GREMLIN Database
SYH - Histidine--tRNA ligase
UniProt: P60906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10453
Length: 424 (407)
Sequences: 8042 (5259)
Seq/√Len: 260.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
396_T409_A3.7301.00
408_T418_H3.2741.00
164_E254_N3.2531.00
31_N154_A3.2021.00
293_E299_A3.0721.00
401_D404_S3.0281.00
107_Y129_G2.9591.00
153_R161_V2.9091.00
399_V418_H2.8801.00
71_E75_G2.7351.00
346_A350_R2.6911.00
343_A346_A2.6551.00
411_A414_S2.6521.00
394_N409_A2.6431.00
414_S417_A2.6291.00
245_E251_Y2.5481.00
396_T411_A2.3611.00
390_S394_N2.3401.00
398_V407_Q2.3101.00
384_A402_L2.2621.00
71_E77_S2.2581.00
348_A360_L2.2511.00
28_T154_A2.2241.00
389_E393_A2.1691.00
32_V154_A2.1591.00
330_D359_K2.1521.00
30_K40_E2.1361.00
333_L348_A2.0571.00
27_G31_N2.0481.00
11_M46_V2.0231.00
33_L128_L2.0111.00
194_E197_K2.0051.00
29_L151_W1.9931.00
23_Q26_E1.9831.00
339_D393_A1.9731.00
264_Y267_T1.9611.00
142_A243_L1.9451.00
173_A230_D1.9401.00
368_N371_K1.9341.00
414_S418_H1.9191.00
18_E317_Q1.8691.00
134_G141_D1.8551.00
49_T53_K1.8371.00
130_C144_L1.8091.00
237_F253_V1.8081.00
189_K192_L1.8041.00
69_T77_S1.7981.00
25_I313_V1.7901.00
179_D183_A1.7891.00
373_F386_V1.7731.00
331_I358_V1.7661.00
343_A392_V1.7581.00
330_D358_V1.7571.00
21_I317_Q1.7391.00
35_S150_R1.7301.00
193_D196_C1.7121.00
189_K197_K1.7021.00
23_Q40_E1.7001.00
41_I88_C1.6961.00
230_D233_S1.6851.00
180_A228_Y1.6591.00
31_N35_S1.6501.00
36_Y150_R1.6471.00
348_A362_T1.6471.00
390_S393_A1.6431.00
24_R28_T1.6431.00
41_I91_A1.6361.00
38_Y104_R1.6211.00
232_E235_E1.6161.00
134_G139_D1.6141.00
148_T271_W1.6021.00
34_G106_W1.6001.00
242_K246_S1.5951.00
383_V399_V1.5901.00
350_R412_Q1.5861.00
35_S154_A1.5771.00
186_E201_Y1.5651.00
231_E235_E1.5611.00
162_T252_T1.5551.00
385_V397_A1.5491.00
146_M150_R1.5371.00
388_G391_E1.5311.00
126_H310_E1.5271.00
383_V419_L1.5211.00
45_I109_G1.5181.00
297_G301_P1.5131.00
45_I112_F1.5131.00
29_L309_L1.5061.00
369_F373_F1.5021.00
72_D76_D1.5011.00
238_A242_K1.4931.00
342_S346_A1.4821.00
296_G301_P1.4661.00
23_Q30_K1.4481.00
54_R93_I1.4461.00
150_R349_E1.4391.00
49_T79_T1.4191.00
348_A352_R1.4171.00
335_A344_A1.4061.00
339_D389_E1.3941.00
198_R202_T1.3891.00
397_A412_Q1.3871.00
332_Y376_A1.3871.00
81_R109_G1.3851.00
335_A372_Q1.3841.00
286_G290_G1.3811.00
8_I46_V1.3801.00
149_A153_R1.3731.00
84_G107_Y1.3711.00
239_G243_L1.3701.00
415_V419_L1.3661.00
110_P124_Q1.3661.00
399_V410_V1.3601.00
383_V401_D1.3591.00
350_R353_D1.3591.00
173_A233_S1.3571.00
337_G389_E1.3561.00
49_T77_S1.3551.00
