LEPA - ECOLI - GREMLIN Contacts

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LEPA - Elongation factor 4

UniProt:	P60785	Sequences: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINGERVDALALITHRDNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10529
Length:	599 (511)
Sequences:	6965 (2943)
Seq/√Len:	130.2

ECOLI - LEPA TYPA EFG RF3
BACSU - LEPA TYPA EFG
HALSA - EF2
SULSO - EF2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
253_G	259_V	5.176	1.00
139_D	142_R	4.670	1.00
192_Q	214_N	4.114	1.00
444_E	473_K	4.076	1.00
161_C	172_V	3.693	1.00
218_R	252_C	3.489	1.00
221_D	276_L	3.426	1.00
375_E	400_R	3.373	1.00
159_V	175_R	3.352	1.00
444_E	476_Q	3.252	1.00
405_E	473_K	3.109	1.00
64_K	70_T	3.095	1.00
398_E	477_A	3.058	1.00
174_E	178_R	2.991	1.00
129_V	161_C	2.984	1.00
175_R	179_D	2.960	1.00
403_I	476_Q	2.882	1.00
405_E	442_T	2.837	1.00
421_L	454_F	2.811	1.00
410_L	418_V	2.789	1.00
186_D	189_G	2.629	1.00
144_A	158_A	2.583	1.00
105_G	135_L	2.503	1.00
431_N	442_T	2.467	1.00
373_E	400_R	2.460	1.00
479_D	501_R	2.449	1.00
422_C	427_G	2.447	1.00
430_T	444_E	2.430	1.00
405_E	471_N	2.425	1.00
62_D	70_T	2.385	1.00
462_S	466_A	2.338	1.00
356_E	362_D	2.337	1.00
23_R	26_Q	2.308	1.00
458_L	466_A	2.263	1.00
7_F	73_L	2.244	1.00
444_E	474_R	2.221	1.00
145_E	149_D	2.188	1.00
421_L	461_T	2.152	1.00
375_E	398_E	2.150	1.00
375_E	396_I	2.132	1.00
406_C	468_L	2.110	1.00
222_K	231_T	2.109	1.00
189_G	214_N	2.092	1.00
31_L	40_V	2.075	1.00
216_T	252_C	2.034	1.00
527_A	530_A	2.021	1.00
428_V	476_Q	2.012	1.00
230_Q	234_A	2.008	1.00
71_Y	177_V	2.007	1.00
27_I	170_Q	1.975	1.00
195_I	208_S	1.961	1.00
434_Y	439_V	1.948	1.00
386_S	391_P	1.908	1.00
133_I	167_V	1.884	1.00
410_L	466_A	1.883	1.00
412_Q	439_V	1.879	1.00
144_A	160_R	1.869	1.00
3_N	71_Y	1.847	1.00
32_S	35_E	1.835	1.00
224_K	231_T	1.816	1.00
412_Q	437_N	1.812	1.00
191_L	223_V	1.799	1.00
212_I	253_G	1.789	1.00
46_L	54_I	1.786	1.00
49_E	357_R	1.781	1.00
208_S	268_A	1.752	1.00
97_G	180_I	1.742	1.00
218_R	221_D	1.736	1.00
391_P	394_N	1.734	1.00
311_R	328_P	1.724	1.00
206_V	319_L	1.723	1.00
142_R	146_E	1.718	1.00
513_E	516_K	1.694	1.00
527_A	532_I	1.681	1.00
250_L	253_G	1.680	1.00
103_D	106_Q	1.679	1.00
428_V	444_E	1.670	1.00
418_V	462_S	1.661	1.00
313_A	355_L	1.659	1.00
372_Y	399_L	1.647	1.00
387_P	391_P	1.647	1.00
