SPEB - ECOLI - GREMLIN Contacts

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SPEB - Agmatinase

UniProt:	P60651	Sequences: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10960
Length:	306 (268)
Sequences:	5218 (3432)
Seq/√Len:	209.6

ECOLI - SPEB
BACSU - HUTG SPEB ARGI
HALSA - HUTG Q9HP79
SULSO - Q97ZX8 Q97VA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_I	122_F	4.038	1.00
110_E	138_K	3.800	1.00
229_F	255_A	3.643	1.00
106_Q	134_R	3.301	1.00
133_L	170_A	3.209	1.00
234_L	288_A	2.994	1.00
106_Q	138_K	2.797	1.00
239_A	285_T	2.712	1.00
231_I	242_T	2.506	1.00
189_E	193_D	2.451	1.00
57_A	90_D	2.408	1.00
39_G	60_R	2.328	1.00
270_M	296_M	2.285	1.00
144_A	223_M	2.066	1.00
30_D	115_A	2.023	1.00
231_I	275_V	2.012	1.00
38_T	112_L	1.979	1.00
234_L	255_A	1.961	1.00
183_Q	186_I	1.953	1.00
103_E	107_A	1.945	1.00
252_S	288_A	1.943	1.00
207_R	215_Q	1.907	1.00
57_A	61_Q	1.901	1.00
36_V	117_K	1.870	1.00
148_F	258_L	1.867	1.00
106_Q	135_A	1.863	1.00
100_E	104_K	1.859	1.00
205_N	253_D	1.855	1.00
114_A	139_H	1.850	1.00
227_L	267_I	1.840	1.00
113_L	135_A	1.815	1.00
109_A	132_L	1.792	1.00
40_V	105_L	1.776	1.00
168_Y	172_K	1.771	1.00
40_V	121_S	1.765	1.00
209_V	213_I	1.762	1.00
109_A	121_S	1.760	1.00
148_F	233_C	1.746	1.00
130_L	173_E	1.737	1.00
272_V	293_A	1.717	1.00
197_T	215_Q	1.716	1.00
142_K	223_M	1.715	1.00
130_L	134_R	1.693	1.00
43_D	53_R	1.681	1.00
122_F	293_A	1.676	1.00
110_E	114_A	1.640	1.00
233_C	250_L	1.638	1.00
186_I	198_V	1.625	1.00
59_I	289_A	1.622	1.00
197_T	219_I	1.616	1.00
120_L	270_M	1.556	1.00
190_F	194_N	1.548	1.00
238_F	252_S	1.523	1.00
251_T	254_R	1.510	1.00
121_S	132_L	1.509	1.00
36_V	112_L	1.508	1.00
211_D	214_A	1.501	1.00
34_D	84_N	1.488	1.00
35_W	297_L	1.474	1.00
226_Y	269_G	1.473	1.00
40_V	101_M	1.468	1.00
231_I	239_A	1.465	1.00
182_V	197_T	1.461	1.00
106_Q	110_E	1.450	1.00
275_V	289_A	1.443	1.00
275_V	285_T	1.429	1.00
233_C	255_A	1.410	1.00
113_L	136_H	1.400	1.00
224_P	266_N	1.398	1.00
180_H	223_M	1.371	1.00
214_A	218_Q	1.370	1.00
128_V	273_V	1.368	1.00
113_L	139_H	1.368	1.00
163_H	244_T	1.367	1.00
102_S	127_F	1.366	1.00
260_R	295_E	1.359	1.00
169_T	172_K	1.349	1.00
231_I	272_V	1.348	1.00
59_I	275_V	1.344	1.00
207_R	211_D	1.341	1.00
208_S	212_V	1.335	1.00
200_D	203_Q	1.328	1.00
108_H	111_K	1.327	1.00
58_A	286_A	1.327	1.00
211_D	215_Q	1.316	1.00
217_K	261_G	1.310	1.00
147_H	183_Q	1.310	1.00
120_L	293_A	1.309	1.00
146_V	262_L	1.308	1.00
87_D	90_D	1.303	1.00
136_H	143_M	1.297	1.00
206_D	257_K	1.292	1.00
241_G	285_T	1.288	1.00
