GREMLIN Database
RL2 - 50S ribosomal protein L2
UniProt: P60422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10865
Length: 273 (272)
Sequences: 2486 (1005)
Seq/√Len: 60.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_A94_V3.6391.00
150_K153_Q3.5421.00
79_E95_L3.1901.00
72_D189_R3.1881.00
26_K80_R3.0251.00
164_I172_V3.0101.00
53_H219_T2.9161.00
172_V186_A2.8871.00
223_T240_F2.8631.00
143_N152_G2.8011.00
139_S192_L2.7401.00
155_A162_V2.6431.00
141_V164_I2.6331.00
141_V174_L2.5881.00
58_H213_W2.5201.00
144_V162_V2.5161.00
216_V219_T2.4971.00
133_R187_D2.3791.00
94_V116_I2.3741.00
174_L184_V2.3291.00
108_K198_A2.3111.00
71_K98_D2.2701.00
37_N60_Q2.2681.00
110_L116_I2.1461.00
105_L152_G2.1311.00
70_N102_R2.1281.00
88_S200_H2.0961.00
251_Q255_K2.0881.00
44_N50_T2.0701.00
173_T181_M2.0511.00
240_F253_K2.0321.00
194_E198_A2.0271.00
111_K114_D2.0121.00
129_T189_R2.0061.00
205_L211_A1.8851.00
71_K100_E1.8591.00
54_I216_V1.8381.00
170_A185_E1.8381.00
246_T250_V1.8271.00
9_T13_R1.8191.00
135_I192_L1.8071.00
223_T239_N1.7750.99
260_N263_T1.7530.99
27_G80_R1.7210.99
131_P134_N1.7010.99
242_K245_V1.6940.99
107_P110_L1.6890.99
51_T219_T1.6750.99
19_V90_N1.6610.99
6_C18_K1.6500.99
95_L101_R1.6500.99
19_V203_R1.6350.99
211_A214_R1.6320.99
114_D125_K1.6320.99
78_V110_L1.6200.99
77_V95_L1.6180.99
92_A106_A1.6110.99
77_V115_Q1.6080.99
40_S54_I1.6020.99
35_E64_I1.5950.99
13_R16_V1.5950.99
144_V174_L1.5730.99
72_D118_S1.5480.99
205_L214_R1.5370.98
73_G121_D1.5360.98
78_V94_V1.5250.98
166_A173_T1.5110.98
108_K194_E1.4980.98
30_F101_R1.4850.98
75_P115_Q1.4700.98
89_A195_V1.4670.98
239_N242_K1.4370.98
119_G122_A1.4340.98
90_N196_G1.4320.98
154_L184_V1.4290.98
122_A130_L1.4250.97
167_R186_A1.4190.97
72_D119_G1.4130.97
252_T255_K1.4060.97
73_G119_G1.4050.97
240_F243_H1.3840.97
146_M184_V1.3760.97
145_E151_G1.3700.97
79_E101_R1.3600.97
34_L61_A1.3430.96
2_A20_V1.3320.96
171_Y185_E1.3190.96
133_R186_A1.3190.96
105_L143_N1.3010.96
24_L27_G1.2980.96
250_V255_K1.2970.96
173_T183_K1.2920.95
232_H240_F1.2780.95
148_P185_E1.2650.95
75_P97_K1.2560.95
232_H245_V1.2540.95
243_H253_K1.2390.94
21_N90_N1.2230.94
236_E240_F1.2100.94
147_K150_K1.1990.93
130_L135_I1.1910.93
65_V91_I1.1900.93
108_K196_G1.1880.93
10_S13_R1.1870.93
154_L176_L1.1780.93
259_S264_D1.1710.92
53_H216_V1.1570.92
140_T161_Y1.1520.92
25_H80_R1.1460.92
15_H204_V1.1420.91
3_V17_V1.1340.91
220_V224_A1.1330.91
54_I219_T1.1280.91
107_P142_H1.1260.91
74_I97_K1.1220.91
52_R225_M1.1090.90
246_T253_K1.1080.90
146_M154_L1.1060.90
60_Q86_N1.0950.90
21_N203_R1.0800.89
6_C16_V1.0690.88
4_V18_K1.0690.88
226_N229_D1.0680.88
173_T268_V1.0550.88
105_L195_V1.0530.88
28_K61_A1.0430.87
12_G16_V1.0430.87
235_G240_F1.0420.87
223_T242_K1.0410.87
53_H220_V1.0350.87
41_G54_I1.0220.86
38_S41_G1.0130.86
121_D130_L1.0120.86
219_T232_H1.0050.85
170_A186_A1.0040.85
129_T191_T0.9990.85