292_K	325_F	1.646	1.00
497_L	517_D	1.639	1.00
76_I	95_C	1.638	1.00
7_F	176_L	1.633	1.00
415_L	439_V	1.623	1.00
214_N	281_A	1.621	1.00
102_V	112_T	1.617	1.00
115_N	118_T	1.610	1.00
420_T	424_E	1.596	1.00
191_L	212_I	1.596	1.00
427_G	445_I	1.596	1.00
374_V	399_L	1.586	1.00
44_M	55_K	1.579	1.00
3_N	70_T	1.575	1.00
406_C	445_I	1.572	1.00
6_N	74_N	1.569	1.00
324_L	351_I	1.568	1.00
99_L	129_V	1.559	1.00
129_V	163_A	1.536	1.00
199_W	209_L	1.535	1.00
391_P	397_Y	1.530	1.00
234_A	237_L	1.529	1.00
391_P	396_I	1.528	1.00
390_L	394_N	1.527	1.00
104_A	130_L	1.514	1.00
385_D	391_P	1.512	1.00
318_S	324_L	1.505	1.00
327_E	341_G	1.499	1.00
421_L	457_R	1.499	1.00
387_P	390_L	1.495	1.00
27_I	169_V	1.487	1.00
98_A	124_L	1.482	1.00
405_E	444_E	1.473	1.00
296_Y	341_G	1.473	1.00
161_C	168_G	1.459	1.00
24_I	61_L	1.455	1.00
353_E	357_R	1.446	1.00
101_V	163_A	1.446	1.00
210_I	258_L	1.443	1.00
219_K	251_K	1.441	1.00
391_P	395_N	1.437	1.00
407_H	440_A	1.425	1.00
21_S	75_F	1.422	1.00
409_L	440_A	1.417	1.00
311_R	315_G	1.409	1.00
63_Y	174_E	1.405	1.00
385_D	396_I	1.393	1.00
302_V	362_D	1.383	1.00
41_L	59_V	1.378	1.00
139_D	143_V	1.378	1.00
60_T	72_Q	1.378	1.00
502_D	505_Q	1.370	1.00
170_Q	174_E	1.365	1.00
20_L	101_V	1.360	1.00
46_L	354_R	1.356	1.00
315_G	328_P	1.351	1.00
394_N	397_Y	1.346	1.00
37_E	48_R	1.338	1.00
140_P	143_V	1.333	1.00
457_R	461_T	1.328	1.00
408_M	422_C	1.325	1.00
212_I	259_V	1.322	1.00
327_E	339_R	1.316	1.00
105_G	137_A	1.311	1.00
375_E	397_Y	1.309	1.00
505_Q	509_R	1.305	1.00
483_V	499_T	1.301	1.00
43_S	57_Q	1.298	1.00
276_L	279_N	1.297	1.00
46_L	350_I	1.297	1.00
5_R	183_P	1.284	1.00
386_S	390_L	1.282	1.00
422_C	445_I	1.279	1.00
324_L	340_C	1.279	1.00
185_G	214_N	1.276	1.00
253_G	257_W	1.276	1.00
24_I	169_V	1.272	1.00
224_K	280_P	1.271	1.00
61_L	75_F	1.270	1.00
230_Q	267_G	1.264	1.00
385_D	390_L	1.264	1.00
31_L	36_M	1.260	1.00
241_T	250_L	1.258	1.00
352_Q	365_T	1.251	1.00
403_I	479_D	1.250	1.00
407_H	442_T	1.244	1.00
372_Y	448_A	1.244	1.00
386_S	393_V	1.240	1.00
306_D	362_D	1.238	1.00
154_D	157_D	1.238	1.00
222_K	233_N	1.238	1.00
227_S	272_D	1.236	1.00
236_R	246_D	1.234	1.00
230_Q	237_L	1.220	1.00
143_V	146_E	1.214	1.00
506_N	510_E	1.212	0.99
219_K	237_L	1.208	0.99
153_I	157_D	1.208	0.99
306_D	309_A	1.203	0.99
25_I	30_G	1.201	0.99
193_A	210_I	1.200	0.99
