GREMLIN Database
KGUA - Guanylate kinase
UniProt: P60546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10965
Length: 207 (181)
Sequences: 4954 (3159)
Seq/√Len: 234.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_E133_R3.5211.00
132_D136_R3.2911.00
64_E68_R2.6901.00
27_T180_K2.6711.00
59_H63_K2.5021.00
39_H57_V2.3421.00
136_R143_E2.3391.00
49_V52_E2.2871.00
87_E91_Q2.2861.00
65_M70_A2.2841.00
61_E64_E2.2831.00
63_K81_Y2.2681.00
39_H85_S2.1741.00
76_E79_G2.0671.00
58_N61_E2.0051.00
174_T178_D1.9991.00
59_H81_Y1.9151.00
34_Q97_V1.9061.00
20_L123_I1.9021.00
23_A26_K1.8591.00
78_F152_Q1.8481.00
66_I74_H1.8461.00
143_E147_A1.8421.00
167_I175_A1.8341.00
86_R90_E1.8241.00
20_L179_L1.8161.00
59_H76_E1.8021.00
70_A87_E1.7951.00
77_V104_D1.7211.00
75_A106_Q1.7201.00
23_A176_L1.6991.00
90_E94_A1.6971.00
10_S163_Y1.6921.00
59_H80_N1.6851.00
88_A91_Q1.6601.00
171_D174_T1.6581.00
49_V53_H1.6031.00
132_D147_A1.6021.00
28_Q180_K1.5731.00
109_Q162_E1.5611.00
142_S145_V1.5461.00
50_H55_F1.5411.00
91_Q95_T1.5381.00
19_S172_F1.5371.00
63_K67_S1.5281.00
112_R164_D1.4841.00
11_A15_A1.4821.00
55_F88_A1.4641.00
63_K66_I1.4471.00
57_V65_M1.4361.00
23_A27_T1.4221.00
34_Q92_V1.4091.00
18_S102_D1.3901.00
20_L176_L1.3841.00
165_Y182_I1.3211.00
85_S88_A1.3211.00
127_S130_E1.3141.00
39_H65_M1.3071.00
76_E81_Y1.3011.00
147_A151_A1.2961.00
167_I179_L1.2941.00
88_A92_V1.2901.00
124_L166_L1.2801.00
23_A173_D1.2721.00
35_V102_D1.2701.00
9_V21_I1.2521.00
66_I81_Y1.2301.00
22_Q53_H1.2181.00
159_H162_E1.2011.00
92_V97_V1.1961.00
57_V61_E1.1851.00
177_T180_K1.1801.00
170_D174_T1.1711.00
178_D184_R1.1611.00
21_I100_F1.1561.00
103_I111_I1.1441.00
7_Y119_R1.1371.00
133_R137_G1.1361.00
180_K184_R1.1331.00
172_F176_L1.1231.00
61_E65_M1.1181.00
112_R120_S1.1051.00
86_R114_K1.0951.00
64_E67_S1.0921.00
92_V99_V1.0901.00
22_Q26_K1.0801.00
124_L157_M1.0651.00
92_V95_T1.0641.00
155_A158_S1.0631.00
105_W159_H1.0611.00
21_I102_D1.0601.00
101_L111_I1.0551.00
27_T176_L1.0491.00
181_T184_R1.0471.00
167_I182_I1.0411.00
151_A154_V1.0411.00
72_L89_I1.0311.00
50_H61_E1.0241.00
148_K152_Q1.0101.00
60_D63_K1.0051.00
11_A18_S0.9921.00
5_T119_R0.9871.00
109_Q159_H0.9831.00
39_H71_F0.9831.00
181_T185_A0.9801.00
141_D146_I0.9791.00
8_I120_S0.9781.00
108_A120_S0.9771.00
69_D114_K0.9761.00
79_G148_K0.9681.00
165_Y178_D0.9671.00
152_Q155_A0.9651.00
160_Y166_L0.9601.00
177_T181_T0.9571.00
74_H81_Y0.9541.00
65_M71_F0.9401.00
9_V179_L0.9361.00
110_Q113_Q0.9321.00
78_F104_D0.9311.00
7_Y183_I0.9051.00
128_K154_V0.8980.99
44_P47_G0.8800.99
27_T177_T0.8760.99
165_Y186_E0.8620.99
65_M85_S0.8490.99
18_S53_H0.8440.99
39_H88_A0.8430.99
48_E53_H0.8400.99
132_D150_M0.8380.99
90_E115_M0.8330.99
57_V62_F0.8320.99
18_S21_I0.8170.99
119_R165_Y0.8000.99
109_Q113_Q0.7940.99
25_L35_V0.7890.99
20_L172_F0.7830.99
44_P50_H0.7760.99
170_D175_A0.7760.99
75_A110_Q0.7720.98
7_Y98_D0.7660.98
50_H56_F0.7660.98
69_D86_R0.7650.98
24_L33_T0.7500.98
65_M68_R0.7480.98
