AQPZ - ECOLI - GREMLIN Contacts

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AQPZ - Aquaporin Z

UniProt:	P60844	Sequences: MFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAGVALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPAKEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFASNGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGGWALEQLWFFWVVPIVGGIIGGLIYRTLLEKRD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13270
Length:	231 (214)
Sequences:	5720 (3405)
Seq/√Len:	232.7

ECOLI - AQPZ GLPF
BACSU - GLPF
SULSO - Q97XW0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_C	94_V	4.031	1.00
71_W	78_A	3.603	1.00
139_L	214_V	3.328	1.00
139_L	218_I	3.220	1.00
67_T	81_V	3.092	1.00
13_F	98_L	3.031	1.00
71_W	81_V	2.981	1.00
135_L	211_V	2.943	1.00
5_L	83_G	2.888	1.00
9_C	90_V	2.746	1.00
72_A	217_I	2.674	1.00
5_L	87_A	2.615	1.00
141_L	177_S	2.605	1.00
148_V	169_A	2.587	1.00
44_G	171_T	2.532	1.00
4_K	80_E	2.417	1.00
135_L	139_L	2.316	1.00
19_G	43_F	2.271	1.00
13_F	95_A	2.255	1.00
85_V	213_I	2.225	1.00
54_V	62_F	2.067	1.00
143_A	219_G	1.941	1.00
68_I	213_I	1.927	1.00
184_S	190_S	1.894	1.00
191_T	209_W	1.847	1.00
174_H	183_T	1.827	1.00
68_I	85_V	1.735	1.00
61_H	84_Y	1.716	1.00
141_L	185_V	1.684	1.00
48_L	167_G	1.673	1.00
50_M	54_V	1.658	1.00
191_T	195_I	1.652	1.00
205_L	209_W	1.598	1.00
173_I	185_V	1.593	1.00
17_F	98_L	1.566	1.00
137_V	180_V	1.538	1.00
41_L	171_T	1.533	1.00
143_A	222_I	1.524	1.00
87_A	91_G	1.515	1.00
107_T	121_Y	1.512	1.00
66_V	149_I	1.504	1.00
97_A	196_F	1.500	1.00
47_V	170_L	1.499	1.00
11_G	62_F	1.492	1.00
69_G	146_L	1.486	1.00
213_I	217_I	1.480	1.00
134_A	181_T	1.441	1.00
104_S	108_G	1.439	1.00
51_A	163_P	1.414	1.00
74_G	224_R	1.392	1.00
81_V	85_V	1.391	1.00
78_A	81_V	1.391	1.00
89_V	209_W	1.387	1.00
215_G	219_G	1.363	1.00
197_Q	200_W	1.347	1.00
20_C	99_L	1.347	1.00
13_F	94_V	1.342	1.00
82_V	86_I	1.340	1.00
40_A	175_L	1.339	1.00
89_V	191_T	1.333	1.00
93_I	192_A	1.326	1.00
174_H	178_I	1.324	1.00
154_D	223_Y	1.315	1.00
67_T	88_Q	1.296	1.00
191_T	205_L	1.274	1.00
93_I	196_F	1.274	1.00
146_L	216_G	1.268	1.00
12_T	92_G	1.264	1.00
67_T	76_F	1.258	1.00
54_V	60_G	1.248	1.00
64_P	188_A	1.245	1.00
70_L	76_F	1.229	1.00
69_G	73_G	1.229	1.00
170_L	185_V	1.221	1.00
132_L	136_V	1.208	1.00
67_T	85_V	1.199	1.00
37_A	41_L	1.180	1.00
46_T	50_M	1.178	1.00
76_F	81_V	1.172	1.00
206_W	210_V	1.168	1.00
21_G	99_L	1.159	1.00
77_P	80_E	1.159	1.00
94_V	97_A	1.151	1.00
23_A	27_A	1.151	1.00
45_L	172_L	1.149	1.00
119_N	123_E	1.148	1.00
143_A	218_I	1.147	1.00
142_S	216_G	1.142	1.00
98_L	140_V	1.135	1.00
97_A	101_L	1.128	1.00
190_S	194_A	1.125	1.00
96_A	193_V	1.120	1.00
45_L	168_L	1.119	1.00
14_W	144_G	1.119	1.00
102_I	137_V	1.115	1.00
68_I	217_I	1.108	1.00
139_L	215_G	1.106	1.00