104_A	133_I	1.200	0.99
473_K	476_Q	1.199	0.99
386_S	397_Y	1.199	0.99
269_P	290_K	1.197	0.99
390_L	395_N	1.196	0.99
20_L	163_A	1.196	0.99
127_V	175_R	1.188	0.99
226_M	275_T	1.183	0.99
20_L	172_V	1.183	0.99
165_T	169_V	1.182	0.99
491_R	533_G	1.173	0.99
419_I	429_Q	1.172	0.99
28_C	173_L	1.170	0.99
216_T	254_E	1.169	0.99
512_V	516_K	1.167	0.99
429_Q	432_M	1.164	0.99
230_Q	233_N	1.160	0.99
272_D	287_G	1.159	0.99
168_G	171_D	1.158	0.99
411_P	465_Y	1.156	0.99
406_C	470_Y	1.150	0.99
223_V	274_L	1.146	0.99
210_I	262_I	1.146	0.99
9_I	21_S	1.145	0.99
345_L	453_D	1.145	0.99
472_F	475_F	1.136	0.99
258_L	274_L	1.135	0.99
168_G	172_V	1.131	0.99
45_D	357_R	1.130	0.99
8_S	95_C	1.129	0.99
190_P	279_N	1.124	0.99
404_A	450_V	1.122	0.99
191_L	217_L	1.122	0.99
21_S	41_L	1.119	0.99
415_L	432_M	1.116	0.99
192_Q	281_A	1.109	0.99
103_D	143_V	1.107	0.99
28_C	61_L	1.106	0.99
10_I	100_L	1.089	0.99
403_I	474_R	1.088	0.99
488_N	492_V	1.087	0.99
116_C	120_M	1.086	0.99
8_S	92_L	1.083	0.99
275_T	280_P	1.081	0.99
157_D	179_D	1.076	0.99
26_Q	33_D	1.075	0.99
302_V	364_I	1.070	0.99
390_L	393_V	1.070	0.99
217_L	234_A	1.069	0.99
498_I	512_V	1.068	0.99
224_K	277_A	1.068	0.99
390_L	397_Y	1.064	0.99
207_V	261_A	1.062	0.99
104_A	138_A	1.056	0.99
510_E	513_E	1.055	0.99
487_I	528_I	1.053	0.99
420_T	423_V	1.052	0.99
185_G	255_V	1.051	0.99
217_L	258_L	1.047	0.99
486_L	531_A	1.045	0.98
64_K	174_E	1.038	0.98
130_L	160_R	1.037	0.98
377_T	397_Y	1.035	0.98
155_A	158_A	1.033	0.98
386_S	395_N	1.033	0.98
236_R	257_W	1.030	0.98
30_G	61_L	1.029	0.98
10_I	98_A	1.027	0.98
413_A	463_R	1.026	0.98
372_Y	475_F	1.025	0.98
331_S	335_G	1.023	0.98
100_L	112_T	1.019	0.98
231_T	277_A	1.018	0.98
127_V	159_V	1.018	0.98
387_P	394_N	1.018	0.98
310_F	361_L	1.013	0.98
508_G	530_A	1.011	0.98
376_T	380_E	1.011	0.98
226_M	284_A	1.010	0.98
24_I	173_L	1.010	0.98
296_Y	339_R	1.009	0.98
62_D	72_Q	1.008	0.98
11_A	14_D	1.007	0.98
454_F	461_T	1.002	0.98
45_D	49_E	1.002	0.98
385_D	397_Y	0.999	0.98
148_E	155_A	0.995	0.98
387_P	396_I	0.994	0.98
403_I	473_K	0.993	0.98
401_E	426_R	0.992	0.98
432_M	439_V	0.987	0.98
188_E	216_T	0.982	0.98
112_T	128_P	0.982	0.98
387_P	393_V	0.980	0.98
223_V	234_A	0.979	0.98
224_K	229_G	0.975	0.98
46_L	50_R	0.974	0.98
406_C	450_V	0.971	0.98
503_N	506_N	0.968	0.98
264_D	267_G	0.964	0.97
25_I	40_V	0.955	0.97
