HIS5 - ECOLI - GREMLIN Contacts

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HIS5 - Imidazole glycerol phosphate synthase subunit HisH

UniProt:	P60595	Sequences: MNVVILDTGCANLNSVKSAIARHGYEPKVSRDPDVVLLADKLFLPGVGTAQAAMDQVRERELFDLIKACTQPVLGICLGMQLLGRRSEESNGVDLLGIIDEDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFYGVQFHPERSGAAGAKLLKNFLEM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10450
Length:	196 (191)
Sequences:	3853 (2536)
Seq/√Len:	183.5

ECOLI - HIS5
BACSU - HIS5
HALSA - HIS5
SULSO - HIS5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_V	30_S	3.340	1.00
85_R	97_G	3.185	1.00
58_R	63_F	2.915	1.00
157_C	165_A	2.839	1.00
86_R	102_D	2.815	1.00
28_K	35_V	2.696	1.00
127_N	168_Q	2.561	1.00
191_K	195_E	2.512	1.00
32_D	35_V	2.296	1.00
20_I	43_F	2.284	1.00
106_M	163_F	2.154	1.00
86_R	92_G	2.150	1.00
4_V	39_A	2.146	1.00
104_P	148_P	2.139	1.00
85_R	100_D	1.996	1.00
50_A	95_L	1.978	1.00
158_N	162_P	1.977	1.00
84_G	147_M	1.977	1.00
156_Q	162_P	1.908	1.00
130_F	166_A	1.895	1.00
121_V	139_F	1.818	1.00
141_F	165_A	1.806	1.00
134_E	137_A	1.805	1.00
18_S	21_A	1.782	1.00
17_K	21_A	1.776	1.00
53_A	78_L	1.772	1.00
55_D	59_E	1.754	1.00
84_G	167_V	1.700	1.00
155_A	166_A	1.691	1.00
88_E	104_P	1.646	1.00
146_A	161_E	1.644	1.00
188_K	191_K	1.644	1.00
56_Q	59_E	1.609	1.00
132_G	192_N	1.602	1.00
154_I	168_Q	1.602	1.00
103_V	147_M	1.600	1.00
111_L	160_G	1.591	1.00
51_Q	90_S	1.571	1.00
139_F	185_A	1.555	1.00
153_T	164_T	1.524	1.00
137_A	185_A	1.523	1.00
5_I	17_K	1.515	1.00
129_L	173_Y	1.492	1.00
3_V	194_L	1.475	1.00
152_W	169_K	1.465	1.00
20_I	25_Y	1.455	1.00
166_A	175_V	1.452	1.00
31_R	60_R	1.451	1.00
88_E	102_D	1.419	1.00
17_K	29_V	1.410	1.00
25_Y	194_L	1.409	1.00
139_F	189_L	1.383	1.00
106_M	146_A	1.377	1.00
104_P	146_A	1.376	1.00
34_D	38_L	1.373	1.00
17_K	27_P	1.363	1.00
13_L	29_V	1.348	1.00
63_F	67_K	1.337	1.00
85_R	101_E	1.337	1.00
51_Q	93_V	1.330	1.00
22_R	187_A	1.326	1.00
83_L	172_F	1.325	1.00
4_V	36_V	1.320	1.00
100_D	152_W	1.311	1.00
5_I	20_I	1.310	1.00
86_R	94_D	1.293	1.00
133_I	137_A	1.283	1.00
107_T	161_E	1.278	1.00
131_Q	195_E	1.272	1.00
67_K	98_I	1.268	1.00
30_S	35_V	1.267	1.00
115_H	163_F	1.265	1.00
76_I	190_L	1.257	1.00
21_A	26_E	1.253	1.00
121_V	155_A	1.244	1.00
175_V	189_L	1.228	1.00
80_M	174_G	1.224	1.00
128_R	168_Q	1.204	1.00
61_E	66_I	1.190	1.00
83_L	98_I	1.177	1.00
90_S	93_V	1.160	1.00
57_V	63_F	1.150	1.00
88_E	92_G	1.143	1.00
4_V	42_L	1.140	1.00
56_Q	60_R	1.133	1.00
