GREMLIN Database
CAIA - Crotonobetainyl-CoA dehydrogenase
UniProt: P60584 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11560
Length: 380 (363)
Sequences: 33920 (19265)
Seq/√Len: 1011.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_K216_E4.1181.00
150_N214_D3.9081.00
289_K327_E3.4301.00
193_K213_D2.9641.00
142_R219_E2.9041.00
103_Q107_D2.8351.00
112_F117_K2.8321.00
143_R216_E2.8311.00
17_R76_E2.7611.00
66_G69_T2.7211.00
181_T222_M2.6821.00
31_E35_D2.6781.00
282_K331_S2.4021.00
261_R265_Q2.3821.00
112_F118_Q2.2751.00
152_S211_T2.2371.00
253_M294_K2.1981.00
302_W306_N2.0961.00
169_A183_W2.0931.00
18_E22_S2.0851.00
272_A275_R2.0521.00
143_R146_K2.0461.00
225_R228_N2.0381.00
103_Q106_I2.0321.00
102_T105_Q1.9991.00
343_G348_S1.9521.00
263_A335_V1.9211.00
75_M294_K1.9001.00
348_S352_R1.8731.00
228_N231_N1.8571.00
57_P98_L1.8511.00
165_I187_M1.8411.00
147_I183_W1.8061.00
323_N364_D1.7891.00
9_Q69_T1.7631.00
152_S209_E1.7501.00
256_F290_L1.7441.00
44_K48_D1.7331.00
45_A48_D1.7311.00
79_R257_E1.7251.00
253_M257_E1.6981.00
142_R226_E1.6911.00
143_R148_Y1.6841.00
148_Y216_E1.6671.00
121_N165_I1.6551.00
267_V272_A1.6471.00
141_T150_N1.6341.00
278_L281_E1.6311.00
76_E79_R1.6281.00
222_M226_E1.6231.00
108_K220_K1.6211.00
303_K313_D1.6151.00
218_D221_D1.6091.00
159_S208_C1.5891.00
147_I219_E1.5871.00
189_K215_V1.5831.00
195_T209_E1.5821.00
263_A279_I1.5681.00
286_M328_V1.5671.00
145_G219_E1.5671.00
148_Y214_D1.5591.00
108_K112_F1.5561.00
271_E275_R1.5541.00
186_D221_D1.5531.00
126_E153_K1.5341.00
193_K211_T1.5251.00
150_N213_D1.5181.00
292_S320_F1.5141.00
125_T155_F1.5081.00
107_D111_A1.5081.00
299_E303_K1.5011.00
20_M80_L1.5011.00
14_A18_E1.4961.00
9_Q66_G1.4951.00
112_F115_T1.4951.00
11_L14_A1.4951.00
10_E13_V1.4861.00
60_H106_I1.4851.00
339_V345_H1.4811.00
58_E64_D1.4801.00
268_Q276_F1.4691.00
160_A208_C1.4541.00
255_A329_V1.4501.00
219_E222_M1.4471.00
140_Y183_W1.4401.00
279_I335_V1.4391.00
258_D261_R1.4281.00
293_M321_C1.4081.00
258_D346_R1.4001.00
104_E108_K1.4001.00
149_L183_W1.3851.00
291_N299_E1.3821.00
254_C258_D1.3821.00
9_Q72_A1.3761.00
11_L15_G1.3721.00
326_F358_R1.3691.00
260_A264_N1.3651.00
319_Y364_D1.3481.00
186_D189_K1.3471.00
75_M298_Y1.3471.00
327_E331_S1.3431.00
142_R146_K1.3431.00
79_R253_M1.3371.00
100_E235_E1.3341.00
286_M331_S1.3291.00
13_V76_E1.3281.00
330_D355_R1.3171.00
217_L221_D1.3081.00
68_V302_W1.3041.00
16_I51_I1.3041.00
104_E220_K1.2921.00
67_F305_D1.2871.00
54_L73_V1.2831.00
28_Y32_C1.2781.00
81_G84_T1.2771.00
75_M253_M1.2731.00
285_H368_I1.2671.00
146_K219_E1.2621.00
32_C204_M1.2531.00
123_A156_I1.2501.00
259_A332_A1.2471.00
105_Q109_I1.2451.00
147_I226_E1.2441.00
252_A290_L1.2431.00
113_R120_W1.2431.00
44_K47_A1.2231.00
246_L297_L1.2231.00
290_L328_V1.2201.00
66_G305_D1.2201.00
330_D358_R1.2161.00
111_A115_T1.2151.00
256_F260_A1.2121.00
252_A328_V1.2111.00
142_R147_I1.2101.00