380_E	386_S	0.951	0.97
303_S	306_D	0.950	0.97
61_L	73_L	0.942	0.97
512_V	528_I	0.942	0.97
433_V	442_T	0.941	0.97
41_L	53_T	0.941	0.97
297_A	365_T	0.940	0.97
483_V	497_L	0.939	0.97
275_T	281_A	0.939	0.97
31_L	34_R	0.936	0.97
119_A	126_V	0.936	0.97
216_T	249_E	0.935	0.97
426_R	449_E	0.934	0.97
130_L	140_P	0.934	0.97
386_S	396_I	0.931	0.97
64_K	177_V	0.930	0.97
219_K	246_D	0.930	0.97
380_E	387_P	0.930	0.97
38_A	48_R	0.926	0.97
265_I	268_A	0.924	0.97
390_L	399_L	0.923	0.97
121_E	289_K	0.923	0.97
212_I	217_L	0.923	0.97
300_F	364_I	0.920	0.97
400_R	477_A	0.918	0.97
415_L	441_L	0.918	0.97
479_D	502_D	0.917	0.97
408_M	418_V	0.916	0.97
386_S	394_N	0.915	0.97
376_T	395_N	0.914	0.96
193_A	212_I	0.912	0.96
141_E	145_E	0.910	0.96
454_F	458_L	0.907	0.96
514_K	517_D	0.907	0.96
18_S	21_S	0.903	0.96
406_C	422_C	0.901	0.96
191_L	216_T	0.900	0.96
52_I	346_L	0.897	0.96
148_E	153_I	0.895	0.96
153_I	158_A	0.891	0.96
120_M	151_V	0.890	0.96
127_V	180_I	0.889	0.96
391_P	398_E	0.887	0.96
372_Y	478_S	0.883	0.96
130_L	144_A	0.879	0.96
10_I	119_A	0.877	0.96
266_H	318_S	0.877	0.96
222_K	277_A	0.876	0.96
161_C	165_T	0.876	0.96
418_V	458_L	0.870	0.95
225_V	274_L	0.865	0.95
210_I	259_V	0.864	0.95
485_V	488_N	0.862	0.95
128_P	147_I	0.848	0.95
385_D	398_E	0.847	0.95
298_G	337_G	0.847	0.95
417_N	461_T	0.846	0.95
315_G	326_Y	0.842	0.94
340_C	351_I	0.841	0.94
190_P	276_L	0.840	0.94
7_F	75_F	0.840	0.94
25_I	59_V	0.838	0.94
522_Q	527_A	0.837	0.94
385_D	393_V	0.834	0.94
387_P	395_N	0.833	0.94
387_P	397_Y	0.833	0.94
24_I	73_L	0.832	0.94
405_E	430_T	0.831	0.94
44_M	354_R	0.831	0.94
393_V	397_Y	0.831	0.94
276_L	280_P	0.831	0.94
488_N	491_R	0.830	0.94
506_N	528_I	0.829	0.94
423_V	443_Y	0.828	0.94
97_G	181_P	0.827	0.94
375_E	395_N	0.826	0.94
374_V	396_I	0.826	0.94
55_K	59_V	0.826	0.94
232_Y	235_D	0.825	0.94
140_P	160_R	0.825	0.94
153_I	156_T	0.824	0.94
396_I	400_R	0.823	0.94
422_C	443_Y	0.821	0.94
403_I	444_E	0.821	0.94
162_S	165_T	0.819	0.94
185_G	189_G	0.818	0.94
412_Q	415_L	0.818	0.94
492_V	496_A	0.817	0.94
204_L	236_R	0.815	0.93
217_L	223_V	0.815	0.93
321_D	347_H	0.814	0.93
404_A	447_M	0.813	0.93
24_I	28_C	0.812	0.93
425_K	453_D	0.812	0.93
226_M	281_A	0.810	0.93
390_L	396_I	0.810	0.93
354_R	358_E	0.808	0.93
323_S	351_I	0.806	0.93
489_G	527_A	0.804	0.93
99_L	159_V	0.804	0.93
