GREMLIN Database
FIXA - Protein FixA
UniProt: P60566 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11562
Length: 256 (244)
Sequences: 3538 (2066)
Seq/√Len: 132.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_T171_S4.2031.00
56_Q83_E3.7031.00
131_G179_A3.2851.00
106_A109_Q3.2811.00
49_K82_D3.2141.00
73_R84_L3.0661.00
110_K206_W2.9681.00
148_K160_E2.9571.00
207_S210_D2.9431.00
240_D243_E2.8601.00
59_A76_V2.6901.00
83_E204_Q2.6261.00
44_A47_Q2.5751.00
2_K56_Q2.3981.00
143_V172_I2.3651.00
118_C134_V2.2571.00
77_L84_L2.2531.00
44_A185_N2.1451.00
148_K151_S2.0741.00
146_V159_V2.0631.00
50_Q188_Q2.0541.00
43_E188_Q2.0441.00
146_V178_V2.0201.00
158_T171_S2.0141.00
172_I176_A2.0051.00
157_L172_I1.9631.00
4_I108_A1.9591.00
34_I70_A1.9251.00
161_R168_E1.9041.00
105_A109_Q1.8861.00
42_I81_P1.8631.00
6_C118_C1.8461.00
58_T85_I1.8061.00
116_I140_I1.7821.00
87_V103_A1.7471.00
35_S38_D1.6921.00
115_L176_A1.6851.00
65_K88_I1.6771.00
101_A137_I1.6661.00
68_T74_K1.6611.00
61_S67_L1.6561.00
121_G126_Y1.6421.00
19_N22_D1.6381.00
157_L174_L1.6321.00
58_T83_E1.6261.00
160_E169_T1.6091.00
180_V184_I1.6021.00
246_A250_E1.5991.00
59_A81_P1.5651.00
57_V81_P1.5491.00
110_K204_Q1.5391.00
4_I113_F1.5391.00
247_A250_E1.5351.00
151_S158_T1.5171.00
95_A103_A1.5161.00
87_V107_A1.5021.00
60_L107_A1.4691.00
241_G245_I1.4671.00
191_S194_A1.4651.00
234_R251_N1.4601.00
236_V244_Q1.4511.00
108_A116_I1.4381.00
48_L52_A1.4131.00
135_G142_A1.4091.00
88_I205_V1.4021.00
91_Q209_A1.3981.00
237_I240_D1.3841.00
64_G67_L1.3681.00
85_I107_A1.3241.00
68_T205_V1.3231.00
58_T113_F1.3181.00
155_D173_P1.3111.00
234_R247_A1.2961.00
2_K58_T1.2961.00
158_T169_T1.2901.00
86_V205_V1.2881.00
242_E245_I1.2881.00
45_A57_V1.2471.00
152_L157_L1.2301.00
147_S160_E1.2191.00
156_T173_P1.2171.00
59_A73_R1.2121.00
58_T111_A1.1980.99
140_I177_V1.1910.99
26_D29_K1.1870.99
153_T158_T1.1780.99
110_K211_I1.1610.99
206_W211_I1.1580.99
104_L134_V1.1520.99
151_S154_A1.1280.99
122_S125_L1.1280.99
245_I249_A1.1190.99
19_N23_G1.1170.99
88_I207_S1.1170.99
102_S106_A1.1150.99
40_N185_N1.1040.99
77_L201_K1.0950.99
83_E111_A1.0950.99
114_D155_D1.0900.99
143_V159_V1.0850.99
44_A184_I1.0830.99
44_A149_I1.0820.99
4_I60_L1.0800.99
85_I206_W1.0800.99
46_C194_A1.0790.99
61_S86_V1.0730.99
193_K197_G1.0720.99
160_E167_T1.0570.99
34_I76_V1.0530.99
102_S137_I1.0520.99
105_A138_L1.0470.99
149_I159_V1.0440.99
49_K55_A1.0430.99
42_I79_R1.0410.99
7_Y42_I1.0360.98
17_A26_D1.0280.98
108_A134_V1.0130.98
65_K68_T0.9970.98
99_Q217_A0.9960.98
52_A55_A0.9920.98
195_I201_K0.9910.98
132_L142_A0.9880.98
46_C79_R0.9830.98
