GREMLIN Database
GUAC - GMP reductase
UniProt: P60560 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10422
Length: 347 (313)
Sequences: 3745 (1506)
Seq/√Len: 85.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_R326_E4.8511.00
76_H80_S4.1471.00
229_A315_A3.8511.00
166_E170_L3.4461.00
136_E140_Q3.4281.00
208_A211_G3.4211.00
237_D328_T3.3881.00
114_K118_D3.2441.00
92_S100_M3.0891.00
166_E208_A2.8211.00
241_L245_L2.7671.00
159_V165_C2.7471.00
232_F312_L2.6751.00
326_E330_R2.6231.00
146_R154_I2.5821.00
117_L152_K2.5801.00
322_S326_E2.5591.00
163_E332_T2.5171.00
146_R174_D2.5031.00
114_K148_A2.3331.00
140_Q143_A2.3081.00
324_L328_T2.2801.00
113_T145_A2.2791.00
273_S292_T2.2751.00
164_M205_C2.2561.00
202_V218_S2.2281.00
52_A74_A2.2201.00
325_K328_T2.2201.00
228_V239_V2.1871.00
169_I209_A2.1841.00
113_T126_V2.1291.00
109_D141_F2.1071.00
165_C205_C2.0961.00
165_C169_I2.0801.00
126_V152_K2.0391.00
159_V164_M2.0001.00
249_E297_L1.9601.00
131_A318_Y1.9591.00
56_T59_T1.9531.00
167_E170_L1.9471.00
325_K329_K1.9461.00
209_A216_I1.9451.00
241_L244_M1.9421.00
229_A327_L1.9311.00
130_V138_F1.8981.00
162_G208_A1.8931.00
159_V205_C1.8431.00
103_T113_T1.7901.00
255_I262_K1.7861.00
53_N77_K1.7791.00
32_E37_F1.7781.00
142_V156_A1.7621.00
178_V216_I1.7561.00
210_H328_T1.7411.00
249_E300_P1.7341.00
139_V143_A1.6961.00
62_M66_L1.6951.00
203_I207_D1.6901.00
165_C216_I1.6831.00
244_M308_I1.6801.00
166_E211_G1.6801.00
160_V196_Y1.6741.00
128_I156_A1.6711.00
37_F42_Q1.6571.00
114_K149_W1.6421.00
206_A216_I1.6261.00
145_A154_I1.6121.00
165_C209_A1.5851.00
52_A55_D1.5711.00
50_I55_D1.5681.00
162_G207_D1.5671.00
125_F155_C1.5411.00
65_A68_S1.5351.00
54_M82_E1.5191.00
39_H42_Q1.5000.99
97_K101_V1.4950.99
104_G108_A1.4890.99
111_E114_K1.4860.99
234_G333_F1.4790.99
170_L212_L1.4580.99
144_K148_A1.4530.99
175_I238_F1.4420.99
59_T62_M1.4340.99
169_I214_G1.4250.99
110_F144_K1.4210.99
49_I55_D1.4180.99
209_A212_L1.4000.99
108_A111_E1.3860.99
250_E300_P1.3730.99
321_A331_T1.3650.99
175_I215_M1.3520.99
232_F328_T1.3510.99
232_F324_L1.3440.99
51_A55_D1.3420.99
315_A327_L1.3150.99
169_I212_L1.3100.99
156_A173_A1.3080.99
128_I142_V1.3080.99
123_L152_K1.3000.99
34_Q37_F1.2990.98
166_E212_L1.2990.98
199_L234_G1.2960.98
215_M237_D1.2950.98
228_V308_I1.2940.98
97_K100_M1.2900.98
245_L301_V1.2900.98
83_E87_F1.2880.98
50_I54_M1.2860.98
162_G166_E1.2730.98
139_V167_E1.2680.98
316_C324_L1.2610.98
94_D99_V1.2510.98
128_I145_A1.2360.98
48_P51_A1.2350.98
237_D325_K1.2280.98
