GREMLIN Database
HIS5 - Imidazole glycerol phosphate synthase subunit HisH
UniProt: P60595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10450
Length: 196 (191)
Sequences: 3853 (2536)
Seq/√Len: 183.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_V30_S3.3401.00
85_R97_G3.1851.00
58_R63_F2.9151.00
157_C165_A2.8391.00
86_R102_D2.8151.00
28_K35_V2.6961.00
127_N168_Q2.5611.00
191_K195_E2.5121.00
32_D35_V2.2961.00
20_I43_F2.2841.00
106_M163_F2.1541.00
86_R92_G2.1501.00
4_V39_A2.1461.00
104_P148_P2.1391.00
85_R100_D1.9961.00
50_A95_L1.9781.00
158_N162_P1.9771.00
84_G147_M1.9771.00
156_Q162_P1.9081.00
130_F166_A1.8951.00
121_V139_F1.8181.00
141_F165_A1.8061.00
134_E137_A1.8051.00
18_S21_A1.7821.00
17_K21_A1.7761.00
53_A78_L1.7721.00
55_D59_E1.7541.00
84_G167_V1.7001.00
155_A166_A1.6911.00
88_E104_P1.6461.00
146_A161_E1.6441.00
188_K191_K1.6441.00
56_Q59_E1.6091.00
132_G192_N1.6021.00
154_I168_Q1.6021.00
103_V147_M1.6001.00
111_L160_G1.5911.00
51_Q90_S1.5711.00
139_F185_A1.5551.00
153_T164_T1.5241.00
137_A185_A1.5231.00
5_I17_K1.5151.00
129_L173_Y1.4921.00
3_V194_L1.4751.00
152_W169_K1.4651.00
20_I25_Y1.4551.00
166_A175_V1.4521.00
31_R60_R1.4511.00
88_E102_D1.4191.00
17_K29_V1.4101.00
25_Y194_L1.4091.00
139_F189_L1.3831.00
106_M146_A1.3771.00
104_P146_A1.3761.00
34_D38_L1.3731.00
17_K27_P1.3631.00
13_L29_V1.3481.00
63_F67_K1.3371.00
85_R101_E1.3371.00
51_Q93_V1.3301.00
22_R187_A1.3261.00
83_L172_F1.3251.00
4_V36_V1.3201.00
100_D152_W1.3111.00
5_I20_I1.3101.00
86_R94_D1.2931.00
133_I137_A1.2831.00
107_T161_E1.2781.00
131_Q195_E1.2721.00
67_K98_I1.2681.00
30_S35_V1.2671.00
115_H163_F1.2651.00
76_I190_L1.2571.00
21_A26_E1.2531.00
121_V155_A1.2441.00
175_V189_L1.2281.00
80_M174_G1.2241.00
128_R168_Q1.2041.00
61_E66_I1.1901.00
83_L98_I1.1771.00
90_S93_V1.1601.00
57_V63_F1.1501.00
88_E92_G1.1431.00
4_V42_L1.1401.00
56_Q60_R1.1331.00
149_V153_T1.1251.00
188_K192_N1.1231.00
132_G188_K1.1181.00
34_D37_L1.1041.00
30_S39_A1.0981.00
124_Q156_Q1.0971.00
122_Y162_P1.0861.00
8_T11_A1.0781.00
84_G103_V1.0751.00
116_M142_V1.0631.00
49_T90_S1.0211.00
61_E64_D1.0120.99
21_A27_P1.0070.99
121_V165_A1.0060.99
63_F66_I1.0050.99
36_V39_A1.0020.99
73_V98_I0.9980.99
84_G99_I0.9910.99
120_R136_G0.9890.99
14_N18_S0.9830.99
129_L192_N0.9780.99
33_P65_L0.9770.99
33_P37_L0.9750.99
62_L66_I0.9750.99
158_N161_E0.9630.99
99_I152_W0.9630.99
85_R102_D0.9620.99
80_M147_M0.9560.99
36_V65_L0.9560.99
44_L73_V0.9550.99
120_R138_Y0.9540.99
20_I27_P0.9500.99
146_A164_T0.9500.99
127_N173_Y0.9470.99
84_G101_E0.9440.99
47_V78_L0.9370.99
157_C163_F0.9330.99
64_D67_K0.9020.99
127_N154_I0.9000.99
133_I192_N0.8960.99
122_Y158_N0.8910.99
74_L175_V0.8870.99
168_Q173_Y0.8850.99
5_I27_P0.8780.99
123_P135_D0.8770.98
88_E105_K0.8770.98
102_D148_P0.8700.98
20_I190_L0.8640.98
154_I166_A0.8630.98
122_Y136_G0.8570.98
141_F157_C0.8470.98
30_S62_L0.8310.98
54_M63_F0.8310.98
115_H143_H0.8230.98
62_L65_L0.8180.98
35_V38_L0.8160.98
3_V41_K0.8150.98
9_G56_Q0.8150.98
106_M113_L0.8040.97
70_T170_D0.7970.97
20_I194_L0.7890.97
42_L65_L0.7860.97
124_Q162_P0.7850.97
