HIS6 - ECOLI - GREMLIN Contacts

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HIS6 - Imidazole glycerol phosphate synthase subunit HisF

UniProt:	P60664	Sequences: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10448
Length:	258 (233)
Sequences:	6056 (3199)
Seq/√Len:	209.5

ECOLI - HIS6 HIS4
BACSU - HIS6 HIS4
HALSA - HIS6 HIS4
SULSO - HIS6 HIS4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
89_A	116_L	3.318	1.00
114_T	169_R	2.596	1.00
109_D	115_R	2.523	1.00
167_Q	202_V	2.522	1.00
21_V	184_V	2.448	1.00
165_E	169_R	2.434	1.00
129_I	163_V	2.397	1.00
85_S	88_D	2.385	1.00
37_K	72_V	2.349	1.00
127_V	166_V	2.330	1.00
37_K	41_E	2.205	1.00
139_K	158_E	2.111	1.00
90_A	94_S	2.094	1.00
240_N	243_E	2.085	1.00
38_R	42_E	2.072	1.00
214_E	217_L	2.068	1.00
185_R	238_I	1.999	1.00
214_E	218_E	1.954	1.00
40_A	74_D	1.949	1.00
83_I	92_I	1.942	1.00
16_Q	28_I	1.884	1.00
116_L	125_I	1.863	1.00
89_A	125_I	1.858	1.00
63_K	91_K	1.849	1.00
56_S	152_T	1.832	1.00
158_E	161_D	1.825	1.00
194_K	198_E	1.761	1.00
176_L	192_Q	1.748	1.00
90_A	119_R	1.739	1.00
167_Q	201_H	1.679	1.00
157_W	165_E	1.652	1.00
217_L	247_Y	1.650	1.00
22_Q	184_V	1.643	1.00
212_T	215_H	1.640	1.00
31_D	34_P	1.640	1.00
62_D	65_W	1.639	1.00
86_L	116_L	1.614	1.00
47_L	75_I	1.599	1.00
230_A	234_F	1.588	1.00
220_F	228_A	1.579	1.00
108_A	143_N	1.571	1.00
140_Y	145_Y	1.569	1.00
233_V	239_I	1.567	1.00
190_L	218_E	1.559	1.00
213_M	239_I	1.545	1.00
42_E	242_G	1.539	1.00
164_Q	199_V	1.536	1.00
165_E	168_K	1.512	1.00
31_D	68_R	1.506	1.00
230_A	233_V	1.500	1.00
140_Y	144_Q	1.492	1.00
14_D	53_T	1.490	1.00
111_T	115_R	1.481	1.00
99_K	126_V	1.473	1.00
141_H	154_V	1.453	1.00
128_G	175_V	1.451	1.00
102_I	105_P	1.449	1.00
64_S	67_S	1.418	1.00
213_M	247_Y	1.401	1.00
105_P	112_L	1.399	1.00
25_N	56_S	1.399	1.00
93_L	124_C	1.393	1.00
140_Y	143_N	1.392	1.00
145_Y	153_R	1.378	1.00
197_R	204_L	1.374	1.00
198_E	224_D	1.369	1.00
8_P	44_A	1.360	1.00
239_I	244_L	1.360	1.00
7_I	46_E	1.354	1.00
68_R	71_E	1.353	1.00
86_L	119_R	1.350	1.00
70_A	77_F	1.350	1.00
24_R	27_E	1.342	1.00
21_V	27_E	1.331	1.00
114_T	118_D	1.325	1.00
87_E	90_A	1.310	1.00
46_E	99_K	1.289	1.00
178_M	189_D	1.286	1.00
216_F	233_V	1.285	1.00
86_L	115_R	1.284	1.00
215_H	218_E	1.284	1.00
49_F	69_V	1.280	1.00
111_T	114_T	1.262	1.00
141_H	144_Q	1.260	1.00
38_R	41_E	1.252	1.00
29_I	35_L	1.249	1.00
141_H	145_Y	1.234	1.00
89_A	100_I	1.231	1.00
42_E	240_N	1.218	1.00
106_A	127_V	1.217	1.00
128_G	177_N	1.212	1.00
66_V	79_V	1.211	1.00
104_S	108_A	1.201	1.00
67_S	71_E	1.197	1.00
176_L	196_V	1.196	1.00
107_L	157_W	1.195	1.00
216_F	230_A	1.195	1.00
242_G	246_A	1.159	1.00
131_T	176_L	1.147	1.00
5_R	46_E	1.144	1.00
117_A	122_V	1.132	1.00
67_S	95_F	1.129	1.00
142_V	145_Y	1.122	1.00
172_G	203_P	1.115	1.00
163_V	196_V	1.112	1.00
188_Y	210_A	1.110	1.00
16_Q	30_G	1.106	1.00
218_E	222_D	1.098	1.00
38_R	237_Q	1.093	1.00
131_T	192_Q	1.090	1.00
108_A	153_R	1.085	1.00
160_L	199_V	1.083	1.00