210_A214_R0.9950.85
250_V253_K0.9940.85
211_A216_V0.9930.84
246_T251_Q0.9830.84
25_H81_L0.9790.84
92_A110_L0.9720.83
242_K253_K0.9660.83
24_L28_K0.9650.83
242_K252_T0.9640.83
9_T12_G0.9620.83
223_T243_H0.9400.81
80_R112_A0.9400.81
232_H252_T0.9390.81
74_I100_E0.9330.81
77_V97_K0.9260.80
121_D134_N0.9250.80
185_E266_F0.9210.80
25_H112_A0.9140.79
6_C13_R0.9110.79
51_T54_I0.9080.79
264_D270_R0.9070.79
232_H246_T0.9070.79
167_R172_V0.8990.78
6_C10_S0.8960.78
10_S16_V0.8950.78
263_T266_F0.8930.78
71_K96_Y0.8820.77
260_N266_F0.8760.76
53_H217_R0.8710.76
80_R92_A0.8670.75
262_R265_K0.8660.75
144_V155_A0.8650.75
24_L90_N0.8620.75
240_F245_V0.8620.75
135_I190_A0.8590.75
237_G240_F0.8560.75
36_K61_A0.8520.74
18_K21_N0.8490.74
4_V16_V0.8480.74
199_E202_L0.8470.74
75_P117_Q0.8340.73
13_R17_V0.8280.72
88_S106_A0.8270.72
171_Y266_F0.8260.72
142_H191_T0.8240.72
228_V243_H0.8220.72
20_V23_E0.8190.71
6_C15_H0.8180.71
76_A102_R0.8180.71
19_V23_E0.8150.71
104_I142_H0.8080.70
227_P236_E0.7990.69
163_Q175_R0.7980.69
135_I164_I0.7950.69
12_G15_H0.7940.69
49_I220_V0.7940.69
93_L103_Y0.7830.68
225_M229_D0.7820.68
164_I186_A0.7790.67
117_Q123_A0.7740.67
33_L93_L0.7720.67
132_M174_L0.7670.66
23_E90_N0.7660.66
70_N100_E0.7660.66
120_V130_L0.7610.66
259_S262_R0.7600.65
84_D87_R0.7540.65
110_L126_P0.7520.65
82_E103_Y0.7480.64
65_V80_R0.7470.64
18_K203_R0.7460.64
17_V203_R0.7440.64
205_L210_A0.7410.64
76_A96_Y0.7380.63
239_N245_V0.7370.63
228_V240_F0.7350.63
228_V253_K0.7350.63
3_V19_V0.7330.63
221_R224_A0.7320.63
246_T252_T0.7310.62
224_A245_V0.7300.62
2_A22_P0.7260.62
118_S189_R0.7240.62
73_G117_Q0.7230.62
5_K17_V0.7220.62
222_G232_H0.7220.62
76_A116_I0.7210.61
223_T253_K0.7210.61
4_V13_R0.7190.61
21_N25_H0.7190.61
124_I130_L0.7160.61
227_P245_V0.7160.61
262_R266_F0.7150.61
155_A174_L0.7120.60
223_T245_V0.7100.60
161_Y194_E0.7090.60
267_I270_R0.7080.60
232_H253_K0.7080.60
240_F246_T0.7080.60
120_V134_N0.7080.60
17_V204_V0.7060.60
79_E94_V0.7050.60
235_G238_R0.7020.59
232_H242_K0.7010.59
104_I107_P0.7000.59
71_K102_R0.6990.59
137_V166_A0.6990.59
256_K270_R0.6980.59
99_G151_G0.6950.59
57_G60_Q0.6950.59
260_N264_D0.6920.58
6_C17_V0.6890.58
110_L142_H0.6870.58
81_L91_I0.6820.57
37_N62_Y0.6810.57
242_K251_Q0.6810.57
9_T16_V0.6800.57
97_K115_Q0.6770.57
256_K272_S0.6770.57
155_A160_T0.6750.56
75_P268_V0.6740.56
118_S129_T0.6730.56
5_K9_T0.6720.56
119_G130_L0.6710.56
53_H225_M0.6710.56
94_V102_R0.6710.56
164_I167_R0.6680.56
62_Y86_N0.6680.56
53_H247_P0.6680.56
69_R142_H0.6680.56
44_N48_R0.6670.55
49_I53_H0.6630.55
223_T237_G0.6600.55
69_R104_I0.6560.54
21_N58_H0.6540.54
142_H195_V0.6530.54
123_A201_M0.6460.53
8_P14_R0.6460.53
240_F252_T0.6460.53
94_V110_L0.6400.52
39_K54_I0.6390.52
152_G191_T0.6390.52
145_E149_G0.6380.52
132_M141_V0.6370.52
141_V144_V0.6360.52
3_V49_I0.6360.52
5_K12_G0.6360.52
16_V196_G0.6290.51
