GREMLIN Database
LIPA - Lipoyl synthase
UniProt: P60716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11306
Length: 321 (283)
Sequences: 2193 (922)
Seq/√Len: 54.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_L111_P5.2601.00
249_M260_L4.2211.00
169_V191_F3.7281.00
200_R244_E3.7081.00
250_R294_M3.6051.00
277_R283_E3.5451.00
211_Y251_D3.5201.00
222_K258_T3.3401.00
288_K292_L3.3241.00
236_V262_L3.2171.00
285_D288_K3.1871.00
199_P212_N3.0501.00
130_Y164_K2.9981.00
242_N286_E2.7421.00
155_A158_E2.6171.00
246_I290_E2.5981.00
119_L152_C2.5601.00
232_S252_L2.4741.00
89_I133_I2.2981.00
114_N117_V2.2781.00
160_S163_I2.2501.00
302_G305_V2.2481.00
153_I167_T2.2061.00
242_N283_E2.2031.00
147_Q151_D2.1941.00
135_S170_P2.1711.00
249_M291_A2.1561.00
205_V273_L2.1171.00
124_A159_K2.1081.00
60_R69_E2.0971.00
216_K219_E2.0591.00
290_E293_A2.0281.00
252_L257_V2.0231.00
130_Y190_V2.0121.00
242_N287_M1.9521.00
144_G179_A1.9421.00
181_D224_A1.9371.00
100_F209_A1.8961.00
92_A104_A1.8790.99
72_S102_D1.8530.99
279_V287_M1.8240.99
117_V155_A1.8220.99
191_F221_F1.8030.99
199_P202_Y1.8010.99
199_P247_E1.7960.99
181_D185_A1.7860.99
153_I186_T1.7730.99
219_E223_E1.7710.99
67_V71_A1.7630.99
218_L257_V1.7410.99
290_E294_M1.7370.99
133_I156_I1.7100.99
172_F183_L1.6840.99
184_T221_F1.6620.99
78_E309_Y1.6470.99
291_A299_A1.6430.99
157_R165_I1.6220.98
51_R54_G1.6180.98
199_P248_V1.6010.98
117_V121_Q1.5830.98
253_R296_F1.5660.98
118_K121_Q1.5440.98
88_M103_V1.5340.98
150_A154_T1.5030.97
283_E287_M1.5020.97
220_R223_E1.4950.97
286_E290_E1.4930.97
82_H312_D1.4700.97
52_I76_L1.4450.97
175_R179_A1.4260.96
212_N216_K1.4080.96
58_A125_D1.3820.96
43_I304_F1.3780.96
155_A159_K1.3760.96
151_D154_T1.3720.96
62_N122_T1.3620.95
236_V287_M1.3530.95
61_K125_D1.3450.95
156_I163_I1.3380.95
181_D220_R1.3360.95
90_L148_H1.3300.95
253_R294_M1.3250.95
146_A182_I1.3060.94
112_D118_K1.2790.94
99_P273_L1.2730.93
289_A293_A1.2640.93
253_R256_G1.2600.93
184_T225_H1.2520.93
62_N125_D1.2460.93
123_I160_S1.2390.92
93_I106_G1.2350.92
216_K220_R1.2330.92
202_Y207_P1.2320.92
282_D285_D1.2310.92
187_P225_H1.2230.92
43_I77_A1.2200.92
95_T108_P1.2030.91
114_N118_K1.1830.91
222_K230_T1.1720.90
285_D289_A1.1550.90
235_M238_L1.1540.90
246_I294_M1.1350.89
176_M220_R1.1250.88
234_L248_V1.1230.88
202_Y210_D1.1160.88
252_L260_L1.1140.88
70_E92_A1.1130.88
117_V159_K1.1030.87
35_L278_Y1.0900.87
121_Q125_D1.0870.87
63_G118_K1.0860.86
137_D213_W1.0820.86
236_V245_I1.0730.86
124_A160_S1.0520.85
220_R224_A1.0460.84
221_F228_I1.0460.84
121_Q159_K1.0440.84
245_I279_V1.0400.84
193_H214_S1.0370.84
279_V283_E1.0230.83
269_S272_H1.0200.83
246_I250_R1.0200.83
180_L220_R1.0190.83
184_T224_A1.0190.83
176_M216_K1.0170.83
135_S149_F1.0120.82
93_I104_A1.0110.82
80_F105_H1.0110.82
157_R188_P1.0060.82
89_I152_C1.0060.82
242_N246_I1.0050.82
192_N233_G1.0030.82
204_Q276_Q1.0030.82
93_I109_V1.0010.82
250_R254_R0.9930.81
245_I277_R0.9930.81
288_K301_C0.9840.80
177_D181_D0.9840.80
247_E251_D0.9720.80
100_F202_Y0.9640.79
56_K69_E0.9560.79
184_T191_F0.9520.78
