GREMLIN Database
RSMH - Ribosomal RNA small subunit methyltransferase H
UniProt: P60390 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11085
Length: 313 (300)
Sequences: 4112 (2726)
Seq/√Len: 157.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_S217_E4.4111.00
152_L204_T4.3151.00
30_G100_L3.2871.00
38_S51_L2.9691.00
40_L43_S2.8261.00
18_G307_I2.8191.00
50_R73_S2.7601.00
96_D231_A2.6821.00
280_Q309_E2.6681.00
100_L222_A2.6601.00
175_Q182_E2.6421.00
77_G81_A2.5841.00
150_W154_T2.4021.00
139_W143_A2.3421.00
54_I77_G2.3261.00
139_W211_W2.2811.00
177_M186_V2.2581.00
143_A211_W2.2281.00
83_G225_S2.1891.00
28_I95_I2.1861.00
34_R107_P2.1781.00
171_R182_E2.1531.00
235_R309_E2.1511.00
58_P130_P2.1191.00
80_S218_E2.1131.00
145_E166_R2.0951.00
121_D181_K2.0511.00
279_R308_A2.0461.00
78_P218_E2.0341.00
12_L40_L2.0301.00
61_I74_I2.0231.00
56_R218_E2.0041.00
77_G85_Y1.9721.00
54_I85_Y1.9631.00
94_K231_A1.9311.00
167_A190_A1.8981.00
144_E147_D1.8891.00
147_D150_W1.8711.00
14_E290_G1.8611.00
104_V109_L1.8461.00
56_R78_P1.8021.00
149_A162_K1.7631.00
87_A229_V1.7631.00
83_G228_N1.7481.00
8_T296_E1.7401.00
227_L279_R1.7341.00
292_E296_E1.7071.00
145_E149_A1.6581.00
22_R96_D1.6531.00
153_K161_A1.6461.00
129_D132_R1.6271.00
138_E142_T1.6101.00
95_I98_I1.5661.00
145_E162_K1.5581.00
58_P76_H1.5501.00
80_S221_Q1.5301.00
45_L49_G1.5141.00
106_S299_R1.5121.00
118_F202_T1.5031.00
139_W208_V1.4931.00
167_A170_E1.4681.00
106_S110_D1.4611.00
157_E244_L1.4561.00
148_I152_L1.4521.00
40_L44_Q1.4461.00
220_E248_I1.4401.00
18_G237_S1.4371.00
102_L219_I1.4311.00
186_V190_A1.4291.00
76_H131_T1.4271.00
171_R174_E1.4161.00
137_A178_T1.4161.00
237_S305_L1.4131.00
135_S138_E1.4071.00
253_M308_A1.4011.00
286_K304_V1.3741.00
11_L287_L1.3671.00
145_E169_V1.3651.00
13_D17_N1.3531.00
153_K162_K1.3491.00
110_D299_R1.3391.00
82_L229_V1.3381.00
86_V92_I1.3361.00
28_I86_V1.3291.00
227_L256_N1.3281.00
187_V204_T1.3271.00
219_I249_V1.3261.00
52_L92_I1.3201.00
257_S281_L1.3121.00
226_S236_L1.2971.00
233_G309_E1.2931.00
170_E173_R1.2861.00
253_M281_L1.2771.00
134_Q142_T1.2731.00
58_P62_A1.2731.00
149_A153_K1.2681.00
256_N278_G1.2431.00
237_S307_I1.2381.00
154_T220_E1.2321.00
75_I89_R1.2311.00
16_V40_L1.2251.00
75_I85_Y1.2131.00
143_A148_I1.2071.00
230_L236_L1.2071.00
291_E295_A1.2031.00
217_E220_E1.1971.00
17_N44_Q1.1931.00
185_E188_A1.1901.00
262_V269_T1.1831.00
