GREMLIN Database
SPEB - Agmatinase
UniProt: P60651 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10960
Length: 306 (268)
Sequences: 5218 (3432)
Seq/√Len: 209.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_I122_F4.0381.00
110_E138_K3.8001.00
229_F255_A3.6431.00
106_Q134_R3.3011.00
133_L170_A3.2091.00
234_L288_A2.9941.00
106_Q138_K2.7971.00
239_A285_T2.7121.00
231_I242_T2.5061.00
189_E193_D2.4511.00
57_A90_D2.4081.00
39_G60_R2.3281.00
270_M296_M2.2851.00
144_A223_M2.0661.00
30_D115_A2.0231.00
231_I275_V2.0121.00
38_T112_L1.9791.00
234_L255_A1.9611.00
183_Q186_I1.9531.00
103_E107_A1.9451.00
252_S288_A1.9431.00
207_R215_Q1.9071.00
57_A61_Q1.9011.00
36_V117_K1.8701.00
148_F258_L1.8671.00
106_Q135_A1.8631.00
100_E104_K1.8591.00
205_N253_D1.8551.00
114_A139_H1.8501.00
227_L267_I1.8401.00
113_L135_A1.8151.00
109_A132_L1.7921.00
40_V105_L1.7761.00
168_Y172_K1.7711.00
40_V121_S1.7651.00
209_V213_I1.7621.00
109_A121_S1.7601.00
148_F233_C1.7461.00
130_L173_E1.7371.00
272_V293_A1.7171.00
197_T215_Q1.7161.00
142_K223_M1.7151.00
130_L134_R1.6931.00
43_D53_R1.6811.00
122_F293_A1.6761.00
110_E114_A1.6401.00
233_C250_L1.6381.00
186_I198_V1.6251.00
59_I289_A1.6221.00
197_T219_I1.6161.00
120_L270_M1.5561.00
190_F194_N1.5481.00
238_F252_S1.5231.00
251_T254_R1.5101.00
121_S132_L1.5091.00
36_V112_L1.5081.00
211_D214_A1.5011.00
34_D84_N1.4881.00
35_W297_L1.4741.00
226_Y269_G1.4731.00
40_V101_M1.4681.00
231_I239_A1.4651.00
182_V197_T1.4611.00
106_Q110_E1.4501.00
275_V289_A1.4431.00
275_V285_T1.4291.00
233_C255_A1.4101.00
113_L136_H1.4001.00
224_P266_N1.3981.00
180_H223_M1.3711.00
214_A218_Q1.3701.00
128_V273_V1.3681.00
113_L139_H1.3681.00
163_H244_T1.3671.00
102_S127_F1.3661.00
260_R295_E1.3591.00
169_T172_K1.3491.00
231_I272_V1.3481.00
59_I275_V1.3441.00
207_R211_D1.3411.00
208_S212_V1.3351.00
200_D203_Q1.3281.00
108_H111_K1.3271.00
58_A286_A1.3271.00
211_D215_Q1.3161.00
217_K261_G1.3101.00
147_H183_Q1.3101.00
120_L293_A1.3091.00
146_V262_L1.3081.00
87_D90_D1.3031.00
136_H143_M1.2971.00
206_D257_K1.2921.00
241_G285_T1.2881.00
227_L270_M1.2651.00
38_T121_S1.2601.00
97_D100_E1.2541.00
163_H243_G1.2391.00
54_H278_A1.2361.00
214_A261_G1.2301.00
144_A222_D1.2251.00
142_K180_H1.2151.00
135_A139_H1.2071.00
205_N254_R1.1971.00
112_L119_M1.1841.00
145_L167_F1.1791.00
126_H228_T1.1741.00
256_I295_E1.1711.00
58_A61_Q1.1561.00
49_R279_Y1.1521.00
140_F268_V1.1451.00
132_L271_D1.1441.00
38_T109_A1.1351.00
105_L121_S1.1331.00
189_E192_K1.1311.00
167_F183_Q1.1311.00
191_D196_F1.1231.00
203_Q207_R1.1211.00
110_E139_H1.1211.00
207_R212_V1.1161.00
182_V219_I1.1151.00
79_M82_R1.1141.00
60_R89_G1.1121.00
201_A205_N1.1081.00
101_M105_L1.1081.00
100_E103_E1.1021.00
38_T108_H1.0891.00
102_S131_P1.0861.00
50_A54_H1.0841.00
285_T289_A1.0791.00
213_I261_G1.0791.00
40_V128_V1.0771.00
224_P268_V1.0711.00
36_V88_C1.0671.00
255_A292_L1.0581.00
151_H232_D1.0511.00