145_V148_K0.7470.98
62_F74_H0.7470.98
28_Q184_R0.7460.98
77_V106_Q0.7420.98
72_L115_M0.7370.98
121_I179_L0.7350.98
15_A18_S0.7340.98
103_I110_Q0.7320.98
169_N175_A0.7310.98
63_K76_E0.7300.98
91_Q94_A0.7290.98
35_V38_S0.7240.98
21_I35_V0.7230.98
15_A123_I0.7130.97
5_T186_E0.7120.97
119_R186_E0.7100.97
129_I132_D0.7100.97
57_V85_S0.7080.97
6_L115_M0.7060.97
77_V152_Q0.7060.97
12_P15_A0.7030.97
21_I25_L0.7020.97
178_D181_T0.6950.97
12_P157_M0.6920.97
124_L160_Y0.6910.97
175_A178_D0.6860.97
50_H57_V0.6840.97
23_A172_F0.6810.97
105_W152_Q0.6780.97
25_L100_F0.6770.97
6_L93_L0.6750.96
176_L180_K0.6730.96
109_Q120_S0.6720.96
128_K132_D0.6710.96
24_L176_L0.6680.96
42_R56_F0.6670.96
177_T184_R0.6580.96
13_S146_I0.6570.96
173_D177_T0.6570.96
78_F148_K0.6560.96
24_L179_L0.6490.96
119_R182_I0.6430.95
70_A86_R0.6430.95
87_E90_E0.6430.95
137_G140_Q0.6380.95
157_M160_Y0.6370.95
134_R138_R0.6360.95
153_A156_E0.6360.95
10_S108_A0.6350.95
136_R146_I0.6340.95
141_D145_V0.6340.95
34_Q88_A0.6330.95
38_S102_D0.6320.95
68_R71_F0.6310.95
42_R48_E0.6310.95
45_R138_R0.6240.95
46_P140_Q0.6190.94
174_T177_T0.6160.94
154_V158_S0.6150.94
28_Q33_T0.6140.94
62_F81_Y0.6090.94
37_V55_F0.6090.94
105_W109_Q0.6070.94
103_I107_G0.6060.94
20_L175_A0.6010.93
4_G98_D0.6000.93
36_S102_D0.5990.93
7_Y121_I0.5980.93
12_P153_A0.5980.93
37_V51_G0.5970.93
8_I118_A0.5970.93
60_D64_E0.5960.93
155_A159_H0.5960.93
7_Y33_T0.5940.93
33_T98_D0.5940.93
154_V157_M0.5910.93
172_F175_A0.5900.93
158_S161_A0.5830.92
72_L86_R0.5800.92
51_G56_F0.5780.92
34_Q99_V0.5770.92
105_W156_E0.5750.92
39_H55_F0.5750.92
43_Q80_N0.5740.92
45_R149_R0.5710.92
13_S131_L0.5700.92
144_E147_A0.5680.91
13_S149_R0.5670.91
106_Q110_Q0.5670.91
23_A171_D0.5620.91
33_T100_F0.5620.91
19_S23_A0.5610.91
72_L111_I0.5590.91
11_A160_Y0.5590.91
110_Q114_K0.5560.90
18_S35_V0.5550.90
43_Q58_N0.5520.90
104_D152_Q0.5520.90
5_T98_D0.5480.90
78_F105_W0.5440.90
24_L180_K0.5410.89
4_G99_V0.5410.89
10_S120_S0.5400.89
66_I71_F0.5390.89
38_S107_G0.5390.89
128_K150_M0.5350.89
16_G169_N0.5340.89
113_Q162_E0.5320.88
176_L179_L0.5270.88
104_D107_G0.5260.88
103_I156_E0.5220.88
106_Q109_Q0.5220.88
76_E80_N0.5190.87
15_A125_P0.5190.87
112_R162_E0.5180.87
71_F85_S0.5170.87
126_P169_N0.5170.87
34_Q95_T0.5170.87
89_I100_F0.5170.87
150_M158_S0.5160.87
42_R45_R0.5150.87
36_S101_L0.5130.87
93_L99_V0.5130.87
16_G19_S0.5120.87
108_A118_A0.5100.86
41_T59_H0.5030.86
138_R141_D0.5010.85
132_D154_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xkxA 2 0.9275 100 0.207 Contact Map
1kjwA 1 0.9275 100 0.215 Contact Map
3tvtA 1 0.9082 100 0.239 Contact Map
1s96A 4 0.9903 100 0.358 Contact Map
4deyA 1 0.7633 100 0.406 Contact Map
3tszA 1 0.7585 100 0.43 Contact Map
1lvgA 1 0.9034 100 0.467 Contact Map
3shwA 1 0.7101 100 0.469 Contact Map
1z6gA 1 0.9034 100 0.484 Contact Map
3kfvA 1 0.7101 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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