HIS1 - ECOLI - GREMLIN Contacts

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HIS1 - ATP phosphoribosyltransferase

UniProt:	P60757	Sequences: MTDNTRLRIAMQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWDGPLSLNGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMEESKQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10449
Length:	299 (278)
Sequences:	1509 (795)
Seq/√Len:	47.7

ECOLI - HIS1
BACSU - HIS1
HALSA - HIS1
SULSO - HIS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_N	145_S	5.892	1.00
98_R	192_K	5.072	1.00
139_L	146_F	4.702	1.00
235_T	263_V	4.149	1.00
237_R	240_E	3.964	1.00
258_G	261_Q	3.947	1.00
122_L	166_A	3.875	1.00
137_R	141_Q	3.480	1.00
117_D	121_S	3.430	1.00
238_L	265_M	3.358	1.00
92_R	199_D	3.330	1.00
233_A	241_V	3.128	1.00
234_P	237_R	3.081	1.00
74_E	95_T	3.002	1.00
127_I	139_L	2.881	1.00
108_L	138_Y	2.862	1.00
236_E	261_Q	2.806	1.00
135_L	168_C	2.804	1.00
187_V	190_R	2.722	1.00
119_P	138_Y	2.709	1.00
62_V	196_I	2.581	1.00
230_M	266_H	2.560	1.00
100_D	192_K	2.427	1.00
30_I	43_A	2.411	1.00
133_H	136_K	2.385	1.00
19_D	23_E	2.376	1.00
77_L	93_Y	2.306	1.00
105_R	184_E	2.177	1.00
235_T	261_Q	2.166	1.00
112_V	181_G	2.150	1.00
208_Q	283_A	2.148	1.00
136_K	140_D	2.145	1.00
245_L	267_M	2.096	1.00
95_T	194_C	2.095	1.00
107_S	184_E	2.069	1.00
120_L	142_K	2.041	1.00
74_E	98_R	1.992	0.99
118_G	121_S	1.983	0.99
207_Q	211_D	1.946	0.99
115_A	183_R	1.897	0.99
240_E	243_A	1.884	0.99
58_I	169_D	1.854	0.99
107_S	171_V	1.849	0.99
90_D	137_R	1.845	0.99
69_L	195_L	1.832	0.99
273_L	276_E	1.822	0.99
94_F	199_D	1.812	0.99
110_T	183_R	1.810	0.99
119_P	144_I	1.786	0.99
110_T	114_E	1.771	0.99
249_E	287_S	1.708	0.98
276_E	280_K	1.644	0.98
97_R	218_Q	1.625	0.98
96_L	197_Q	1.624	0.98
104_C	191_S	1.603	0.97
106_L	170_L	1.570	0.97
232_H	249_E	1.547	0.97
226_S	270_S	1.545	0.97
241_V	284_L	1.535	0.97
38_R	179_A	1.520	0.96
268_V	294_I	1.520	0.96
138_Y	186_E	1.478	0.96
109_A	177_L	1.443	0.95
113_D	183_R	1.432	0.95
13_K	154_S	1.430	0.95
248_A	288_S	1.404	0.94
78_E	137_R	1.394	0.94
103_G	172_S	1.311	0.92
114_E	121_S	1.308	0.92
291_V	295_E	1.285	0.91
24_L	217_I	1.282	0.91
32_I	41_A	1.282	0.91
108_L	122_L	1.276	0.91
155_V	171_V	1.262	0.90
78_E	189_Y	1.238	0.89
162_G	176_T	1.233	0.89
110_T	116_W	1.228	0.89
139_L	168_C	1.225	0.89
250_R	258_G	1.220	0.89
97_R	214_L	1.210	0.88
93_Y	196_I	1.202	0.88
227_K	295_E	1.200	0.88
270_S	273_L	1.196	0.88
233_A	284_L	1.176	0.87
55_D	72_I	1.164	0.86
250_R	256_L	1.134	0.85
130_S	155_V	1.130	0.85
120_L	144_I	1.128	0.85
136_K	148_S	1.126	0.84
239_D	243_A	1.125	0.84
280_K	283_A	1.116	0.84
175_A	179_A	1.106	0.83