53_A72_F1.1821.00
76_H129_D1.1811.00
39_R43_S1.1811.00
262_V271_E1.1801.00
288_M304_V1.1781.00
59_Q111_D1.1731.00
73_S89_R1.1681.00
282_R307_I1.1661.00
24_D48_E1.1621.00
121_D179_R1.1561.00
26_I52_L1.1551.00
150_W153_K1.1531.00
27_Y97_G1.1491.00
85_Y88_E1.1481.00
15_A237_S1.1421.00
15_A99_L1.1301.00
81_A84_E1.1271.00
59_Q107_P1.1141.00
289_P303_S1.1101.00
252_F256_N1.0940.99
157_E247_R1.0930.99
178_T182_E1.0880.99
134_Q143_A1.0870.99
216_L248_I1.0870.99
166_R170_E1.0810.99
112_A120_R1.0730.99
85_Y89_R1.0710.99
39_R69_D1.0670.99
137_A176_P1.0670.99
42_L72_F1.0630.99
27_Y41_I1.0620.99
260_P269_T1.0570.99
32_F53_A1.0570.99
171_R189_A1.0560.99
260_P271_E1.0550.99
25_G97_G1.0540.99
256_N279_R1.0520.99
232_P311_T1.0510.99
175_Q178_T1.0410.99
163_R190_A1.0380.99
9_T15_A1.0360.99
11_L239_I1.0360.99
188_A199_H1.0350.99
123_P137_A1.0330.99
98_I226_S1.0320.99
62_A65_K1.0310.99
160_F191_T1.0300.99
184_A187_V1.0280.99
185_E189_A1.0280.99
171_R186_V1.0200.99
58_P131_T1.0130.99
140_L177_M1.0080.99
171_R177_M1.0040.99
228_N278_G0.9950.99
149_A165_A0.9940.99
41_I49_G0.9920.99
184_A201_A0.9880.99
172_N175_Q0.9850.99
52_L89_R0.9820.99
62_A66_T0.9810.99
155_Y210_I0.9740.99
34_R63_V0.9740.99
181_K185_E0.9720.99
169_V172_N0.9690.99
9_T16_V0.9660.99
52_L75_I0.9530.99
236_L253_M0.9530.99
269_T272_Q0.9400.98
27_Y49_G0.9330.98
61_I76_H0.9300.98
38_S53_A0.9280.98
164_I204_T0.9280.98
214_S218_E0.9270.98
37_H239_I0.9270.98
42_L71_R0.9230.98
21_I45_L0.9220.98
145_E165_A0.9180.98
139_W151_V0.9150.98
198_K202_T0.9140.98
136_A208_V0.9120.98
288_M294_V0.9090.98
37_H99_L0.9080.98
26_I92_I0.9080.98
51_L72_F0.9030.98
102_L238_I0.9030.98
264_A267_P0.9010.98
24_D45_L0.8980.98
63_V107_P0.8930.98
28_I54_I0.8930.98
80_S214_S0.8870.98
26_I95_I0.8850.98
160_F192_P0.8750.97
224_K252_F0.8740.97
38_S72_F0.8730.97
163_R192_P0.8710.97
294_V300_A0.8710.97
38_S41_I0.8710.97
265_G268_M0.8700.97
149_A161_A0.8640.97
262_V270_E0.8560.97
167_A189_A0.8540.97
167_A171_R0.8530.97
21_I41_I0.8530.97
8_T300_A0.8520.97
107_P111_D0.8510.97
13_D40_L0.8480.97
98_I229_V0.8440.97
134_Q139_W0.8380.97
177_M182_E0.8370.97
59_Q62_A0.8360.97
141_Q177_M0.8350.97
246_D306_R0.8320.97
251_R254_R0.8300.97
83_G229_V0.8290.96
82_L226_S0.8290.96
257_S279_R0.8280.96
298_P301_R0.8210.96
263_P267_P0.8210.96
160_F163_R0.8190.96
283_A286_K0.8190.96
217_E221_Q0.8140.96
214_S221_Q0.8120.96
158_E164_I0.8100.96