326_Y	338_F	0.800	0.93
493_D	504_S	0.799	0.93
399_L	478_S	0.799	0.93
329_E	337_G	0.796	0.93
406_C	427_G	0.796	0.93
311_R	338_F	0.794	0.93
254_E	257_W	0.794	0.93
385_D	395_N	0.794	0.93
488_N	496_A	0.791	0.92
233_N	236_R	0.791	0.92
428_V	479_D	0.790	0.92
232_Y	268_A	0.788	0.92
85_S	118_T	0.788	0.92
20_L	169_V	0.788	0.92
28_C	62_D	0.786	0.92
45_D	48_R	0.786	0.92
225_V	268_A	0.786	0.92
380_E	397_Y	0.783	0.92
96_E	211_R	0.782	0.92
414_Y	465_Y	0.781	0.92
102_V	147_I	0.780	0.92
93_A	213_K	0.778	0.92
504_S	510_E	0.778	0.92
419_I	441_L	0.777	0.92
219_K	249_E	0.776	0.92
232_Y	236_R	0.775	0.92
10_I	92_L	0.773	0.92
28_C	63_Y	0.773	0.92
424_E	457_R	0.773	0.92
246_D	257_W	0.772	0.91
491_R	496_A	0.771	0.91
140_P	144_A	0.770	0.91
318_S	326_Y	0.765	0.91
380_E	391_P	0.765	0.91
192_Q	285_L	0.765	0.91
328_P	335_G	0.765	0.91
117_Y	438_Q	0.764	0.91
230_Q	236_R	0.761	0.91
498_I	516_K	0.760	0.91
236_R	249_E	0.759	0.91
103_D	135_L	0.758	0.91
36_M	40_V	0.754	0.90
93_A	288_F	0.754	0.90
490_E	496_A	0.751	0.90
454_F	466_A	0.748	0.90
29_G	32_S	0.745	0.90
425_K	457_R	0.743	0.90
492_V	497_L	0.742	0.90
351_I	355_L	0.740	0.90
516_K	522_Q	0.739	0.90
379_R	397_Y	0.737	0.89
33_D	36_M	0.735	0.89
117_Y	121_E	0.735	0.89
352_Q	363_L	0.734	0.89
50_R	349_E	0.734	0.89
329_E	335_G	0.733	0.89
217_L	237_L	0.732	0.89
485_V	489_G	0.732	0.89
297_A	340_C	0.730	0.89
506_N	509_R	0.729	0.89
231_T	234_A	0.727	0.89
498_I	513_E	0.726	0.89
193_A	262_I	0.724	0.89
161_C	167_V	0.723	0.89
300_F	366_T	0.722	0.89
429_Q	443_Y	0.722	0.89
281_A	284_A	0.721	0.88
312_D	315_G	0.721	0.88
152_G	157_D	0.720	0.88
44_M	54_I	0.719	0.88
414_Y	463_R	0.719	0.88
498_I	501_R	0.718	0.88
46_L	353_E	0.718	0.88
92_L	122_M	0.717	0.88
427_G	443_Y	0.717	0.88
39_Q	48_R	0.717	0.88
352_Q	356_E	0.717	0.88
193_A	217_L	0.716	0.88
102_V	128_P	0.716	0.88
208_S	262_I	0.714	0.88
37_E	40_V	0.713	0.88
122_M	213_K	0.713	0.88
489_G	492_V	0.711	0.88
380_E	390_L	0.710	0.88
228_T	287_G	0.710	0.88
175_R	178_R	0.710	0.88
115_N	119_A	0.707	0.87
56_A	76_I	0.707	0.87
60_T	247_R	0.706	0.87
89_S	115_N	0.704	0.87
148_E	154_D	0.703	0.87
377_T	477_A	0.703	0.87
415_L	419_I	0.702	0.87
78_T	88_V	0.702	0.87
380_E	394_N	0.701	0.87
485_V	492_V	0.701	0.87
317_L	359_Y	0.699	0.87
14_D	52_I	0.698	0.87
410_L	414_Y	0.697	0.87
73_L	177_V	0.696	0.87
294_Q	404_A	0.696	0.87
