GREMLIN Database
HIS6 - Imidazole glycerol phosphate synthase subunit HisF
UniProt: P60664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10448
Length: 258 (233)
Sequences: 6056 (3199)
Seq/√Len: 209.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_A116_L3.3181.00
114_T169_R2.5961.00
109_D115_R2.5231.00
167_Q202_V2.5221.00
21_V184_V2.4481.00
165_E169_R2.4341.00
129_I163_V2.3971.00
85_S88_D2.3851.00
37_K72_V2.3491.00
127_V166_V2.3301.00
37_K41_E2.2051.00
139_K158_E2.1111.00
90_A94_S2.0941.00
240_N243_E2.0851.00
38_R42_E2.0721.00
214_E217_L2.0681.00
185_R238_I1.9991.00
214_E218_E1.9541.00
40_A74_D1.9491.00
83_I92_I1.9421.00
16_Q28_I1.8841.00
116_L125_I1.8631.00
89_A125_I1.8581.00
63_K91_K1.8491.00
56_S152_T1.8321.00
158_E161_D1.8251.00
194_K198_E1.7611.00
176_L192_Q1.7481.00
90_A119_R1.7391.00
167_Q201_H1.6791.00
157_W165_E1.6521.00
217_L247_Y1.6501.00
22_Q184_V1.6431.00
212_T215_H1.6401.00
31_D34_P1.6401.00
62_D65_W1.6391.00
86_L116_L1.6141.00
47_L75_I1.5991.00
230_A234_F1.5881.00
220_F228_A1.5791.00
108_A143_N1.5711.00
140_Y145_Y1.5691.00
233_V239_I1.5671.00
190_L218_E1.5591.00
213_M239_I1.5451.00
42_E242_G1.5391.00
164_Q199_V1.5361.00
165_E168_K1.5121.00
31_D68_R1.5061.00
230_A233_V1.5001.00
140_Y144_Q1.4921.00
14_D53_T1.4901.00
111_T115_R1.4811.00
99_K126_V1.4731.00
141_H154_V1.4531.00
128_G175_V1.4511.00
102_I105_P1.4491.00
64_S67_S1.4181.00
213_M247_Y1.4011.00
105_P112_L1.3991.00
25_N56_S1.3991.00
93_L124_C1.3931.00
140_Y143_N1.3921.00
145_Y153_R1.3781.00
197_R204_L1.3741.00
198_E224_D1.3691.00
8_P44_A1.3601.00
239_I244_L1.3601.00
7_I46_E1.3541.00
68_R71_E1.3531.00
86_L119_R1.3501.00
70_A77_F1.3501.00
24_R27_E1.3421.00
21_V27_E1.3311.00
114_T118_D1.3251.00
87_E90_A1.3101.00
46_E99_K1.2891.00
178_M189_D1.2861.00
216_F233_V1.2851.00
86_L115_R1.2841.00
215_H218_E1.2841.00
49_F69_V1.2801.00
111_T114_T1.2621.00
141_H144_Q1.2601.00
38_R41_E1.2521.00
29_I35_L1.2491.00
141_H145_Y1.2341.00
89_A100_I1.2311.00
42_E240_N1.2181.00
106_A127_V1.2171.00
128_G177_N1.2121.00
66_V79_V1.2111.00
104_S108_A1.2011.00
67_S71_E1.1971.00
176_L196_V1.1961.00
107_L157_W1.1951.00
216_F230_A1.1951.00
242_G246_A1.1591.00
131_T176_L1.1471.00
5_R46_E1.1441.00
117_A122_V1.1321.00
67_S95_F1.1291.00
142_V145_Y1.1221.00
172_G203_P1.1151.00
163_V196_V1.1121.00
188_Y210_A1.1101.00
16_Q30_G1.1061.00
218_E222_D1.0981.00
38_R237_Q1.0931.00
131_T192_Q1.0901.00
108_A153_R1.0851.00
160_L199_V1.0831.00
196_V204_L1.0821.00
195_K199_V1.0821.00
195_K198_E1.0811.00
126_V175_V1.0771.00