146_M247_A1.3551.00
209_D213_P1.3551.00
84_G129_G1.3461.00
223_P238_A1.3451.00
222_A225_L1.3421.00
162_T274_N1.3311.00
130_C147_L1.3271.00
170_S230_D1.3061.00
8_I11_M1.3051.00
132_V140_I1.2991.00
23_Q27_G1.2831.00
148_T283_C1.2781.00
331_I351_L1.2771.00
206_R209_D1.2751.00
21_I313_V1.2741.00
398_V409_A1.2701.00
234_R238_A1.2661.00
246_S342_S1.2591.00
17_G20_A1.2471.00
354_E416_A1.2441.00
241_C245_E1.2411.00
217_A220_N1.2401.00
349_E353_D1.2381.00
213_P217_A1.2321.00
316_V326_D1.2311.00
395_G413_D1.2231.00
195_D198_R1.2091.00
26_E42_R1.2081.00
239_G242_K1.2081.00
104_R361_M1.1981.00
242_K245_E1.1961.00
196_C210_S1.1961.00
128_L309_L1.1891.00
23_Q34_G1.1831.00
238_A241_C1.1811.00
337_G340_T1.1811.00
245_E250_A1.1791.00
164_E252_T1.1761.00
49_T69_T1.1761.00
343_A412_Q1.1661.00
22_W126_H1.1651.00
89_V292_V1.1631.00
331_I385_V1.1601.00
149_A163_L1.1521.00
333_L344_A1.1431.00
334_V369_F1.1421.00
206_R211_K1.1401.00
367_G371_K1.1381.00
286_G302_A1.1371.00
208_L211_K1.1331.00
84_G111_M1.1251.00
350_R416_A1.1241.00
196_C199_R1.1221.00
73_R114_H1.1211.00
122_Y310_E1.1191.00
9_R116_R1.1161.00
257_L260_G1.1141.00
264_Y269_F1.1131.00
331_I360_L1.1101.00
89_V133_F1.1071.00
231_E234_R1.1071.00
26_E30_K1.1031.00
233_S237_F1.1021.00
19_T23_Q1.1001.00
209_D217_A1.0991.00
235_E239_G1.0951.00
241_C251_Y1.0901.00
29_L128_L1.0891.00
36_Y147_L1.0801.00
373_F377_D1.0731.00
264_Y268_V1.0721.00
76_D114_H1.0721.00
237_F240_L1.0681.00
38_Y132_V1.0671.00
22_W310_E1.0651.00
276_L279_Q1.0621.00
176_N179_D1.0601.00
8_I78_L1.0561.00
242_K342_S1.0531.00
194_E199_R1.0471.00
243_L246_S1.0471.00
350_R354_E1.0471.00
92_G105_L1.0461.00
390_S409_A1.0461.00
382_R401_D1.0441.00
206_R210_S1.0441.00
45_I124_Q1.0391.00
40_E106_W1.0361.00
241_C253_V1.0281.00
186_E189_K1.0271.00
125_F306_A1.0271.00
399_V415_V1.0231.00
215_V219_L1.0171.00
336_S369_F1.0141.00
30_K108_I1.0121.00
216_Q219_L1.0121.00
400_K407_Q1.0101.00
412_Q416_A1.0101.00
333_L347_L1.0071.00
234_R237_F1.0021.00
189_K201_Y1.0001.00
397_A410_V1.0001.00
53_K77_S0.9981.00
189_K200_M0.9971.00
410_V415_V0.9961.00
261_L264_Y0.9961.00
185_L207_V0.9941.00
211_K214_E0.9861.00
401_D406_E0.9821.00
354_E357_G0.9811.00
193_D210_S0.9811.00
12_N310_E0.9811.00
209_D215_V0.9771.00
46_V80_L0.9761.00
50_P53_K0.9741.00
15_L91_A0.9731.00
207_V211_K0.9691.00
214_E217_A0.9671.00
345_M349_E0.9631.00
172_E176_N0.9601.00
343_A387_L0.9551.00
20_A34_G0.9551.00
335_A362_T0.9481.00
188_H191_K0.9441.00
149_A161_V0.9431.00
400_K405_G0.9421.00
243_L247_A0.9381.00
29_L33_L0.9371.00
45_I110_P0.9361.00
170_S173_A0.9351.00