208_A212_L1.2190.98
134_Y167_E1.2140.98
160_V180_I1.2080.98
153_T175_I1.1980.97
258_E294_K1.1850.97
48_P55_D1.1810.97
155_C217_V1.1790.97
248_H304_T1.1770.97
154_I173_A1.1710.97
57_V63_A1.1610.97
245_L305_A1.1610.97
98_H101_V1.1410.97
200_S204_E1.1340.96
162_G204_E1.1310.96
33_R62_M1.1240.96
321_A326_E1.1130.96
113_T149_W1.1060.96
57_V61_S1.0890.96
232_F327_L1.0800.95
286_R314_S1.0740.95
48_P54_M1.0710.95
128_I138_F1.0610.95
142_V154_I1.0600.95
165_C176_V1.0590.95
103_T109_D1.0550.95
241_L308_I1.0540.95
111_E115_Q1.0510.95
100_M125_F1.0290.94
143_A170_L1.0260.94
95_V100_M1.0220.94
114_K117_L1.0190.94
48_P52_A1.0110.93
169_I208_A1.0000.93
321_A330_R1.0000.93
245_L340_E0.9960.93
232_F331_T0.9930.93
233_G331_T0.9820.92
94_D98_H0.9750.92
118_D121_P0.9730.92
256_V294_K0.9720.92
109_D113_T0.9660.92
139_V171_S0.9640.92
228_V312_L0.9580.91
54_M77_K0.9520.91
176_V209_A0.9440.91
210_H237_D0.9400.91
146_R150_P0.9390.90
269_M274_A0.9360.90
34_Q44_W0.9340.90
204_E207_D0.9330.90
165_C208_A0.9280.90
205_C209_A0.9270.90
94_D97_K0.9250.90
195_G198_Q0.9240.90
284_E303_N0.9200.90
142_V173_A0.9180.89
51_A54_M0.9180.89
314_S317_T0.9180.89
110_F148_A0.9170.89
300_P303_N0.9100.89
115_Q118_D0.9090.89
199_L331_T0.9080.89
327_L331_T0.9020.89
103_T126_V0.9010.89
76_H82_E0.8970.88
175_I214_G0.8870.88
62_M301_V0.8860.88
207_D211_G0.8830.88
104_G107_D0.8750.87
61_S85_Q0.8750.87
210_H329_K0.8740.87
170_L211_G0.8710.87
49_I52_A0.8560.86
113_T117_L0.8550.86
108_A141_F0.8470.85
110_F114_K0.8460.85
141_F144_K0.8460.85
163_E167_E0.8440.85
75_V79_Y0.8430.85
248_H301_V0.8420.85
152_K174_D0.8420.85
321_A329_K0.8400.85
60_F72_L0.8380.85
83_E86_A0.8350.85
106_S109_D0.8310.84
241_L301_V0.8300.84
209_A237_D0.8260.84
200_S203_I0.8250.84
95_V99_V0.8240.84
258_E261_E0.8220.84
159_V176_V0.8200.83
107_D111_E0.8150.83
106_S284_E0.8090.83
206_A213_G0.8060.82
244_M304_T0.8060.82
182_P227_D0.8040.82
143_A147_E0.8040.82
60_F73_T0.8040.82
173_A176_V0.8010.82
174_D214_G0.7980.82
202_V216_I0.7970.82
315_A319_V0.7960.82
153_T238_F0.7930.81
142_V171_S0.7870.81
94_D100_M0.7870.81
337_Q340_E0.7860.81
146_R173_A0.7850.81
239_V245_L0.7820.80
25_S60_F0.7770.80
177_K182_P0.7680.79
79_Y82_E0.7680.79
103_T108_A0.7620.79
83_E223_T0.7620.79
130_V137_H0.7590.78
225_P308_I0.7580.78
229_A312_L0.7570.78
205_C208_A0.7550.78
182_P198_Q0.7550.78
29_V57_V0.7520.78
256_V265_L0.7500.78
32_E35_F0.7430.77
286_R306_R0.7400.77
107_D110_F0.7330.76
162_G165_C0.7300.76
267_Y273_S0.7290.76
226_G230_K0.7290.76