187_M192_I1.2081.00
106_I110_M1.2031.00
192_I215_V1.2021.00
108_K221_D1.2021.00
10_E14_A1.2011.00
30_A34_R1.1991.00
78_G85_Y1.1951.00
145_G216_E1.1931.00
325_A354_L1.1881.00
254_C350_F1.1861.00
101_G105_Q1.1831.00
240_E361_G1.1811.00
13_V72_A1.1781.00
56_I114_G1.1771.00
128_G137_K1.1741.00
271_E276_F1.1741.00
28_Y31_E1.1721.00
71_A301_A1.1671.00
171_D181_T1.1611.00
282_K365_E1.1591.00
189_K221_D1.1571.00
230_F234_K1.1541.00
65_A69_T1.1531.00
332_A347_I1.1521.00
15_G49_M1.1461.00
303_K308_T1.1451.00
299_E302_W1.1451.00
258_D336_L1.1411.00
287_A291_N1.1411.00
71_A246_L1.1371.00
141_T148_Y1.1371.00
109_I164_Y1.1351.00
118_Q163_P1.1301.00
45_A49_M1.1211.00
138_T149_L1.1191.00
238_D311_S1.1161.00
139_T150_N1.1151.00
105_Q184_F1.1071.00
168_M182_E1.1071.00
315_A367_Q1.1071.00
355_R358_R1.1001.00
326_F330_D1.0941.00
187_M194_V1.0871.00
149_L167_V1.0861.00
191_G215_V1.0851.00
47_A52_D1.0841.00
293_M324_A1.0821.00
289_K331_S1.0761.00
19_L45_A1.0721.00
59_E107_D1.0711.00
288_I316_M1.0641.00
167_V185_V1.0641.00
147_I171_D1.0521.00
16_I20_M1.0511.00
249_Y290_L1.0501.00
168_M180_Y1.0491.00
44_K117_K1.0471.00
123_A165_I1.0461.00
120_W164_Y1.0461.00
192_I210_I1.0451.00
104_E107_D1.0411.00
140_Y169_A1.0361.00
141_T214_D1.0301.00
216_E219_E1.0291.00
358_R364_D1.0271.00
15_G51_I1.0221.00
41_R44_K1.0051.00
144_N216_E1.0051.00
167_V212_F1.0021.00
289_K324_A0.9971.00
323_N327_E0.9951.00
132_D135_S0.9921.00
329_V354_L0.9911.00
105_Q221_D0.9881.00
326_F351_W0.9871.00
40_E44_K0.9861.00
201_G353_D0.9761.00
149_L169_A0.9721.00
198_E343_G0.9681.00
123_A212_F0.9671.00
172_G179_V0.9661.00
181_T226_E0.9641.00
319_Y368_I0.9641.00
248_N357_D0.9631.00
249_Y297_L0.9611.00
99_R235_E0.9571.00
263_A273_I0.9561.00
295_N299_E0.9531.00
323_N358_R0.9511.00
93_G120_W0.9511.00
108_K186_D0.9421.00
165_I210_I0.9411.00
165_I192_I0.9411.00
260_A283_F0.9391.00
255_A350_F0.9351.00
59_E103_Q0.9341.00
200_L351_W0.9341.00
183_W222_M0.9321.00
172_G175_P0.9301.00
141_T172_G0.9281.00
264_N274_G0.9261.00
364_D368_I0.9221.00
155_F339_V0.9181.00
159_S194_V0.9151.00
324_A327_E0.9141.00
100_E232_R0.9081.00
16_I73_V0.9081.00
149_L217_L0.9071.00
56_I94_F0.9051.00
195_T198_E0.9001.00
300_A317_C0.8991.00
322_A364_D0.8981.00
93_G166_V0.8981.00
356_V360_S0.8981.00
285_H289_K0.8941.00
19_L49_M0.8861.00
124_I237_F0.8801.00
287_A316_M0.8801.00
164_Y186_D0.8761.00
17_R21_A0.8761.00
57_P60_H0.8761.00
263_A274_G0.8711.00
68_V305_D0.8681.00
121_N162_T0.8671.00
202_L356_V0.8661.00
20_M77_L0.8651.00
121_N187_M0.8641.00
154_C209_E0.8621.00
190_P216_E0.8611.00
323_N368_I0.8591.00
131_S366_M0.8571.00
170_R180_Y0.8531.00
333_M351_W0.8491.00
155_F342_A0.8481.00
102_T106_I0.8461.00
163_P188_S0.8441.00
259_A335_V0.8431.00
324_A328_V0.8411.00
257_E261_R0.8401.00
261_R264_N0.8381.00
195_T211_T0.8361.00
26_E29_F0.8291.00
46_L51_I0.8291.00
357_D360_S0.8271.00
34_R343_G0.8271.00
