GREMLIN Database
LGT - Prolipoprotein diacylglyceryl transferase
UniProt: P60955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12128
Length: 291 (247)
Sequences: 4384 (3092)
Seq/√Len: 196.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_P163_A3.6181.00
91_Y97_D3.5431.00
196_H201_Y3.4581.00
276_I280_W3.2971.00
91_Y94_R3.0381.00
88_D91_Y3.0361.00
17_S22_A2.9111.00
241_I245_F2.8611.00
27_G31_L2.8091.00
205_L238_F2.6541.00
94_R97_D2.5071.00
82_F86_M2.4831.00
209_V234_G2.4311.00
236_G271_I2.3921.00
115_I119_R2.3741.00
233_I274_G2.3001.00
229_G277_M2.2301.00
124_F128_S2.2271.00
156_V193_L2.1771.00
144_L203_L2.1631.00
226_A282_Y2.1261.00
229_G274_G2.1101.00
67_G112_V2.0781.00
233_I271_I2.0621.00
56_E120_T2.0281.00
84_Q88_D1.9891.00
16_F23_L1.9851.00
240_I244_F1.9851.00
46_N54_K1.9211.00
53_T56_E1.9101.00
86_M89_P1.9091.00
108_G112_V1.8701.00
71_G108_G1.8671.00
103_H263_G1.8411.00
169_S191_G1.8391.00
17_S20_P1.8241.00
15_I28_L1.8181.00
226_A278_M1.7071.00
117_A127_V1.7021.00
160_F163_A1.6971.00
89_P93_F1.6611.00
223_P226_A1.6521.00
45_A57_V1.6251.00
128_S228_S1.6111.00
81_N84_Q1.5951.00
13_P24_H1.5761.00
41_A134_L1.5721.00
67_G108_G1.5421.00
210_L214_L1.5281.00
163_A194_P1.5231.00
125_F225_G1.5031.00
140_G207_G1.5001.00
15_I23_L1.4961.00
139_L231_F1.4841.00
43_R46_N1.4811.00
126_Q224_M1.4761.00
244_F264_Q1.4661.00
207_G211_F1.4661.00
114_I118_R1.4631.00
153_W195_R1.4481.00
63_A67_G1.4461.00
84_Q91_Y1.4391.00
29_M145_G1.4381.00
60_L127_V1.4351.00
44_R218_I1.4321.00
116_F120_T1.4131.00
129_D225_G1.4041.00
137_F210_L1.3971.00
240_I264_Q1.3721.00
36_F141_A1.3711.00
43_R47_R1.3381.00
229_G278_M1.3221.00
268_I272_V1.3181.00
38_M61_L1.3101.00
147_F164_M1.3031.00
205_L242_V1.3021.00
77_V92_L1.2981.00
39_W43_R1.2941.00
90_L93_F1.2921.00
165_L194_P1.2901.00
275_V279_V1.2891.00
90_L94_R1.2861.00
198_S242_V1.2731.00
44_R47_R1.2731.00
37_A64_G1.2671.00
233_I275_V1.2601.00
230_L278_M1.2411.00
158_P162_F1.2341.00
146_N151_E1.2331.00
11_F148_I1.2321.00
233_I278_M1.2181.00
42_T46_N1.2171.00
169_S192_V1.2051.00
229_G281_A1.2031.00
95_V98_G1.1921.00
34_F68_V1.1911.00
56_E122_R1.1891.00
204_L208_V1.1861.00
123_S224_M1.1831.00
210_L234_G1.1711.00
252_F262_M1.1631.00
212_I216_L1.1551.00
34_F65_F1.1541.00
147_F200_L1.1401.00
114_I124_F1.1381.00
238_F242_V1.1341.00
200_L204_L1.1321.00
42_T58_E1.1261.00
133_P136_P1.1261.00
211_F215_N1.1221.00
84_Q87_A1.1081.00
88_D94_R1.1071.00
78_L82_F1.0931.00
140_G203_L1.0931.00
15_I25_W1.0921.00
107_I111_V1.0921.00
207_G210_L1.0821.00
14_V24_H1.0801.00
123_S126_Q1.0781.00
122_R127_V1.0761.00
217_Y230_L1.0691.00
143_R239_R1.0511.00
63_A112_V1.0491.00
166_F199_Q1.0481.00