149_V	153_T	1.125	1.00
188_K	192_N	1.123	1.00
132_G	188_K	1.118	1.00
34_D	37_L	1.104	1.00
30_S	39_A	1.098	1.00
124_Q	156_Q	1.097	1.00
122_Y	162_P	1.086	1.00
8_T	11_A	1.078	1.00
84_G	103_V	1.075	1.00
116_M	142_V	1.063	1.00
49_T	90_S	1.021	1.00
61_E	64_D	1.012	0.99
21_A	27_P	1.007	0.99
121_V	165_A	1.006	0.99
63_F	66_I	1.005	0.99
36_V	39_A	1.002	0.99
73_V	98_I	0.998	0.99
84_G	99_I	0.991	0.99
120_R	136_G	0.989	0.99
14_N	18_S	0.983	0.99
129_L	192_N	0.978	0.99
33_P	65_L	0.977	0.99
33_P	37_L	0.975	0.99
62_L	66_I	0.975	0.99
158_N	161_E	0.963	0.99
99_I	152_W	0.963	0.99
85_R	102_D	0.962	0.99
80_M	147_M	0.956	0.99
36_V	65_L	0.956	0.99
44_L	73_V	0.955	0.99
120_R	138_Y	0.954	0.99
20_I	27_P	0.950	0.99
146_A	164_T	0.950	0.99
127_N	173_Y	0.947	0.99
84_G	101_E	0.944	0.99
47_V	78_L	0.937	0.99
157_C	163_F	0.933	0.99
64_D	67_K	0.902	0.99
127_N	154_I	0.900	0.99
133_I	192_N	0.896	0.99
122_Y	158_N	0.891	0.99
74_L	175_V	0.887	0.99
168_Q	173_Y	0.885	0.99
5_I	27_P	0.878	0.99
123_P	135_D	0.877	0.98
88_E	105_K	0.877	0.98
102_D	148_P	0.870	0.98
20_I	190_L	0.864	0.98
154_I	166_A	0.863	0.98
122_Y	136_G	0.857	0.98
141_F	157_C	0.847	0.98
30_S	62_L	0.831	0.98
54_M	63_F	0.831	0.98
115_H	143_H	0.823	0.98
62_L	65_L	0.818	0.98
35_V	38_L	0.816	0.98
3_V	41_K	0.815	0.98
9_G	56_Q	0.815	0.98
106_M	113_L	0.804	0.97
70_T	170_D	0.797	0.97
20_I	194_L	0.789	0.97
42_L	65_L	0.786	0.97
124_Q	162_P	0.785	0.97
14_N	17_K	0.780	0.97
53_A	82_L	0.777	0.97
24_G	27_P	0.777	0.97
121_V	189_L	0.772	0.97
23_H	194_L	0.772	0.97
85_R	99_I	0.770	0.97
42_L	69_C	0.764	0.96
66_I	98_I	0.762	0.96
50_A	82_L	0.761	0.96
94_D	97_G	0.759	0.96
54_M	58_R	0.758	0.96
6_L	44_L	0.758	0.96
3_V	25_Y	0.755	0.96
54_M	93_V	0.755	0.96
122_Y	156_Q	0.754	0.96
57_V	62_L	0.753	0.96
41_K	193_F	0.746	0.96
73_V	83_L	0.745	0.96
111_L	159_Y	0.743	0.96
19_A	23_H	0.740	0.96
6_L	66_I	0.737	0.96
122_Y	135_D	0.737	0.96
131_Q	188_K	0.736	0.96
36_V	62_L	0.734	0.96
33_P	36_V	0.734	0.96
99_I	167_V	0.734	0.96
50_A	93_V	0.733	0.95
133_I	136_G	0.728	0.95
155_A	165_A	0.728	0.95
148_P	161_E	0.726	0.95
4_V	35_V	0.725	0.95
47_V	80_M	0.723	0.95
98_I	172_F	0.719	0.95
115_H	119_N	0.718	0.95
49_T	93_V	0.713	0.95
115_H	157_C	0.708	0.95
58_R	94_D	0.707	0.95
4_V	28_K	0.703	0.94
73_V	172_F	0.703	0.94
51_Q	92_G	0.701	0.94
7_D	31_R	0.697	0.94
60_R	66_I	0.696	0.94
108_D	111_L	0.691	0.94
6_L	42_L	0.676	0.93
57_V	66_I	0.672	0.93
51_Q	55_D	0.671	0.93
9_G	60_R	0.667	0.93
116_M	138_Y	0.666	0.93
30_S	65_L	0.662	0.92
