GREMLIN Database
CAN - Carbonic anhydrase 2
UniProt: P61517 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12319
Length: 220 (188)
Sequences: 4072 (2498)
Seq/√Len: 182.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_V178_G4.5811.00
159_G168_W3.9681.00
36_R91_E3.9401.00
170_R173_K3.8911.00
155_V178_G3.0571.00
67_A103_G2.9471.00
5_D9_S2.7421.00
155_V176_I2.6451.00
165_Q169_K2.5961.00
38_L81_V2.4011.00
92_H177_H2.3031.00
82_Q86_D2.2311.00
105_Q109_E2.1821.00
66_V80_V2.1721.00
105_Q143_L2.1701.00
99_Y180_A2.1461.00
148_E189_R2.1301.00
166_S170_R2.1131.00
147_C180_A2.0311.00
33_Q45_S2.0091.00
8_I190_D1.9771.00
43_S61_F1.9391.00
9_S13_L1.8751.00
91_E173_K1.8491.00
179_W188_L1.8481.00
13_L54_G1.8291.00
85_V164_M1.7741.00
182_G189_R1.7531.00
84_A90_V1.7461.00
78_L161_S1.7431.00
85_V167_A1.7351.00
12_A16_K1.7121.00
53_T60_L1.6951.00
167_A173_K1.6451.00
89_E167_A1.6451.00
12_A187_L1.6011.00
83_Y87_V1.5861.00
38_L90_V1.5681.00
25_F28_K1.5591.00
148_E180_A1.5221.00
69_L123_I1.5211.00
159_G176_I1.5021.00
38_L80_V1.4981.00
33_Q102_G1.4621.00
9_S12_A1.4501.00
108_V146_L1.4421.00
63_H80_V1.4291.00
182_G185_D1.4151.00
149_L152_M1.3901.00
100_G184_H1.3791.00
151_V155_V1.3781.00
10_N54_G1.3781.00
92_H175_T1.3631.00
81_V158_L1.3631.00
65_N68_N1.3351.00
68_N150_N1.3231.00
157_N160_H1.3041.00
32_A100_G1.3011.00
107_A123_I1.2801.00
104_V123_I1.2791.00
126_I153_E1.2561.00
38_L93_I1.2491.00
13_L17_M1.2451.00
99_Y182_G1.2181.00
70_V77_C1.1731.00
121_L124_R1.1711.00
85_V90_V1.1671.00
130_H149_L1.1591.00
94_I179_W1.1591.00
124_R127_W1.1501.00
167_A174_V1.1501.00
164_M174_V1.1441.00
144_D148_E1.1421.00
83_Y102_G1.1391.00
140_E144_D1.1131.00
39_W96_C1.0971.00
109_E139_Q1.0951.00
96_C179_W1.0921.00
179_W190_D1.0911.00
100_G105_Q1.0901.00
11_N15_S1.0661.00
24_G27_E1.0641.00
87_V113_L1.0210.99
152_M191_L1.0200.99
41_G47_V0.9890.99
40_I81_V0.9780.99
53_T179_W0.9780.99
43_S88_L0.9770.99
185_D189_R0.9710.99
66_V103_G0.9680.99
108_V143_L0.9680.99
75_L118_N0.9630.99
86_D166_S0.9580.99
134_L137_M0.9570.99
143_L147_C0.9480.99
190_D193_V0.9460.99
129_K149_L0.9460.99
77_C81_V0.9460.99
153_E156_Y0.9250.99
6_T10_N0.9220.99
122_H125_D0.9140.99
112_E120_L0.9130.99
43_S63_H0.9120.99
22_D56_E0.9080.99
41_G96_C0.9080.99
50_E60_L0.9060.99
32_A45_S0.9050.99
30_A100_G0.9030.99
55_L60_L0.8990.99
22_D28_K0.8950.99
34_K89_E0.8930.99
110_N124_R0.8920.99
139_Q142_R0.8840.99
50_E55_L0.8780.98
150_N154_Q0.8750.98
124_R128_F0.8740.98
10_N14_W0.8650.98
70_V154_Q0.8630.98
104_V147_C0.8620.98
24_G28_K0.8610.98
10_N13_L0.8480.98
139_Q143_L0.8480.98
7_L53_T0.8440.98
39_W53_T0.8430.98
134_L145_T0.8420.98
152_M178_G0.8380.98
87_V116_I0.8360.98
17_M21_E0.8330.98
104_V146_L0.8290.98
112_E117_N0.8250.98
149_L153_E0.8240.98
8_I188_L0.8210.98
48_P52_L0.8110.97
140_E145_T0.7970.97
4_I92_H0.7970.97
113_L117_N0.7940.97
85_V93_I0.7810.97
138_P141_R0.7800.97
45_S102_G0.7760.97
75_L115_L0.7720.97
27_E30_A0.7720.97
61_F102_G0.7690.96
68_N154_Q0.7660.96
123_I126_I0.7610.96
86_D167_A0.7600.96
33_Q61_F0.7600.96
50_E62_V0.7600.96
63_H77_C0.7600.96