14_Y22_W0.9341.00
246_S249_I0.9261.00
164_E272_V0.9231.00
197_K201_Y0.9221.00
145_I163_L0.9211.00
210_S219_L0.9191.00
340_T343_A0.9191.00
36_Y104_R0.9181.00
377_D400_K0.9141.00
43_L87_G0.9111.00
334_V384_A0.9091.00
382_R403_R0.9031.00
212_N215_V0.9021.00
24_R359_K0.9011.00
8_I48_Q0.8981.00
298_R301_P0.8921.00
119_K122_Y0.8921.00
27_G30_K0.8921.00
12_N18_E0.8921.00
332_Y381_A0.8901.00
137_G302_A0.8821.00
257_L268_V0.8811.00
69_T79_T0.8731.00
143_E352_R0.8721.00
28_T31_N0.8721.00
397_A415_V0.8711.00
178_R181_L0.8701.00
377_D402_L0.8701.00
335_A341_Q0.8701.00
245_E249_I0.8691.00
70_F78_L0.8671.00
204_P209_D0.8641.00
151_W307_M0.8631.00
296_G300_T0.8611.00
210_S215_V0.8581.00
133_F292_V0.8541.00
196_C201_Y0.8521.00
260_G263_Y0.8521.00
287_R291_L0.8510.99
237_F241_C0.8500.99
104_R130_C0.8500.99
170_S233_S0.8480.99
236_H240_L0.8460.99
215_V220_N0.8460.99
205_L211_K0.8450.99
205_L208_L0.8450.99
84_G109_G0.8440.99
205_L209_D0.8440.99
204_P211_K0.8430.99
385_V399_V0.8410.99
112_F124_Q0.8410.99
206_R213_P0.8350.99
346_A412_Q0.8350.99
28_T155_L0.8340.99
88_C129_G0.8330.99
36_Y143_E0.8320.99
211_K215_V0.8310.99
314_L317_Q0.8310.99
231_E238_A0.8300.99
181_L184_F0.8300.99
46_V78_L0.8290.99
183_A186_E0.8280.99
178_R182_V0.8280.99
261_L269_F0.8260.99
150_R153_R0.8260.99
258_V261_L0.8240.99
194_E201_Y0.8220.99
192_L199_R0.8200.99
259_R270_E0.8190.99
27_G34_G0.8160.99
371_K374_A0.8130.99
144_L303_V0.8110.99
333_L360_L0.8100.99
340_T392_V0.8100.99
207_V220_N0.8090.99
152_W283_C0.8070.99
208_L213_P0.8060.99
385_V415_V0.8060.99
108_I128_L0.8060.99
260_G265_N0.8050.99
121_R308_G0.8040.99
410_V418_H0.7980.99
43_L88_C0.7980.99
81_R84_G0.7980.99
358_V419_L0.7970.99
22_W42_R0.7960.99
58_E79_T0.7950.99
411_A415_V0.7940.99
285_G288_Y0.7910.99
216_Q220_N0.7910.99
244_L249_I0.7910.99
297_G300_T0.7890.99
237_F249_I0.7880.99
384_A407_Q0.7860.99
232_E236_H0.7850.99
308_G311_R0.7830.99
149_A250_A0.7830.99
150_R154_A0.7820.99
210_S213_P0.7820.99
30_K106_W0.7820.99
233_S236_H0.7800.99
150_R353_D0.7770.99
207_V213_P0.7760.99
26_E40_E0.7760.99
19_T22_W0.7760.99
158_S319_V0.7740.99
194_E198_R0.7740.99
173_A176_N0.7740.99
209_D218_L0.7740.99
30_K34_G0.7730.99
221_D224_A0.7730.99
53_K59_V0.7720.99
377_D384_A0.7720.99
228_Y231_E0.7700.99
213_P216_Q0.7660.99
361_M381_A0.7640.99
387_L397_A0.7590.99
226_G229_L0.7590.99
20_A39_S0.7590.99
26_E309_L0.7570.99
204_P207_V0.7520.99
259_R262_D0.7490.99
7_A94_E0.7490.99
32_V151_W0.7470.99
258_V262_D0.7460.99
182_V186_E0.7460.99
207_V218_L0.7450.99
263_Y268_V0.7440.99
234_R241_C0.7430.99
166_N169_G0.7430.99
