GREMLIN Database
LOLB - Outer-membrane lipoprotein LolB
UniProt: P61320 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11293
Length: 207 (187)
Sequences: 807 (604)
Seq/√Len: 44.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_D156_R5.8421.00
137_Q145_D5.0351.00
75_Q81_Y4.8801.00
87_N93_E3.3601.00
54_T71_F2.8451.00
117_D120_E2.7101.00
81_Y98_A2.6501.00
104_Q114_T2.3411.00
87_N92_T2.3331.00
104_Q112_R2.2991.00
113_Y125_L2.2811.00
119_E133_N2.2521.00
99_Q102_N2.1991.00
84_L95_E2.0230.99
39_W151_L2.0100.99
80_R99_Q1.9910.99
159_E170_K1.9760.99
59_A198_K1.9740.99
149_Y157_L1.9280.99
14_L20_T1.9150.99
97_N106_V1.8770.99
157_L176_Y1.8570.99
59_A68_Y1.8450.99
39_W143_P1.7770.98
145_D166_G1.7650.98
54_T139_I1.7590.98
57_A202_D1.7520.98
83_L96_L1.7390.98
98_A118_A1.6900.98
58_F177_D1.6870.98
123_G129_P1.6640.97
160_I173_Y1.6630.97
175_G186_A1.6590.97
111_Q198_K1.6500.97
52_Y65_Q1.6300.97
39_W42_H1.6180.97
60_Y128_M1.6170.97
159_E172_V1.5710.96
63_D66_K1.5600.96
98_A103_V1.5480.96
57_A68_Y1.5300.96
189_E198_K1.4550.94
115_A121_M1.4460.94
138_W169_W1.4400.94
107_D111_Q1.4300.94
73_W138_W1.4220.93
115_A120_E1.4080.93
196_R199_L1.3890.93
82_R97_N1.3880.93
56_G71_F1.3860.93
160_I176_Y1.3780.92
59_A189_E1.3430.91
14_L17_L1.3190.91
94_L126_T1.2990.90
42_H46_V1.2940.90
88_P126_T1.2930.90
75_Q128_M1.2640.89
150_K159_E1.2610.88
75_Q98_A1.2460.88
110_G198_K1.2310.87
85_L126_T1.2190.87
105_L115_A1.2140.86
69_A87_N1.2110.86
52_Y71_F1.1980.86
87_N90_G1.1950.86
148_D161_T1.1920.85
81_Y199_L1.1850.85
57_A70_R1.1750.85
192_D195_Q1.1660.84
179_K182_P1.1470.83
57_A86_T1.1380.83
115_A133_N1.1360.83
12_L15_A1.1350.82
73_W169_W1.1300.82
189_E196_R1.1290.82
42_H176_Y1.1280.82
119_E129_P1.1180.81
67_V93_E1.1100.81
57_A88_P1.0900.80
117_D199_L1.0840.79
15_A18_V1.0760.79
187_N200_K1.0740.79
61_I198_K1.0660.78
42_H143_P1.0570.78
14_L23_S1.0480.77
11_L14_L1.0390.76
118_A132_L1.0290.76
171_V190_L1.0280.76
9_I13_P1.0280.76
57_A168_N1.0240.75
122_I156_R1.0160.75
16_A193_G1.0140.75
21_A35_D1.0040.74
24_V28_K0.9970.73
59_A92_T0.9830.72
140_L197_I0.9730.72
55_R203_N0.9730.72
158_S201_M0.9660.71
62_S118_A0.9480.70
141_G185_P0.9470.69
126_T195_Q0.9460.69
21_A156_R0.9460.69
21_A132_L0.9410.69
107_D128_M0.9300.68
24_V83_L0.9150.67
134_S144_G0.9070.66
44_Q48_N0.9040.66
9_I12_L0.9030.66
40_R145_D0.9010.66
57_A90_G0.8930.65
89_L92_T0.8910.65
185_P204_W0.8830.64
20_T183_A0.8760.63
42_H157_L0.8700.63
67_V126_T0.8640.62
23_S105_L0.8630.62
67_V87_N0.8620.62
59_A115_A0.8610.62
52_Y204_W0.8560.62
79_D186_A0.8560.62
64_Q193_G0.8560.62
98_A139_I0.8540.61
25_T135_L0.8480.61
122_I129_P0.8450.61
87_N113_Y0.8300.59
21_A64_Q0.8230.59
70_R202_D0.8200.58
67_V75_Q0.8010.56
61_I66_K0.7990.56
58_F197_I0.7980.56
96_L107_D0.7970.56
172_V191_T0.7960.56
123_G126_T0.7950.56
111_Q176_Y0.7930.56
102_N114_T0.7930.56
173_Y204_W0.7910.56
48_N194_G0.7890.55
166_G199_L0.7850.55
104_Q132_L0.7830.55
23_S91_S0.7800.54
24_V76_T0.7800.54
126_T132_L0.7780.54
174_G187_N0.7770.54
63_D194_G0.7700.54
110_G130_I0.7700.54
15_A100_P0.7670.53
81_Y103_V0.7640.53