131_A192_T0.7240.75
41_G46_G0.7230.75
169_I215_M0.7210.75
105_T128_I0.7200.75
63_A66_L0.7180.74
228_V241_L0.7180.74
140_Q144_K0.7160.74
36_T42_Q0.7150.74
293_V297_L0.7140.74
164_M167_E0.7130.74
192_T340_E0.7100.74
153_T215_M0.7090.74
162_G206_A0.7070.73
257_E262_K0.7050.73
110_F113_T0.7050.73
301_V305_A0.7050.73
126_V130_V0.7040.73
169_I211_G0.7010.73
275_M285_Y0.6990.72
182_P189_R0.6980.72
77_K80_S0.6960.72
155_C175_I0.6960.72
205_C216_I0.6950.72
270_S317_T0.6940.72
103_T107_D0.6920.72
290_G293_V0.6870.71
113_T152_K0.6870.71
64_S72_L0.6850.71
182_P187_T0.6840.71
275_M278_H0.6830.71
52_A63_A0.6820.71
332_T335_R0.6810.71
95_V101_V0.6800.70
312_L316_C0.6790.70
316_C327_L0.6790.70
160_V205_C0.6780.70
145_A322_S0.6780.70
48_P53_N0.6770.70
32_E43_S0.6720.70
58_G73_T0.6710.69
125_F175_I0.6710.69
49_I54_M0.6650.69
51_A66_L0.6640.69
266_F271_S0.6640.69
229_A232_F0.6630.68
187_T225_P0.6600.68
105_T319_V0.6590.68
142_V164_M0.6590.68
34_Q42_Q0.6580.68
58_G61_S0.6570.68
106_S317_T0.6570.68
50_I72_L0.6570.68
146_R175_I0.6550.68
24_K27_S0.6540.67
114_K144_K0.6510.67
189_R195_G0.6500.67
222_C239_V0.6500.67
61_S68_S0.6500.67
206_A210_H0.6500.67
112_K115_Q0.6480.67
123_L126_V0.6430.66
130_V164_M0.6420.66
297_L300_P0.6410.66
128_I165_C0.6410.66
148_A151_T0.6400.66
101_V123_L0.6390.66
265_L294_K0.6380.66
322_S330_R0.6380.66
51_A73_T0.6360.65
137_H140_Q0.6350.65
255_I303_N0.6320.65
136_E167_E0.6310.65
94_D101_V0.6300.65
138_F317_T0.6290.64
189_R198_Q0.6280.64
214_G236_A0.6280.64
198_Q201_A0.6280.64
153_T324_L0.6260.64
31_L34_Q0.6230.64
259_N294_K0.6210.63
166_E169_I0.6210.63
192_T318_Y0.6200.63
139_V164_M0.6200.63
289_E297_L0.6190.63
25_S53_N0.6180.63
58_G63_A0.6180.63
275_M287_A0.6170.63
290_G299_G0.6140.63
269_M275_M0.6130.62
256_V263_F0.6130.62
24_K28_D0.6120.62
66_L73_T0.6080.62
54_M76_H0.6070.62
166_E209_A0.6040.61
190_V340_E0.6040.61
217_V240_M0.6040.61
138_F270_S0.6030.61
130_V270_S0.6030.61
307_D310_G0.6030.61
85_Q203_I0.6030.61
55_D74_A0.6030.61
53_N78_H0.6020.61
73_T79_Y0.6020.61
134_Y163_E0.6010.61
275_M317_T0.6010.61
183_G221_G0.6000.61
162_G205_C0.6000.61
223_T261_E0.5970.60
105_T137_H0.5970.60
45_S71_I0.5970.60
99_V124_N0.5960.60
185_V293_V0.5960.60
270_S278_H0.5940.60
62_M65_A0.5930.60
84_W88_I0.5930.60
295_L298_R0.5920.60
249_E255_I0.5920.60
50_I53_N0.5920.60
41_G210_H0.5890.59
147_E207_D0.5880.59
92_S95_V0.5850.59
103_T128_I0.5820.58
70_D98_H0.5820.58
165_C212_L0.5810.58
54_M57_V0.5810.58
53_N59_T0.5800.58
203_I335_R0.5780.58