78_A	82_V	1.092	1.00
93_I	195_I	1.091	1.00
135_L	207_F	1.082	1.00
92_G	96_A	1.081	1.00
189_R	193_V	1.062	1.00
23_A	39_V	1.062	1.00
138_E	181_T	1.060	1.00
20_C	96_A	1.053	1.00
72_A	220_G	1.047	1.00
15_L	47_V	1.025	1.00
65_A	187_P	1.023	1.00
22_S	42_A	1.020	1.00
135_L	210_V	1.014	1.00
139_L	211_V	1.006	1.00
16_V	20_C	1.002	1.00
61_H	67_T	1.001	1.00
12_T	188_A	0.997	1.00
137_V	181_T	0.985	1.00
50_M	60_G	0.983	1.00
7_A	57_I	0.983	1.00
143_A	147_L	0.981	1.00
58_S	84_Y	0.976	1.00
45_L	171_T	0.968	1.00
71_W	76_F	0.966	1.00
102_I	180_V	0.963	1.00
7_A	58_S	0.956	1.00
25_L	31_E	0.954	1.00
13_F	17_F	0.952	1.00
14_W	50_M	0.943	1.00
52_F	163_P	0.940	1.00
149_I	166_I	0.939	1.00
16_V	99_L	0.935	1.00
130_S	133_S	0.935	1.00
34_I	38_G	0.934	1.00
50_M	62_F	0.927	1.00
118_S	121_Y	0.925	1.00
18_G	46_T	0.919	1.00
11_G	15_L	0.912	1.00
48_L	52_F	0.910	1.00
92_G	192_A	0.901	0.99
137_V	141_L	0.898	0.99
69_G	220_G	0.879	0.99
37_A	175_L	0.878	0.99
66_V	146_L	0.876	0.99
85_V	89_V	0.871	0.99
164_I	168_L	0.867	0.99
37_A	40_A	0.867	0.99
51_A	66_V	0.865	0.99
26_A	38_G	0.856	0.99
145_F	170_L	0.852	0.99
53_A	148_V	0.838	0.99
216_G	220_G	0.837	0.99
70_L	75_R	0.833	0.99
135_L	206_W	0.831	0.99
125_S	134_A	0.829	0.99
104_S	107_T	0.827	0.99
152_A	169_A	0.827	0.99
147_L	222_I	0.824	0.99
96_A	196_F	0.816	0.99
48_L	164_I	0.812	0.99
21_G	176_I	0.812	0.99
27_A	117_A	0.812	0.99
65_A	216_G	0.811	0.99
61_H	88_Q	0.806	0.99
93_I	191_T	0.805	0.99
35_G	38_G	0.801	0.99
61_H	76_F	0.801	0.99
5_L	9_C	0.799	0.99
38_G	175_L	0.799	0.99
129_Y	134_A	0.795	0.99
72_A	221_L	0.794	0.99
150_H	219_G	0.781	0.99
105_G	133_S	0.775	0.98
129_Y	180_V	0.771	0.98
162_A	166_I	0.768	0.98
73_G	220_G	0.743	0.98
61_H	66_V	0.738	0.98
89_V	192_A	0.738	0.98
177_S	183_T	0.730	0.98
119_N	125_S	0.730	0.98
9_C	13_F	0.729	0.98
91_G	95_A	0.728	0.98
123_E	126_P	0.725	0.98
204_Q	208_F	0.723	0.98
183_T	208_F	0.716	0.97
188_A	192_A	0.716	0.97
17_F	144_G	0.712	0.97
42_A	175_L	0.708	0.97
171_T	175_L	0.706	0.97
7_A	59_G	0.704	0.97
17_F	102_I	0.700	0.97
73_G	150_H	0.700	0.97
20_C	95_A	0.697	0.97
76_F	80_E	0.695	0.97
202_L	205_L	0.694	0.97
207_F	212_P	0.694	0.97
52_F	165_A	0.692	0.97
131_M	207_F	0.690	0.97
150_H	223_Y	0.686	0.97
124_H	200_W	0.686	0.97
135_L	214_V	0.684	0.97
65_A	69_G	0.682	0.97
117_A	120_G	0.678	0.96
151_G	154_D	0.677	0.96
77_P	82_V	0.676	0.96
211_V	215_G	0.675	0.96
119_N	122_G	0.675	0.96
137_V	177_S	0.674	0.96
36_F	178_I	0.673	0.96
12_T	16_V	0.672	0.96
96_A	192_A	0.671	0.96
100_Y	104_S	0.670	0.96
55_G	58_S	0.667	0.96
32_L	36_F	0.667	0.96
68_I	81_V	0.666	0.96
49_T	148_V	0.664	0.96
100_Y	196_F	0.662	0.96
23_A	43_F	0.661	0.96
70_L	149_I	0.660	0.96
210_V	213_I	0.659	0.96
25_L	180_V	0.657	0.96
198_G	202_L	0.656	0.96
76_F	83_G	0.648	0.95
40_A	174_H	0.648	0.95