48_P62_V0.7540.96
97_G151_V0.7520.96
102_G116_I0.7510.96
136_E139_Q0.7500.96
128_F131_S0.7500.96
72_H122_H0.7460.96
17_M54_G0.7450.96
141_R145_T0.7440.96
70_V78_L0.7420.96
22_D25_F0.7420.96
113_L116_I0.7390.96
18_L51_R0.7390.96
53_T96_C0.7310.95
86_D163_I0.7280.95
114_G117_N0.7270.95
156_Y159_G0.7230.95
105_Q108_V0.7200.95
25_F29_L0.7180.95
158_L164_M0.7100.95
145_T149_L0.7090.94
43_S83_Y0.7070.94
151_V180_A0.7020.94
167_A170_R0.7020.94
112_E166_S0.7020.94
76_N79_S0.6990.94
15_S19_V0.6990.94
108_V142_R0.6980.94
141_R144_D0.6980.94
49_A57_P0.6950.94
132_S135_G0.6930.94
37_F91_E0.6910.94
15_S187_L0.6860.93
65_N119_W0.6860.93
55_L59_E0.6830.93
49_A62_V0.6810.93
144_D180_A0.6800.93
122_H126_I0.6790.93
19_V24_G0.6780.93
40_I70_V0.6750.93
41_G81_V0.6720.93
82_Q115_L0.6720.93
144_D147_C0.6720.93
137_M142_R0.6670.93
144_D182_G0.6640.92
37_F92_H0.6640.92
28_K56_E0.6640.92
145_T148_E0.6540.92
78_L115_L0.6530.92
65_N76_N0.6520.92
7_L39_W0.6510.92
89_E173_K0.6480.91
129_K153_E0.6460.91
142_R146_L0.6430.91
129_K156_Y0.6400.91
74_D114_G0.6370.91
18_L56_E0.6360.91
26_F29_L0.6350.91
6_T36_R0.6330.90
102_G106_A0.6310.90
158_L176_I0.6310.90
83_Y88_L0.6170.89
115_L118_N0.6170.89
110_N114_G0.6090.89
180_A189_R0.6060.88
37_F82_Q0.6060.88
26_F183_I0.6030.88
82_Q186_G0.6010.88
168_W175_T0.6010.88
99_Y183_I0.6010.88
86_D112_E0.6000.88
37_F94_I0.5990.88
162_T165_Q0.5950.88
164_M167_A0.5950.88
104_V107_A0.5950.88
85_V174_V0.5940.87
36_R55_L0.5870.87
108_V127_W0.5820.86
122_H157_N0.5810.86
8_I94_I0.5780.86
68_N97_G0.5770.86
41_G49_A0.5770.86
94_I190_D0.5740.86
144_D184_H0.5740.86
123_I127_W0.5730.86
177_H190_D0.5730.86
37_F60_L0.5700.85
83_Y105_Q0.5670.85
132_S136_E0.5670.85
28_K31_Q0.5620.84
76_N90_V0.5600.84
62_V65_N0.5570.84
118_N121_L0.5530.83
100_G140_E0.5520.83
107_A127_W0.5510.83
76_N119_W0.5490.83
155_V159_G0.5490.83
61_F84_A0.5490.83
107_A146_L0.5480.83
42_C101_C0.5470.83
106_A116_I0.5470.83
159_G165_Q0.5440.82
30_A183_I0.5430.82
83_Y116_I0.5430.82
49_A60_L0.5430.82
176_I193_V0.5430.82
51_R57_P0.5420.82
39_W49_A0.5410.82
118_N122_H0.5400.82
66_V79_S0.5390.82
94_I177_H0.5390.82
65_N77_C0.5370.82
131_S135_G0.5360.82
42_C98_H0.5300.81
116_I162_T0.5300.81
52_L188_L0.5280.81
11_N188_L0.5280.81
96_C181_Y0.5260.80
122_H153_E0.5260.80
134_L142_R0.5210.80
6_T55_L0.5200.80
93_I164_M0.5200.80
38_L84_A0.5190.79
40_I49_A0.5170.79
10_N193_V0.5100.78
131_S142_R0.5080.78
162_T166_S0.5080.78
26_F57_P0.5070.78
69_L126_I0.5060.78
95_I154_Q0.5060.78
75_L114_G0.5050.78
73_T162_T0.5040.77
70_V157_N0.5040.77
78_L158_L0.5030.77
41_G48_P0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qy1A 4 0.9818 100 0.152 Contact Map
1ddzA 2 1 100 0.156 Contact Map
4rxyA 4 0.9455 100 0.162 Contact Map
3e3iA 6 0.9636 100 0.163 Contact Map
4o1kA 4 0.9455 100 0.173 Contact Map
2w3qA 2 0.8545 100 0.179 Contact Map
3ucjA 4 0.9864 100 0.18 Contact Map
4o1jA 4 0.8864 100 0.187 Contact Map
1ekjA 5 0.9182 100 0.19 Contact Map
3eyxA 2 0.8591 100 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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