GREMLIN Database
RL22 - 50S ribosomal protein L22
UniProt: P61175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10882
Length: 110 (106)
Sequences: 2229 (1040)
Seq/√Len: 101.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_H50_V2.6481.00
48_K52_E2.4871.00
7_H10_A2.4281.00
9_H80_P2.4221.00
21_A76_V2.3801.00
21_A74_I2.2501.00
27_K35_I2.1591.00
29_V55_I2.1531.00
85_I93_A2.1371.00
72_T108_S2.0941.00
37_T48_K2.0411.00
27_K31_Q1.9861.00
22_D25_R1.9701.00
88_R94_D1.9411.00
78_E81_S1.8921.00
24_I51_L1.7961.00
81_S97_L1.7131.00
21_A47_V1.6931.00
42_K46_L1.6581.00
33_L48_K1.6571.00
51_L105_V1.6261.00
51_L55_I1.5891.00
59_E66_I1.5791.00
18_R77_D1.5621.00
85_I94_D1.5571.00
78_E99_R1.5361.00
73_K106_V1.5131.00
81_S99_R1.5021.00
10_A46_L1.4631.00
85_I95_R1.4601.00
75_F104_T1.4431.00
12_S17_V1.4401.00
86_M94_D1.4001.00
28_K31_Q1.3800.99
12_S43_A1.3790.99
17_V103_I1.3760.99
19_L41_K1.3720.99
72_T106_V1.3420.99
33_L55_I1.3280.99
3_T107_V1.3000.99
77_D104_T1.2920.99
74_I105_V1.2870.99
51_L71_V1.2310.99
58_A69_L1.2050.99
61_N64_A1.1920.99
18_R78_E1.1780.98
87_P94_D1.1330.98
50_V103_I1.1050.98
33_L51_L1.0950.97
79_G100_T1.0710.97
33_L52_E1.0610.97
17_V47_V1.0480.97
3_T62_D1.0370.96
79_G102_H1.0210.96
87_P93_A1.0080.96
65_D68_D0.9920.95
47_V74_I0.9910.95
14_A18_R0.9690.95
23_L39_T0.9690.95
24_I74_I0.9620.95
5_A53_S0.9550.94
18_R22_D0.9520.94
6_K77_D0.9350.94
23_L27_K0.9300.93
90_K94_D0.9260.93
50_V107_V0.9150.93
25_R73_K0.9100.93
43_A46_L0.9090.93
15_Q19_L0.9070.93
89_A94_D0.9040.92
14_A78_E0.9040.92
80_P100_T0.8890.92
12_S46_L0.8870.92
23_L35_I0.8820.92
3_T64_A0.8590.90
12_S99_R0.8450.90
34_D38_Y0.8380.89
5_A50_V0.8370.89
86_M96_I0.8220.88
30_S66_I0.8170.88
14_A101_S0.8120.88
6_K104_T0.8100.88
88_R96_I0.8000.87
90_K93_A0.7950.87
31_Q34_D0.7950.87
69_L107_V0.7840.86
70_K108_S0.7670.85
25_R72_T0.7620.84
8_R102_H0.7520.84
25_R75_F0.7470.83
13_S42_K0.7450.83
50_V105_V0.7440.83
15_Q97_L0.7350.82
53_S57_N0.7240.81
31_Q35_I0.7150.80
77_D102_H0.7120.80
35_I39_T0.6980.79
42_K45_V0.6930.78
59_E64_A0.6820.77
65_D92_R0.6800.77
30_S34_D0.6680.76
33_L37_T0.6650.75
64_A68_D0.6620.75
71_V74_I0.6620.75
9_H102_H0.6580.75
87_P91_G0.6510.74
10_A103_I0.6500.74
14_A81_S0.6350.72
52_E56_A0.6300.71
80_P102_H0.6270.71
27_K70_K0.6250.71
72_T107_V0.6240.71
93_A96_I0.6180.70
24_I42_K0.6180.70
76_V101_S0.6140.69
4_I106_V0.6110.69
40_N46_L0.6010.68
17_V46_L0.6010.68
62_D68_D0.6000.68
60_H90_K0.5990.68
88_R95_R0.5990.68
17_V101_S0.5990.68
61_N90_K0.5950.67
11_R80_P0.5910.67
11_R101_S0.5910.67
47_V76_V0.5870.66
17_V43_A0.5800.65
44_A48_K0.5760.65
34_D62_D0.5710.64
32_A93_A0.5690.64
86_M93_A0.5670.63
53_S56_A0.5650.63
45_V48_K0.5640.63
30_S38_Y0.5510.61
39_T43_A0.5420.60
76_V103_I0.5420.60
58_A61_N0.5400.60
4_I8_R0.5390.59
29_V44_A0.5380.59
84_R93_A0.5360.59
26_G29_V0.5330.59
89_A100_T0.5310.58
47_V103_I0.5300.58
55_I69_L0.5300.58
55_I66_I0.5250.58
38_Y45_V0.5240.57
11_R76_V0.5160.56
11_R84_R0.5140.56
30_S33_L0.5140.56
81_S86_M0.5130.56
24_I71_V0.5090.55
81_S100_T0.5080.55
60_H64_A0.5070.55
56_A60_H0.5060.55
82_M90_K0.5060.55
34_D40_N0.5040.54
12_S101_S0.5030.54
63_G67_D0.5000.54
18_R107_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tp9S 1 1 100 0.118 Contact Map
3j3wS 1 1 100 0.131 Contact Map
3bboU 1 1 100 0.133 Contact Map
4ce4W 1 0.9909 100 0.157 Contact Map
3j7yT 1 1 100 0.161 Contact Map
2zjrP 1 1 100 0.161 Contact Map
1i4jA 2 0.9727 100 0.164 Contact Map
1vw4O 1 0.9909 100 0.178 Contact Map
1vq8R 1 0.9909 100 0.213 Contact Map
3j3bP 1 0.9909 100 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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