14_N17_K0.7800.97
53_A82_L0.7770.97
24_G27_P0.7770.97
121_V189_L0.7720.97
23_H194_L0.7720.97
85_R99_I0.7700.97
42_L69_C0.7640.96
66_I98_I0.7620.96
50_A82_L0.7610.96
94_D97_G0.7590.96
54_M58_R0.7580.96
6_L44_L0.7580.96
3_V25_Y0.7550.96
54_M93_V0.7550.96
122_Y156_Q0.7540.96
57_V62_L0.7530.96
41_K193_F0.7460.96
73_V83_L0.7450.96
111_L159_Y0.7430.96
19_A23_H0.7400.96
6_L66_I0.7370.96
122_Y135_D0.7370.96
131_Q188_K0.7360.96
36_V62_L0.7340.96
33_P36_V0.7340.96
99_I167_V0.7340.96
50_A93_V0.7330.95
133_I136_G0.7280.95
155_A165_A0.7280.95
148_P161_E0.7260.95
4_V35_V0.7250.95
47_V80_M0.7230.95
98_I172_F0.7190.95
115_H119_N0.7180.95
49_T93_V0.7130.95
115_H157_C0.7080.95
58_R94_D0.7070.95
4_V28_K0.7030.94
73_V172_F0.7030.94
51_Q92_G0.7010.94
7_D31_R0.6970.94
60_R66_I0.6960.94
108_D111_L0.6910.94
6_L42_L0.6760.93
57_V66_I0.6720.93
51_Q55_D0.6710.93
9_G60_R0.6670.93
116_M138_Y0.6660.93
30_S65_L0.6620.92
10_C13_L0.6610.92
10_C14_N0.6560.92
78_L82_L0.6540.92
41_K72_P0.6530.92
8_T53_A0.6440.91
16_V76_I0.6400.91
99_I172_F0.6390.91
101_E147_M0.6380.91
57_V60_R0.6380.91
30_S36_V0.6370.91
20_I23_H0.6360.91
126_G131_Q0.6290.90
149_V164_T0.6280.90
137_A188_K0.6260.90
16_V19_A0.6250.90
129_L189_L0.6240.90
123_P155_A0.6190.90
70_T171_N0.6180.90
6_L36_V0.6170.89
5_I29_V0.6150.89
65_L69_C0.6150.89
148_P151_P0.6140.89
60_R78_L0.6140.89
23_H187_A0.6100.89
167_V174_G0.6000.88
27_P43_F0.5990.88
55_D58_R0.5960.88
100_D169_K0.5930.88
153_T156_Q0.5930.88
87_S106_M0.5930.88
41_K183_G0.5890.87
42_L66_I0.5880.87
154_I173_Y0.5840.87
42_L71_Q0.5810.86
33_P61_E0.5800.86
18_S187_A0.5740.86
88_E107_T0.5730.86
61_E65_L0.5730.86
105_K145_Y0.5720.86
58_R93_V0.5680.85
16_V78_L0.5680.85
130_F155_A0.5650.85
138_Y185_A0.5640.85
53_A56_Q0.5640.85
134_E185_A0.5640.85
33_P64_D0.5610.85
10_C53_A0.5590.84
107_T110_G0.5560.84
125_A154_I0.5540.84
62_L67_K0.5530.84
50_A87_S0.5530.84
121_V137_A0.5500.83
70_T172_F0.5470.83
10_C52_A0.5450.83
54_M88_E0.5430.83
98_I174_G0.5390.82
23_H190_L0.5390.82
54_M82_L0.5360.82
14_N163_F0.5350.82
150_N153_T0.5330.81
87_S93_V0.5290.81
133_I139_F0.5280.81
27_P78_L0.5250.80
16_V43_F0.5240.80
44_L82_L0.5240.80
43_F76_I0.5240.80
52_A112_P0.5210.80
41_K194_L0.5200.80
87_S183_G0.5190.80
119_N159_Y0.5190.80
13_L112_P0.5170.79
37_L69_C0.5160.79
15_S18_S0.5150.79
49_T52_A0.5150.79
44_L47_V0.5130.79
10_C78_L0.5120.79
173_Y193_F0.5100.79
128_R131_Q0.5100.79
116_M141_F0.5090.78
49_T142_V0.5070.78
9_G103_V0.5060.78
94_D151_P0.5050.78
121_V163_F0.5050.78
114_P144_S0.5050.78
41_K173_Y0.5030.78
27_P194_L0.5020.77
69_C98_I0.5020.77
9_G52_A0.5020.77
60_R65_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9847 100 0.427 Contact Map
4gudA 1 0.9949 100 0.461 Contact Map
1ka9H 1 0.9643 100 0.506 Contact Map
1gpwB 1 0.949 100 0.521 Contact Map
3uowA 2 0.9337 100 0.529 Contact Map
2v4uA 1 0.9439 100 0.56 Contact Map
2ywdA 1 0.9133 100 0.571 Contact Map
2ywjA 1 0.9031 100 0.573 Contact Map
2issD 1 0.8571 100 0.581 Contact Map
2ywbA 4 0.8622 100 0.583 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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