37_K72_S0.9500.78
206_R209_A0.9500.78
128_L131_V0.9480.78
184_T228_I0.9480.78
151_D155_A0.9440.78
65_H92_A0.9390.77
183_L187_P0.9380.77
283_E286_E0.9330.77
52_I80_F0.9320.77
54_G83_G0.9260.76
156_I160_S0.9170.76
150_A183_L0.9120.75
267_Q278_Y0.9000.74
87_F119_L0.8950.74
300_A310_H0.8930.74
147_Q182_I0.8900.73
167_T192_N0.8900.73
102_D269_S0.8870.73
250_R290_E0.8780.72
258_T297_T0.8770.72
83_G126_M0.8760.72
167_T188_P0.8710.72
39_E43_I0.8710.72
202_Y208_G0.8630.71
249_M290_E0.8560.70
55_I126_M0.8480.70
232_S262_L0.8470.70
174_G213_W0.8430.69
123_I131_V0.8420.69
123_I163_I0.8420.69
176_M180_L0.8390.69
207_P233_G0.8350.69
152_C156_I0.8330.68
202_Y209_A0.8320.68
34_L37_K0.8300.68
219_E255_H0.8300.68
120_A159_K0.8290.68
111_P148_H0.8260.68
105_H137_D0.8210.67
83_G127_A0.8210.67
55_I81_N0.8160.67
46_P77_A0.8150.67
246_I286_E0.8120.66
169_V183_L0.8110.66
70_E102_D0.8050.66
86_T311_A0.8040.66
131_V163_I0.8030.65
117_V158_E0.8000.65
253_R258_T0.7990.65
154_T185_A0.7970.65
137_D202_Y0.7970.65
113_A148_H0.7960.65
40_W281_P0.7900.64
170_P183_L0.7870.64
36_R39_E0.7870.64
58_A62_N0.7720.62
76_L80_F0.7690.62
249_M253_R0.7680.62
137_D172_F0.7670.62
195_L248_V0.7670.62
221_F225_H0.7660.62
243_E246_I0.7640.62
150_A182_I0.7620.61
88_M300_A0.7610.61
123_I156_I0.7610.61
219_E256_G0.7590.61
252_L255_H0.7510.60
280_S283_E0.7470.60
45_L77_A0.7450.60
230_T258_T0.7430.59
102_D137_D0.7410.59
169_V172_F0.7350.59
199_P203_R0.7350.59
164_K189_D0.7330.58
59_M80_F0.7320.58
144_G173_R0.7320.58
249_M294_M0.7310.58
273_L276_Q0.7260.58
183_L221_F0.7220.57
65_H109_V0.7220.57
234_L245_I0.7210.57
50_T53_Q0.7190.57
169_V221_F0.7180.57
298_H310_H0.7160.57
180_L217_L0.7160.57
215_L255_H0.7140.56
280_S285_D0.7130.56
153_I165_I0.7130.56
292_L299_A0.7100.56
173_R179_A0.7100.56
242_N279_V0.7100.56
238_L273_L0.7090.56
154_T186_T0.7090.56
247_E250_R0.7080.56
202_Y248_V0.7080.56
157_R191_F0.7080.56
173_R208_G0.7070.56
51_R83_G0.7020.55
288_K291_A0.6970.55
229_P259_M0.6920.54
202_Y212_N0.6880.54
167_T191_F0.6880.54
129_R312_D0.6850.53
300_A314_Q0.6850.53
202_Y233_G0.6850.53
191_F217_L0.6830.53
135_S172_F0.6820.53
261_T305_V0.6810.53
57_A61_K0.6810.53
37_K266_L0.6800.53
249_M296_F0.6790.53
180_L191_F0.6790.53
259_M314_Q0.6780.53
241_T276_Q0.6760.52
250_R293_A0.6740.52
246_I293_A0.6710.52
80_F202_Y0.6710.52
195_L214_S0.6680.51
215_L251_D0.6660.51
219_E254_R0.6660.51
50_T54_G0.6660.51
277_R287_M0.6660.51
60_R70_E0.6650.51
286_E289_A0.6640.51
45_L72_S0.6610.51
133_I167_T0.6590.51
97_R208_G0.6590.51
69_E76_L0.6580.50
120_A156_I0.6580.50
41_M304_F0.6570.50
151_D156_I0.6570.50
241_T244_E0.6560.50
44_K47_A0.6540.50
192_N310_H0.6530.50
176_M181_D0.6530.50
209_A235_M0.6520.50
87_F131_V0.6510.50
211_Y247_E0.6500.50
39_E282_D0.6480.49
291_A300_A0.6470.49
232_S255_H0.6470.49
183_L186_T0.6460.49
184_T222_K0.6460.49
148_H300_A0.6440.49
65_H69_E0.6420.49
97_R105_H0.6410.49
236_V279_V0.6400.48
121_Q124_A0.6350.48
176_M213_W0.6320.48
69_E137_D0.6310.48
192_N207_P0.6310.48
157_R189_D0.6300.47
103_V310_H0.6290.47
260_L291_A0.6290.47
