GREMLIN Database
LIPB - Octanoyltransferase
UniProt: P60720 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11591
Length: 213 (195)
Sequences: 2934 (1845)
Seq/√Len: 132.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_V137_C3.9481.00
85_M152_L3.5411.00
107_Q111_N3.4271.00
115_E198_N3.0371.00
14_Q41_V2.6431.00
138_S176_M2.5421.00
10_Q192_A2.4611.00
30_R36_D2.4091.00
111_N201_A2.4001.00
14_Q19_I2.3631.00
118_I179_I2.1761.00
40_L85_M2.1661.00
158_M178_K2.0781.00
116_L194_R2.0391.00
112_T198_N2.0311.00
107_Q122_P2.0281.00
101_L141_L2.0151.00
17_E21_Q1.9881.00
108_T199_I1.9531.00
134_K175_E1.9381.00
113_L136_I1.9271.00
178_K181_Q1.8341.00
57_H74_Q1.8321.00
110_V122_P1.8291.00
118_I131_V1.8281.00
115_E194_R1.8251.00
134_K182_W1.8171.00
111_N202_L1.7911.00
87_V105_L1.7901.00
25_E29_T1.7411.00
15_P18_P1.6901.00
58_I75_V1.6791.00
13_L42_E1.6761.00
45_P77_Y1.6731.00
24_H70_D1.6731.00
47_F165_R1.6441.00
27_T149_F1.6371.00
13_L44_Y1.6341.00
15_P44_Y1.6181.00
152_L195_L1.6111.00
15_P65_P1.5591.00
157_N180_S1.5551.00
154_L191_I1.5411.00
64_I162_P1.5101.00
115_E197_E1.5001.00
55_A68_Q1.4931.00
83_Q195_L1.4821.00
114_A119_E1.4411.00
187_T190_N1.4311.00
100_E104_L1.4241.00
20_S24_H1.4141.00
111_N198_N1.4121.00
17_E67_I1.3841.00
154_L179_I1.3831.00
177_A182_W1.3451.00
96_L146_G1.3441.00
199_I203_L1.3411.00
21_Q24_H1.3401.00
98_V143_I1.3331.00
113_L120_A1.3171.00
17_E65_P1.2991.00
112_T116_L1.2621.00
92_K96_L1.2601.00
158_M162_P1.2501.00
99_R103_T1.2451.00
77_Y158_M1.2411.00
143_I148_S1.2371.00
26_F34_T1.2351.00
11_L39_W1.2321.00
26_F39_W1.2271.00
112_T194_R1.2261.00
167_N171_Y1.2171.00
87_V101_L1.2081.00
21_Q25_E1.2040.99
30_R88_L1.1880.99
30_R34_T1.1780.99
161_S164_L1.1740.99
97_G100_E1.1720.99
110_V120_A1.1650.99
19_I44_Y1.1560.99
45_P162_P1.1450.99
77_Y162_P1.1350.99
156_V188_T1.1240.99
138_S174_M1.1240.99
179_I191_I1.1180.99
36_D94_R1.1010.99
45_P80_P1.1000.99
180_S185_E1.0980.99
51_Q142_R1.0880.99
101_L148_S1.0860.99
113_L179_I1.0800.99
188_T192_A1.0780.99
198_N201_A1.0660.99
85_M195_L1.0640.99
70_D142_R1.0600.99
85_M109_V1.0540.99
168_P176_M1.0500.99
20_S70_D1.0470.99
47_F64_I1.0430.99
109_V154_L1.0400.99
171_Y174_M1.0400.99
194_R198_N1.0360.98
107_Q202_L1.0350.98
190_N194_R1.0300.98
109_V152_L1.0000.98
136_I177_A0.9990.98
9_R39_W0.9930.98
123_R126_A0.9900.98
97_G146_G0.9830.98
121_H133_E0.9620.98
104_L202_L0.9590.97
163_F166_I0.9550.97
18_P21_Q0.9440.97
42_E189_N0.9440.97
26_F37_E0.9280.97
177_A181_Q0.9210.97
106_E110_V0.9080.97
156_V191_I0.9020.96
134_K181_Q0.9010.96
49_Q53_G0.8970.96
184_P190_N0.8950.96
24_H28_D0.8890.96
109_V195_L0.8840.96
79_G162_P0.8840.96
103_T122_P0.8790.96
38_I85_M0.8700.96
22_A25_E0.8660.95
198_N202_L0.8630.95
157_N185_E0.8590.95
112_T191_I0.8540.95
144_R149_F0.8500.95
196_L200_L0.8460.95
20_S69_S0.8460.95
22_A39_W0.8420.95
9_R37_E0.8400.95
110_V129_V0.8360.94
39_W88_L0.8360.94
91_L143_I0.8310.94
137_C153_A0.8300.94
83_Q188_T0.8300.94
28_D31_D0.8210.94
156_V180_S0.8140.94
89_L148_S0.8130.94
91_L148_S0.8050.93
105_L152_L0.8000.93
64_I77_Y0.7950.93
83_Q192_A0.7920.93
137_C152_L0.7890.93
23_M39_W0.7860.92
42_E192_A0.7820.92
99_R102_V0.7750.92
194_R197_E0.7700.92
189_N193_P0.7690.92
95_K100_E0.7670.92