251_T350_F0.8241.00
251_T325_A0.8241.00
28_Y41_R0.8241.00
326_F355_R0.8231.00
280_Q369_L0.8231.00
200_L348_S0.8201.00
289_K320_F0.8181.00
281_E369_L0.8181.00
33_D352_R0.8181.00
140_Y147_I0.8151.00
333_M347_I0.8121.00
123_A167_V0.8111.00
59_E62_G0.8101.00
212_F215_V0.8091.00
263_A283_F0.8081.00
68_V72_A0.8081.00
19_L46_L0.8071.00
15_G18_E0.8051.00
68_V298_Y0.8051.00
21_A79_R0.8051.00
147_I222_M0.8051.00
164_Y184_F0.8031.00
118_Q164_Y0.8011.00
259_A336_L0.7991.00
146_K218_D0.7981.00
329_V350_F0.7981.00
251_T354_L0.7941.00
83_P204_M0.7941.00
146_K220_K0.7911.00
189_K192_I0.7901.00
109_I184_F0.7891.00
194_V210_I0.7881.00
9_Q68_V0.7881.00
252_A324_A0.7861.00
291_N294_K0.7851.00
330_D351_W0.7841.00
136_L168_M0.7821.00
281_E285_H0.7821.00
55_L70_L0.7791.00
60_H103_Q0.7771.00
13_V17_R0.7761.00
166_V182_E0.7731.00
30_A349_R0.7721.00
183_W217_L0.7721.00
291_N295_N0.7691.00
140_Y171_D0.7691.00
31_E34_R0.7681.00
282_K335_V0.7681.00
244_V361_G0.7651.00
329_V351_W0.7631.00
259_A263_A0.7611.00
286_M332_A0.7581.00
42_F84_T0.7571.00
72_A76_E0.7561.00
288_I320_F0.7561.00
170_R173_A0.7561.00
181_T227_G0.7561.00
59_E106_I0.7541.00
249_Y293_M0.7511.00
285_H331_S0.7471.00
310_T313_D0.7471.00
258_D350_F0.7431.00
123_A210_I0.7431.00
138_T153_K0.7411.00
351_W355_R0.7391.00
245_A317_C0.7391.00
253_M287_A0.7341.00
136_L180_Y0.7321.00
163_P187_M0.7311.00
256_F287_A0.7301.00
262_Y339_V0.7261.00
149_L185_V0.7261.00
277_Q281_E0.7241.00
181_T224_G0.7241.00
21_A26_E0.7231.00
172_G227_G0.7211.00
255_A332_A0.7211.00
126_E138_T0.7201.00
109_I221_D0.7201.00
334_Q355_R0.7201.00
72_A298_Y0.7181.00
94_F113_R0.7161.00
175_P178_P0.7131.00
122_S233_V0.7131.00
320_F324_A0.7131.00
188_S192_I0.7121.00
285_H327_E0.7111.00
245_A297_L0.7071.00
369_L373_R0.7071.00
142_R148_Y0.7051.00
166_V223_F0.7041.00
296_M316_M0.7031.00
296_M317_C0.6981.00
41_R45_A0.6981.00
21_A80_L0.6981.00
276_F280_Q0.6931.00
288_I319_Y0.6911.00
273_I276_F0.6911.00
248_N322_A0.6901.00
25_W42_F0.6901.00
292_S296_M0.6881.00
349_R353_D0.6871.00
79_R254_C0.6841.00
170_R179_V0.6841.00
18_E21_A0.6841.00
327_E330_D0.6831.00
56_I60_H0.6801.00
124_I133_V0.6791.00
145_G220_K0.6761.00
42_F45_A0.6751.00
40_E163_P0.6731.00
57_P62_G0.6711.00
222_M225_R0.6711.00
226_E229_G0.6701.00
301_A305_D0.6691.00
329_V347_I0.6681.00
367_Q370_T0.6671.00
59_E64_D0.6671.00
37_V40_E0.6631.00
325_A329_V0.6621.00
13_V75_M0.6611.00
203_R343_G0.6591.00
266_R269_F0.6591.00
113_R164_Y0.6591.00
333_M340_G0.6571.00
228_N232_R0.6561.00
297_L321_C0.6561.00
268_Q273_I0.6551.00
280_Q372_G0.6551.00
54_L65_A0.6521.00
336_L347_I0.6521.00
171_D179_V0.6521.00
136_L170_R0.6491.00
171_D226_E0.6451.00
25_W28_Y0.6451.00
12_F73_V0.6431.00
199_K207_C0.6421.00
312_G374_A0.6411.00
202_L360_S0.6401.00
160_A206_S0.6401.00
245_A321_C0.6401.00
101_G106_I0.6401.00
109_I118_Q0.6361.00
363_S366_M0.6361.00
20_M25_W0.6351.00
289_K292_S0.6351.00