243_A	283_A	1.103	0.83
108_L	135_L	1.095	0.83
239_D	242_I	1.084	0.82
122_L	127_I	1.071	0.81
240_E	244_L	1.068	0.81
123_N	144_I	1.051	0.80
131_Y	134_L	1.049	0.80
56_D	76_V	1.046	0.80
237_R	284_L	1.046	0.80
240_E	284_L	1.045	0.80
235_T	255_P	1.045	0.80
110_T	185_V	1.031	0.79
231_M	267_M	1.029	0.79
108_L	168_C	1.025	0.78
50_I	58_I	1.021	0.78
12_Q	75_N	1.019	0.78
274_F	291_V	1.009	0.77
218_Q	222_Q	1.005	0.77
231_M	245_L	0.989	0.76
171_V	216_R	0.989	0.76
32_I	50_I	0.988	0.76
208_Q	212_K	0.988	0.76
43_A	48_I	0.983	0.75
98_R	194_C	0.983	0.75
105_R	190_R	0.982	0.75
219_G	278_M	0.978	0.75
47_P	209_L	0.976	0.75
34_L	38_R	0.973	0.75
228_Y	266_H	0.973	0.75
72_I	75_N	0.971	0.74
28_C	222_Q	0.966	0.74
233_A	265_M	0.965	0.74
107_S	187_V	0.963	0.74
254_L	266_H	0.959	0.74
287_S	294_I	0.958	0.73
109_A	128_A	0.954	0.73
16_R	172_S	0.952	0.73
97_R	221_I	0.949	0.73
76_V	168_C	0.949	0.73
12_Q	55_D	0.946	0.72
112_V	137_R	0.942	0.72
78_E	90_D	0.942	0.72
159_P	180_N	0.938	0.72
110_T	115_A	0.937	0.72
80_E	91_P	0.936	0.72
78_E	134_L	0.909	0.69
290_L	294_I	0.895	0.68
237_R	253_I	0.892	0.68
45_N	209_L	0.889	0.68
175_A	219_G	0.885	0.67
154_S	209_L	0.885	0.67
139_L	142_K	0.883	0.67
127_I	188_I	0.879	0.67
17_L	193_A	0.877	0.67
130_S	171_V	0.864	0.65
211_D	214_L	0.861	0.65
78_E	95_T	0.858	0.65
21_S	101_F	0.858	0.65
63_M	93_Y	0.857	0.65
11_M	25_L	0.857	0.65
69_L	214_L	0.850	0.64
142_K	186_E	0.847	0.64
241_V	245_L	0.847	0.64
246_P	290_L	0.847	0.64
57_D	151_L	0.845	0.64
59_P	106_L	0.844	0.64
155_V	216_R	0.835	0.63
212_K	279_E	0.833	0.63
74_E	194_C	0.832	0.63
233_A	237_R	0.823	0.62
92_R	145_S	0.822	0.62
18_S	21_S	0.822	0.62
11_M	22_R	0.819	0.61
29_G	128_A	0.816	0.61
13_K	61_L	0.813	0.61
55_D	106_L	0.810	0.60
179_A	219_G	0.802	0.60
18_S	151_L	0.801	0.60
235_T	259_D	0.800	0.59
255_P	263_V	0.794	0.59
119_P	186_E	0.792	0.59
22_R	26_A	0.784	0.58
240_E	280_K	0.780	0.58
125_K	166_A	0.779	0.57
71_I	193_A	0.778	0.57
40_I	210_I	0.774	0.57
168_C	188_I	0.772	0.57
117_D	136_K	0.771	0.57
96_L	210_I	0.769	0.56
112_V	183_R	0.768	0.56
114_E	183_R	0.768	0.56
128_A	164_A	0.767	0.56
136_K	145_S	0.764	0.56
8_R	144_I	0.761	0.56
74_E	78_E	0.760	0.56
59_P	80_E	0.758	0.55
157_V	172_S	0.758	0.55
242_I	257_A	0.757	0.55
171_V	184_E	0.756	0.55
37_Q	70_G	0.754	0.55
36_T	138_Y	0.752	0.55
143_G	283_A	0.751	0.55
12_Q	72_I	0.751	0.55
173_T	184_E	0.749	0.54
95_T	98_R	0.741	0.54
232_H	256_L	0.738	0.53
27_R	220_V	0.737	0.53
141_Q	206_K	0.736	0.53
32_I	180_N	0.736	0.53
241_V	268_V	0.735	0.53
90_D	133_H	0.730	0.53
149_C	173_T	0.729	0.52
128_A	149_C	0.727	0.52
235_T	258_G	0.725	0.52
74_E	189_Y	0.725	0.52
172_S	184_E	0.724	0.52