406_C	443_Y	0.695	0.87
355_L	361_L	0.693	0.86
159_V	172_V	0.693	0.86
295_V	452_L	0.690	0.86
139_D	146_E	0.690	0.86
34_R	37_E	0.690	0.86
105_G	138_A	0.689	0.86
509_R	513_E	0.686	0.86
147_I	155_A	0.685	0.86
407_H	471_N	0.684	0.86
410_L	441_L	0.684	0.86
377_T	395_N	0.683	0.86
60_T	74_N	0.682	0.86
219_K	236_R	0.682	0.86
43_S	55_K	0.681	0.85
192_Q	213_K	0.680	0.85
395_N	398_E	0.679	0.85
7_F	21_S	0.678	0.85
148_E	158_A	0.678	0.85
199_W	240_F	0.677	0.85
50_R	353_E	0.676	0.85
387_P	398_E	0.675	0.85
89_S	118_T	0.671	0.85
187_P	216_T	0.669	0.84
380_E	395_N	0.669	0.84
403_I	478_S	0.665	0.84
385_D	394_N	0.665	0.84
224_K	232_Y	0.664	0.84
518_L	522_Q	0.663	0.84
508_G	531_A	0.662	0.84
64_K	71_Y	0.662	0.84
137_A	140_P	0.662	0.84
99_L	172_V	0.660	0.84
52_I	81_H	0.660	0.84
127_V	179_D	0.659	0.84
159_V	179_D	0.658	0.83
195_I	268_A	0.655	0.83
82_V	114_A	0.652	0.83
419_I	423_V	0.652	0.83
373_E	398_E	0.651	0.83
147_I	158_A	0.651	0.83
129_V	172_V	0.650	0.83
232_Y	265_I	0.650	0.83
499_T	504_S	0.649	0.83
305_D	364_I	0.649	0.83
250_L	259_V	0.648	0.83
309_A	313_A	0.646	0.82
97_G	183_P	0.643	0.82
505_Q	513_E	0.643	0.82
504_S	532_I	0.642	0.82
73_L	173_L	0.641	0.82
113_L	465_Y	0.640	0.82
522_Q	526_I	0.640	0.82
72_Q	241_T	0.639	0.82
430_T	473_K	0.639	0.82
230_Q	235_D	0.637	0.81
242_P	261_A	0.637	0.81
199_W	429_Q	0.636	0.81
317_L	355_L	0.636	0.81
277_A	280_P	0.636	0.81
14_D	81_H	0.634	0.81
25_I	31_L	0.634	0.81
113_L	117_Y	0.633	0.81
145_E	148_E	0.633	0.81
510_E	534_T	0.630	0.81
86_Y	323_S	0.629	0.81
450_V	468_L	0.628	0.81
225_V	232_Y	0.627	0.80
91_S	95_C	0.627	0.80
430_T	442_T	0.627	0.80
494_A	497_L	0.626	0.80
276_L	281_A	0.624	0.80
11_A	111_Q	0.623	0.80
42_D	47_E	0.622	0.80
217_L	221_D	0.622	0.80
7_F	18_S	0.620	0.80
240_F	249_E	0.619	0.80
489_G	523_Q	0.618	0.79
503_N	510_E	0.618	0.79
497_L	511_L	0.618	0.79
520_P	533_G	0.617	0.79
201_D	207_V	0.617	0.79
173_L	176_L	0.617	0.79
109_E	135_L	0.616	0.79
400_R	475_F	0.615	0.79
120_M	126_V	0.615	0.79
210_I	253_G	0.613	0.79
8_S	176_L	0.611	0.79
458_L	462_S	0.611	0.79
511_L	526_I	0.610	0.79
4_I	74_N	0.610	0.79
326_Y	340_C	0.609	0.78
23_R	169_V	0.609	0.78
513_E	517_D	0.608	0.78
303_S	362_D	0.608	0.78
116_C	126_V	0.606	0.78
484_D	488_N	0.606	0.78
64_K	170_Q	0.604	0.78
492_V	495_L	0.603	0.78
292_K	469_D	0.603	0.78
8_S	122_M	0.602	0.78
