GREMLIN Database
LOLA - Outer-membrane lipoprotein carrier protein
UniProt: P61316 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12684
Length: 203 (185)
Sequences: 1762 (1406)
Seq/√Len: 103.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_K185_A5.5561.00
40_S177_S4.9701.00
38_H178_Q3.3001.00
183_V187_K3.2801.00
18_S21_A3.2691.00
69_N79_I3.1291.00
36_S180_N3.0331.00
86_T99_A3.0111.00
39_A60_L2.8481.00
135_V147_Q2.4821.00
184_D187_K2.3651.00
88_W190_F2.3321.00
63_K67_L2.2971.00
71_H79_I2.2891.00
133_D151_N2.1921.00
61_W187_K2.1011.00
82_S102_L2.0051.00
88_W97_A1.9861.00
25_S29_S1.9751.00
83_D189_T1.9611.00
44_K174_Q1.9301.00
160_Q172_S1.9291.00
80_L89_F1.8841.00
57_Q74_Q1.8711.00
61_W183_V1.8661.00
128_K135_V1.8221.00
135_V149_T1.8161.00
152_V158_I1.7761.00
97_A192_P1.7501.00
40_S59_D1.7351.00
71_H77_E1.7181.00
23_A31_L1.6501.00
41_F58_G1.6421.00
147_Q164_V1.6071.00
36_S181_G1.5941.00
17_S20_W1.5821.00
59_D71_H1.5741.00
26_D29_S1.5711.00
17_S21_A1.5581.00
161_F175_L1.5361.00
160_Q174_Q1.5251.00
90_Y190_F1.4861.00
37_F60_L1.4311.00
9_A12_S1.4221.00
10_L13_S1.4181.00
164_V170_R1.3630.99
36_S183_V1.3550.99
90_Y97_A1.3430.99
78_S93_F1.3230.99
88_W192_P1.3090.99
165_E173_Y1.2960.99
87_L102_L1.2940.99
137_T147_Q1.2920.99
162_S172_S1.2730.99
44_K55_E1.2690.99
165_E169_Q1.2500.99
29_S33_K1.2410.99
91_N94_V1.2330.99
34_V179_Q1.2170.99
16_A21_A1.2000.99
38_H61_W1.1990.99
40_S73_T1.1940.99
8_C11_L1.1910.99
29_S32_D1.1810.99
42_T55_E1.1740.98
45_V56_G1.1650.98
130_N135_V1.1610.98
41_F70_W1.1480.98
149_T162_S1.1440.98
14_L21_A1.1040.98
38_H59_D1.1010.98
39_A115_A1.1000.98
126_N137_T1.0920.98
37_F62_V1.0880.97
178_Q181_G1.0860.97
127_I136_L1.0820.97
126_N139_K1.0740.97
149_T164_V1.0650.97
110_P114_I1.0600.97
57_Q73_T1.0480.97
14_L18_S1.0460.97
180_N183_V1.0400.97
90_Y193_P1.0330.97
7_T12_S1.0300.97
40_S57_Q1.0270.96
78_S100_T1.0230.96
109_T113_L1.0080.96
14_L17_S1.0070.96
162_S170_R0.9950.96
36_S182_A0.9920.96
111_F165_E0.9660.95
83_D86_T0.9650.95
64_R109_T0.9590.95
136_L148_F0.9540.95
7_T10_L0.9450.94
154_R159_H0.9350.94
126_N132_D0.9300.94
7_T18_S0.9290.94
34_V134_F0.9280.94
22_D25_S0.9240.94
16_A20_W0.9220.94
79_I187_K0.9160.93
72_M115_A0.9060.93
10_L15_V0.9010.93
76_D93_F0.8960.93
6_I14_L0.8950.93
6_I13_S0.8950.93
154_R157_T0.8940.93
15_V18_S0.8920.92
133_D139_K0.8900.92
69_N187_K0.8890.92
9_A13_S0.8860.92
40_S176_K0.8750.92
111_F158_I0.8720.92
115_A158_I0.8720.92
35_S63_K0.8660.91
39_A96_Q0.8500.91
45_V54_Q0.8460.90
91_N152_V0.8380.90
78_S94_V0.8280.89
125_Y138_P0.8260.89
43_Q72_M0.8230.89
15_V20_W0.8230.89
41_F72_M0.8220.89
30_R34_V0.8210.89
17_S155_D0.8180.89
118_Q136_L0.8180.89
43_Q58_G0.8100.88
45_V169_Q0.8040.88
127_I134_F0.8020.88
143_G146_K0.7940.87
88_W99_A0.7920.87
47_D169_Q0.7880.87
22_D129_Q0.7880.87
42_T57_Q0.7840.87
60_L150_I0.7820.86
30_R72_M0.7820.86
11_L17_S0.7820.86
7_T13_S0.7740.86
24_A122_W0.7730.86
70_W116_R0.7650.85
110_P113_L0.7650.85
97_A190_F0.7630.85
140_A146_K0.7620.85
43_Q70_W0.7510.84
96_Q190_F0.7510.84