227_L	270_M	1.265	1.00
38_T	121_S	1.260	1.00
97_D	100_E	1.254	1.00
163_H	243_G	1.239	1.00
54_H	278_A	1.236	1.00
214_A	261_G	1.230	1.00
144_A	222_D	1.225	1.00
142_K	180_H	1.215	1.00
135_A	139_H	1.207	1.00
205_N	254_R	1.197	1.00
112_L	119_M	1.184	1.00
145_L	167_F	1.179	1.00
126_H	228_T	1.174	1.00
256_I	295_E	1.171	1.00
58_A	61_Q	1.156	1.00
49_R	279_Y	1.152	1.00
140_F	268_V	1.145	1.00
132_L	271_D	1.144	1.00
38_T	109_A	1.135	1.00
105_L	121_S	1.133	1.00
189_E	192_K	1.131	1.00
167_F	183_Q	1.131	1.00
191_D	196_F	1.123	1.00
203_Q	207_R	1.121	1.00
110_E	139_H	1.121	1.00
207_R	212_V	1.116	1.00
182_V	219_I	1.115	1.00
79_M	82_R	1.114	1.00
60_R	89_G	1.112	1.00
201_A	205_N	1.108	1.00
101_M	105_L	1.108	1.00
100_E	103_E	1.102	1.00
38_T	108_H	1.089	1.00
102_S	131_P	1.086	1.00
50_A	54_H	1.084	1.00
285_T	289_A	1.079	1.00
213_I	261_G	1.079	1.00
40_V	128_V	1.077	1.00
224_P	268_V	1.071	1.00
36_V	88_C	1.067	1.00
255_A	292_L	1.058	1.00
151_H	232_D	1.051	1.00
231_I	289_A	1.045	1.00
35_W	118_R	1.037	1.00
109_A	119_M	1.033	1.00
134_R	173_E	1.033	1.00
43_D	51_G	1.030	1.00
118_R	270_M	1.025	1.00
199_L	204_V	1.024	1.00
210_D	214_A	1.017	1.00
250_L	258_L	1.016	1.00
50_A	53_R	1.015	1.00
46_T	52_G	1.013	1.00
241_G	280_D	1.010	1.00
107_A	111_K	1.009	1.00
60_R	90_D	1.009	1.00
132_L	226_Y	1.009	1.00
111_K	114_A	1.008	1.00
162_D	165_T	0.998	1.00
276_A	279_Y	0.997	1.00
110_E	135_A	0.997	1.00
37_I	122_F	0.993	1.00
168_Y	190_F	0.993	1.00
141_G	224_P	0.989	1.00
140_F	224_P	0.978	1.00
227_L	259_V	0.965	1.00
212_V	216_V	0.959	1.00
52_G	276_A	0.953	1.00
149_D	153_D	0.947	0.99
58_A	62_V	0.944	0.99
152_T	186_I	0.944	0.99
129_T	133_L	0.944	0.99
208_S	211_D	0.938	0.99
281_Q	284_I	0.937	0.99
239_A	288_A	0.934	0.99
147_H	228_T	0.929	0.99
148_F	250_L	0.922	0.99
136_H	269_G	0.917	0.99
39_G	90_D	0.916	0.99
152_T	183_Q	0.916	0.99
146_V	220_V	0.911	0.99
133_L	145_L	0.910	0.99
216_V	219_I	0.891	0.99
163_H	242_T	0.889	0.99
187_R	236_P	0.888	0.99
167_F	181_S	0.888	0.99
144_A	180_H	0.886	0.99
192_K	198_V	0.883	0.99
103_E	106_Q	0.879	0.99
190_F	193_D	0.877	0.99
163_H	274_E	0.876	0.99
202_C	260_R	0.867	0.99
210_D	261_G	0.863	0.99
74_P	77_F	0.861	0.99
176_I	181_S	0.850	0.99
184_I	216_V	0.847	0.99
43_D	49_R	0.842	0.99
93_Y	101_M	0.841	0.99
177_D	180_H	0.839	0.99
234_L	252_S	0.838	0.99
152_T	198_V	0.838	0.99
143_M	268_V	0.833	0.99
142_K	177_D	0.833	0.99
283_E	286_A	0.829	0.99
229_F	292_L	0.825	0.99
164_G	244_T	0.823	0.99
39_G	89_G	0.821	0.99
43_D	52_G	0.820	0.99
126_H	163_H	0.818	0.98
112_L	117_K	0.810	0.98