174_I202_V1.0761.00
175_V229_L1.0661.00
133_Y191_E1.0501.00
55_S104_S1.0491.00
167_Q200_C1.0471.00
127_V171_A1.0411.00
193_L197_R1.0391.00
46_E76_P1.0341.00
164_Q168_K1.0331.00
133_Y180_N1.0291.00
190_L194_K1.0271.00
213_M244_L1.0251.00
79_V92_I1.0221.00
33_V65_W1.0201.00
17_V35_L1.0071.00
197_R223_A1.0061.00
13_R25_N1.0041.00
131_T159_T1.0031.00
191_E194_K1.0031.00
163_V200_C0.9901.00
159_T163_V0.9771.00
90_A120_F0.9761.00
35_L38_R0.9701.00
243_E246_A0.9651.00
110_P165_E0.9641.00
159_T196_V0.9601.00
60_V91_K0.9541.00
87_E91_K0.9541.00
33_V68_R0.9531.00
117_A171_A0.9500.99
79_V97_A0.9480.99
109_D112_L0.9390.99
112_L116_L0.9380.99
46_E126_V0.9380.99
197_R225_V0.9380.99
42_E241_I0.9370.99
173_E203_P0.9310.99
70_A97_A0.9300.99
194_K223_A0.9300.99
160_L195_K0.9280.99
194_K222_D0.9260.99
113_I166_V0.9180.99
126_V173_E0.9180.99
5_R45_D0.9110.99
161_D165_E0.9110.99
40_A73_I0.9080.99
19_K232_S0.9080.99
67_S91_K0.9010.99
64_S68_R0.8980.99
93_L120_F0.8970.99
70_A98_D0.8950.99
232_S236_K0.8800.99
132_W180_N0.8760.99
213_M243_E0.8760.99
213_M217_L0.8730.99
102_I116_L0.8690.99
113_I127_V0.8690.99
78_C101_S0.8680.99
164_Q167_Q0.8620.99
50_Y175_V0.8590.99
139_K142_V0.8530.99
45_D76_P0.8480.99
197_R226_D0.8430.99
91_K95_F0.8370.99
13_R26_H0.8360.99
160_L164_Q0.8350.99
89_A120_F0.8320.99
88_D91_K0.8280.99
217_L221_R0.8270.99
191_E195_K0.8260.99
37_K40_A0.8230.99
68_R72_V0.8200.99
39_Y235_H0.8180.98
73_I76_P0.8150.98
66_V97_A0.8140.98
40_A75_I0.8130.98
181_Q186_N0.8130.98
143_N153_R0.8040.98
160_L163_V0.7940.98
107_L144_Q0.7940.98
211_G215_H0.7930.98
240_N244_L0.7910.98
212_T238_I0.7910.98
212_T216_F0.7870.98
76_P98_D0.7870.98
138_G145_Y0.7870.98
114_T165_E0.7870.98
60_V88_D0.7770.98
63_K92_I0.7770.98
21_V232_S0.7710.98
6_I230_A0.7590.98
173_E226_D0.7550.97
190_L223_A0.7540.97
13_R53_T0.7540.97
220_F223_A0.7530.97
6_I228_A0.7510.97
86_L120_F0.7510.97
86_L90_A0.7450.97
210_A228_A0.7420.97
5_R227_G0.7360.97
216_F244_L0.7360.97
138_G195_K0.7350.97
141_H156_Q0.7350.97
198_E223_A0.7290.97
144_Q153_R0.7280.97
54_A61_V0.7270.97
44_A241_I0.7190.97
107_L162_W0.7190.97
7_I205_I0.7170.97
181_Q184_V0.7140.96
203_P226_D0.7130.96
159_T192_Q0.7130.96
193_L204_L0.7120.96
161_D164_Q0.7110.96
34_P38_R0.7090.96
133_Y138_G0.7080.96
69_V77_F0.7060.96
84_K108_A0.7000.96
60_V84_K0.6990.96
216_F239_I0.6980.96
127_V174_I0.6960.96
33_V72_V0.6920.96
99_K172_G0.6900.96
50_Y177_N0.6890.96
61_V66_V0.6880.96
138_G141_H0.6830.95
24_R56_S0.6810.95
129_I162_W0.6780.95
53_T62_D0.6770.95
