GREMLIN Database
HIS1 - ATP phosphoribosyltransferase
UniProt: P60757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10449
Length: 299 (278)
Sequences: 1509 (795)
Seq/√Len: 47.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_N145_S5.8921.00
98_R192_K5.0721.00
139_L146_F4.7021.00
235_T263_V4.1491.00
237_R240_E3.9641.00
258_G261_Q3.9471.00
122_L166_A3.8751.00
137_R141_Q3.4801.00
117_D121_S3.4301.00
238_L265_M3.3581.00
92_R199_D3.3301.00
233_A241_V3.1281.00
234_P237_R3.0811.00
74_E95_T3.0021.00
127_I139_L2.8811.00
108_L138_Y2.8621.00
236_E261_Q2.8061.00
135_L168_C2.8041.00
187_V190_R2.7221.00
119_P138_Y2.7091.00
62_V196_I2.5811.00
230_M266_H2.5601.00
100_D192_K2.4271.00
30_I43_A2.4111.00
133_H136_K2.3851.00
19_D23_E2.3761.00
77_L93_Y2.3061.00
105_R184_E2.1771.00
235_T261_Q2.1661.00
112_V181_G2.1501.00
208_Q283_A2.1481.00
136_K140_D2.1451.00
245_L267_M2.0961.00
95_T194_C2.0951.00
107_S184_E2.0691.00
120_L142_K2.0411.00
74_E98_R1.9920.99
118_G121_S1.9830.99
207_Q211_D1.9460.99
115_A183_R1.8970.99
240_E243_A1.8840.99
58_I169_D1.8540.99
107_S171_V1.8490.99
90_D137_R1.8450.99
69_L195_L1.8320.99
273_L276_E1.8220.99
94_F199_D1.8120.99
110_T183_R1.8100.99
119_P144_I1.7860.99
110_T114_E1.7710.99
249_E287_S1.7080.98
276_E280_K1.6440.98
97_R218_Q1.6250.98
96_L197_Q1.6240.98
104_C191_S1.6030.97
106_L170_L1.5700.97
232_H249_E1.5470.97
226_S270_S1.5450.97
241_V284_L1.5350.97
38_R179_A1.5200.96
268_V294_I1.5200.96
138_Y186_E1.4780.96
109_A177_L1.4430.95
113_D183_R1.4320.95
13_K154_S1.4300.95
248_A288_S1.4040.94
78_E137_R1.3940.94
103_G172_S1.3110.92
114_E121_S1.3080.92
291_V295_E1.2850.91
24_L217_I1.2820.91
32_I41_A1.2820.91
108_L122_L1.2760.91
155_V171_V1.2620.90
78_E189_Y1.2380.89
162_G176_T1.2330.89
110_T116_W1.2280.89
139_L168_C1.2250.89
250_R258_G1.2200.89
97_R214_L1.2100.88
93_Y196_I1.2020.88
227_K295_E1.2000.88
270_S273_L1.1960.88
233_A284_L1.1760.87
55_D72_I1.1640.86
250_R256_L1.1340.85
130_S155_V1.1300.85
120_L144_I1.1280.85
136_K148_S1.1260.84
239_D243_A1.1250.84
280_K283_A1.1160.84
175_A179_A1.1060.83
243_A283_A1.1030.83
108_L135_L1.0950.83
239_D242_I1.0840.82
122_L127_I1.0710.81
240_E244_L1.0680.81
123_N144_I1.0510.80
131_Y134_L1.0490.80
56_D76_V1.0460.80
237_R284_L1.0460.80
240_E284_L1.0450.80
235_T255_P1.0450.80
110_T185_V1.0310.79
231_M267_M1.0290.79
108_L168_C1.0250.78
50_I58_I1.0210.78
12_Q75_N1.0190.78
274_F291_V1.0090.77
218_Q222_Q1.0050.77
231_M245_L0.9890.76
171_V216_R0.9890.76
32_I50_I0.9880.76
208_Q212_K0.9880.76
43_A48_I0.9830.75
98_R194_C0.9830.75
105_R190_R0.9820.75
219_G278_M0.9780.75
47_P209_L0.9760.75
34_L38_R0.9730.75
228_Y266_H0.9730.75
72_I75_N0.9710.74
28_C222_Q0.9660.74
233_A265_M0.9650.74
107_S187_V0.9630.74
254_L266_H0.9590.74
287_S294_I0.9580.73
109_A128_A0.9540.73
16_R172_S0.9520.73
97_R221_I0.9490.73
76_V168_C0.9490.73
12_Q55_D0.9460.72
112_V137_R0.9420.72
78_E90_D0.9420.72
159_P180_N0.9380.72
110_T115_A0.9370.72
80_E91_P0.9360.72
78_E134_L0.9090.69
290_L294_I0.8950.68