208_A213_F0.9800.98
37_Y120_D0.9780.98
7_Y76_V0.9670.98
249_A252_L0.9640.98
43_E187_P0.9630.98
230_R233_Q0.9610.98
237_I243_E0.9560.97
91_Q208_A0.9560.97
141_P176_A0.9550.97
117_L178_V0.9440.97
43_E47_Q0.9420.97
44_A148_K0.9380.97
152_L174_L0.9360.97
247_A251_N0.9330.97
193_K196_L0.9330.97
40_N183_D0.9280.97
89_D95_A0.9260.97
51_Q151_S0.9250.97
163_L166_E0.9210.97
106_A211_I0.9160.97
98_Q102_S0.9110.97
6_C134_V0.9100.97
209_A212_G0.9050.96
62_V100_T0.9020.96
133_L137_I0.9010.96
7_Y70_A0.8990.96
128_Q132_L0.8950.96
208_A215_A0.8950.96
149_I157_L0.8950.96
105_A134_V0.8930.96
39_L79_R0.8930.96
79_R187_P0.8900.96
67_L86_V0.8860.96
117_L180_V0.8830.96
153_T156_T0.8820.96
9_C70_A0.8810.96
116_I134_V0.8800.96
4_I111_A0.8740.96
101_A133_L0.8670.95
103_A208_A0.8640.95
196_L199_A0.8570.95
226_A229_Q0.8560.95
118_C177_V0.8540.95
96_L218_A0.8520.95
106_A110_K0.8520.95
68_T86_V0.8510.95
46_C50_Q0.8510.95
108_A138_L0.8450.95
108_A113_F0.8450.95
189_I195_I0.8380.95
103_A211_I0.8320.94
5_T57_V0.8320.94
41_A180_V0.8280.94
13_E33_K0.8240.94
75_D79_R0.8210.94
122_S126_Y0.8170.94
39_L75_D0.8170.94
113_F140_I0.8150.94
214_N217_A0.8150.94
241_G244_Q0.8110.94
244_Q252_L0.8100.94
6_C104_L0.8080.93
7_Y59_A0.8070.93
120_D126_Y0.8050.93
95_A99_Q0.8040.93
91_Q215_A0.8040.93
132_L144_N0.7970.93
85_I111_A0.7930.93
162_E183_D0.7840.92
79_R190_P0.7830.92
120_D182_T0.7810.92
97_P133_L0.7770.92
85_I204_Q0.7730.92
27_F64_G0.7710.92
157_L178_V0.7680.92
11_P27_F0.7660.91
244_Q249_A0.7610.91
41_A117_L0.7590.91
243_E247_A0.7570.91
143_V170_L0.7560.91
221_E224_V0.7520.91
33_K123_S0.7500.91
84_L203_V0.7500.91
5_T45_A0.7500.91
89_D208_A0.7490.91
37_Y40_N0.7480.91
198_A201_K0.7470.90
136_E142_A0.7440.90
107_A206_W0.7440.90
64_G86_V0.7420.90
111_A206_W0.7420.90
206_W210_D0.7390.90
106_A212_G0.7390.90
197_G201_K0.7370.90
45_A117_L0.7350.90
44_A51_Q0.7310.89
108_A112_G0.7270.89
34_I39_L0.7270.89
40_N181_S0.7250.89
151_S155_D0.7240.89
24_S221_E0.7210.89
60_L104_L0.7150.88
142_A177_V0.7150.88
6_C108_A0.7130.88
34_I75_D0.7060.88
109_Q112_G0.7030.88
68_T203_V0.7030.88
22_D225_A0.7000.87
66_A69_N0.6960.87
100_T125_L0.6960.87
127_A219_W0.6950.87
47_Q188_Q0.6940.87
134_V177_V0.6860.86
115_L157_L0.6830.86
3_I57_V0.6780.86
62_V87_V0.6780.86
96_L99_Q0.6770.86
50_Q55_A0.6730.85
74_K199_A0.6710.85
96_L217_A0.6700.85
243_E246_A0.6640.84
42_I59_A0.6610.84
89_D94_Q0.6550.84
35_S123_S0.6510.83
107_A111_A0.6500.83
120_D181_S0.6490.83
73_R86_V0.6490.83
115_L178_V0.6490.83
9_C32_A0.6480.83
62_V95_A0.6460.83
32_A66_A0.6460.83
109_Q139_N0.6450.83
48_L115_L0.6410.82
38_D125_L0.6380.82
161_R170_L0.6380.82