195_D199_R0.7430.99
232_E237_F0.7430.99
258_V271_W0.7420.99
35_S352_R0.7400.99
161_V271_W0.7370.99
363_N367_G0.7340.99
12_N122_Y0.7310.98
46_V68_Y0.7300.98
74_N114_H0.7290.98
260_G264_Y0.7290.98
264_Y270_E0.7270.98
209_D212_N0.7240.98
196_C215_V0.7230.98
274_N277_G0.7210.98
28_T32_V0.7210.98
35_S358_V0.7190.98
225_L230_D0.7180.98
88_C105_L0.7180.98
19_T42_R0.7160.98
369_F386_V0.7160.98
192_L200_M0.7060.98
182_V201_Y0.7020.98
45_I80_L0.6990.98
370_K374_A0.6980.98
32_V36_Y0.6970.98
235_E238_A0.6960.98
233_S238_A0.6940.98
32_V150_R0.6920.98
145_I149_A0.6910.98
96_G103_Q0.6910.98
228_Y232_E0.6890.98
200_M207_V0.6880.98
266_R271_W0.6880.98
196_C200_M0.6850.98
211_K216_Q0.6850.98
350_R413_D0.6840.98
34_G359_K0.6830.98
125_F311_R0.6830.98
324_K383_V0.6820.98
340_T389_E0.6780.98
186_E192_L0.6760.97
11_M43_L0.6750.97
26_E108_I0.6710.97
295_L298_R0.6700.97
333_L362_T0.6690.97
24_R27_G0.6690.97
115_E311_R0.6670.97
263_Y270_E0.6670.97
236_H239_G0.6650.97
273_T276_L0.6650.97
163_L271_W0.6640.97
233_S240_L0.6630.97
9_R117_P0.6610.97
24_R323_F0.6600.97
192_L198_R0.6550.97
231_E243_L0.6550.97
207_V215_V0.6540.97
227_D230_D0.6540.97
330_D382_R0.6520.97
341_Q345_M0.6520.97
347_L350_R0.6510.97
192_L201_Y0.6500.97
210_S216_Q0.6490.97
136_Q301_P0.6470.97
408_T414_S0.6470.97
92_G96_G0.6450.97
145_I177_Y0.6440.97
152_W312_L0.6430.97
240_L243_L0.6420.97
212_N216_Q0.6420.97
296_G299_A0.6360.96
200_M203_N0.6340.96
190_E193_D0.6340.96
213_P218_L0.6340.96
321_P324_K0.6330.96
115_E308_G0.6330.96
259_R264_Y0.6300.96
266_R269_F0.6300.96
253_V257_L0.6260.96
211_K219_L0.6250.96
14_Y18_E0.6250.96
192_L197_K0.6240.96
199_R203_N0.6240.96
186_E200_M0.6230.96
217_A221_D0.6230.96
83_E86_A0.6210.96
239_G244_L0.6210.96
257_L263_Y0.6190.96
261_L265_N0.6180.96
209_D214_E0.6180.96
290_G293_E0.6170.96
145_I282_V0.6160.96
289_D294_Q0.6160.96
347_L412_Q0.6160.96
32_V35_S0.6140.96
374_A377_D0.6140.96
142_A247_A0.6110.95
199_R202_T0.6110.95
408_T412_Q0.6110.95
46_V70_F0.6100.95
347_L387_L0.6100.95
115_E121_R0.6100.95
41_I105_L0.6080.95
192_L267_T0.6070.95
374_A378_K0.6070.95
157_I315_L0.6060.95
140_I284_A0.6020.95
212_N219_L0.6000.95
239_G245_E0.6000.95
263_Y266_R0.5990.95
92_G300_T0.5980.95
236_H266_R0.5970.95
146_M149_A0.5970.95
258_V264_Y0.5960.95
20_A359_K0.5960.95
66_E69_T0.5930.95
275_S278_S0.5910.95
324_K330_D0.5910.95
63_V66_E0.5900.95
42_R109_G0.5900.95
239_G246_S0.5890.94
257_L261_L0.5890.94
232_E243_L0.5890.94
404_S407_Q0.5890.94
215_V218_L0.5880.94
152_W161_V0.5880.94
316_V320_N0.5870.94
239_G249_I0.5860.94
92_G101_Q0.5830.94