237_R253_I0.8920.68
45_N209_L0.8890.68
175_A219_G0.8850.67
154_S209_L0.8850.67
139_L142_K0.8830.67
127_I188_I0.8790.67
17_L193_A0.8770.67
130_S171_V0.8640.65
211_D214_L0.8610.65
78_E95_T0.8580.65
21_S101_F0.8580.65
63_M93_Y0.8570.65
11_M25_L0.8570.65
69_L214_L0.8500.64
142_K186_E0.8470.64
241_V245_L0.8470.64
246_P290_L0.8470.64
57_D151_L0.8450.64
59_P106_L0.8440.64
155_V216_R0.8350.63
212_K279_E0.8330.63
74_E194_C0.8320.63
233_A237_R0.8230.62
92_R145_S0.8220.62
18_S21_S0.8220.62
11_M22_R0.8190.61
29_G128_A0.8160.61
13_K61_L0.8130.61
55_D106_L0.8100.60
179_A219_G0.8020.60
18_S151_L0.8010.60
235_T259_D0.8000.59
255_P263_V0.7940.59
119_P186_E0.7920.59
22_R26_A0.7840.58
240_E280_K0.7800.58
125_K166_A0.7790.57
71_I193_A0.7780.57
40_I210_I0.7740.57
168_C188_I0.7720.57
117_D136_K0.7710.57
96_L210_I0.7690.56
112_V183_R0.7680.56
114_E183_R0.7680.56
128_A164_A0.7670.56
136_K145_S0.7640.56
8_R144_I0.7610.56
74_E78_E0.7600.56
59_P80_E0.7580.55
157_V172_S0.7580.55
242_I257_A0.7570.55
171_V184_E0.7560.55
37_Q70_G0.7540.55
36_T138_Y0.7520.55
143_G283_A0.7510.55
12_Q72_I0.7510.55
173_T184_E0.7490.54
95_T98_R0.7410.54
232_H256_L0.7380.53
27_R220_V0.7370.53
141_Q206_K0.7360.53
32_I180_N0.7360.53
241_V268_V0.7350.53
90_D133_H0.7300.53
149_C173_T0.7290.52
128_A149_C0.7270.52
235_T258_G0.7250.52
74_E189_Y0.7250.52
172_S184_E0.7240.52
249_E288_S0.7230.52
58_I126_R0.7210.52
68_D206_K0.7200.52
16_R159_P0.7200.52
37_Q179_A0.7160.51
110_T122_L0.7150.51
10_A291_V0.7140.51
152_N288_S0.7130.51
173_T181_G0.7120.51
133_H137_R0.7100.51
23_E27_R0.7080.50
128_A151_L0.7050.50
147_K239_D0.7020.50
132_P179_A0.7020.50
271_E296_K0.7020.50
60_G149_C0.6980.49
114_E125_K0.6970.49
39_L151_L0.6950.49
229_I270_S0.6940.49
234_P261_Q0.6930.49
37_Q196_I0.6930.49
151_L155_V0.6920.49
10_A67_V0.6910.49
259_D262_R0.6910.49
39_L43_A0.6910.49
54_R146_F0.6900.49
127_I166_A0.6890.48
104_C162_G0.6880.48
32_I110_T0.6870.48
119_P280_K0.6860.48
115_A140_D0.6850.48
252_T264_A0.6850.48
7_L175_A0.6830.48
214_L218_Q0.6820.48
38_R172_S0.6820.48
42_M224_R0.6810.48
70_G134_L0.6780.47
55_D70_G0.6780.47
69_L210_I0.6770.47
70_G196_I0.6760.47
93_Y96_L0.6730.47
159_P167_I0.6730.47
31_K221_I0.6720.47
118_G141_Q0.6710.47
42_M69_L0.6690.46
126_R173_T0.6660.46
232_H287_S0.6620.46
64_D293_P0.6620.46
30_I48_I0.6570.45
25_L50_I0.6550.45
172_S176_T0.6540.45
49_D175_A0.6520.45
177_L180_N0.6510.45
94_F207_Q0.6510.45
107_S155_V0.6500.45
104_C176_T0.6490.45
14_S226_S0.6490.45
136_K218_Q0.6490.45
19_D273_L0.6470.44
55_D76_V0.6470.44
208_Q211_D0.6460.44
233_A238_L0.6440.44
273_L280_K0.6440.44
101_F193_A0.6400.44
271_E293_P0.6400.44
9_I50_I0.6350.43
13_K76_V0.6350.43
43_A50_I0.6340.43
159_P164_A0.6330.43
96_L214_L0.6320.43
125_K165_D0.6310.43
109_A159_P0.6310.43
44_E125_K0.6300.43
216_R279_E0.6290.43
212_K283_A0.6280.42
140_D145_S0.6280.42
147_K236_E0.6270.42
137_R201_E0.6270.42
236_E240_E0.6270.42
48_I59_P0.6260.42
52_R179_A0.6230.42
62_V70_G0.6220.42
228_Y292_L0.6220.42