9_C	87_A	0.647	0.95
222_I	226_L	0.644	0.95
200_W	205_L	0.644	0.95
155_K	159_A	0.642	0.95
97_A	100_Y	0.641	0.95
129_Y	133_S	0.640	0.95
77_P	81_V	0.635	0.95
52_F	160_G	0.633	0.95
148_V	152_A	0.624	0.94
133_S	136_V	0.623	0.94
90_V	94_V	0.617	0.94
190_S	212_P	0.616	0.94
44_G	167_G	0.614	0.94
221_L	225_T	0.614	0.94
199_G	203_E	0.609	0.94
36_F	174_H	0.605	0.93
142_S	193_V	0.605	0.93
93_I	97_A	0.603	0.93
121_Y	125_S	0.603	0.93
70_L	153_T	0.602	0.93
18_G	144_G	0.601	0.93
151_G	223_Y	0.600	0.93
18_G	172_L	0.600	0.93
25_L	179_P	0.599	0.93
187_P	209_W	0.596	0.93
105_G	130_S	0.596	0.93
134_A	207_F	0.589	0.93
173_I	183_T	0.589	0.93
56_H	157_A	0.588	0.93
71_W	82_V	0.583	0.92
133_S	137_V	0.581	0.92
12_T	47_V	0.579	0.92
26_A	39_V	0.578	0.92
6_A	226_L	0.578	0.92
141_L	173_I	0.578	0.92
51_A	60_G	0.570	0.91
131_M	203_E	0.569	0.91
199_G	202_L	0.568	0.91
17_F	99_L	0.568	0.91
32_L	37_A	0.566	0.91
184_S	208_F	0.566	0.91
221_L	224_R	0.565	0.91
11_G	54_V	0.563	0.91
41_L	168_L	0.562	0.91
102_I	133_S	0.561	0.91
27_A	39_V	0.560	0.91
14_W	49_T	0.560	0.91
48_L	165_A	0.560	0.91
207_F	211_V	0.557	0.90
12_T	15_L	0.555	0.90
79_K	82_V	0.554	0.90
59_G	84_Y	0.551	0.90
106_K	128_G	0.551	0.90
105_G	108_G	0.550	0.90
41_L	175_L	0.549	0.90
6_A	225_T	0.546	0.89
136_V	140_V	0.545	0.89
144_G	169_A	0.544	0.89
48_L	55_G	0.544	0.89
157_A	163_P	0.543	0.89
21_G	103_A	0.542	0.89
43_F	174_H	0.542	0.89
217_I	220_G	0.541	0.89
17_F	21_G	0.540	0.89
192_A	196_F	0.539	0.89
206_W	212_P	0.539	0.89
25_L	103_A	0.538	0.89
84_Y	88_Q	0.530	0.88
147_L	151_G	0.530	0.88
104_S	133_S	0.530	0.88
141_L	145_F	0.530	0.88
172_L	176_I	0.529	0.88
28_G	31_E	0.528	0.88
117_A	121_Y	0.527	0.88
144_G	177_S	0.526	0.88
52_F	167_G	0.523	0.87
169_A	173_I	0.522	0.87
56_H	154_D	0.521	0.87
16_V	92_G	0.521	0.87
22_S	39_V	0.521	0.87
118_S	200_W	0.520	0.87
152_A	165_A	0.520	0.87
152_A	155_K	0.520	0.87
20_C	121_Y	0.519	0.87
121_Y	126_P	0.518	0.87
145_F	149_I	0.515	0.87
214_V	218_I	0.513	0.86
10_F	222_I	0.512	0.86
49_T	172_L	0.511	0.86
71_W	77_P	0.510	0.86
5_L	86_I	0.509	0.86
6_A	10_F	0.509	0.86
102_I	136_V	0.505	0.86
8_E	11_G	0.505	0.86
48_L	168_L	0.504	0.85
52_F	161_F	0.503	0.85
16_V	96_A	0.503	0.85
24_V	99_L	0.501	0.85
83_G	86_I	0.500	0.85
174_H	185_V	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o9gA	3	0.9913	100	0.065	Contact Map
3llqA	3	0.987	100	0.086	Contact Map
1ldfA	3	0.9957	100	0.105	Contact Map
3iyzA	3	0.9351	100	0.111	Contact Map
3cn5A	3	0.9654	100	0.111	Contact Map
3c02A	3	0.974	100	0.115	Contact Map
1j4nA	4	0.9524	100	0.117	Contact Map
2zz9A	3	0.9351	100	0.119	Contact Map
4oj2X	3	0.9394	100	0.122	Contact Map
2f2bA	4	0.9567	100	0.122	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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