89_A102_I0.6760.95
65_W69_V0.6760.95
197_R224_D0.6740.95
101_S175_V0.6710.95
34_P37_K0.6660.95
189_D192_Q0.6650.95
105_P109_D0.6630.95
175_V205_I0.6610.95
58_G62_D0.6590.94
138_G142_V0.6580.94
60_V63_K0.6570.94
118_D168_K0.6570.94
223_A226_D0.6550.94
53_T58_G0.6540.94
7_I126_V0.6520.94
196_V200_C0.6510.94
139_K154_V0.6510.94
63_K67_S0.6490.94
220_F248_L0.6490.94
139_K156_Q0.6470.94
70_A95_F0.6470.94
138_G144_Q0.6470.94
121_G173_E0.6460.94
163_V174_I0.6440.94
241_I245_K0.6400.94
89_A93_L0.6380.93
234_F244_L0.6370.93
57_D61_V0.6350.93
30_G34_P0.6350.93
83_I89_A0.6310.93
91_K94_S0.6250.93
89_A124_C0.6210.93
164_Q200_C0.6210.93
188_Y211_G0.6190.92
205_I227_G0.6190.92
216_F228_A0.6180.92
211_G238_I0.6150.92
216_F234_F0.6140.92
98_D123_Q0.6130.92
67_S94_S0.6130.92
36_A69_V0.6100.92
83_I102_I0.6070.92
138_G143_N0.6070.92
45_D245_K0.6050.92
99_K173_E0.6020.91
115_R118_D0.6010.91
133_Y189_D0.6010.91
29_I236_K0.5940.91
210_A239_I0.5940.91
183_G209_G0.5930.91
7_I78_C0.5930.91
167_Q174_I0.5920.91
231_A235_H0.5880.90
102_I113_I0.5870.90
216_F248_L0.5860.90
65_W77_F0.5820.90
117_A121_G0.5800.90
7_I99_K0.5790.90
12_V69_V0.5750.89
49_F77_F0.5710.89
19_K182_D0.5700.89
105_P116_L0.5650.89
13_R56_S0.5650.89
54_A60_V0.5590.88
210_A230_A0.5580.88
60_V92_I0.5580.88
87_E94_S0.5580.88
73_I77_F0.5570.88
220_F224_D0.5560.88
25_N152_T0.5550.88
54_A59_R0.5520.87
129_I166_V0.5490.87
193_L206_A0.5480.87
173_E205_I0.5450.87
132_W141_H0.5430.87
12_V49_F0.5410.86
79_V83_I0.5410.86
188_Y216_F0.5410.86
183_G187_G0.5330.86
117_A127_V0.5310.85
109_D118_D0.5290.85
128_G205_I0.5280.85
142_V155_T0.5280.85
114_T168_K0.5280.85
108_A142_V0.5250.85
12_V65_W0.5240.85
187_G209_G0.5230.84
35_L39_Y0.5230.84
20_G26_H0.5220.84
66_V77_F0.5190.84
22_Q27_E0.5160.84
44_A244_L0.5150.84
188_Y215_H0.5150.84
193_L225_V0.5150.84
22_Q180_N0.5120.83
36_A73_I0.5090.83
59_R88_D0.5060.83
27_E236_K0.5060.83
123_Q173_E0.5060.83
217_L248_L0.5060.83
46_E98_D0.5050.82
89_A112_L0.5030.82
177_N207_S0.5030.82
19_K181_Q0.5010.82
22_Q25_N0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9574 100 0.287 Contact Map
2agkA 1 0.8411 100 0.303 Contact Map
1qo2A 1 0.9031 100 0.473 Contact Map
4gj1A 1 0.8605 100 0.481 Contact Map
1thfD 2 0.9729 100 0.488 Contact Map
4evzA 1 0.9767 100 0.496 Contact Map
2y88A 1 0.9302 100 0.519 Contact Map
1h5yA 1 0.969 100 0.527 Contact Map
4u28A 1 0.8915 100 0.528 Contact Map
2w6rA 1 0.845 100 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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