154_T	171_P	0.808	0.98
111_K	115_A	0.808	0.98
144_A	220_V	0.805	0.98
215_Q	219_I	0.803	0.98
107_A	110_E	0.802	0.98
188_T	246_V	0.800	0.98
199_L	215_Q	0.799	0.98
154_T	191_D	0.797	0.98
129_T	271_D	0.794	0.98
187_R	235_D	0.791	0.98
109_A	135_A	0.790	0.98
215_Q	218_Q	0.789	0.98
38_T	119_M	0.787	0.98
277_P	280_D	0.785	0.98
136_H	268_V	0.785	0.98
145_L	176_I	0.783	0.98
126_H	271_D	0.783	0.98
171_P	178_P	0.782	0.98
126_H	274_E	0.782	0.98
242_T	245_P	0.782	0.98
258_L	261_G	0.779	0.98
129_T	166_M	0.775	0.98
259_V	299_I	0.774	0.98
144_A	182_V	0.773	0.98
252_S	256_I	0.769	0.98
217_K	220_V	0.761	0.98
284_I	288_A	0.760	0.98
225_V	266_N	0.759	0.98
150_A	187_R	0.757	0.97
205_N	257_K	0.755	0.97
146_V	182_V	0.754	0.97
250_L	255_A	0.750	0.97
218_Q	221_G	0.744	0.97
261_G	264_D	0.743	0.97
34_D	117_K	0.740	0.97
227_L	296_M	0.738	0.97
55_G	58_A	0.736	0.97
145_L	170_A	0.735	0.97
105_L	131_P	0.735	0.97
191_D	198_V	0.734	0.97
133_L	143_M	0.732	0.97
199_L	219_I	0.731	0.97
280_D	283_E	0.725	0.97
132_L	269_G	0.725	0.97
182_V	216_V	0.722	0.97
217_K	264_D	0.720	0.97
80_R	85_V	0.716	0.96
234_L	238_F	0.713	0.96
60_R	87_D	0.711	0.96
187_R	246_V	0.698	0.96
35_W	83_L	0.695	0.96
146_V	184_I	0.693	0.96
43_D	50_A	0.692	0.96
62_V	286_A	0.691	0.96
42_F	101_M	0.690	0.96
148_F	184_I	0.688	0.96
55_G	276_A	0.688	0.96
94_A	98_A	0.686	0.96
73_F	76_N	0.685	0.95
189_E	194_N	0.684	0.95
55_G	243_G	0.682	0.95
216_V	220_V	0.682	0.95
181_S	196_F	0.679	0.95
275_V	286_A	0.679	0.95
238_F	251_T	0.677	0.95
88_C	112_L	0.674	0.95
148_F	227_L	0.671	0.95
119_M	136_H	0.670	0.95
171_P	196_F	0.668	0.95
184_I	250_L	0.668	0.95
40_V	132_L	0.666	0.95
210_D	257_K	0.665	0.95
256_I	292_L	0.662	0.95
153_D	274_E	0.661	0.95
30_D	117_K	0.660	0.95
127_F	161_F	0.659	0.94
49_R	245_P	0.658	0.94
239_A	275_V	0.654	0.94
199_L	203_Q	0.649	0.94
47_S	163_H	0.649	0.94
146_V	225_V	0.648	0.94
121_S	128_V	0.648	0.94
206_D	210_D	0.641	0.94
191_D	195_G	0.640	0.94
55_G	277_P	0.640	0.94
45_A	125_D	0.636	0.93
209_V	257_K	0.634	0.93
203_Q	206_D	0.634	0.93
74_P	79_M	0.632	0.93
120_L	297_L	0.632	0.93
37_I	120_L	0.630	0.93
61_Q	283_E	0.630	0.93
226_Y	271_D	0.625	0.93
171_P	181_S	0.623	0.93
44_M	101_M	0.623	0.93
257_K	261_G	0.621	0.93
293_A	296_M	0.618	0.92
129_T	167_F	0.613	0.92
237_A	252_S	0.613	0.92
82_R	87_D	0.612	0.92
58_A	277_P	0.611	0.92
253_D	257_K	0.609	0.92
241_G	275_V	0.608	0.92
154_T	194_N	0.607	0.92
147_H	167_F	0.606	0.92
126_H	226_Y	0.602	0.91
154_T	190_F	0.601	0.91
295_E	298_Y	0.600	0.91
213_I	216_V	0.600	0.91
182_V	199_L	0.599	0.91
58_A	283_E	0.599	0.91