324_L	347_H	0.601	0.78
5_R	182_P	0.600	0.77
310_F	363_L	0.599	0.77
23_R	166_G	0.599	0.77
58_S	209_L	0.599	0.77
46_L	57_Q	0.599	0.77
415_L	429_Q	0.596	0.77
11_A	15_H	0.595	0.77
31_L	35_E	0.591	0.76
489_G	493_D	0.591	0.76
191_L	234_A	0.589	0.76
499_T	503_N	0.588	0.76
331_S	336_F	0.588	0.76
494_A	520_P	0.587	0.76
491_R	497_L	0.587	0.76
12_H	15_H	0.586	0.76
275_T	279_N	0.585	0.76
24_I	99_L	0.584	0.76
5_R	97_G	0.584	0.76
501_R	510_E	0.583	0.75
121_E	152_G	0.583	0.75
208_S	306_D	0.583	0.75
100_L	126_V	0.582	0.75
201_D	204_L	0.582	0.75
26_Q	36_M	0.582	0.75
386_S	398_E	0.581	0.75
425_K	449_E	0.581	0.75
505_Q	528_I	0.581	0.75
163_A	169_V	0.580	0.75
206_V	268_A	0.579	0.75
507_R	510_E	0.578	0.75
13_I	52_I	0.577	0.75
141_E	160_R	0.577	0.75
39_Q	135_L	0.575	0.74
447_M	470_Y	0.574	0.74
404_A	470_Y	0.574	0.74
101_V	131_N	0.574	0.74
32_S	36_M	0.573	0.74
408_M	466_A	0.573	0.74
407_H	469_D	0.571	0.74
49_E	358_E	0.571	0.74
219_K	235_D	0.571	0.74
13_I	44_M	0.570	0.74
250_L	257_W	0.569	0.74
113_L	116_C	0.568	0.74
160_R	168_G	0.568	0.74
100_L	128_P	0.567	0.73
309_A	312_D	0.566	0.73
172_V	176_L	0.566	0.73
509_R	512_V	0.563	0.73
341_G	347_H	0.563	0.73
414_Y	417_N	0.562	0.73
504_S	530_A	0.562	0.73
499_T	502_D	0.561	0.73
510_E	518_L	0.561	0.73
159_V	168_G	0.560	0.73
5_R	181_P	0.560	0.73
212_I	216_T	0.557	0.72
14_D	53_T	0.557	0.72
103_D	132_K	0.557	0.72
30_G	243_K	0.557	0.72
40_V	243_K	0.556	0.72
192_Q	280_P	0.555	0.72
50_R	84_F	0.555	0.72
19_T	51_G	0.555	0.72
54_I	357_R	0.555	0.72
510_E	523_Q	0.555	0.72
318_S	351_I	0.553	0.72
8_S	98_A	0.553	0.72
506_N	516_K	0.553	0.72
426_R	448_A	0.552	0.71
44_M	357_R	0.552	0.71
501_R	504_S	0.552	0.71
285_L	288_F	0.552	0.71
144_A	157_D	0.551	0.71
147_I	151_V	0.549	0.71
342_F	347_H	0.548	0.71
416_G	420_T	0.548	0.71
50_R	346_L	0.547	0.71
485_V	491_R	0.547	0.71
297_A	352_Q	0.546	0.71
5_R	9_I	0.544	0.70
404_A	468_L	0.544	0.70
493_D	497_L	0.543	0.70
13_I	81_H	0.543	0.70
78_T	90_R	0.542	0.70
81_H	88_V	0.542	0.70
116_C	150_I	0.542	0.70
56_A	91_S	0.540	0.70
422_C	454_F	0.540	0.70
506_N	513_E	0.540	0.70
27_I	161_C	0.540	0.70
173_L	177_V	0.540	0.70
315_G	318_S	0.539	0.70
426_R	445_I	0.538	0.70
146_E	149_D	0.538	0.70
62_D	243_K	0.538	0.70
430_T	476_Q	0.537	0.69
52_I	83_D	0.537	0.69
479_D	482_R	0.537	0.69
163_A	172_V	0.537	0.69
209_L	242_P	0.537	0.69
