GREMLIN Database
AQPZ - Aquaporin Z
UniProt: P60844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13270
Length: 231 (214)
Sequences: 5720 (3405)
Seq/√Len: 232.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_C94_V4.0311.00
71_W78_A3.6031.00
139_L214_V3.3281.00
139_L218_I3.2201.00
67_T81_V3.0921.00
13_F98_L3.0311.00
71_W81_V2.9811.00
135_L211_V2.9431.00
5_L83_G2.8881.00
9_C90_V2.7461.00
72_A217_I2.6741.00
5_L87_A2.6151.00
141_L177_S2.6051.00
148_V169_A2.5871.00
44_G171_T2.5321.00
4_K80_E2.4171.00
135_L139_L2.3161.00
19_G43_F2.2711.00
13_F95_A2.2551.00
85_V213_I2.2251.00
54_V62_F2.0671.00
143_A219_G1.9411.00
68_I213_I1.9271.00
184_S190_S1.8941.00
191_T209_W1.8471.00
174_H183_T1.8271.00
68_I85_V1.7351.00
61_H84_Y1.7161.00
141_L185_V1.6841.00
48_L167_G1.6731.00
50_M54_V1.6581.00
191_T195_I1.6521.00
205_L209_W1.5981.00
173_I185_V1.5931.00
17_F98_L1.5661.00
137_V180_V1.5381.00
41_L171_T1.5331.00
143_A222_I1.5241.00
87_A91_G1.5151.00
107_T121_Y1.5121.00
66_V149_I1.5041.00
97_A196_F1.5001.00
47_V170_L1.4991.00
11_G62_F1.4921.00
69_G146_L1.4861.00
213_I217_I1.4801.00
134_A181_T1.4411.00
104_S108_G1.4391.00
51_A163_P1.4141.00
74_G224_R1.3921.00
81_V85_V1.3911.00
78_A81_V1.3911.00
89_V209_W1.3871.00
215_G219_G1.3631.00
197_Q200_W1.3471.00
20_C99_L1.3471.00
13_F94_V1.3421.00
82_V86_I1.3401.00
40_A175_L1.3391.00
89_V191_T1.3331.00
93_I192_A1.3261.00
174_H178_I1.3241.00
154_D223_Y1.3151.00
67_T88_Q1.2961.00
191_T205_L1.2741.00
93_I196_F1.2741.00
146_L216_G1.2681.00
12_T92_G1.2641.00
67_T76_F1.2581.00
54_V60_G1.2481.00
64_P188_A1.2451.00
70_L76_F1.2291.00
69_G73_G1.2291.00
170_L185_V1.2211.00
132_L136_V1.2081.00
67_T85_V1.1991.00
37_A41_L1.1801.00
46_T50_M1.1781.00
76_F81_V1.1721.00
206_W210_V1.1681.00
21_G99_L1.1591.00
77_P80_E1.1591.00
94_V97_A1.1511.00
23_A27_A1.1511.00
45_L172_L1.1491.00
119_N123_E1.1481.00
143_A218_I1.1471.00
142_S216_G1.1421.00
98_L140_V1.1351.00
97_A101_L1.1281.00
190_S194_A1.1251.00
96_A193_V1.1201.00
45_L168_L1.1191.00
14_W144_G1.1191.00
102_I137_V1.1151.00
68_I217_I1.1081.00
139_L215_G1.1061.00
78_A82_V1.0921.00
93_I195_I1.0911.00
135_L207_F1.0821.00
92_G96_A1.0811.00
189_R193_V1.0621.00
23_A39_V1.0621.00
138_E181_T1.0601.00
20_C96_A1.0531.00
72_A220_G1.0471.00
15_L47_V1.0251.00
65_A187_P1.0231.00
22_S42_A1.0201.00
135_L210_V1.0141.00
139_L211_V1.0061.00
16_V20_C1.0021.00
61_H67_T1.0011.00
12_T188_A0.9971.00
137_V181_T0.9851.00
50_M60_G0.9831.00
7_A57_I0.9831.00
143_A147_L0.9811.00
58_S84_Y0.9761.00
45_L171_T0.9681.00
71_W76_F0.9661.00
102_I180_V0.9631.00
7_A58_S0.9561.00
25_L31_E0.9541.00
13_F17_F0.9521.00
14_W50_M0.9431.00
52_F163_P0.9401.00
149_I166_I0.9391.00
16_V99_L0.9351.00
130_S133_S0.9351.00
34_I38_G0.9341.00
50_M62_F0.9271.00
118_S121_Y0.9251.00
18_G46_T0.9191.00
11_G15_L0.9121.00
48_L52_F0.9101.00
92_G192_A0.9010.99
137_V141_L0.8980.99
69_G220_G0.8790.99
37_A175_L0.8780.99
66_V146_L0.8760.99
85_V89_V0.8710.99
164_I168_L0.8670.99
37_A40_A0.8670.99
51_A66_V0.8650.99
26_A38_G0.8560.99
145_F170_L0.8520.99
53_A148_V0.8380.99
216_G220_G0.8370.99
70_L75_R0.8330.99
135_L206_W0.8310.99
125_S134_A0.8290.99
104_S107_T0.8270.99
152_A169_A0.8270.99
147_L222_I0.8240.99
96_A196_F0.8160.99
48_L164_I0.8120.99
21_G176_I0.8120.99
27_A117_A0.8120.99
65_A216_G0.8110.99
61_H88_Q0.8060.99
93_I191_T0.8050.99
35_G38_G0.8010.99
61_H76_F0.8010.99
5_L9_C0.7990.99
38_G175_L0.7990.99
129_Y134_A0.7950.99
72_A221_L0.7940.99
150_H219_G0.7810.99