87_V211_I0.6370.82
98_Q218_A0.6370.82
123_S126_Y0.6360.82
220_S223_Q0.6340.82
153_T171_S0.6330.82
149_I178_V0.6320.81
234_R237_I0.6300.81
97_P129_Q0.6280.81
61_S73_R0.6260.81
12_D33_K0.6250.81
108_A140_I0.6240.81
135_G177_V0.6230.81
143_V157_L0.6230.81
97_P125_L0.6180.80
78_S194_A0.6180.80
196_L200_K0.6170.80
122_S127_A0.6140.80
163_L168_E0.6070.79
98_Q137_I0.6070.79
60_L111_A0.6060.79
38_D127_A0.6060.79
120_D145_G0.6050.79
5_T41_A0.6050.79
43_E50_Q0.6050.79
213_F216_E0.6040.78
108_A177_V0.6030.78
11_P30_A0.6010.78
113_F116_I0.5960.78
95_A217_A0.5920.77
8_K61_S0.5910.77
145_G181_S0.5900.77
162_E181_S0.5880.77
148_K169_T0.5850.76
95_A100_T0.5840.76
103_A215_A0.5840.76
42_I180_V0.5830.76
37_Y126_Y0.5820.76
96_L219_W0.5820.76
19_N26_D0.5810.76
118_C131_G0.5800.76
117_L149_I0.5790.76
13_E36_Q0.5780.75
12_D31_D0.5760.75
244_Q251_N0.5740.75
47_Q50_Q0.5700.74
3_I6_C0.5690.74
146_V149_I0.5680.74
159_V176_A0.5680.74
42_I46_C0.5640.74
103_A107_A0.5610.73
99_Q214_N0.5590.73
109_Q138_L0.5590.73
22_D26_D0.5550.72
64_G94_Q0.5550.72
78_S198_A0.5530.72
15_D18_V0.5530.72
53_A152_L0.5510.72
42_I76_V0.5500.72
147_S162_E0.5480.72
27_F94_Q0.5470.71
152_L155_D0.5470.71
38_D70_A0.5460.71
141_P172_I0.5460.71
217_A221_E0.5450.71
15_D19_N0.5450.71
228_K231_E0.5450.71
40_N182_T0.5430.71
9_C63_G0.5420.71
3_I117_L0.5410.71
233_Q237_I0.5410.71
73_R203_V0.5400.70
48_L55_A0.5400.70
102_S213_F0.5390.70
26_D30_A0.5390.70
186_S195_I0.5380.70
129_Q133_L0.5360.70
240_D244_Q0.5350.70
74_K203_V0.5300.69
105_A137_I0.5300.69
62_V104_L0.5290.69
20_N26_D0.5290.69
62_V96_L0.5280.69
63_G76_V0.5260.68
192_M199_A0.5260.68
115_L174_L0.5240.68
9_C66_A0.5230.68
41_A119_G0.5230.68
79_R200_K0.5230.68
132_L179_A0.5220.68
34_I42_I0.5220.68
18_V226_A0.5210.68
98_Q131_G0.5200.68
2_K113_F0.5170.67
27_F62_V0.5170.67
76_V81_P0.5160.67
24_S27_F0.5160.67
97_P127_A0.5150.67
40_N162_E0.5150.67
151_S160_E0.5110.66
128_Q145_G0.5110.66
36_Q126_Y0.5080.66
48_L117_L0.5050.65
17_A30_A0.5050.65
61_S69_N0.5050.65
74_K202_P0.5040.65
121_G227_P0.5030.65
208_A212_G0.5020.65
36_Q120_D0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2iB 1 0.9805 100 0.181 Contact Map
1o97C 1 0.9336 100 0.184 Contact Map
1efpB 1 0.9492 100 0.206 Contact Map
1efvB 1 0.9648 100 0.229 Contact Map
3ih5A 6 0.7734 100 0.605 Contact Map
4l2iA 1 0.8945 100 0.616 Contact Map
1o97D 1 0.8281 100 0.623 Contact Map
1efvA 1 0.8242 99.9 0.659 Contact Map
1efpA 1 0.8047 99.9 0.667 Contact Map
3fetA 2 0.6367 99.9 0.685 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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