236_L308_A0.8090.96
263_P268_M0.8080.96
139_W212_V0.8070.96
222_A226_S0.7990.96
283_A287_L0.7970.96
32_F64_A0.7920.95
82_L225_S0.7900.95
163_R167_A0.7890.95
216_L244_L0.7890.95
191_T197_F0.7880.95
65_K74_I0.7860.95
6_K34_R0.7830.95
35_G39_R0.7830.95
143_A147_D0.7810.95
210_I242_H0.7800.95
56_R80_S0.7790.95
227_L252_F0.7780.95
64_A67_I0.7770.95
32_F39_R0.7730.95
19_L41_I0.7720.95
15_A239_I0.7710.95
19_L97_G0.7670.95
221_Q225_S0.7650.95
158_E203_R0.7620.94
82_L98_I0.7620.94
290_G294_V0.7600.94
254_R258_R0.7590.94
223_L252_F0.7590.94
43_S69_D0.7560.94
171_R175_Q0.7560.94
199_H202_T0.7520.94
100_L238_I0.7430.94
41_I51_L0.7430.94
32_F35_G0.7420.94
9_T241_F0.7420.94
227_L308_A0.7350.93
223_L238_I0.7350.93
59_Q130_P0.7340.93
152_L164_I0.7330.93
139_W148_I0.7330.93
184_A205_F0.7310.93
15_A305_L0.7310.93
12_L15_A0.7300.93
53_A74_I0.7270.93
21_I49_G0.7250.93
133_G138_E0.7240.93
39_R67_I0.7230.93
158_E204_T0.7210.93
15_A41_I0.7200.93
266_L270_E0.7190.92
122_G180_T0.7190.92
22_R25_G0.7140.92
152_L158_E0.7100.92
256_N308_A0.7060.92
181_K184_A0.7040.92
266_L269_T0.7040.92
65_K68_D0.7030.92
63_V66_T0.7020.92
202_T301_R0.7020.92
134_Q138_E0.7000.91
14_E287_L0.7000.91
191_T194_K0.6980.91
261_Q271_E0.6980.91
279_R310_R0.6970.91
21_I27_Y0.6950.91
289_P294_V0.6930.91
264_A268_M0.6920.91
168_I183_L0.6880.91
123_P135_S0.6870.91
7_H10_V0.6860.91
151_V211_W0.6810.90
30_G222_A0.6770.90
32_F74_I0.6760.90
160_F167_A0.6750.90
11_L15_A0.6740.90
141_Q172_N0.6730.90
64_A74_I0.6710.90
27_Y45_L0.6680.89
100_L219_I0.6650.89
98_I230_L0.6650.89
104_V128_M0.6650.89
135_S212_V0.6640.89
42_L70_P0.6640.89
6_K107_P0.6630.89
265_G269_T0.6560.89
167_A186_V0.6550.89
112_A122_G0.6550.89
287_L307_I0.6540.88
163_R166_R0.6540.88
198_K301_R0.6510.88
5_Y34_R0.6510.88
193_V196_K0.6490.88
13_D292_E0.6440.88
208_V212_V0.6430.88
13_D44_Q0.6420.88
86_V229_V0.6410.87
23_P48_E0.6400.87
109_L119_M0.6400.87
261_Q269_T0.6380.87
282_R309_E0.6350.87
58_P129_D0.6320.87
56_R128_M0.6320.87
257_S308_A0.6240.86
281_L284_L0.6220.86
99_L239_I0.6180.86
32_F61_I0.6160.85
41_I99_L0.6150.85
211_W214_S0.6150.85
146_A162_K0.6140.85
54_I75_I0.6130.85
23_P49_G0.6120.85
61_I72_F0.6110.85
140_L208_V0.6100.85
170_E174_E0.6080.85
137_A208_V0.6040.84
239_I303_S0.6020.84
28_I82_L0.6020.84
18_G21_I0.6010.84
148_I211_W0.5990.84
210_I244_L0.5940.83
260_P272_Q0.5930.83
255_E258_R0.5930.83
