GREMLIN Database
RL24 - 50S ribosomal protein L24
UniProt: P60624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10884
Length: 104 (99)
Sequences: 2634 (1455)
Seq/√Len: 146.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_V70_V3.0461.00
43_K60_E3.0051.00
5_I25_V2.5361.00
12_I22_R2.5221.00
43_K58_I2.1321.00
42_V63_A2.0741.00
32_G66_Q2.0331.00
24_K37_E2.0261.00
76_A101_E1.9151.00
87_F92_K1.8661.00
84_G97_K1.8611.00
10_E22_R1.8581.00
74_N99_N1.8191.00
86_R95_F1.7391.00
81_D96_F1.7311.00
96_F99_N1.7201.00
74_N96_F1.7151.00
74_N77_T1.6961.00
14_L71_A1.6701.00
13_V39_I1.6641.00
77_T99_N1.6341.00
18_D21_K1.5291.00
33_K64_A1.5181.00
49_V54_Q1.5181.00
29_L35_I1.4981.00
72_I83_V1.4881.00
15_T69_N1.4781.00
12_I80_A1.4411.00
84_G95_F1.3901.00
85_F92_K1.3811.00
66_Q69_N1.3661.00
10_E24_K1.3421.00
72_I103_I1.2921.00
77_T96_F1.2871.00
3_A67_V1.2811.00
18_D39_I1.2631.00
77_T98_S1.2561.00
48_P56_G1.2551.00
8_D24_K1.2371.00
46_Q59_V1.2361.00
49_V53_N1.2211.00
45_H58_I1.2191.00
93_V102_T1.2121.00
21_K39_I1.1911.00
4_K85_F1.1841.00
34_V67_V1.1821.00
41_L60_E1.1721.00
28_V67_V1.1671.00
44_K61_K1.1370.99
26_K37_E1.1140.99
73_F78_G1.0980.99
22_R73_F1.0730.99
32_G67_V1.0650.99
86_R102_T1.0630.99
22_R78_G1.0540.99
27_N35_I1.0520.99
29_L33_K1.0440.99
12_I73_F1.0400.99
37_E62_E0.9910.99
74_N81_D0.9790.98
79_K98_S0.9700.98
35_I64_A0.9600.98
3_A28_V0.9200.98
41_L62_E0.8750.97
46_Q61_K0.8440.96
17_K42_V0.8360.96
88_E91_K0.8240.95
87_F95_F0.8090.95
3_A85_F0.8000.95
81_D98_S0.7970.95
7_R28_V0.7900.94
46_Q49_V0.7880.94
49_V56_G0.7850.94
42_V61_K0.7830.94
17_K40_N0.7820.94
41_L63_A0.7620.93
33_K66_Q0.7580.93
33_K69_N0.7480.93
89_D92_K0.7460.92
48_P53_N0.7380.92
49_V52_L0.7370.92
95_F102_T0.7350.92
25_V34_V0.7340.92
4_K72_I0.7320.92
73_F80_A0.7240.91
61_K64_A0.7240.91
10_E73_F0.7210.91
73_F81_D0.7150.91
4_K83_V0.7150.91
23_G36_V0.7140.91
71_A82_R0.7030.90
3_A6_R0.7030.90
15_T19_K0.6960.90
67_V70_V0.6940.89
74_N98_S0.6920.89
87_F90_G0.6900.89
23_G38_G0.6740.88
35_I61_K0.6710.88
82_R97_K0.6500.86
49_V55_P0.6390.85
76_A99_N0.6350.85
4_K71_A0.6340.85
85_F97_K0.6310.85
71_A83_V0.6290.84
81_D99_N0.6270.84
87_F91_K0.6270.84
75_A99_N0.6260.84
4_K67_V0.6250.84
73_F96_F0.6100.83
75_A78_G0.6090.82
65_I69_N0.6070.82
20_G23_G0.6050.82
13_V65_I0.5950.81
71_A80_A0.5920.81
8_D78_G0.5890.80
27_N64_A0.5870.80
5_I70_V0.5810.79
18_D36_V0.5780.79
3_A32_G0.5740.79
5_I67_V0.5710.78
5_I28_V0.5650.77
88_E102_T0.5640.77
48_P60_E0.5620.77
12_I71_A0.5580.77
43_K59_V0.5550.76
46_Q65_I0.5520.76
86_R93_V0.5480.75
5_I72_I0.5450.75
22_R80_A0.5430.75
72_I81_D0.5430.75
86_R100_S0.5400.74
73_F77_T0.5390.74
33_K63_A0.5380.74
96_F103_I0.5370.74
59_V93_V0.5360.74
28_V31_S0.5340.73
46_Q54_Q0.5310.73
26_K62_E0.5280.73
42_V62_E0.5220.72
77_T101_E0.5210.72
95_F100_S0.5160.71
87_F93_V0.5130.70
5_I36_V0.5120.70
48_P54_Q0.5050.69
45_H59_V0.5030.69
42_V57_G0.5020.69
26_K34_V0.5020.69
53_N59_V0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboW 1 0.9904 100 0.129 Contact Map
4rb6Y 1 0.9904 100 0.147 Contact Map
2zjrR 1 0.9712 100 0.151 Contact Map
4tp9U 1 0.9808 100 0.152 Contact Map
3j3wU 1 0.9712 100 0.186 Contact Map
3j7yV 1 0.9808 100 0.189 Contact Map
1vw4Q 1 0.9038 100 0.282 Contact Map
4a17S 1 0.7788 99.9 0.45 Contact Map
1vq8T 1 0.7788 99.9 0.454 Contact Map
3j21U 1 0.7596 99.9 0.462 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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