89_L101_L0.7610.91
10_Q193_P0.7600.91
159_D162_P0.7590.91
187_T193_P0.7580.91
193_P197_E0.7580.91
163_F168_P0.7570.91
97_G103_T0.7520.91
159_D178_K0.7490.91
122_P125_D0.7490.91
62_G165_R0.7490.91
32_D90_N0.7430.90
36_D93_R0.7410.90
98_V102_V0.7390.90
142_R149_F0.7380.90
27_T147_C0.7370.90
195_L199_I0.7320.90
29_T33_S0.7210.89
54_K74_Q0.7210.89
137_C154_L0.7180.89
66_V75_V0.7180.89
26_F30_R0.7170.89
102_V139_L0.7160.88
172_A175_E0.7160.88
106_E122_P0.7140.88
60_M165_R0.7130.88
138_S163_F0.7090.88
61_P165_R0.7080.88
46_V67_I0.7060.88
89_L94_R0.7040.88
60_M63_D0.7020.87
43_H86_Y0.7010.87
161_S165_R0.6950.87
27_T30_R0.6930.87
11_L14_Q0.6900.87
123_R174_M0.6880.86
103_T107_Q0.6860.86
123_R133_E0.6830.86
171_Y175_E0.6810.86
138_S175_E0.6810.86
59_L167_N0.6750.85
79_G158_M0.6750.85
160_L177_A0.6730.85
89_L203_L0.6720.85
90_N93_R0.6670.85
41_V85_M0.6640.84
102_V127_P0.6630.84
186_A190_N0.6620.84
53_G75_V0.6530.83
49_Q68_Q0.6530.83
116_L179_I0.6530.83
99_R146_G0.6500.83
112_T195_L0.6470.83
118_I136_I0.6460.83
53_G59_L0.6450.83
162_P165_R0.6440.83
179_I184_P0.6430.83
10_Q196_L0.6430.83
108_T195_L0.6410.82
130_Y147_C0.6400.82
47_F75_V0.6320.81
108_T203_L0.6310.81
49_Q55_A0.6310.81
19_I41_V0.6300.81
64_I165_R0.6270.81
104_L108_T0.6270.81
192_A196_L0.6250.81
96_L104_L0.6230.81
126_A174_M0.6200.80
164_L175_E0.6180.80
131_V182_W0.6180.80
126_A171_Y0.6140.80
22_A37_E0.6120.79
34_T90_N0.6080.79
29_T34_T0.6070.79
131_V134_K0.6040.78
96_L100_E0.6020.78
127_P139_L0.5990.78
40_L196_L0.5970.78
108_T202_L0.5970.78
143_I146_G0.5950.77
116_L191_I0.5930.77
153_A176_M0.5910.77
104_L203_L0.5890.77
44_Y84_V0.5880.77
175_E181_Q0.5870.76
47_F142_R0.5860.76
9_R22_A0.5860.76
153_A168_P0.5850.76
113_L137_C0.5810.76
112_T179_I0.5780.75
183_K186_A0.5770.75
129_V137_C0.5750.75
130_Y174_M0.5740.75
99_R127_P0.5710.74
88_L147_C0.5690.74
18_P22_A0.5680.74
60_M75_V0.5610.73
38_I199_I0.5600.73
40_L112_T0.5580.73
70_D141_L0.5580.73
58_I61_P0.5580.73
162_P178_K0.5560.73
28_D144_R0.5550.72
112_T186_A0.5530.72
193_P196_L0.5520.72
101_L105_L0.5510.72
90_N146_G0.5480.71
136_I182_W0.5480.71
61_P64_I0.5460.71
197_E201_A0.5440.71
40_L152_L0.5430.71
191_I194_R0.5430.71
99_R122_P0.5410.71
120_A129_V0.5400.70
197_E200_L0.5400.70
120_A131_V0.5380.70
103_T124_A0.5370.70
193_P198_N0.5360.70
178_K182_W0.5350.70
135_K169_C0.5350.70
88_L130_Y0.5330.69
30_R147_C0.5290.69
111_N115_E0.5270.69
62_G66_V0.5250.68
22_A26_F0.5240.68
179_I186_A0.5240.68
53_G74_Q0.5240.68
156_V179_I0.5190.67
85_M199_I0.5190.67
164_L172_A0.5140.67
16_Y150_H0.5130.66
105_L141_L0.5120.66
100_E146_G0.5100.66
76_T169_C0.5080.66
121_H132_G0.5020.65
103_T129_V0.5010.65
180_S188_T0.5010.65
189_N192_A0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w66A 1 0.9671 100 0.36 Contact Map
2qhsA 1 0.9437 100 0.384 Contact Map
2p0lA 1 0.9859 100 0.5 Contact Map
2c8mA 1 0.9343 100 0.501 Contact Map
3a7rA 1 0.9484 100 0.528 Contact Map
2p5iA 1 0.9577 100 0.54 Contact Map
2e5aA 1 0.9484 100 0.547 Contact Map
1vqzA 1 0.9437 100 0.615 Contact Map
1biaA 1 0.8263 95.5 0.917 Contact Map
2dxuA 2 0.8216 95.1 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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