111_V115_I1.0461.00
272_V276_I1.0421.00
68_V109_V1.0361.00
205_L209_V1.0201.00
60_L64_G1.0181.00
106_L135_I1.0181.00
77_V85_F1.0151.00
237_A271_I1.0141.00
223_P282_Y1.0091.00
44_R133_P1.0041.00
211_F214_L0.9971.00
228_S232_L0.9941.00
230_L234_G0.9810.99
240_I271_I0.9760.99
85_F92_L0.9660.99
155_R247_Q0.9600.99
260_I265_I0.9580.99
277_M281_A0.9580.99
202_E242_V0.9550.99
169_S190_Y0.9530.99
113_M128_S0.9440.99
158_P161_P0.9420.99
237_A241_I0.9410.99
29_M32_V0.9260.99
280_W284_R0.9260.99
102_F139_L0.9260.99
156_V195_R0.9200.99
276_I279_V0.9180.99
55_N58_E0.9140.99
36_F137_F0.9050.99
162_F196_H0.8970.99
165_L169_S0.8940.99
218_I227_V0.8870.99
273_A276_I0.8820.99
159_N163_A0.8820.99
236_G270_M0.8800.99
14_V22_A0.8800.99
258_Q265_I0.8760.99
232_L270_M0.8700.99
35_I39_W0.8700.99
215_N218_I0.8690.99
59_N120_T0.8690.99
159_N162_F0.8670.99
62_Y66_L0.8610.99
144_L148_I0.8570.99
212_I215_N0.8550.99
164_M167_P0.8540.99
232_L274_G0.8330.98
29_M144_L0.8320.98
260_I268_I0.8280.98
146_N152_L0.8270.98
40_L137_F0.8240.98
66_L70_L0.8190.98
30_Y33_G0.8180.98
100_M105_G0.8170.98
19_G22_A0.8160.98
125_F229_G0.8140.98
203_L208_V0.8130.98
195_R247_Q0.8120.98
141_A203_L0.7940.98
74_I92_L0.7850.98
60_L116_F0.7840.98
213_I216_L0.7820.97
37_A134_L0.7800.97
29_M148_I0.7780.97
40_L134_L0.7760.97
25_W148_I0.7750.97
103_H267_S0.7710.97
158_P196_H0.7670.97
229_G233_I0.7610.97
15_I22_A0.7540.97
74_I78_L0.7530.97
267_S270_M0.7500.97
282_Y285_S0.7470.97
136_P209_V0.7470.97
150_G168_G0.7470.97
103_H236_G0.7420.97
132_A228_S0.7410.97
234_G238_F0.7410.97
132_A135_I0.7350.96
52_W122_R0.7320.96
142_G235_Y0.7320.96
36_F40_L0.7300.96
165_L192_V0.7290.96
26_Y146_N0.7270.96
71_G100_M0.7270.96
146_N149_N0.7190.96
32_V141_A0.7170.96
213_I238_F0.7140.96
125_F277_M0.7110.96
56_E116_F0.7110.96
140_G206_E0.7110.96
166_F194_P0.7110.96
278_M282_Y0.7080.96
260_I264_Q0.7010.95
12_D25_W0.7000.95
67_G71_G0.6990.95
190_Y193_L0.6980.95
162_F201_Y0.6970.95
16_F22_A0.6970.95
222_R226_A0.6960.95
251_Q262_M0.6950.95
105_G109_V0.6920.95
41_A135_I0.6890.95
151_E199_Q0.6880.95
110_I124_F0.6850.95
89_P92_L0.6840.95
72_G100_M0.6830.95
14_V17_S0.6810.94
226_A281_A0.6810.94
68_V72_G0.6800.94
137_F140_G0.6790.94
233_I237_A0.6760.94
73_R100_M0.6740.94
169_S193_L0.6710.94
150_G167_P0.6660.94
215_N219_R0.6630.94
274_G277_M0.6600.93
41_A130_F0.6570.93
198_S245_F0.6570.93
163_A167_P0.6550.93
217_Y226_A0.6530.93
139_L206_E0.6530.93
117_A124_F0.6470.93
251_Q261_S0.6450.93
33_G36_F0.6450.93
155_R196_H0.6440.93
155_R245_F0.6420.93
42_T54_K0.6380.92
33_G142_G0.6320.92
110_I114_I0.6300.92
161_P164_M0.6300.92
102_F231_F0.6260.92
106_L132_A0.6250.92
44_R48_P0.6180.91
