Length: 156 (143)
Sequences: 3246 (1642)
Seq/√Len: 137.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_H107_D3.4101.00
75_A144_A3.2331.00
16_A67_L3.0811.00
50_T73_Y2.6741.00
31_L51_V2.5451.00
37_A138_A2.3261.00
19_I31_L2.2781.00
10_T44_V2.1701.00
13_A148_I2.1571.00
52_V67_L2.0561.00
64_A78_A2.0461.00
65_G107_D2.0351.00
69_K109_E1.9131.00
25_F126_I1.8611.00
35_I39_K1.8441.00
78_A101_L1.8241.00
84_R120_E1.8231.00
37_A142_L1.7961.00
96_G99_N1.7711.00
136_K139_E1.7571.00
60_L116_V1.7431.00
39_K46_D1.7411.00
24_N28_D1.7261.00
86_G127_E1.7181.00
65_G69_K1.7041.00
12_D48_N1.6941.00
21_R146_E1.6941.00
99_N103_H1.6391.00
62_L151_L1.5941.00
38_L44_V1.5771.00
25_F122_I1.5581.00
113_A143_T1.5541.00
13_A152_K1.5511.00
97_A116_V1.4751.00
15_V148_I1.4591.00
88_A91_E1.4461.00
28_D53_W1.4231.00
82_V93_V1.4181.00
66_A109_E1.4091.00
65_G106_Q1.4071.00
123_E127_E1.3991.00
62_L105_A1.3901.00
29_S32_E1.3751.00
16_A73_Y1.3751.00
58_Y114_F1.3661.00
18_T64_A1.3181.00
91_E94_A1.2931.00
19_I51_V1.2771.00
120_E124_Q1.2671.00
14_R48_N1.2601.00
26_I81_T1.2581.00
88_A92_Y1.2531.00
41_I145_L1.2461.00
68_A108_S1.1981.00
129_A135_N1.1891.00
54_V63_A1.1610.99
35_I49_I1.1460.99
66_A151_L1.1330.99
18_T60_L1.1320.99
95_G99_N1.1300.99
82_V94_A1.1260.99
90_F94_A1.1200.99
113_A140_A1.1080.99
68_A110_I1.0930.99
63_A151_L1.0790.99
20_A27_N1.0740.99
97_A114_F1.0700.99
19_I27_N1.0690.99
68_A76_V1.0560.99
65_G109_E1.0550.99
37_A40_R1.0510.99
127_E131_T1.0480.99
38_L77_I1.0420.99
92_Y95_G1.0410.99
38_L141_A1.0400.99
61_P100_G1.0360.99
70_T73_Y1.0240.99
88_A120_E1.0200.99
15_V38_L1.0040.98
83_I122_I0.9840.98
69_K108_S0.9770.98
122_I131_T0.9730.98
65_G108_S0.9670.98
79_L115_G0.9590.98
64_A76_V0.9580.98
37_A41_I0.9530.98
15_V144_A0.9480.98
26_I126_I0.9480.98
144_A148_I0.9250.97
115_G140_A0.9250.97
55_P147_M0.9240.97
36_D40_R0.9210.97
84_R88_A0.9010.97
28_D32_E0.9010.97
113_A144_A0.8980.97
102_A105_A0.8980.97
31_L35_I0.8950.97
32_E36_D0.8920.97
61_P102_A0.8600.96
31_L53_W0.8560.96
24_N53_W0.8550.96
138_A142_L0.8530.96
35_I51_V0.8480.95
23_N81_T0.8470.95
68_A104_V0.8420.95
104_V112_V0.8340.95
32_E35_I0.8320.95
39_K49_I0.8300.95
90_F120_E0.8250.95
98_S114_F0.8190.94
19_I53_W0.8190.94
16_A52_V0.8100.94
10_T13_A0.8070.94
122_I126_I0.7970.94
50_T72_K0.7910.93
17_I31_L0.7800.93
26_I122_I0.7720.93
76_V110_I0.7600.92