231_I289_A1.0451.00
35_W118_R1.0371.00
109_A119_M1.0331.00
134_R173_E1.0331.00
43_D51_G1.0301.00
118_R270_M1.0251.00
199_L204_V1.0241.00
210_D214_A1.0171.00
250_L258_L1.0161.00
50_A53_R1.0151.00
46_T52_G1.0131.00
241_G280_D1.0101.00
107_A111_K1.0091.00
60_R90_D1.0091.00
132_L226_Y1.0091.00
111_K114_A1.0081.00
162_D165_T0.9981.00
276_A279_Y0.9971.00
110_E135_A0.9971.00
37_I122_F0.9931.00
168_Y190_F0.9931.00
141_G224_P0.9891.00
140_F224_P0.9781.00
227_L259_V0.9651.00
212_V216_V0.9591.00
52_G276_A0.9531.00
149_D153_D0.9470.99
58_A62_V0.9440.99
152_T186_I0.9440.99
129_T133_L0.9440.99
208_S211_D0.9380.99
281_Q284_I0.9370.99
239_A288_A0.9340.99
147_H228_T0.9290.99
148_F250_L0.9220.99
136_H269_G0.9170.99
39_G90_D0.9160.99
152_T183_Q0.9160.99
146_V220_V0.9110.99
133_L145_L0.9100.99
216_V219_I0.8910.99
163_H242_T0.8890.99
187_R236_P0.8880.99
167_F181_S0.8880.99
144_A180_H0.8860.99
192_K198_V0.8830.99
103_E106_Q0.8790.99
190_F193_D0.8770.99
163_H274_E0.8760.99
202_C260_R0.8670.99
210_D261_G0.8630.99
74_P77_F0.8610.99
176_I181_S0.8500.99
184_I216_V0.8470.99
43_D49_R0.8420.99
93_Y101_M0.8410.99
177_D180_H0.8390.99
234_L252_S0.8380.99
152_T198_V0.8380.99
143_M268_V0.8330.99
142_K177_D0.8330.99
283_E286_A0.8290.99
229_F292_L0.8250.99
164_G244_T0.8230.99
39_G89_G0.8210.99
43_D52_G0.8200.99
126_H163_H0.8180.98
112_L117_K0.8100.98
154_T171_P0.8080.98
111_K115_A0.8080.98
144_A220_V0.8050.98
215_Q219_I0.8030.98
107_A110_E0.8020.98
188_T246_V0.8000.98
199_L215_Q0.7990.98
154_T191_D0.7970.98
129_T271_D0.7940.98
187_R235_D0.7910.98
109_A135_A0.7900.98
215_Q218_Q0.7890.98
38_T119_M0.7870.98
277_P280_D0.7850.98
136_H268_V0.7850.98
145_L176_I0.7830.98
126_H271_D0.7830.98
171_P178_P0.7820.98
126_H274_E0.7820.98
242_T245_P0.7820.98
258_L261_G0.7790.98
129_T166_M0.7750.98
259_V299_I0.7740.98
144_A182_V0.7730.98
252_S256_I0.7690.98
217_K220_V0.7610.98
284_I288_A0.7600.98
225_V266_N0.7590.98
150_A187_R0.7570.97
205_N257_K0.7550.97
146_V182_V0.7540.97
250_L255_A0.7500.97
218_Q221_G0.7440.97
261_G264_D0.7430.97
34_D117_K0.7400.97
227_L296_M0.7380.97
55_G58_A0.7360.97
145_L170_A0.7350.97
105_L131_P0.7350.97
191_D198_V0.7340.97
133_L143_M0.7320.97
199_L219_I0.7310.97
280_D283_E0.7250.97
132_L269_G0.7250.97
182_V216_V0.7220.97
217_K264_D0.7200.97
80_R85_V0.7160.96
234_L238_F0.7130.96
60_R87_D0.7110.96
187_R246_V0.6980.96
35_W83_L0.6950.96
146_V184_I0.6930.96
43_D50_A0.6920.96
62_V286_A0.6910.96
42_F101_M0.6900.96
148_F184_I0.6880.96
55_G276_A0.6880.96
94_A98_A0.6860.96
73_F76_N0.6850.95
189_E194_N0.6840.95
55_G243_G0.6820.95
216_V220_V0.6820.95
181_S196_F0.6790.95
275_V286_A0.6790.95
238_F251_T0.6770.95
88_C112_L0.6740.95
148_F227_L0.6710.95
119_M136_H0.6700.95
171_P196_F0.6680.95
184_I250_L0.6680.95
40_V132_L0.6660.95
210_D257_K0.6650.95
256_I292_L0.6620.95
153_D274_E0.6610.95
30_D117_K0.6600.95
127_F161_F0.6590.94
49_R245_P0.6580.94
239_A275_V0.6540.94