59_A87_N0.7630.53
103_V118_A0.7570.52
161_T170_K0.7500.52
108_N134_S0.7490.52
11_L153_D0.7430.51
45_D182_P0.7380.50
101_G194_G0.7380.50
61_I196_R0.7370.50
116_D145_D0.7350.50
140_L166_G0.7330.50
79_D172_V0.7320.50
39_W43_Q0.7240.49
49_L157_L0.7240.49
120_E201_M0.7220.49
20_T182_P0.7180.49
97_N104_Q0.7170.48
137_Q144_G0.7150.48
102_N115_A0.7140.48
12_L80_R0.7130.48
75_Q140_L0.7090.48
190_L197_I0.7060.47
44_Q129_P0.7050.47
81_Y93_E0.7000.47
10_R194_G0.6900.46
12_L21_A0.6880.46
85_L125_L0.6860.45
104_Q143_P0.6820.45
157_L160_I0.6790.45
128_M176_Y0.6770.45
108_N112_R0.6730.44
60_Y89_L0.6730.44
79_D181_Q0.6730.44
59_A202_D0.6720.44
13_P44_Q0.6720.44
137_Q166_G0.6680.44
106_V174_G0.6640.43
120_E124_K0.6610.43
14_L145_D0.6610.43
56_G138_W0.6600.43
54_T201_M0.6580.43
107_D113_Y0.6580.43
83_L142_L0.6520.42
70_R90_G0.6490.42
42_H151_L0.6490.42
13_P16_A0.6490.42
98_A128_M0.6480.42
11_L17_L0.6460.42
21_A169_W0.6400.41
52_Y166_G0.6390.41
21_A167_K0.6350.41
95_E139_I0.6330.40
143_P176_Y0.6330.40
77_G186_A0.6310.40
75_Q79_D0.6310.40
173_Y190_L0.6270.40
81_Y128_M0.6240.40
47_R104_Q0.6230.40
23_S107_D0.6180.39
62_S65_Q0.6170.39
87_N117_D0.6170.39
18_V77_G0.6150.39
16_A21_A0.6110.38
81_Y132_L0.6110.38
140_L199_L0.6100.38
21_A43_Q0.6090.38
52_Y139_I0.6080.38
51_Q119_E0.6010.38
57_A155_Y0.5990.37
136_R157_L0.5990.37
12_L150_K0.5960.37
95_E106_V0.5950.37
21_A66_K0.5920.37
26_T203_N0.5900.37
11_L79_D0.5870.36
20_T77_G0.5800.36
70_R87_N0.5780.35
144_G166_G0.5770.35
40_R46_V0.5750.35
184_M204_W0.5730.35
145_D168_N0.5720.35
63_D68_Y0.5700.35
132_L193_G0.5670.34
23_S181_Q0.5640.34
16_A76_T0.5640.34
113_Y124_K0.5630.34
17_L96_L0.5630.34
60_Y98_A0.5590.34
124_K181_Q0.5580.34
102_N150_K0.5570.34
71_F183_A0.5550.33
96_L142_L0.5540.33
155_Y195_Q0.5540.33
81_Y118_A0.5530.33
23_S203_N0.5510.33
18_V146_A0.5500.33
9_I129_P0.5450.33
52_Y87_N0.5430.32
147_T160_I0.5430.32
79_D100_P0.5420.32
43_Q49_L0.5420.32
11_L18_V0.5410.32
107_D110_G0.5390.32
66_K94_L0.5390.32
75_Q188_M0.5370.32
42_H183_A0.5370.32
72_F188_M0.5360.32
59_A200_K0.5350.32
71_F98_A0.5350.32
58_F69_A0.5330.32
16_A99_Q0.5330.32
79_D116_D0.5330.32
66_K139_I0.5320.32
183_A191_T0.5290.31
85_L176_Y0.5270.31
81_Y94_L0.5270.31
19_L197_I0.5260.31
43_Q46_V0.5240.31
87_N139_I0.5240.31
77_G144_G0.5240.31
47_R188_M0.5230.31
137_Q146_A0.5220.31
10_R13_P0.5220.31
94_L125_L0.5180.30
170_K201_M0.5170.30
122_I126_T0.5150.30
75_Q96_L0.5140.30
52_Y132_L0.5130.30
50_N114_T0.5130.30
137_Q142_L0.5110.30
146_A150_K0.5080.30
199_L202_D0.5030.29
52_Y107_D0.5030.29
95_E101_G0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wjtA 1 0.8454 100 0.232 Contact Map
3zbiC 1 0.1353 73.2 0.926 Contact Map
1fftB 1 0.6715 70.6 0.928 Contact Map
4jg9A 2 0.6329 44.8 0.938 Contact Map
3buuA 1 0.8261 37.2 0.941 Contact Map
4qa8A 1 0.8406 30 0.944 Contact Map
2q1fA 1 0.6957 23.8 0.947 Contact Map
4immA 1 0.5362 17.9 0.95 Contact Map
3mh9C 1 0.8454 16 0.951 Contact Map
1iwlA 1 0.7198 12.8 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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