309_L313_R0.5780.58
226_G310_G0.5730.57
167_E205_C0.5730.57
186_C271_S0.5720.57
37_F53_N0.5710.57
153_T174_D0.5700.57
36_T39_H0.5700.57
109_D112_K0.5690.57
187_T270_S0.5680.57
139_V156_A0.5660.56
273_S276_K0.5660.56
89_N93_A0.5650.56
277_R280_G0.5620.56
175_I178_V0.5610.56
126_V192_T0.5600.56
177_K189_R0.5600.56
136_E139_V0.5590.55
40_S282_V0.5570.55
199_L202_V0.5560.55
146_R153_T0.5550.55
280_G285_Y0.5540.55
312_L315_A0.5540.55
215_M238_F0.5540.55
276_K304_T0.5510.54
159_V216_I0.5490.54
186_C221_G0.5480.54
84_W93_A0.5470.54
182_P195_G0.5460.54
76_H81_V0.5450.54
303_N306_R0.5430.53
68_S261_E0.5420.53
334_I338_E0.5400.53
53_N82_E0.5400.53
195_G221_G0.5390.53
249_E262_K0.5390.53
237_D300_P0.5370.53
92_S96_L0.5360.52
33_R323_R0.5360.52
197_P310_G0.5350.52
319_V333_F0.5350.52
181_G195_G0.5340.52
182_P201_A0.5340.52
144_K147_E0.5340.52
86_A89_N0.5330.52
96_L259_N0.5320.52
132_N318_Y0.5320.52
54_M80_S0.5320.52
214_G237_D0.5320.52
287_A293_V0.5320.52
34_Q45_S0.5290.51
58_G62_M0.5280.51
89_N124_N0.5280.51
105_T142_V0.5280.51
196_Y200_S0.5270.51
206_A283_A0.5270.51
29_V43_S0.5250.51
207_D332_T0.5240.51
289_E293_V0.5240.51
265_L306_R0.5230.51
130_V318_Y0.5230.51
204_E212_L0.5210.50
45_S70_D0.5210.50
60_F63_A0.5200.50
100_M153_T0.5190.50
24_K34_Q0.5190.50
105_T164_M0.5180.50
188_T221_G0.5180.50
259_N340_E0.5170.50
25_S48_P0.5170.50
33_R48_P0.5170.50
229_A308_I0.5160.50
57_V76_H0.5160.50
309_L316_C0.5160.50
117_L123_L0.5160.50
163_E166_E0.5150.50
140_Q236_A0.5150.50
28_D44_W0.5150.50
226_G311_G0.5150.50
127_C131_A0.5150.50
313_R334_I0.5140.49
51_A75_V0.5130.49
143_A171_S0.5120.49
321_A327_L0.5120.49
314_S318_Y0.5120.49
117_L176_V0.5110.49
75_V98_H0.5100.49
202_V206_A0.5100.49
210_H213_G0.5090.49
164_M318_Y0.5080.49
259_N265_L0.5080.49
207_D329_K0.5070.49
32_E65_A0.5060.48
287_A314_S0.5050.48
308_I311_G0.5040.48
127_C238_F0.5040.48
237_D305_A0.5030.48
160_V194_V0.5020.48
107_D148_A0.5010.48
103_T130_V0.5010.48
128_I141_F0.5010.48
67_A70_D0.5000.48
30_E70_D0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.8818 100 0.499 Contact Map
2cu0A 4 0.951 100 0.507 Contact Map
4af0A 3 0.9568 100 0.52 Contact Map
1vrdA 3 0.879 100 0.537 Contact Map
1jcnA 6 0.8357 100 0.544 Contact Map
4zqmA 3 0.9308 100 0.548 Contact Map
2c6qA 4 0.9424 100 0.555 Contact Map
1zfjA 4 0.9568 100 0.561 Contact Map
1eepA 4 0.879 100 0.581 Contact Map
1me8A 3 0.9424 100 0.584 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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