196_V	204_L	1.082	1.00
195_K	199_V	1.082	1.00
195_K	198_E	1.081	1.00
126_V	175_V	1.077	1.00
174_I	202_V	1.076	1.00
175_V	229_L	1.066	1.00
133_Y	191_E	1.050	1.00
55_S	104_S	1.049	1.00
167_Q	200_C	1.047	1.00
127_V	171_A	1.041	1.00
193_L	197_R	1.039	1.00
46_E	76_P	1.034	1.00
164_Q	168_K	1.033	1.00
133_Y	180_N	1.029	1.00
190_L	194_K	1.027	1.00
213_M	244_L	1.025	1.00
79_V	92_I	1.022	1.00
33_V	65_W	1.020	1.00
17_V	35_L	1.007	1.00
197_R	223_A	1.006	1.00
13_R	25_N	1.004	1.00
131_T	159_T	1.003	1.00
191_E	194_K	1.003	1.00
163_V	200_C	0.990	1.00
159_T	163_V	0.977	1.00
90_A	120_F	0.976	1.00
35_L	38_R	0.970	1.00
243_E	246_A	0.965	1.00
110_P	165_E	0.964	1.00
159_T	196_V	0.960	1.00
60_V	91_K	0.954	1.00
87_E	91_K	0.954	1.00
33_V	68_R	0.953	1.00
117_A	171_A	0.950	0.99
79_V	97_A	0.948	0.99
109_D	112_L	0.939	0.99
112_L	116_L	0.938	0.99
46_E	126_V	0.938	0.99
197_R	225_V	0.938	0.99
42_E	241_I	0.937	0.99
173_E	203_P	0.931	0.99
70_A	97_A	0.930	0.99
194_K	223_A	0.930	0.99
160_L	195_K	0.928	0.99
194_K	222_D	0.926	0.99
113_I	166_V	0.918	0.99
126_V	173_E	0.918	0.99
5_R	45_D	0.911	0.99
161_D	165_E	0.911	0.99
40_A	73_I	0.908	0.99
19_K	232_S	0.908	0.99
67_S	91_K	0.901	0.99
64_S	68_R	0.898	0.99
93_L	120_F	0.897	0.99
70_A	98_D	0.895	0.99
232_S	236_K	0.880	0.99
132_W	180_N	0.876	0.99
213_M	243_E	0.876	0.99
213_M	217_L	0.873	0.99
102_I	116_L	0.869	0.99
113_I	127_V	0.869	0.99
78_C	101_S	0.868	0.99
164_Q	167_Q	0.862	0.99
50_Y	175_V	0.859	0.99
139_K	142_V	0.853	0.99
45_D	76_P	0.848	0.99
197_R	226_D	0.843	0.99
91_K	95_F	0.837	0.99
13_R	26_H	0.836	0.99
160_L	164_Q	0.835	0.99
89_A	120_F	0.832	0.99
88_D	91_K	0.828	0.99
217_L	221_R	0.827	0.99
191_E	195_K	0.826	0.99
37_K	40_A	0.823	0.99
68_R	72_V	0.820	0.99
39_Y	235_H	0.818	0.98
73_I	76_P	0.815	0.98
66_V	97_A	0.814	0.98
40_A	75_I	0.813	0.98
181_Q	186_N	0.813	0.98
143_N	153_R	0.804	0.98
160_L	163_V	0.794	0.98
107_L	144_Q	0.794	0.98
211_G	215_H	0.793	0.98
240_N	244_L	0.791	0.98
212_T	238_I	0.791	0.98
212_T	216_F	0.787	0.98
76_P	98_D	0.787	0.98
138_G	145_Y	0.787	0.98
114_T	165_E	0.787	0.98
60_V	88_D	0.777	0.98
63_K	92_I	0.777	0.98
21_V	232_S	0.771	0.98
6_I	230_A	0.759	0.98
173_E	226_D	0.755	0.97
190_L	223_A	0.754	0.97
13_R	53_T	0.754	0.97
220_F	223_A	0.753	0.97
6_I	228_A	0.751	0.97
86_L	120_F	0.751	0.97
86_L	90_A	0.745	0.97
210_A	228_A	0.742	0.97
5_R	227_G	0.736	0.97
216_F	244_L	0.736	0.97
138_G	195_K	0.735	0.97
141_H	156_Q	0.735	0.97
198_E	223_A	0.729	0.97
144_Q	153_R	0.728	0.97
54_A	61_V	0.727	0.97
44_A	241_I	0.719	0.97
107_L	162_W	0.719	0.97
7_I	205_I	0.717	0.97
181_Q	184_V	0.714	0.96
203_P	226_D	0.713	0.96
159_T	192_Q	0.713	0.96
193_L	204_L	0.712	0.96
161_D	164_Q	0.711	0.96
34_P	38_R	0.709	0.96
133_Y	138_G	0.708	0.96
69_V	77_F	0.706	0.96
84_K	108_A	0.700	0.96
60_V	84_K	0.699	0.96
216_F	239_I	0.698	0.96
127_V	174_I	0.696	0.96
33_V	72_V	0.692	0.96
99_K	172_G	0.690	0.96
50_Y	177_N	0.689	0.96
61_V	66_V	0.688	0.96
138_G	141_H	0.683	0.95