70_E149_F0.6270.47
169_V217_L0.6260.47
285_D292_L0.6250.47
82_H313_L0.6240.47
206_R235_M0.6240.47
42_K302_G0.6230.47
191_F230_T0.6190.46
88_M137_D0.6190.46
298_H314_Q0.6180.46
97_R137_D0.6130.46
180_L224_A0.6130.46
167_T186_T0.6110.45
197_N236_V0.6110.45
48_D52_I0.6110.45
245_I262_L0.6080.45
207_P210_D0.6070.45
280_S301_C0.6060.45
51_R81_N0.6050.45
33_A270_R0.6040.45
149_F192_N0.6040.45
167_T233_G0.6010.44
145_G170_P0.6000.44
132_V263_G0.5980.44
110_A148_H0.5970.44
195_L232_S0.5960.44
80_F210_D0.5960.44
137_D257_V0.5930.43
262_L287_M0.5930.43
253_R260_L0.5910.43
272_H307_S0.5900.43
52_I55_I0.5890.43
99_P102_D0.5870.43
187_P221_F0.5860.43
87_F126_M0.5840.43
197_N205_V0.5820.42
266_L278_Y0.5810.42
200_R266_L0.5810.42
199_P210_D0.5810.42
289_A292_L0.5800.42
202_Y217_L0.5790.42
200_R247_E0.5790.42
217_L220_R0.5770.42
102_D105_H0.5760.42
110_A113_A0.5710.41
221_F229_P0.5710.41
233_G310_H0.5700.41
62_N118_K0.5690.41
284_F301_C0.5680.41
122_T125_D0.5670.41
67_V207_P0.5660.41
181_D291_A0.5660.41
195_L211_Y0.5660.41
130_Y165_I0.5600.40
238_L276_Q0.5590.40
197_N201_I0.5590.40
62_N126_M0.5590.40
99_P208_G0.5580.40
37_K43_I0.5580.40
56_K76_L0.5570.40
208_G233_G0.5560.40
242_N245_I0.5550.40
233_G248_V0.5540.39
199_P207_P0.5530.39
188_P192_N0.5530.39
133_I152_C0.5520.39
90_L135_S0.5510.39
62_N121_Q0.5510.39
259_M300_A0.5500.39
312_D315_A0.5490.39
43_I76_L0.5480.39
291_A314_Q0.5470.39
55_I59_M0.5460.39
259_M267_Q0.5450.39
43_I46_P0.5440.38
52_I257_V0.5440.38
167_T172_F0.5440.38
42_K287_M0.5400.38
244_E247_E0.5380.38
88_M133_I0.5360.38
102_D126_M0.5350.37
58_A118_K0.5350.37
124_A250_R0.5340.37
100_F195_L0.5340.37
119_L131_V0.5330.37
72_S97_R0.5310.37
51_R55_I0.5300.37
281_P303_P0.5300.37
88_M148_H0.5290.37
192_N261_T0.5290.37
157_R187_P0.5270.37
183_L225_H0.5250.36
162_Q165_I0.5240.36
67_V103_V0.5220.36
106_G109_V0.5220.36
164_K315_A0.5220.36
104_A267_Q0.5220.36
44_K51_R0.5210.36
245_I287_M0.5210.36
245_I249_M0.5200.36
129_R156_I0.5190.36
37_K44_K0.5180.36
310_H314_Q0.5170.36
34_L267_Q0.5170.36
37_K169_V0.5160.36
67_V88_M0.5160.36
205_V235_M0.5160.36
140_D208_G0.5150.36
288_K300_A0.5140.35
298_H315_A0.5140.35
212_N247_E0.5120.35
235_M307_S0.5120.35
243_E253_R0.5120.35
169_V180_L0.5120.35
93_I107_R0.5100.35
197_N209_A0.5100.35
157_R192_N0.5100.35
243_E282_D0.5090.35
182_I187_P0.5090.35
117_V151_D0.5070.35
129_R158_E0.5060.35
135_S202_Y0.5060.35
37_K69_E0.5040.34
113_A147_Q0.5020.34
99_P202_Y0.5020.34
197_N211_Y0.5010.34
267_Q274_P0.5010.34
106_G167_T0.5000.34
137_D140_D0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0oB 1 0.8287 100 0.653 Contact Map
4r33A 2 0.8816 99.8 0.873 Contact Map
4wcxA 1 0.9159 99.7 0.879 Contact Map
3t7vA 1 0.8567 99.7 0.88 Contact Map
3iixA 1 0.8629 99.7 0.884 Contact Map
1r30A 2 0.8131 99.6 0.885 Contact Map
4rtbA 2 0.9097 99.6 0.886 Contact Map
2qgqA 1 0.6698 99.5 0.895 Contact Map
1oltA 1 0.8411 99.4 0.9 Contact Map
4jc0A 1 0.9595 99.4 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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