111_F115_A0.7500.84
128_K137_T0.7490.84
116_R145_L0.7490.84
8_C13_S0.7460.84
109_T169_Q0.7450.84
31_L134_F0.7450.84
38_H181_G0.7430.84
116_R163_A0.7380.83
82_S136_L0.7380.83
186_A189_T0.7360.83
60_L158_I0.7360.83
9_A16_A0.7330.83
36_S63_K0.7320.83
82_S167_D0.7300.82
9_A17_S0.7300.82
23_A134_F0.7180.81
15_V29_S0.7180.81
60_L64_R0.7160.81
27_L161_F0.7100.81
144_N165_E0.7090.81
23_A129_Q0.7080.81
94_V100_T0.7020.80
7_T16_A0.7010.80
6_I9_A0.6980.80
174_Q194_Q0.6950.79
80_L173_Y0.6930.79
45_V125_Y0.6920.79
72_M171_S0.6850.78
154_R174_Q0.6800.78
14_L189_T0.6780.78
66_N114_I0.6760.77
68_F167_D0.6750.77
121_D165_E0.6720.77
54_Q89_F0.6670.76
35_S180_N0.6600.76
6_I10_L0.6570.75
117_N121_D0.6570.75
109_T165_E0.6530.75
69_N84_G0.6490.74
74_Q95_E0.6430.74
80_L106_T0.6420.74
138_P145_L0.6380.73
11_L14_L0.6380.73
57_Q186_A0.6380.73
27_L136_L0.6370.73
135_V163_A0.6350.73
85_K189_T0.6330.73
30_R156_G0.6320.73
91_N110_P0.6300.72
13_S17_S0.6280.72
137_T194_Q0.6280.72
26_D154_R0.6270.72
68_F90_Y0.6210.71
129_Q134_F0.6210.71
48_G101_W0.6200.71
10_L178_Q0.6200.71
47_D62_V0.6180.71
103_K106_T0.6180.71
64_R158_I0.6170.71
34_V172_S0.6170.71
14_L40_S0.6160.71
82_S161_F0.6150.70
146_K156_G0.6110.70
87_L144_N0.6080.70
31_L152_V0.6070.70
27_L152_V0.6070.70
39_A114_I0.6040.69
124_Q143_G0.6040.69
150_I160_Q0.6030.69
28_K122_W0.5990.68
13_S185_A0.5990.68
46_T53_V0.5970.68
39_A90_Y0.5900.67
6_I11_L0.5890.67
56_G145_L0.5880.67
9_A14_L0.5860.67
10_L17_S0.5850.67
141_S144_N0.5840.67
47_D110_P0.5780.66
15_V19_V0.5760.66
68_F93_F0.5750.65
12_S15_V0.5710.65
96_Q99_A0.5710.65
191_T194_Q0.5690.65
6_I12_S0.5680.64
53_V113_L0.5680.64
26_D134_F0.5650.64
13_S189_T0.5650.64
48_G107_G0.5630.64
112_M134_F0.5580.63
133_D149_T0.5560.63
18_S22_D0.5550.63
62_V115_A0.5530.62
37_F70_W0.5500.62
86_T97_A0.5460.61
42_T176_K0.5450.61
98_T110_P0.5440.61
113_L165_E0.5410.61
15_V22_D0.5410.61
31_L113_L0.5410.61
11_L15_V0.5370.60
190_F193_P0.5350.60
151_N160_Q0.5330.60
25_S28_K0.5280.59
67_L83_D0.5270.59
13_S21_A0.5270.59
52_A166_Q0.5260.59
107_G118_Q0.5260.59
145_L148_F0.5250.58
87_L110_P0.5240.58
23_A128_K0.5210.58
70_W163_A0.5200.58
183_V186_A0.5190.58
70_W125_Y0.5180.57
155_D159_H0.5170.57
68_F78_S0.5160.57
65_P92_P0.5150.57
45_V165_E0.5140.57
112_M169_Q0.5130.57
94_V98_T0.5120.57
148_F163_A0.5120.57
48_G74_Q0.5110.56
39_A89_F0.5090.56
7_T20_W0.5080.56
165_E168_D0.5070.56
81_V192_P0.5060.56
66_N117_N0.5050.56
148_F151_N0.5050.56
68_F72_M0.5030.55
39_A158_I0.5020.55
128_K141_S0.5010.55
47_D51_A0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iwlA 1 0.8719 100 0.249 Contact Map
2w7qA 1 0.9212 100 0.293 Contact Map
4mxtA 2 0.8522 100 0.422 Contact Map
2yzyA 1 0.7291 99.9 0.545 Contact Map
3buuA 1 0.8719 99.8 0.582 Contact Map
3m4wA 2 0.8768 99.4 0.706 Contact Map
3bk5A 1 0.8768 99.4 0.709 Contact Map
4z48A 1 0.8768 99.4 0.714 Contact Map
4jg9A 2 0.5616 73.8 0.915 Contact Map
3a24A 1 0.6108 65.5 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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