296_Y	355_L	0.534	0.69
530_A	533_G	0.534	0.69
308_E	312_D	0.533	0.69
262_I	371_V	0.533	0.69
43_S	46_L	0.533	0.69
24_I	27_I	0.532	0.69
210_I	217_L	0.532	0.69
523_Q	527_A	0.532	0.69
98_A	119_A	0.532	0.69
502_D	506_N	0.532	0.69
89_S	121_E	0.531	0.69
106_Q	135_L	0.531	0.69
196_I	209_L	0.531	0.69
78_T	81_H	0.530	0.68
393_V	398_E	0.530	0.68
105_G	109_E	0.529	0.68
227_S	230_Q	0.529	0.68
14_D	19_T	0.529	0.68
224_K	278_R	0.527	0.68
120_M	123_D	0.526	0.68
107_G	112_T	0.525	0.68
27_I	168_G	0.524	0.68
253_G	262_I	0.524	0.68
318_S	340_C	0.523	0.67
197_D	533_G	0.523	0.67
197_D	270_V	0.522	0.67
445_I	450_V	0.522	0.67
213_K	285_L	0.522	0.67
49_E	353_E	0.522	0.67
509_R	526_I	0.521	0.67
176_L	385_D	0.521	0.67
241_T	245_V	0.521	0.67
53_T	111_Q	0.520	0.67
480_M	484_D	0.520	0.67
13_I	53_T	0.519	0.67
339_R	369_T	0.519	0.67
426_R	446_P	0.518	0.67
150_I	153_I	0.517	0.66
11_A	53_T	0.517	0.66
484_D	489_G	0.517	0.66
410_L	439_V	0.516	0.66
421_L	425_K	0.516	0.66
525_D	534_T	0.516	0.66
83_D	88_V	0.513	0.66
485_V	490_E	0.512	0.66
512_V	522_Q	0.512	0.66
374_V	390_L	0.512	0.66
353_E	356_E	0.512	0.66
317_L	321_D	0.511	0.66
478_S	481_V	0.511	0.66
490_E	493_D	0.511	0.66
476_Q	479_D	0.511	0.66
498_I	502_D	0.511	0.66
187_P	252_C	0.510	0.65
375_E	477_A	0.510	0.65
419_I	432_M	0.509	0.65
4_I	72_Q	0.509	0.65
20_L	129_V	0.509	0.65
404_A	445_I	0.509	0.65
209_L	429_Q	0.508	0.65
103_D	146_E	0.507	0.65
378_S	395_N	0.507	0.65
8_S	61_L	0.506	0.65
103_D	112_T	0.505	0.65
435_H	440_A	0.504	0.65
216_T	251_K	0.504	0.65
23_R	27_I	0.504	0.65
433_V	440_A	0.504	0.65
497_L	508_G	0.503	0.64
72_Q	257_W	0.503	0.64
374_V	400_R	0.503	0.64
408_M	445_I	0.502	0.64
504_S	528_I	0.502	0.64
64_K	173_L	0.501	0.64
144_A	148_E	0.501	0.64
158_A	167_V	0.501	0.64
427_G	446_P	0.500	0.64
373_E	475_F	0.500	0.64
108_V	112_T	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cb4D	1	0.8715	100	0.172	Contact Map
2yweA	1	0.8648	100	0.179	Contact Map
4qjty	1	0.9416	100	0.191	Contact Map
4zciA	1	0.8698	100	0.366	Contact Map
4kiyV	1	0.788	100	0.39	Contact Map
1darA	1	0.6728	100	0.391	Contact Map
2xexA	1	0.778	100	0.396	Contact Map
3j25A	1	0.8114	100	0.403	Contact Map
4fn5A	1	0.7596	100	0.406	Contact Map
4w224	1	0.8414	100	0.417	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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