105_G133_S0.7750.98
129_Y180_V0.7710.98
162_A166_I0.7680.98
73_G220_G0.7430.98
61_H66_V0.7380.98
89_V192_A0.7380.98
177_S183_T0.7300.98
119_N125_S0.7300.98
9_C13_F0.7290.98
91_G95_A0.7280.98
123_E126_P0.7250.98
204_Q208_F0.7230.98
183_T208_F0.7160.97
188_A192_A0.7160.97
17_F144_G0.7120.97
42_A175_L0.7080.97
171_T175_L0.7060.97
7_A59_G0.7040.97
17_F102_I0.7000.97
73_G150_H0.7000.97
20_C95_A0.6970.97
76_F80_E0.6950.97
202_L205_L0.6940.97
207_F212_P0.6940.97
52_F165_A0.6920.97
131_M207_F0.6900.97
150_H223_Y0.6860.97
124_H200_W0.6860.97
135_L214_V0.6840.97
65_A69_G0.6820.97
117_A120_G0.6780.96
151_G154_D0.6770.96
77_P82_V0.6760.96
211_V215_G0.6750.96
119_N122_G0.6750.96
137_V177_S0.6740.96
36_F178_I0.6730.96
12_T16_V0.6720.96
96_A192_A0.6710.96
100_Y104_S0.6700.96
55_G58_S0.6670.96
32_L36_F0.6670.96
68_I81_V0.6660.96
49_T148_V0.6640.96
100_Y196_F0.6620.96
23_A43_F0.6610.96
70_L149_I0.6600.96
210_V213_I0.6590.96
25_L180_V0.6570.96
198_G202_L0.6560.96
76_F83_G0.6480.95
40_A174_H0.6480.95
9_C87_A0.6470.95
222_I226_L0.6440.95
200_W205_L0.6440.95
155_K159_A0.6420.95
97_A100_Y0.6410.95
129_Y133_S0.6400.95
77_P81_V0.6350.95
52_F160_G0.6330.95
148_V152_A0.6240.94
133_S136_V0.6230.94
90_V94_V0.6170.94
190_S212_P0.6160.94
44_G167_G0.6140.94
221_L225_T0.6140.94
199_G203_E0.6090.94
36_F174_H0.6050.93
142_S193_V0.6050.93
93_I97_A0.6030.93
121_Y125_S0.6030.93
70_L153_T0.6020.93
18_G144_G0.6010.93
151_G223_Y0.6000.93
18_G172_L0.6000.93
25_L179_P0.5990.93
187_P209_W0.5960.93
105_G130_S0.5960.93
134_A207_F0.5890.93
173_I183_T0.5890.93
56_H157_A0.5880.93
71_W82_V0.5830.92
133_S137_V0.5810.92
12_T47_V0.5790.92
26_A39_V0.5780.92
6_A226_L0.5780.92
141_L173_I0.5780.92
51_A60_G0.5700.91
131_M203_E0.5690.91
199_G202_L0.5680.91
17_F99_L0.5680.91
32_L37_A0.5660.91
184_S208_F0.5660.91
221_L224_R0.5650.91
11_G54_V0.5630.91
41_L168_L0.5620.91
102_I133_S0.5610.91
27_A39_V0.5600.91
14_W49_T0.5600.91
48_L165_A0.5600.91
207_F211_V0.5570.90
12_T15_L0.5550.90
79_K82_V0.5540.90
59_G84_Y0.5510.90
106_K128_G0.5510.90
105_G108_G0.5500.90
41_L175_L0.5490.90
6_A225_T0.5460.89
136_V140_V0.5450.89
144_G169_A0.5440.89
48_L55_G0.5440.89
157_A163_P0.5430.89
21_G103_A0.5420.89
43_F174_H0.5420.89
217_I220_G0.5410.89
17_F21_G0.5400.89
192_A196_F0.5390.89
206_W212_P0.5390.89
25_L103_A0.5380.89
84_Y88_Q0.5300.88
147_L151_G0.5300.88
104_S133_S0.5300.88
141_L145_F0.5300.88
172_L176_I0.5290.88
28_G31_E0.5280.88
117_A121_Y0.5270.88
144_G177_S0.5260.88
52_F167_G0.5230.87
169_A173_I0.5220.87
56_H154_D0.5210.87
16_V92_G0.5210.87
22_S39_V0.5210.87
118_S200_W0.5200.87
152_A165_A0.5200.87
152_A155_K0.5200.87
20_C121_Y0.5190.87
121_Y126_P0.5180.87
145_F149_I0.5150.87
214_V218_I0.5130.86
10_F222_I0.5120.86
49_T172_L0.5110.86
71_W77_P0.5100.86
5_L86_I0.5090.86
6_A10_F0.5090.86
102_I136_V0.5050.86
8_E11_G0.5050.86
48_L168_L0.5040.85
52_F161_F0.5030.85
16_V96_A0.5030.85
24_V99_L0.5010.85
83_G86_I0.5000.85
174_H185_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o9gA 3 0.9913 100 0.065 Contact Map
3llqA 3 0.987 100 0.086 Contact Map
1ldfA 3 0.9957 100 0.105 Contact Map
3iyzA 3 0.9351 100 0.111 Contact Map
3cn5A 3 0.9654 100 0.111 Contact Map
3c02A 3 0.974 100 0.115 Contact Map
1j4nA 4 0.9524 100 0.117 Contact Map
2zz9A 3 0.9351 100 0.119 Contact Map
4oj2X 3 0.9394 100 0.122 Contact Map
2f2bA 4 0.9567 100 0.122 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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