GREMLIN Database
ADIC - Arginine/agmatine antiporter
UniProt: P60061 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12462
Length: 445 (413)
Sequences: 24681 (15895)
Seq/√Len: 782.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_V331_G4.3961.00
313_I325_A4.3121.00
374_L378_G3.3491.00
50_I236_A3.2261.00
316_R325_A3.1281.00
222_R226_I2.9781.00
366_L395_F2.9121.00
11_G218_K2.8611.00
219_N222_R2.7271.00
74_Y307_D2.6871.00
217_V223_N2.6871.00
90_N304_A2.6041.00
305_A315_A2.5681.00
169_G245_A2.5651.00
318_N324_V2.5621.00
313_I316_R2.4811.00
130_V335_T2.4791.00
62_K376_G2.4601.00
16_T230_G2.4151.00
12_L230_G2.3741.00
167_V171_F2.3721.00
215_G306_D2.2901.00
264_D267_R2.2871.00
78_R86_G2.2341.00
369_C394_A2.2201.00
12_L223_N2.2011.00
328_I332_I2.1671.00
302_K306_D2.1491.00
216_V299_Q2.1331.00
134_W335_T2.1151.00
422_A426_L2.0981.00
137_V327_L2.0971.00
15_V217_V2.0881.00
141_I324_V2.0841.00
392_T396_L2.0821.00
12_L16_T2.0801.00
138_L142_V2.0731.00
81_F374_L2.0621.00
145_K149_R2.0481.00
129_C338_Q2.0041.00
254_A268_M1.9891.00
273_T277_I1.9781.00
59_V369_C1.9741.00
226_I230_G1.9691.00
156_V160_I1.9391.00
308_G312_P1.9351.00
78_R83_P1.9131.00
314_F329_I1.9121.00
130_V338_Q1.9111.00
11_G14_P1.8991.00
416_T420_I1.8941.00
94_W330_V1.8931.00
81_F370_A1.8561.00
251_P254_A1.8531.00
51_I55_G1.8401.00
389_A393_I1.8301.00
264_D268_M1.8071.00
6_D317_V1.8001.00
14_P152_A1.7511.00
219_N223_N1.7491.00
370_A395_F1.7481.00
134_W331_G1.7371.00
35_L42_A1.7291.00
414_F418_M1.7291.00
318_N322_T1.7061.00
105_V290_L1.6891.00
140_N291_G1.6831.00
396_L400_W1.6781.00
77_A89_T1.6761.00
101_N334_M1.6621.00
52_G397_Y1.6501.00
229_I233_L1.6501.00
45_G196_T1.6491.00
133_L334_M1.6341.00
16_T234_I1.6341.00
374_L377_H1.6201.00
160_I164_G1.6191.00
141_I328_I1.6151.00
320_A324_V1.6021.00
112_L128_T1.5811.00
89_T367_Y1.5781.00
10_V14_P1.5691.00
82_G85_L1.5431.00
124_V127_I1.5361.00
19_V231_G1.5291.00
233_L237_V1.5221.00
105_V133_L1.4881.00
142_V320_A1.4721.00
410_V413_S1.4681.00
267_R275_G1.4581.00
258_S261_P1.4581.00
400_W404_G1.4561.00
49_T200_T1.4521.00
137_V328_I1.4481.00
302_K317_V1.4421.00
213_A295_L1.4411.00
108_G132_V1.4291.00
301_A326_G1.4271.00
297_A330_V1.4241.00
77_A367_Y1.4211.00
325_A329_I1.4191.00
161_P281_C1.4181.00
276_A280_F1.4171.00
7_A321_G1.4061.00
258_S264_D1.4061.00
170_W245_A1.4021.00
57_S232_V1.3931.00
91_V420_I1.3871.00
55_G393_I1.3871.00
312_P315_A1.3831.00
14_P148_T1.3831.00
370_A374_L1.3781.00
57_S228_T1.3781.00
133_L331_G1.3771.00
219_N226_I1.3731.00
312_P316_R1.3681.00
159_L163_V1.3591.00
380_F384_R1.3591.00
316_R324_V1.3591.00
70_P215_G1.3561.00
415_V419_V1.3541.00
425_A429_N1.3431.00
130_V134_W1.3411.00
123_L127_I1.3381.00
67_D79_R1.3361.00
173_F248_G1.3341.00
108_G283_A1.3341.00
81_F85_L1.3271.00
220_P225_P1.3041.00
385_P388_L1.3031.00
223_N226_I1.3021.00
166_A241_L1.3021.00
423_M427_N1.3021.00
298_G327_L1.2951.00
267_R272_D1.2911.00
237_V241_L1.2901.00
43_I244_T1.2901.00
56_L369_C1.2861.00
270_L274_A1.2801.00
51_I393_I1.2731.00
387_Y391_T1.2711.00
30_L107_I1.2691.00
389_A392_T1.2661.00
189_T192_A1.2661.00
388_L392_T1.2621.00
379_H382_K1.2601.00