228_N256_N0.5920.83
118_F198_K0.5890.83
34_R59_Q0.5890.83
119_M301_R0.5880.83
262_V272_Q0.5870.82
22_R27_Y0.5860.82
18_G305_L0.5860.82
25_G309_E0.5850.82
251_R255_E0.5850.82
45_L71_R0.5830.82
222_A225_S0.5820.82
113_E179_R0.5790.82
81_A85_Y0.5790.82
136_A212_V0.5770.81
148_I204_T0.5760.81
261_Q270_E0.5760.81
52_L86_V0.5730.81
145_E173_R0.5690.81
165_A169_V0.5660.80
146_A150_W0.5660.80
254_R281_L0.5650.80
9_T40_L0.5650.80
220_E251_R0.5600.79
30_G95_I0.5590.79
30_G82_L0.5580.79
21_I96_D0.5550.79
30_G98_I0.5550.79
278_G308_A0.5540.79
250_K306_R0.5530.79
130_P135_S0.5530.79
47_E71_R0.5520.79
18_G282_R0.5510.78
292_E295_A0.5510.78
182_E186_V0.5500.78
26_I50_R0.5500.78
38_S99_L0.5500.78
240_S304_V0.5500.78
5_Y63_V0.5500.78
171_R185_E0.5500.78
242_H302_S0.5480.78
150_W162_K0.5480.78
19_L235_R0.5460.78
162_K166_R0.5460.78
224_K256_N0.5450.78
284_L304_V0.5450.78
232_P310_R0.5430.77
184_A199_H0.5410.77
140_L168_I0.5400.77
254_R257_S0.5400.77
226_S238_I0.5340.76
35_G99_L0.5330.76
147_D211_W0.5310.76
41_I97_G0.5300.76
150_W161_A0.5290.76
184_A188_A0.5280.75
21_I24_D0.5280.75
224_K255_E0.5280.75
100_L226_S0.5270.75
140_L143_A0.5260.75
18_G287_L0.5260.75
20_N309_E0.5250.75
25_G96_D0.5240.75
152_L208_V0.5220.75
280_Q311_T0.5220.75
182_E185_E0.5210.74
239_I289_P0.5210.74
86_V89_R0.5210.74
268_M272_Q0.5190.74
56_R129_D0.5190.74
79_F218_E0.5170.74
28_I98_I0.5170.74
123_P180_T0.5150.74
191_T195_D0.5150.74
60_A128_M0.5140.73
219_I223_L0.5140.73
19_L49_G0.5130.73
89_R92_I0.5130.73
160_F164_I0.5130.73
193_V197_F0.5130.73
191_T204_T0.5110.73
223_L249_V0.5100.73
86_V95_I0.5100.73
201_A204_T0.5100.73
24_D47_E0.5090.73
202_T241_F0.5090.73
222_A227_L0.5080.73
286_K289_P0.5070.72
140_L180_T0.5050.72
264_A269_T0.5040.72
197_F203_R0.5040.72
13_D290_G0.5030.72
13_D296_E0.5030.72
120_R181_K0.5020.72
98_I222_A0.5010.72
259_G269_T0.5000.71
22_R48_E0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tkaA 2 0.901 100 0.196 Contact Map
1wg8A 1 0.8978 100 0.244 Contact Map
1m6yA 1 0.9105 100 0.301 Contact Map
3eeyA 3 0.5847 98.9 0.905 Contact Map
1jsxA 1 0.4824 98.7 0.911 Contact Map
4ponA 2 0.5367 98.7 0.912 Contact Map
1sqgA 1 0.6326 98.7 0.913 Contact Map
3mb5A 3 0.5687 98.7 0.913 Contact Map
1o54A 4 0.5623 98.7 0.913 Contact Map
1i1nA 1 0.5176 98.6 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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