26_Y151_E0.6170.91
18_I21_V0.6150.91
160_F196_H0.6150.91
166_F195_R0.6140.91
263_G266_L0.6130.91
156_V194_P0.6090.90
197_P200_L0.6070.90
101_S152_L0.6060.90
15_I24_H0.6050.90
44_R217_Y0.6040.90
262_M266_L0.6040.90
166_F169_S0.6040.90
115_I120_T0.6030.90
13_P22_A0.6030.90
81_N85_F0.6000.90
250_A261_S0.6000.90
12_D150_G0.5970.90
73_R98_G0.5930.89
45_A52_W0.5920.89
48_P130_F0.5910.89
36_F39_W0.5910.89
227_V230_L0.5880.89
191_G195_R0.5870.89
38_M42_T0.5870.89
39_W42_T0.5840.89
153_W198_S0.5830.88
110_I128_S0.5830.88
152_L198_S0.5810.88
158_P164_M0.5800.88
94_R98_G0.5800.88
60_L113_M0.5790.88
85_F91_Y0.5790.88
226_A230_L0.5780.88
63_A116_F0.5760.88
16_F19_G0.5730.88
106_L110_I0.5730.88
152_L249_D0.5720.88
33_G137_F0.5720.88
25_W146_N0.5710.87
168_G191_G0.5670.87
75_G101_S0.5650.87
122_R126_Q0.5630.87
14_V25_W0.5620.87
248_P251_Q0.5610.87
265_I269_P0.5600.86
280_W283_R0.5590.86
113_M131_I0.5580.86
153_W169_S0.5550.86
242_V245_F0.5540.86
102_F106_L0.5530.86
156_V159_N0.5490.85
210_L213_I0.5470.85
192_V195_R0.5460.85
34_F63_A0.5460.85
40_L210_L0.5460.85
84_Q94_R0.5450.85
241_I244_F0.5420.85
110_I113_M0.5410.85
32_V36_F0.5390.84
209_V238_F0.5360.84
41_A131_I0.5350.84
114_I117_A0.5350.84
244_F261_S0.5340.84
82_F87_A0.5320.84
279_V283_R0.5320.84
72_G105_G0.5320.84
267_S271_I0.5310.83
12_D17_S0.5310.83
63_A120_T0.5280.83
198_S261_S0.5280.83
269_P273_A0.5280.83
142_G231_F0.5280.83
131_I135_I0.5260.83
84_Q89_P0.5240.83
83_P86_M0.5240.83
45_A130_F0.5240.83
150_G169_S0.5190.82
112_V115_I0.5190.82
48_P126_Q0.5190.82
257_V260_I0.5180.82
152_L248_P0.5180.82
198_S248_P0.5160.82
208_V212_I0.5150.82
40_L214_L0.5150.82
81_N251_Q0.5140.81
240_I245_F0.5140.81
15_I18_I0.5120.81
152_L263_G0.5120.81
191_G194_P0.5120.81
76_Y251_Q0.5120.81
136_P211_F0.5110.81
18_I22_A0.5100.81
204_L209_V0.5090.81
140_G211_F0.5080.81
75_G266_L0.5070.81
13_P16_F0.5070.81
136_P213_I0.5060.80
259_Y265_I0.5060.80
76_Y101_S0.5060.80
223_P278_M0.5050.80
261_S265_I0.5040.80
81_N87_A0.5040.80
133_P227_V0.5030.80
273_A277_M0.5030.80
40_L215_N0.5030.80
160_F164_M0.5020.80
190_Y195_R0.5020.80
63_A119_R0.5010.80
42_T55_N0.5010.80
101_S146_N0.5000.80
139_L142_G0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1237 16.8 0.962 Contact Map
2kluA 1 0.1478 15.1 0.962 Contact Map
2rddB 1 0.1065 15 0.963 Contact Map
2ks1B 1 0.1478 8.8 0.966 Contact Map
2i68A 2 0.2646 7.8 0.967 Contact Map
2l2tA 2 0.1478 6.3 0.968 Contact Map
4o6yA 2 0.3162 6.1 0.969 Contact Map
4gxbB 1 0.0034 6.1 0.969 Contact Map
2jwaA 2 0.1512 6 0.969 Contact Map
4px7A 1 0.7457 5.9 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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