199_L203_Q0.6490.94
47_S163_H0.6490.94
146_V225_V0.6480.94
121_S128_V0.6480.94
206_D210_D0.6410.94
191_D195_G0.6400.94
55_G277_P0.6400.94
45_A125_D0.6360.93
209_V257_K0.6340.93
203_Q206_D0.6340.93
74_P79_M0.6320.93
120_L297_L0.6320.93
37_I120_L0.6300.93
61_Q283_E0.6300.93
226_Y271_D0.6250.93
171_P181_S0.6230.93
44_M101_M0.6230.93
257_K261_G0.6210.93
293_A296_M0.6180.92
129_T167_F0.6130.92
237_A252_S0.6130.92
82_R87_D0.6120.92
58_A277_P0.6110.92
253_D257_K0.6090.92
241_G275_V0.6080.92
154_T194_N0.6070.92
147_H167_F0.6060.92
126_H226_Y0.6020.91
154_T190_F0.6010.91
295_E298_Y0.6000.91
213_I216_V0.6000.91
182_V199_L0.5990.91
58_A283_E0.5990.91
104_K108_H0.5980.91
152_T191_D0.5970.91
143_M224_P0.5940.91
201_A250_L0.5920.91
147_H244_T0.5920.91
39_G87_D0.5890.90
145_L181_S0.5890.90
217_K221_G0.5880.90
69_E76_N0.5840.90
152_T155_Y0.5810.90
62_V290_A0.5810.90
171_P179_N0.5810.90
41_P90_D0.5790.90
131_P135_A0.5790.90
134_R170_A0.5780.90
132_L136_H0.5760.89
30_D33_A0.5760.89
47_S243_G0.5740.89
155_Y244_T0.5740.89
101_M104_K0.5730.89
104_K107_A0.5730.89
77_F81_E0.5730.89
137_A173_E0.5720.89
126_H151_H0.5710.89
33_A117_K0.5700.89
130_L169_T0.5690.89
213_I258_L0.5690.89
153_D232_D0.5670.89
108_H112_L0.5670.89
44_M47_S0.5660.89
228_T271_D0.5620.88
202_C257_K0.5620.88
223_M266_N0.5610.88
228_T273_V0.5610.88
222_D225_V0.5600.88
204_V258_L0.5580.88
59_I290_A0.5570.88
94_A104_K0.5540.88
136_H140_F0.5540.88
149_D232_D0.5500.87
116_G139_H0.5460.87
204_V254_R0.5450.87
97_D159_C0.5440.87
63_S66_L0.5430.87
242_T276_A0.5410.86
46_T50_A0.5410.86
243_G246_V0.5380.86
35_W120_L0.5380.86
156_A164_G0.5360.86
248_G256_I0.5360.86
137_A143_M0.5350.86
185_G233_C0.5330.86
208_S213_I0.5320.85
257_K260_R0.5310.85
129_T226_Y0.5310.85
133_L176_I0.5310.85
201_A254_R0.5270.85
165_T169_T0.5250.85
123_G128_V0.5240.85
209_V258_L0.5230.84
126_H273_V0.5230.84
66_L69_E0.5220.84
221_G266_N0.5210.84
81_E87_D0.5200.84
62_V283_E0.5190.84
225_V265_L0.5180.84
247_I288_A0.5160.84
187_R244_T0.5150.84
159_C165_T0.5150.84
182_V220_V0.5120.83
191_D194_N0.5110.83
70_H295_E0.5110.83
236_P239_A0.5090.83
243_G274_E0.5070.83
226_Y268_V0.5070.83
147_H166_M0.5070.83
171_P176_I0.5060.83
156_A159_C0.5050.82
278_A282_S0.5040.82
84_N87_D0.5040.82
188_T200_D0.5030.82
81_E86_V0.5030.82
75_W78_D0.5030.82
42_F105_L0.5020.82
262_L265_L0.5010.82
155_Y164_G0.5000.82
79_M83_L0.5000.82
171_P174_G0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dz4A 5 0.9837 100 0.13 Contact Map
3nioA 5 0.9608 100 0.13 Contact Map
1gq6A 5 0.951 100 0.132 Contact Map
3niqA 5 0.9739 100 0.132 Contact Map
3m1rA 5 0.9771 100 0.15 Contact Map
1wohA 5 0.951 100 0.164 Contact Map
4mykA 3 0.8954 100 0.17 Contact Map
1xfkA 1 0.9379 100 0.206 Contact Map
3pzlA 5 0.9183 100 0.207 Contact Map
4q40A 5 0.8725 100 0.216 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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