249_E	288_S	0.723	0.52
58_I	126_R	0.721	0.52
68_D	206_K	0.720	0.52
16_R	159_P	0.720	0.52
37_Q	179_A	0.716	0.51
110_T	122_L	0.715	0.51
10_A	291_V	0.714	0.51
152_N	288_S	0.713	0.51
173_T	181_G	0.712	0.51
133_H	137_R	0.710	0.51
23_E	27_R	0.708	0.50
128_A	151_L	0.705	0.50
147_K	239_D	0.702	0.50
132_P	179_A	0.702	0.50
271_E	296_K	0.702	0.50
60_G	149_C	0.698	0.49
114_E	125_K	0.697	0.49
39_L	151_L	0.695	0.49
229_I	270_S	0.694	0.49
234_P	261_Q	0.693	0.49
37_Q	196_I	0.693	0.49
151_L	155_V	0.692	0.49
10_A	67_V	0.691	0.49
259_D	262_R	0.691	0.49
39_L	43_A	0.691	0.49
54_R	146_F	0.690	0.49
127_I	166_A	0.689	0.48
104_C	162_G	0.688	0.48
32_I	110_T	0.687	0.48
119_P	280_K	0.686	0.48
115_A	140_D	0.685	0.48
252_T	264_A	0.685	0.48
7_L	175_A	0.683	0.48
214_L	218_Q	0.682	0.48
38_R	172_S	0.682	0.48
42_M	224_R	0.681	0.48
70_G	134_L	0.678	0.47
55_D	70_G	0.678	0.47
69_L	210_I	0.677	0.47
70_G	196_I	0.676	0.47
93_Y	96_L	0.673	0.47
159_P	167_I	0.673	0.47
31_K	221_I	0.672	0.47
118_G	141_Q	0.671	0.47
42_M	69_L	0.669	0.46
126_R	173_T	0.666	0.46
232_H	287_S	0.662	0.46
64_D	293_P	0.662	0.46
30_I	48_I	0.657	0.45
25_L	50_I	0.655	0.45
172_S	176_T	0.654	0.45
49_D	175_A	0.652	0.45
177_L	180_N	0.651	0.45
94_F	207_Q	0.651	0.45
107_S	155_V	0.650	0.45
104_C	176_T	0.649	0.45
14_S	226_S	0.649	0.45
136_K	218_Q	0.649	0.45
19_D	273_L	0.647	0.44
55_D	76_V	0.647	0.44
208_Q	211_D	0.646	0.44
233_A	238_L	0.644	0.44
273_L	280_K	0.644	0.44
101_F	193_A	0.640	0.44
271_E	293_P	0.640	0.44
9_I	50_I	0.635	0.43
13_K	76_V	0.635	0.43
43_A	50_I	0.634	0.43
159_P	164_A	0.633	0.43
96_L	214_L	0.632	0.43
125_K	165_D	0.631	0.43
109_A	159_P	0.631	0.43
44_E	125_K	0.630	0.43
216_R	279_E	0.629	0.43
212_K	283_A	0.628	0.42
140_D	145_S	0.628	0.42
147_K	236_E	0.627	0.42
137_R	201_E	0.627	0.42
236_E	240_E	0.627	0.42
48_I	59_P	0.626	0.42
52_R	179_A	0.623	0.42
62_V	70_G	0.622	0.42
228_Y	292_L	0.622	0.42
98_R	103_G	0.620	0.42
159_P	230_M	0.620	0.42
40_I	291_V	0.618	0.41
269_S	277_T	0.618	0.41
228_Y	268_V	0.618	0.41
177_L	191_S	0.615	0.41
198_R	201_E	0.610	0.41
117_D	183_R	0.609	0.41
197_Q	210_I	0.606	0.40
106_L	131_Y	0.605	0.40
120_L	123_N	0.604	0.40
228_Y	290_L	0.603	0.40
28_C	91_P	0.603	0.40
137_R	204_E	0.599	0.40
28_C	168_C	0.598	0.40
203_E	259_D	0.598	0.40
90_D	143_G	0.597	0.39
74_E	191_S	0.597	0.39
143_G	211_D	0.596	0.39
106_L	152_N	0.596	0.39
52_R	277_T	0.594	0.39
8_R	20_D	0.591	0.39
74_E	192_K	0.591	0.39
207_Q	210_I	0.590	0.39
25_L	36_T	0.589	0.39
254_L	264_A	0.588	0.39
54_R	177_L	0.588	0.39
205_S	253_I	0.587	0.38
247_G	251_P	0.586	0.38
139_L	144_I	0.586	0.38
14_S	28_C	0.586	0.38
160_R	173_T	0.584	0.38
16_R	20_D	0.583	0.38