10_C	13_L	0.661	0.92
10_C	14_N	0.656	0.92
78_L	82_L	0.654	0.92
41_K	72_P	0.653	0.92
8_T	53_A	0.644	0.91
16_V	76_I	0.640	0.91
99_I	172_F	0.639	0.91
101_E	147_M	0.638	0.91
57_V	60_R	0.638	0.91
30_S	36_V	0.637	0.91
20_I	23_H	0.636	0.91
126_G	131_Q	0.629	0.90
149_V	164_T	0.628	0.90
137_A	188_K	0.626	0.90
16_V	19_A	0.625	0.90
129_L	189_L	0.624	0.90
123_P	155_A	0.619	0.90
70_T	171_N	0.618	0.90
6_L	36_V	0.617	0.89
5_I	29_V	0.615	0.89
65_L	69_C	0.615	0.89
148_P	151_P	0.614	0.89
60_R	78_L	0.614	0.89
23_H	187_A	0.610	0.89
167_V	174_G	0.600	0.88
27_P	43_F	0.599	0.88
55_D	58_R	0.596	0.88
100_D	169_K	0.593	0.88
153_T	156_Q	0.593	0.88
87_S	106_M	0.593	0.88
41_K	183_G	0.589	0.87
42_L	66_I	0.588	0.87
154_I	173_Y	0.584	0.87
42_L	71_Q	0.581	0.86
33_P	61_E	0.580	0.86
18_S	187_A	0.574	0.86
88_E	107_T	0.573	0.86
61_E	65_L	0.573	0.86
105_K	145_Y	0.572	0.86
58_R	93_V	0.568	0.85
16_V	78_L	0.568	0.85
130_F	155_A	0.565	0.85
138_Y	185_A	0.564	0.85
53_A	56_Q	0.564	0.85
134_E	185_A	0.564	0.85
33_P	64_D	0.561	0.85
10_C	53_A	0.559	0.84
107_T	110_G	0.556	0.84
125_A	154_I	0.554	0.84
62_L	67_K	0.553	0.84
50_A	87_S	0.553	0.84
121_V	137_A	0.550	0.83
70_T	172_F	0.547	0.83
10_C	52_A	0.545	0.83
54_M	88_E	0.543	0.83
98_I	174_G	0.539	0.82
23_H	190_L	0.539	0.82
54_M	82_L	0.536	0.82
14_N	163_F	0.535	0.82
150_N	153_T	0.533	0.81
87_S	93_V	0.529	0.81
133_I	139_F	0.528	0.81
27_P	78_L	0.525	0.80
16_V	43_F	0.524	0.80
44_L	82_L	0.524	0.80
43_F	76_I	0.524	0.80
52_A	112_P	0.521	0.80
41_K	194_L	0.520	0.80
87_S	183_G	0.519	0.80
119_N	159_Y	0.519	0.80
13_L	112_P	0.517	0.79
37_L	69_C	0.516	0.79
15_S	18_S	0.515	0.79
49_T	52_A	0.515	0.79
44_L	47_V	0.513	0.79
10_C	78_L	0.512	0.79
173_Y	193_F	0.510	0.79
128_R	131_Q	0.510	0.79
116_M	141_F	0.509	0.78
49_T	142_V	0.507	0.78
9_G	103_V	0.506	0.78
94_D	151_P	0.505	0.78
121_V	163_F	0.505	0.78
114_P	144_S	0.505	0.78
41_K	173_Y	0.503	0.78
27_P	194_L	0.502	0.77
69_C	98_I	0.502	0.77
9_G	52_A	0.502	0.77
60_R	65_L	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jvnA	1	0.9847	100	0.427	Contact Map
4gudA	1	0.9949	100	0.461	Contact Map
1ka9H	1	0.9643	100	0.506	Contact Map
1gpwB	1	0.949	100	0.521	Contact Map
3uowA	2	0.9337	100	0.529	Contact Map
2v4uA	1	0.9439	100	0.56	Contact Map
2ywdA	1	0.9133	100	0.571	Contact Map
2ywjA	1	0.9031	100	0.573	Contact Map
2issD	1	0.8571	100	0.581	Contact Map
2ywbA	4	0.8622	100	0.583	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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