6_D302_K1.2521.00
75_A79_R1.2521.00
58_M229_I1.2511.00
420_I423_M1.2471.00
10_V15_V1.2461.00
136_F290_L1.2461.00
80_C371_A1.2421.00
406_G409_E1.2401.00
104_M289_S1.2351.00
10_V148_T1.2341.00
12_L226_I1.2291.00
412_W415_V1.2281.00
169_G249_M1.2131.00
421_T425_A1.2111.00
418_M422_A1.2071.00
94_W301_A1.2071.00
386_A390_V1.2041.00
23_I235_A1.2021.00
423_M426_L1.1991.00
84_F427_N1.1971.00
13_I17_L1.1941.00
426_L429_N1.1891.00
413_S417_L1.1861.00
411_M415_V1.1791.00
165_I169_G1.1791.00
301_A310_F1.1731.00
377_H380_F1.1621.00
62_K65_F1.1611.00
15_V227_A1.1591.00
69_S75_A1.1581.00
410_V414_F1.1561.00
126_T130_V1.1481.00
218_K223_N1.1461.00
411_M414_F1.1371.00
60_Y73_S1.1291.00
306_D315_A1.1241.00
325_A328_I1.1221.00
398_C401_A1.1211.00
394_A398_C1.1201.00
366_L399_I1.1171.00
139_L150_V1.1171.00
77_A85_L1.0991.00
36_A42_A1.0981.00
18_M213_A1.0971.00
79_R379_H1.0961.00
64_S76_Y1.0931.00
174_R177_T1.0911.00
399_I403_V1.0861.00
380_F383_A1.0841.00
9_K218_K1.0841.00
127_I131_V1.0831.00
19_V210_A1.0771.00
137_V141_I1.0691.00
164_G168_F1.0691.00
109_V128_T1.0621.00
20_S234_I1.0591.00
332_I336_I1.0561.00
87_Y91_V1.0551.00
251_P268_M1.0541.00
415_V418_M1.0541.00
149_R153_V1.0531.00
150_V154_A1.0421.00
131_V135_I1.0401.00
66_L382_K1.0351.00
410_V415_V1.0331.00
151_Q291_G1.0321.00
317_V321_G1.0311.00
47_L240_V1.0241.00
260_S264_D1.0231.00
69_S79_R1.0141.00
59_V391_T1.0141.00
66_L384_R1.0141.00
419_V423_M1.0111.00
373_L392_T1.0041.00
74_Y303_A1.0031.00
20_S235_A1.0001.00
163_V167_V0.9961.00
190_F193_I0.9921.00
379_H384_R0.9921.00
395_F399_I0.9921.00
194_Q400_W0.9891.00
134_W138_L0.9871.00
144_P295_L0.9781.00
413_S416_T0.9771.00
403_V407_A0.9761.00
415_V422_A0.9741.00
135_I287_L0.9731.00
175_G178_Y0.9601.00
214_A224_V0.9601.00
381_G384_R0.9501.00
272_D276_A0.9491.00
394_A397_Y0.9421.00
413_S422_A0.9391.00
166_A245_A0.9311.00
84_F88_Q0.9281.00
165_I266_A0.9271.00
369_C395_F0.9261.00
249_M265_A0.9241.00
141_I318_N0.9241.00
112_L116_F0.9231.00
174_R178_Y0.9221.00
400_W403_V0.9171.00
141_I322_T0.9161.00
171_F175_G0.9151.00
154_A288_G0.9081.00
386_A389_A0.9081.00
205_I361_T0.9041.00
366_L370_A0.9011.00
43_I247_M0.9001.00
136_F291_G0.8991.00
244_T248_G0.8981.00
391_T398_C0.8961.00
402_V405_S0.8951.00
294_T331_G0.8921.00
180_A183_N0.8921.00
318_N321_G0.8901.00
103_A354_S0.8901.00
423_M429_N0.8901.00
17_L152_A0.8891.00
391_T395_F0.8891.00
411_M416_T0.8881.00
109_V129_C0.8861.00
128_T131_V0.8861.00
9_K145_K0.8851.00
372_L391_T0.8841.00
208_E212_V0.8841.00
405_S408_K0.8811.00
420_I424_Y0.8811.00
71_G74_Y0.8801.00
416_T423_M0.8801.00
190_F194_Q0.8791.00
376_G380_F0.8781.00
71_G75_A0.8741.00
85_L367_Y0.8691.00
91_V310_F0.8691.00
314_F325_A0.8671.00
414_F417_L0.8651.00
195_S199_V0.8641.00
103_A202_W0.8571.00
159_L238_C0.8561.00
78_R307_D0.8551.00
50_I204_F0.8531.00
14_P149_R0.8521.00
236_A240_V0.8511.00
230_G234_I0.8511.00
44_Y193_I0.8441.00
158_A285_G0.8421.00
331_G335_T0.8351.00
209_S296_L0.8351.00
324_V328_I0.8351.00
55_G390_V0.8271.00
166_A170_W0.8251.00
366_L398_C0.8241.00
359_I413_S0.8221.00
13_I152_A0.8221.00
410_V417_L0.8191.00
424_Y428_Y0.8191.00