240_L244_L0.5810.94
338_A341_Q0.5790.94
191_K218_L0.5790.94
354_E417_A0.5790.94
113_R125_F0.5770.94
257_L271_W0.5770.94
333_L385_V0.5760.94
38_Y130_C0.5750.94
88_C133_F0.5750.94
238_A243_L0.5730.94
214_E219_L0.5730.94
261_L270_E0.5730.94
168_I177_Y0.5720.94
90_R94_E0.5690.93
174_R177_Y0.5680.93
36_Y352_R0.5680.93
262_D276_L0.5680.93
184_F188_H0.5670.93
19_T40_E0.5670.93
93_I295_L0.5670.93
331_I415_V0.5660.93
210_S214_E0.5640.93
352_R360_L0.5640.93
121_R125_F0.5630.93
273_T277_G0.5620.93
36_Y144_L0.5610.93
214_E218_L0.5610.93
185_L203_N0.5600.93
205_L210_S0.5600.93
346_A349_E0.5590.93
241_C244_L0.5590.93
88_C107_Y0.5580.93
168_I172_E0.5580.93
110_P126_H0.5580.93
92_G98_L0.5570.93
104_R143_E0.5560.93
386_V407_Q0.5550.93
344_A362_T0.5550.93
55_A63_V0.5530.92
226_G231_E0.5530.92
271_W283_C0.5510.92
176_N229_L0.5510.92
123_R308_G0.5500.92
334_V372_Q0.5490.92
258_V263_Y0.5480.92
55_A284_A0.5480.92
395_G412_Q0.5450.92
254_N257_L0.5450.92
247_A345_M0.5440.92
90_R93_I0.5440.92
233_S241_C0.5430.92
351_L415_V0.5430.92
258_V267_T0.5430.92
181_L185_L0.5390.91
130_C305_F0.5380.91
244_L248_G0.5370.91
283_C307_M0.5370.91
242_K247_A0.5360.91
373_F402_L0.5350.91
51_L90_R0.5350.91
188_H200_M0.5340.91
233_S243_L0.5340.91
263_Y267_T0.5340.91
257_L264_Y0.5340.91
292_V300_T0.5330.91
255_Q264_Y0.5310.91
401_D405_G0.5310.91
260_G270_E0.5290.91
141_D144_L0.5270.91
111_M127_Q0.5260.90
260_G268_V0.5260.90
138_P236_H0.5230.90
193_D215_V0.5210.90
330_D381_A0.5210.90
331_I383_V0.5210.90
333_L387_L0.5200.90
167_S171_L0.5200.90
91_A95_H0.5200.90
393_A396_T0.5190.90
373_F384_A0.5190.90
153_R158_S0.5190.90
332_Y335_A0.5180.90
51_L295_L0.5170.90
264_Y271_W0.5160.90
92_G133_F0.5150.89
259_R263_Y0.5150.89
401_D407_Q0.5140.89
272_V277_G0.5140.89
329_V381_A0.5130.89
189_K193_D0.5120.89
132_V144_L0.5120.89
227_D231_E0.5110.89
22_W26_E0.5100.89
205_L213_P0.5070.89
238_A245_E0.5070.89
396_T412_Q0.5070.89
206_R215_V0.5060.89
290_G299_A0.5050.89
256_R260_G0.5050.89
234_R243_L0.5050.89
397_A416_A0.5030.88
255_Q262_D0.5030.88
265_N277_G0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1httA 2 0.8608 100 0.181 Contact Map
1h4vB 2 0.9458 100 0.197 Contact Map
1qe0A 2 0.908 100 0.213 Contact Map
4e51A 2 0.9646 100 0.22 Contact Map
4phcA 2 0.9693 100 0.223 Contact Map
1wu7A 2 0.9575 100 0.224 Contact Map
3netA 2 0.9458 100 0.224 Contact Map
3lc0A 2 0.9363 100 0.229 Contact Map
4g84A 2 0.9599 100 0.237 Contact Map
3od1A 2 0.8632 100 0.281 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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