24_R	56_S	0.681	0.95
129_I	162_W	0.678	0.95
53_T	62_D	0.677	0.95
89_A	102_I	0.676	0.95
65_W	69_V	0.676	0.95
197_R	224_D	0.674	0.95
101_S	175_V	0.671	0.95
34_P	37_K	0.666	0.95
189_D	192_Q	0.665	0.95
105_P	109_D	0.663	0.95
175_V	205_I	0.661	0.95
58_G	62_D	0.659	0.94
138_G	142_V	0.658	0.94
60_V	63_K	0.657	0.94
118_D	168_K	0.657	0.94
223_A	226_D	0.655	0.94
53_T	58_G	0.654	0.94
7_I	126_V	0.652	0.94
196_V	200_C	0.651	0.94
139_K	154_V	0.651	0.94
63_K	67_S	0.649	0.94
220_F	248_L	0.649	0.94
139_K	156_Q	0.647	0.94
70_A	95_F	0.647	0.94
138_G	144_Q	0.647	0.94
121_G	173_E	0.646	0.94
163_V	174_I	0.644	0.94
241_I	245_K	0.640	0.94
89_A	93_L	0.638	0.93
234_F	244_L	0.637	0.93
57_D	61_V	0.635	0.93
30_G	34_P	0.635	0.93
83_I	89_A	0.631	0.93
91_K	94_S	0.625	0.93
89_A	124_C	0.621	0.93
164_Q	200_C	0.621	0.93
188_Y	211_G	0.619	0.92
205_I	227_G	0.619	0.92
216_F	228_A	0.618	0.92
211_G	238_I	0.615	0.92
216_F	234_F	0.614	0.92
98_D	123_Q	0.613	0.92
67_S	94_S	0.613	0.92
36_A	69_V	0.610	0.92
83_I	102_I	0.607	0.92
138_G	143_N	0.607	0.92
45_D	245_K	0.605	0.92
99_K	173_E	0.602	0.91
115_R	118_D	0.601	0.91
133_Y	189_D	0.601	0.91
29_I	236_K	0.594	0.91
210_A	239_I	0.594	0.91
183_G	209_G	0.593	0.91
7_I	78_C	0.593	0.91
167_Q	174_I	0.592	0.91
231_A	235_H	0.588	0.90
102_I	113_I	0.587	0.90
216_F	248_L	0.586	0.90
65_W	77_F	0.582	0.90
117_A	121_G	0.580	0.90
7_I	99_K	0.579	0.90
12_V	69_V	0.575	0.89
49_F	77_F	0.571	0.89
19_K	182_D	0.570	0.89
105_P	116_L	0.565	0.89
13_R	56_S	0.565	0.89
54_A	60_V	0.559	0.88
210_A	230_A	0.558	0.88
60_V	92_I	0.558	0.88
87_E	94_S	0.558	0.88
73_I	77_F	0.557	0.88
220_F	224_D	0.556	0.88
25_N	152_T	0.555	0.88
54_A	59_R	0.552	0.87
129_I	166_V	0.549	0.87
193_L	206_A	0.548	0.87
173_E	205_I	0.545	0.87
132_W	141_H	0.543	0.87
12_V	49_F	0.541	0.86
79_V	83_I	0.541	0.86
188_Y	216_F	0.541	0.86
183_G	187_G	0.533	0.86
117_A	127_V	0.531	0.85
109_D	118_D	0.529	0.85
128_G	205_I	0.528	0.85
142_V	155_T	0.528	0.85
114_T	168_K	0.528	0.85
108_A	142_V	0.525	0.85
12_V	65_W	0.524	0.85
187_G	209_G	0.523	0.84
35_L	39_Y	0.523	0.84
20_G	26_H	0.522	0.84
66_V	77_F	0.519	0.84
22_Q	27_E	0.516	0.84
44_A	244_L	0.515	0.84
188_Y	215_H	0.515	0.84
193_L	225_V	0.515	0.84
22_Q	180_N	0.512	0.83
36_A	73_I	0.509	0.83
59_R	88_D	0.506	0.83
27_E	236_K	0.506	0.83
123_Q	173_E	0.506	0.83
217_L	248_L	0.506	0.83
46_E	98_D	0.505	0.82
89_A	112_L	0.503	0.82
177_N	207_S	0.503	0.82
19_K	181_Q	0.501	0.82
22_Q	25_N	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jvnA	1	0.9574	100	0.287	Contact Map
2agkA	1	0.8411	100	0.303	Contact Map
1qo2A	1	0.9031	100	0.473	Contact Map
4gj1A	1	0.8605	100	0.481	Contact Map
1thfD	2	0.9729	100	0.488	Contact Map
4evzA	1	0.9767	100	0.496	Contact Map
2y88A	1	0.9302	100	0.519	Contact Map
1h5yA	1	0.969	100	0.527	Contact Map
4u28A	1	0.8915	100	0.528	Contact Map
2w6rA	1	0.845	100	0.536	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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