GREMLIN Database
YOHJ - UPF0299 membrane protein YohJ
UniProt: P60632 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12023
Length: 132 (112)
Sequences: 1825 (1377)
Seq/√Len: 130.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_C49_L4.5551.00
113_W116_Q2.8491.00
110_V114_S2.7551.00
48_V52_L2.6521.00
109_L113_W2.4281.00
112_S116_Q2.3751.00
44_L48_V2.3581.00
29_A41_I2.1041.00
20_A24_A2.0021.00
102_V106_V1.9931.00
89_L96_V1.9201.00
25_G38_G1.8701.00
95_P99_S1.8451.00
83_M86_F1.8301.00
26_I30_S1.8181.00
24_A49_L1.7941.00
14_A63_G1.7931.00
92_Q95_P1.7831.00
22_L26_I1.7071.00
21_C45_I1.7061.00
39_S74_L1.6721.00
41_I45_I1.6721.00
13_R59_W1.6301.00
22_L39_S1.5951.00
114_S117_L1.5721.00
113_W117_L1.5161.00
56_P59_W1.5081.00
57_A60_V1.4921.00
37_P78_I1.4781.00
27_F31_L1.4311.00
117_L121_E1.4201.00
98_V102_V1.3751.00
82_V85_Y1.3511.00
28_I31_L1.3511.00
45_I49_L1.3331.00
43_M79_G1.3291.00
118_V121_E1.3131.00
87_D90_R1.3111.00
53_Q56_P1.2681.00
115_S119_H1.1900.99
85_Y88_L1.1860.99
61_N65_Y1.1850.99
29_A33_P1.1530.99
25_G41_I1.1140.99
44_L66_V1.1090.99
86_F90_R1.1070.99
57_A61_N1.0950.99
28_I45_I1.0940.99
21_C25_G1.0850.99
100_C107_V1.0810.99
43_M115_S1.0790.99
29_A32_L1.0270.98
88_L92_Q1.0160.98
15_F63_G1.0050.98
87_D91_A1.0000.98
29_A38_G0.9870.98
83_M101_A0.9640.97
107_V111_V0.9620.97
14_A21_C0.9610.97
72_A76_V0.9600.97
117_L120_G0.9600.97
49_L55_L0.9560.97
69_R78_I0.9550.97
49_L54_I0.9410.97
28_I61_N0.9350.97
27_F30_S0.9310.97
28_I33_P0.9190.97
54_I57_A0.9160.97
28_I41_I0.9120.96
26_I38_G0.9040.96
13_R16_V0.9030.96
46_L55_L0.8880.96
112_S121_E0.8830.96
47_F51_A0.8770.96
18_I63_G0.8690.95
43_M60_V0.8660.95
25_G81_G0.8600.95
40_I72_A0.8540.95
111_V115_S0.8450.95
92_Q96_V0.8400.94
24_A45_I0.8340.94
104_T107_V0.8330.94
55_L59_W0.8210.94
61_N81_G0.8210.94
15_F25_G0.8010.93
40_I68_I0.7900.92
19_Y111_V0.7740.92
35_T40_I0.7740.92
17_L20_A0.7680.91
55_L60_V0.7570.91
19_Y81_G0.7540.90
48_V114_S0.7530.90
116_Q121_E0.7440.90
49_L52_L0.7430.90
70_Y73_L0.7370.89
68_I71_M0.7350.89
39_S108_F0.7340.89
67_L72_A0.7250.89
75_F78_I0.7240.89
72_A79_G0.7210.88
44_L47_F0.7200.88
79_G86_F0.7090.88
38_G41_I0.7070.87
60_V68_I0.7050.87
105_L109_L0.7000.87
29_A34_V0.6980.87
28_I32_L0.6980.87
80_V83_M0.6980.87
84_Q87_D0.6920.86
13_R17_L0.6920.86
100_C104_T0.6900.86
55_L71_M0.6860.86
33_P44_L0.6800.85
22_L37_P0.6760.85
11_Y62_P0.6730.85
57_A64_C0.6620.84
104_T108_F0.6610.84
15_F103_S0.6570.83
58_K67_L0.6530.83
12_L122_R0.6450.82
72_A103_S0.6440.82
79_G82_V0.6390.82
99_S108_F0.6340.81
14_A66_V0.6210.80
115_S118_V0.6150.79
32_L41_I0.6070.78
30_S89_L0.6040.78
64_C105_L0.6040.78
36_I42_G0.5970.77
46_L60_V0.5930.77
13_R58_K0.5930.77
88_L96_V0.5880.76
31_L101_A0.5860.76
27_F101_A0.5860.76
19_Y25_G0.5840.76
66_V71_M0.5820.75
18_I59_W0.5820.75
71_M107_V0.5810.75
73_L76_V0.5800.75
23_Y105_L0.5780.75
79_G85_Y0.5770.75
58_K117_L0.5650.73
54_I58_K0.5600.72
12_L31_L0.5570.72
53_Q57_A0.5560.72
73_L88_L0.5500.71
61_N107_V0.5500.71
56_P102_V0.5490.71
80_V87_D0.5420.70
99_S109_L0.5360.69
19_Y80_V0.5290.68
40_I104_T0.5280.68
49_L53_Q0.5270.68
40_I85_Y0.5270.68
36_I81_G0.5260.68
58_K61_N0.5260.68
40_I80_V0.5200.67
11_Y82_V0.5190.67
51_A54_I0.5180.67
63_G85_Y0.5170.66
38_G81_G0.5150.66
22_L115_S0.5140.66
25_G45_I0.5100.65
17_L49_L0.5070.65
13_R90_R0.5060.65
60_V64_C0.5030.64
70_Y74_L0.5020.64
71_M75_F0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.9091 58.6 0.903 Contact Map
4mt1A 3 0.9015 57.2 0.904 Contact Map
2kncA 1 0.3864 52.2 0.907 Contact Map
4k0jA 3 0.8864 48.4 0.908 Contact Map
4cz8A 2 0.9318 47 0.909 Contact Map
4czbA 2 0.9318 39.8 0.913 Contact Map
2kv5A 1 0.25 39.3 0.913 Contact Map
4dx5A 3 0.9773 39.3 0.913 Contact Map
3w9iA 3 0.9394 37.6 0.914 Contact Map
3ne5A 3 0.9318 36.2 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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