63_R85_P0.6280.51
36_K60_Q0.6210.50
137_V167_R0.6200.50
54_I57_G0.6200.50
77_V113_G0.6100.49
19_V24_L0.6090.49
5_K15_H0.6090.49
24_L81_L0.6060.49
40_S51_T0.6050.48
7_K125_K0.6040.48
119_G189_R0.6030.48
49_I219_T0.6030.48
232_H244_P0.6020.48
21_N24_L0.6010.48
94_V196_G0.6000.48
123_A189_R0.6000.48
131_P187_D0.5990.48
155_A177_R0.5990.48
58_H214_R0.5980.48
80_R91_I0.5970.48
115_Q214_R0.5940.47
17_V269_R0.5930.47
183_K268_V0.5930.47
269_R272_S0.5920.47
213_W216_V0.5900.47
124_I192_L0.5900.47
80_R93_L0.5890.47
69_R129_T0.5880.47
223_T235_G0.5870.46
50_T148_P0.5860.46
120_V133_R0.5830.46
141_V162_V0.5820.46
81_L90_N0.5780.45
59_K157_S0.5760.45
122_A134_N0.5740.45
203_R210_A0.5740.45
13_R18_K0.5740.45
53_H248_W0.5730.45
37_N40_S0.5720.45
137_V256_K0.5720.45
25_H28_K0.5720.45
19_V196_G0.5710.45
162_V176_L0.5710.45
133_R172_V0.5680.44
81_L92_A0.5670.44
11_P165_V0.5670.44
109_G179_G0.5660.44
29_P34_L0.5660.44
16_V204_V0.5650.44
240_F250_V0.5650.44
243_H265_K0.5640.44
15_H239_N0.5620.44
71_K74_I0.5600.43
85_P156_R0.5590.43
88_S203_R0.5590.43
120_V131_P0.5590.43
80_R101_R0.5580.43
55_G60_Q0.5580.43
172_V184_V0.5580.43
96_Y99_G0.5570.43
227_P241_G0.5570.43
51_T220_V0.5560.43
166_A177_R0.5560.43
27_G112_A0.5540.43
115_Q265_K0.5520.43
62_Y157_S0.5510.42
24_L80_R0.5500.42
82_E91_I0.5490.42
245_V251_Q0.5480.42
4_V31_A0.5480.42
10_S22_P0.5460.42
63_R66_D0.5460.42
93_L101_R0.5440.42
161_Y198_A0.5440.42
35_E62_Y0.5430.42
243_H252_T0.5420.41
74_I117_Q0.5420.41
10_S14_R0.5410.41
25_H177_R0.5390.41
74_I259_S0.5380.41
88_S157_S0.5380.41
21_N28_K0.5360.41
54_I60_Q0.5350.41
81_L101_R0.5330.40
19_V22_P0.5320.40
15_H242_K0.5300.40
58_H211_A0.5280.40
80_R196_G0.5270.40
140_T163_Q0.5260.40
108_K269_R0.5250.40
69_R118_S0.5240.39
174_L266_F0.5230.39
259_S265_K0.5230.39
71_K99_G0.5220.39
108_K202_L0.5210.39
5_K16_V0.5210.39
129_T142_H0.5200.39
198_A201_M0.5190.39
167_R175_R0.5190.39
223_T232_H0.5190.39
41_G51_T0.5180.39
16_V203_R0.5170.39
6_C9_T0.5150.39
155_A161_Y0.5150.39
256_K271_R0.5140.38
88_S196_G0.5140.38
11_P15_H0.5130.38
204_V238_R0.5120.38
173_T186_A0.5120.38
97_K117_Q0.5120.38
20_V90_N0.5110.38
147_K260_N0.5090.38
32_P101_R0.5080.38
219_T248_W0.5080.38
165_V269_R0.5060.38
105_L142_H0.5050.37
95_L99_G0.5050.37
73_G120_V0.5030.37
253_K257_T0.5020.37
157_S160_T0.5020.37
19_V27_G0.5020.37
263_T272_S0.5010.37
42_G55_G0.5000.37
96_Y100_E0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb6D 1 0.9963 100 -0.002 Contact Map
4tp9C 1 0.0073 100 -0 Contact Map
3j3wC 1 1 100 0.012 Contact Map
1vw3B 1 0.9963 100 0.014 Contact Map
3bboE 1 0.9597 100 0.029 Contact Map
3j7yD 1 0.8095 100 0.226 Contact Map
1vq8A 1 0.8205 100 0.244 Contact Map
3j61A 1 0.8645 100 0.252 Contact Map
3j21B 1 0.8315 100 0.252 Contact Map
1vx7D 1 0.8498 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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