100_G104_V0.7540.92
64_A101_L0.7480.91
30_L33_G0.7480.91
119_T125_A0.7430.91
23_N27_N0.7400.91
62_L104_V0.7370.91
58_Y98_S0.7340.91
69_K107_D0.7290.90
60_L78_A0.7260.90
103_H106_Q0.7260.90
35_I46_D0.7180.90
27_N81_T0.7090.89
100_G106_Q0.7090.89
58_Y92_Y0.7070.89
86_G131_T0.6980.88
66_A69_K0.6970.88
20_A60_L0.6960.88
62_L66_A0.6960.88
126_I131_T0.6960.88
55_P146_E0.6910.88
44_V145_L0.6900.88
60_L101_L0.6860.87
149_N153_A0.6810.87
15_V75_A0.6740.86
75_A113_A0.6720.86
147_M150_V0.6670.86
15_V44_V0.6640.86
13_A16_A0.6620.85
17_I34_A0.6560.85
13_A149_N0.6520.85
140_A143_T0.6510.84
67_L73_Y0.6510.84
9_A149_N0.6480.84
89_H128_R0.6470.84
75_A148_I0.6430.84
14_R71_G0.6420.84
95_G98_S0.6330.83
63_A147_M0.6320.83
60_L97_A0.6290.82
62_L65_G0.6220.82
147_M151_L0.6190.81
10_T15_V0.6170.81
92_Y114_F0.6150.81
136_K140_A0.6130.81
76_V111_P0.6080.80
52_V63_A0.6080.80
21_R28_D0.6070.80
19_I79_L0.6010.79
74_D152_K0.6010.79
18_T76_V0.5910.78
29_S131_T0.5860.78
72_K110_I0.5850.78
125_A128_R0.5840.78
14_R72_K0.5840.78
90_F117_L0.5770.77
62_L106_Q0.5760.77
13_A74_D0.5750.76
71_G110_I0.5750.76
37_A145_L0.5720.76
86_G98_S0.5670.75
88_A94_A0.5610.75
33_G137_G0.5600.75
87_T128_R0.5600.75
33_G115_G0.5600.75
96_G100_G0.5590.74
84_R91_E0.5560.74
9_A12_D0.5540.74
86_G122_I0.5510.73
121_S124_Q0.5490.73
33_G135_N0.5470.73
126_I129_A0.5430.72
131_T134_G0.5430.72
29_S129_A0.5420.72
130_G134_G0.5350.71
127_E132_K0.5330.71
40_R138_A0.5300.70
123_E126_I0.5280.70
62_L147_M0.5280.70
64_A104_V0.5250.70
26_I129_A0.5250.70
26_I125_A0.5210.69
20_A119_T0.5180.69
68_A71_G0.5160.68
146_E150_V0.5110.68
36_D138_A0.5100.68
70_T110_I0.5080.67
58_Y93_V0.5070.67
58_Y102_A0.5050.67
18_T67_L0.5040.67
15_V77_I0.5030.67
11_P47_E0.5030.67
57_A82_V0.5030.67
15_V141_A0.5020.66
130_G133_A0.5020.66
122_I127_E0.5000.66
12_D152_K0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hqkA 6 0.9872 100 0.046 Contact Map
1rvvA 6 0.9872 100 0.048 Contact Map
3nq4A 6 0.9872 100 0.054 Contact Map
1c2yA 6 0.9808 100 0.061 Contact Map
1kz1A 5 0.9295 100 0.073 Contact Map
2obxA 4 0.9487 100 0.077 Contact Map
1di0A 5 0.9295 100 0.08 Contact Map
1ejbA 3 0.9872 100 0.09 Contact Map
2i0fA 3 0.9103 100 0.091 Contact Map
1c41A 6 0.9744 100 0.094 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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