104_K	108_H	0.598	0.91
152_T	191_D	0.597	0.91
143_M	224_P	0.594	0.91
201_A	250_L	0.592	0.91
147_H	244_T	0.592	0.91
39_G	87_D	0.589	0.90
145_L	181_S	0.589	0.90
217_K	221_G	0.588	0.90
69_E	76_N	0.584	0.90
152_T	155_Y	0.581	0.90
62_V	290_A	0.581	0.90
171_P	179_N	0.581	0.90
41_P	90_D	0.579	0.90
131_P	135_A	0.579	0.90
134_R	170_A	0.578	0.90
132_L	136_H	0.576	0.89
30_D	33_A	0.576	0.89
47_S	243_G	0.574	0.89
155_Y	244_T	0.574	0.89
101_M	104_K	0.573	0.89
104_K	107_A	0.573	0.89
77_F	81_E	0.573	0.89
137_A	173_E	0.572	0.89
126_H	151_H	0.571	0.89
33_A	117_K	0.570	0.89
130_L	169_T	0.569	0.89
213_I	258_L	0.569	0.89
153_D	232_D	0.567	0.89
108_H	112_L	0.567	0.89
44_M	47_S	0.566	0.89
228_T	271_D	0.562	0.88
202_C	257_K	0.562	0.88
223_M	266_N	0.561	0.88
228_T	273_V	0.561	0.88
222_D	225_V	0.560	0.88
204_V	258_L	0.558	0.88
59_I	290_A	0.557	0.88
94_A	104_K	0.554	0.88
136_H	140_F	0.554	0.88
149_D	232_D	0.550	0.87
116_G	139_H	0.546	0.87
204_V	254_R	0.545	0.87
97_D	159_C	0.544	0.87
63_S	66_L	0.543	0.87
242_T	276_A	0.541	0.86
46_T	50_A	0.541	0.86
243_G	246_V	0.538	0.86
35_W	120_L	0.538	0.86
156_A	164_G	0.536	0.86
248_G	256_I	0.536	0.86
137_A	143_M	0.535	0.86
185_G	233_C	0.533	0.86
208_S	213_I	0.532	0.85
257_K	260_R	0.531	0.85
129_T	226_Y	0.531	0.85
133_L	176_I	0.531	0.85
201_A	254_R	0.527	0.85
165_T	169_T	0.525	0.85
123_G	128_V	0.524	0.85
209_V	258_L	0.523	0.84
126_H	273_V	0.523	0.84
66_L	69_E	0.522	0.84
221_G	266_N	0.521	0.84
81_E	87_D	0.520	0.84
62_V	283_E	0.519	0.84
225_V	265_L	0.518	0.84
247_I	288_A	0.516	0.84
187_R	244_T	0.515	0.84
159_C	165_T	0.515	0.84
182_V	220_V	0.512	0.83
191_D	194_N	0.511	0.83
70_H	295_E	0.511	0.83
236_P	239_A	0.509	0.83
243_G	274_E	0.507	0.83
226_Y	268_V	0.507	0.83
147_H	166_M	0.507	0.83
171_P	176_I	0.506	0.83
156_A	159_C	0.505	0.82
278_A	282_S	0.504	0.82
84_N	87_D	0.504	0.82
188_T	200_D	0.503	0.82
81_E	86_V	0.503	0.82
75_W	78_D	0.503	0.82
42_F	105_L	0.502	0.82
262_L	265_L	0.501	0.82
155_Y	164_G	0.500	0.82
79_M	83_L	0.500	0.82
171_P	174_G	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dz4A	5	0.9837	100	0.13	Contact Map
3nioA	5	0.9608	100	0.13	Contact Map
1gq6A	5	0.951	100	0.132	Contact Map
3niqA	5	0.9739	100	0.132	Contact Map
3m1rA	5	0.9771	100	0.15	Contact Map
1wohA	5	0.951	100	0.164	Contact Map
4mykA	3	0.8954	100	0.17	Contact Map
1xfkA	1	0.9379	100	0.206	Contact Map
3pzlA	5	0.9183	100	0.207	Contact Map
4q40A	5	0.8725	100	0.216	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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