98_R103_G0.6200.42
159_P230_M0.6200.42
40_I291_V0.6180.41
269_S277_T0.6180.41
228_Y268_V0.6180.41
177_L191_S0.6150.41
198_R201_E0.6100.41
117_D183_R0.6090.41
197_Q210_I0.6060.40
106_L131_Y0.6050.40
120_L123_N0.6040.40
228_Y290_L0.6030.40
28_C91_P0.6030.40
137_R204_E0.5990.40
28_C168_C0.5980.40
203_E259_D0.5980.40
90_D143_G0.5970.39
74_E191_S0.5970.39
143_G211_D0.5960.39
106_L152_N0.5960.39
52_R277_T0.5940.39
8_R20_D0.5910.39
74_E192_K0.5910.39
207_Q210_I0.5900.39
25_L36_T0.5890.39
254_L264_A0.5880.39
54_R177_L0.5880.39
205_S253_I0.5870.38
247_G251_P0.5860.38
139_L144_I0.5860.38
14_S28_C0.5860.38
160_R173_T0.5840.38
16_R20_D0.5830.38
116_W121_S0.5820.38
221_I253_I0.5820.38
115_A217_I0.5810.38
122_L265_M0.5800.38
54_R109_A0.5790.38
75_N275_W0.5770.38
117_D272_T0.5770.38
146_F168_C0.5760.37
78_E103_G0.5750.37
55_D75_N0.5750.37
30_I50_I0.5740.37
10_A58_I0.5730.37
148_S179_A0.5730.37
133_H141_Q0.5720.37
91_P158_A0.5710.37
140_D203_E0.5700.37
237_R261_Q0.5700.37
137_R284_L0.5680.37
136_K237_R0.5660.37
41_A180_N0.5660.37
16_R79_E0.5650.36
238_L242_I0.5650.36
268_V290_L0.5640.36
123_N240_E0.5610.36
9_I110_T0.5600.36
252_T256_L0.5600.36
41_A50_I0.5580.36
103_G190_R0.5570.36
145_S280_K0.5550.36
48_I98_R0.5550.36
55_D179_A0.5540.35
133_H243_A0.5510.35
246_P252_T0.5500.35
246_P267_M0.5500.35
77_L196_I0.5500.35
22_R32_I0.5490.35
25_L103_G0.5480.35
59_P91_P0.5480.35
75_N131_Y0.5470.35
227_K291_V0.5470.35
21_S45_N0.5470.35
132_P182_L0.5460.35
112_V264_A0.5460.35
198_R277_T0.5460.35
70_G106_L0.5450.35
232_H251_P0.5430.34
118_G203_E0.5410.34
181_G289_I0.5390.34
90_D136_K0.5390.34
105_R185_V0.5390.34
45_N175_A0.5380.34
69_L119_P0.5370.34
129_T158_A0.5360.34
16_R135_L0.5350.34
28_C226_S0.5340.34
12_Q275_W0.5340.34
226_S262_R0.5330.34
8_R293_P0.5330.34
204_E243_A0.5320.33
124_G246_P0.5320.33
77_L244_L0.5310.33
51_L159_P0.5310.33
223_A278_M0.5310.33
44_E190_R0.5310.33
130_S216_R0.5300.33
115_A120_L0.5290.33
25_L217_I0.5280.33
53_V256_L0.5260.33
33_N134_L0.5250.33
76_V104_C0.5220.33
14_S37_Q0.5220.33
7_L201_E0.5220.33
52_R199_D0.5210.32
16_R30_I0.5200.32
256_L262_R0.5200.32
151_L158_A0.5190.32
26_A90_D0.5180.32
261_Q288_S0.5170.32
127_I199_D0.5170.32
144_I217_I0.5160.32
38_R52_R0.5140.32
230_M292_L0.5130.32
31_K97_R0.5130.32
12_Q15_G0.5100.31
232_H252_T0.5070.31
115_A236_E0.5070.31
56_D106_L0.5030.31
8_R54_R0.5020.31
107_S130_S0.5020.31
37_Q210_I0.5010.31
72_I139_L0.5010.31
197_Q207_Q0.5000.31
104_C154_S0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h3dA 4 0.9632 100 0.072 Contact Map
1nh8A 5 0.9197 100 0.101 Contact Map
2vd3A 5 0.9599 100 0.103 Contact Map
2vd2A 2 0.6957 100 0.351 Contact Map
1z7mE 2 0.6756 100 0.366 Contact Map
1o63A 2 0.6789 100 0.369 Contact Map
1ve4A 1 0.6722 100 0.375 Contact Map
3qslA 1 0.9064 99.1 0.879 Contact Map
3ix1A 2 0.8963 98.8 0.893 Contact Map
3ksxA 1 0.8997 98.7 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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