116_W	121_S	0.582	0.38
221_I	253_I	0.582	0.38
115_A	217_I	0.581	0.38
122_L	265_M	0.580	0.38
54_R	109_A	0.579	0.38
75_N	275_W	0.577	0.38
117_D	272_T	0.577	0.38
146_F	168_C	0.576	0.37
78_E	103_G	0.575	0.37
55_D	75_N	0.575	0.37
30_I	50_I	0.574	0.37
10_A	58_I	0.573	0.37
148_S	179_A	0.573	0.37
133_H	141_Q	0.572	0.37
91_P	158_A	0.571	0.37
140_D	203_E	0.570	0.37
237_R	261_Q	0.570	0.37
137_R	284_L	0.568	0.37
136_K	237_R	0.566	0.37
41_A	180_N	0.566	0.37
16_R	79_E	0.565	0.36
238_L	242_I	0.565	0.36
268_V	290_L	0.564	0.36
123_N	240_E	0.561	0.36
9_I	110_T	0.560	0.36
252_T	256_L	0.560	0.36
41_A	50_I	0.558	0.36
103_G	190_R	0.557	0.36
145_S	280_K	0.555	0.36
48_I	98_R	0.555	0.36
55_D	179_A	0.554	0.35
133_H	243_A	0.551	0.35
246_P	252_T	0.550	0.35
246_P	267_M	0.550	0.35
77_L	196_I	0.550	0.35
22_R	32_I	0.549	0.35
25_L	103_G	0.548	0.35
59_P	91_P	0.548	0.35
75_N	131_Y	0.547	0.35
227_K	291_V	0.547	0.35
21_S	45_N	0.547	0.35
132_P	182_L	0.546	0.35
112_V	264_A	0.546	0.35
198_R	277_T	0.546	0.35
70_G	106_L	0.545	0.35
232_H	251_P	0.543	0.34
118_G	203_E	0.541	0.34
181_G	289_I	0.539	0.34
90_D	136_K	0.539	0.34
105_R	185_V	0.539	0.34
45_N	175_A	0.538	0.34
69_L	119_P	0.537	0.34
129_T	158_A	0.536	0.34
16_R	135_L	0.535	0.34
28_C	226_S	0.534	0.34
12_Q	275_W	0.534	0.34
226_S	262_R	0.533	0.34
8_R	293_P	0.533	0.34
204_E	243_A	0.532	0.33
124_G	246_P	0.532	0.33
77_L	244_L	0.531	0.33
51_L	159_P	0.531	0.33
223_A	278_M	0.531	0.33
44_E	190_R	0.531	0.33
130_S	216_R	0.530	0.33
115_A	120_L	0.529	0.33
25_L	217_I	0.528	0.33
53_V	256_L	0.526	0.33
33_N	134_L	0.525	0.33
76_V	104_C	0.522	0.33
14_S	37_Q	0.522	0.33
7_L	201_E	0.522	0.33
52_R	199_D	0.521	0.32
16_R	30_I	0.520	0.32
256_L	262_R	0.520	0.32
151_L	158_A	0.519	0.32
26_A	90_D	0.518	0.32
261_Q	288_S	0.517	0.32
127_I	199_D	0.517	0.32
144_I	217_I	0.516	0.32
38_R	52_R	0.514	0.32
230_M	292_L	0.513	0.32
31_K	97_R	0.513	0.32
12_Q	15_G	0.510	0.31
232_H	252_T	0.507	0.31
115_A	236_E	0.507	0.31
56_D	106_L	0.503	0.31
8_R	54_R	0.502	0.31
107_S	130_S	0.502	0.31
37_Q	210_I	0.501	0.31
72_I	139_L	0.501	0.31
197_Q	207_Q	0.500	0.31
104_C	154_S	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h3dA	4	0.9632	100	0.072	Contact Map
1nh8A	5	0.9197	100	0.101	Contact Map
2vd3A	5	0.9599	100	0.103	Contact Map
2vd2A	2	0.6957	100	0.351	Contact Map
1z7mE	2	0.6756	100	0.366	Contact Map
1o63A	2	0.6789	100	0.369	Contact Map
1ve4A	1	0.6722	100	0.375	Contact Map
3qslA	1	0.9064	99.1	0.879	Contact Map
3ix1A	2	0.8963	98.8	0.893	Contact Map
3ksxA	1	0.8997	98.7	0.897	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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