219_E226_E0.6281.00
29_F349_R0.6271.00
319_Y371_L0.6261.00
156_I210_I0.6261.00
294_K298_Y0.6251.00
246_L250_G0.6181.00
201_G341_I0.6171.00
143_R219_E0.6171.00
242_F301_A0.6161.00
138_T212_F0.6161.00
34_R198_E0.6151.00
279_I283_F0.6151.00
296_M320_F0.6141.00
252_A293_M0.6111.00
144_N148_Y0.6111.00
168_M233_V0.6091.00
316_M371_L0.6081.00
97_F101_G0.6021.00
94_F110_M0.6021.00
96_T236_E0.6011.00
139_T173_A0.6001.00
12_F69_T0.5991.00
282_K334_Q0.5991.00
176_D179_V0.5971.00
185_V212_F0.5941.00
259_A286_M0.5941.00
269_F276_F0.5861.00
293_M320_F0.5861.00
299_E313_D0.5821.00
127_P152_S0.5821.00
252_A255_A0.5801.00
238_D314_A0.5791.00
254_C346_R0.5771.00
33_D203_R0.5771.00
17_R79_R0.5771.00
138_T151_G0.5771.00
254_C257_E0.5751.00
282_K285_H0.5741.00
293_M317_C0.5741.00
289_K323_N0.5731.00
17_R80_L0.5691.00
70_L243_L0.5681.00
96_T100_E0.5671.00
249_Y253_M0.5671.00
183_W219_E0.5661.00
40_E161_Y0.5661.00
338_G341_I0.5661.00
82_A251_T0.5651.00
279_I282_K0.5641.00
60_H107_D0.5641.00
183_W221_D0.5631.00
105_Q108_K0.5631.00
159_S210_I0.5611.00
30_A346_R0.5611.00
167_V215_V0.5601.00
291_N296_M0.5551.00
157_T207_C0.5531.00
160_A196_K0.5531.00
22_S45_A0.5521.00
98_L106_I0.5511.00
124_I168_M0.5491.00
12_F16_I0.5481.00
322_A357_D0.5471.00
161_Y206_S0.5461.00
288_I292_S0.5451.00
53_S63_L0.5441.00
285_H288_I0.5441.00
286_M335_V0.5381.00
164_Y221_D0.5371.00
142_R145_G0.5361.00
293_M328_V0.5361.00
138_T169_A0.5341.00
138_T167_V0.5331.00
46_L84_T0.5331.00
237_F240_E0.5331.00
67_F304_A0.5321.00
253_M290_L0.5291.00
60_H111_A0.5291.00
326_F354_L0.5291.00
224_G227_G0.5281.00
142_R172_G0.5271.00
334_Q365_E0.5261.00
51_I73_V0.5261.00
366_M369_L0.5261.00
96_T232_R0.5261.00
262_Y345_H0.5251.00
319_Y323_N0.5251.00
346_R349_R0.5251.00
296_M300_A0.5241.00
355_R359_V0.5241.00
129_A137_K0.5241.00
266_R338_G0.5231.00
231_N235_E0.5221.00
15_G63_L0.5221.00
185_V215_V0.5221.00
184_F223_F0.5191.00
242_F297_L0.5171.00
192_I212_F0.5171.00
36_S203_R0.5161.00
267_V275_R0.5161.00
285_H323_N0.5121.00
139_T172_G0.5121.00
188_S194_V0.5121.00
262_Y265_Q0.5101.00
147_I217_L0.5081.00
108_K111_A0.5071.00
171_D183_W0.5061.00
170_R177_K0.5061.00
197_L209_E0.5051.00
276_F279_I0.5041.00
194_V208_C0.5041.00
188_S191_G0.5031.00
40_E119_M0.5031.00
273_I279_I0.5031.00
237_F241_R0.5021.00
225_R232_R0.5011.00
121_N156_I0.5011.00
286_M324_A0.5011.00
53_S114_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rm7A 4 0.9684 100 0.099 Contact Map
4l1fA 4 0.9921 100 0.101 Contact Map
2d29A 4 0.9947 100 0.105 Contact Map
1ivhA 4 0.9921 100 0.106 Contact Map
2jifA 4 0.9921 100 0.106 Contact Map
1bucA 4 0.9895 100 0.111 Contact Map
4p13A 4 0.9974 100 0.111 Contact Map
4m9aA 4 0.9816 100 0.111 Contact Map
3pfdA 4 0.9658 100 0.112 Contact Map
4ktoA 4 0.9921 100 0.113 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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