24_M27_G0.8131.00
410_V423_M0.8101.00
6_D216_V0.8081.00
410_V424_Y0.8051.00
12_L227_A0.8041.00
310_F314_F0.8041.00
138_L141_I0.8011.00
108_G286_C0.7971.00
44_Y48_V0.7961.00
413_S418_M0.7951.00
77_A371_A0.7951.00
54_L58_M0.7951.00
356_V360_F0.7941.00
123_L126_T0.7931.00
149_R152_A0.7921.00
108_G287_L0.7901.00
415_V420_I0.7841.00
372_L376_G0.7811.00
173_F245_A0.7771.00
225_P228_T0.7751.00
66_L380_F0.7731.00
373_L377_H0.7731.00
54_L229_I0.7731.00
405_S409_E0.7701.00
106_V353_V0.7691.00
6_D299_Q0.7691.00
112_L283_A0.7671.00
55_G59_V0.7621.00
136_F294_T0.7611.00
271_G274_A0.7581.00
178_Y248_G0.7561.00
417_L421_T0.7561.00
63_M372_L0.7551.00
130_V339_L0.7551.00
81_F371_A0.7541.00
171_F174_R0.7511.00
100_G357_S0.7491.00
424_Y427_N0.7481.00
9_K144_P0.7471.00
179_M183_N0.7441.00
371_A375_L0.7421.00
319_K324_V0.7421.00
395_F398_C0.7421.00
133_L338_Q0.7421.00
170_W241_L0.7421.00
47_L51_I0.7411.00
377_H388_L0.7401.00
142_V146_M0.7381.00
425_A428_Y0.7371.00
412_W416_T0.7361.00
219_N225_P0.7341.00
140_N327_L0.7311.00
126_T338_Q0.7291.00
183_N186_G0.7281.00
56_L398_C0.7271.00
421_T424_Y0.7241.00
332_I335_T0.7241.00
60_Y368_T0.7181.00
410_V429_N0.7171.00
391_T394_A0.7161.00
16_T227_A0.7131.00
166_A242_S0.7111.00
305_A314_F0.7091.00
313_I329_I0.7071.00
386_A391_T0.7071.00
100_G103_A0.7061.00
180_A184_V0.7061.00
53_A207_V0.7051.00
413_S420_I0.7051.00
314_F326_G0.7041.00
298_G326_G0.7041.00
74_Y78_R0.7031.00
415_V426_L0.7021.00
38_T195_S0.7021.00
410_V425_A0.7011.00
13_I149_R0.6981.00
63_M76_Y0.6951.00
413_S427_N0.6931.00
416_T419_V0.6921.00
403_V406_G0.6921.00
84_F421_T0.6921.00
98_W333_L0.6911.00
44_Y47_L0.6911.00
113_S117_P0.6901.00
24_M158_A0.6901.00
422_A425_A0.6891.00
109_V125_L0.6891.00
301_A329_I0.6891.00
140_N295_L0.6871.00
273_T276_A0.6871.00
294_T298_G0.6861.00
148_T152_A0.6861.00
16_T19_V0.6841.00
93_Y97_C0.6831.00
410_V427_N0.6831.00
205_I365_Y0.6831.00
102_I337_F0.6821.00
373_L388_L0.6811.00
241_L245_A0.6801.00
396_L399_I0.6781.00
23_I231_G0.6751.00
141_I320_A0.6751.00
401_A404_G0.6741.00
42_A243_T0.6731.00
412_W424_Y0.6711.00
299_Q302_K0.6691.00
418_M421_T0.6671.00
401_A405_S0.6631.00
64_S224_V0.6621.00
109_V112_L0.6591.00
416_T424_Y0.6571.00
171_F176_E0.6571.00
82_G428_Y0.6571.00
414_F423_M0.6551.00
413_S423_M0.6551.00
242_S262_F0.6551.00
141_I327_L0.6501.00
22_N293_W0.6491.00
22_N292_G0.6481.00
100_G104_M0.6481.00
80_C374_L0.6471.00
419_V427_N0.6471.00
261_P266_A0.6471.00
410_V420_I0.6461.00
146_M149_R0.6451.00
96_A361_T0.6441.00
168_F172_W0.6431.00
9_K13_I0.6421.00
392_T395_F0.6381.00
179_M182_W0.6381.00
157_L281_C0.6381.00
419_V422_A0.6371.00
180_A185_S0.6371.00
113_S125_L0.6361.00
215_G302_K0.6361.00
24_M238_C0.6351.00
424_Y429_N0.6341.00
99_I356_V0.6331.00
423_M428_Y0.6331.00
104_M290_L0.6331.00
41_I247_M0.6321.00
242_S246_I0.6291.00
234_I238_C0.6271.00
34_N37_S0.6271.00
266_A271_G0.6271.00
70_P302_K0.6271.00
92_L364_P0.6251.00
205_I208_E0.6241.00
136_F287_L0.6241.00
230_G233_L0.6241.00
35_L39_G0.6231.00
211_S228_T0.6221.00
64_S211_S0.6211.00
13_I16_T0.6211.00
192_A195_S0.6211.00
46_W203_S0.6191.00
349_E352_L0.6181.00
115_F280_F0.6181.00
412_W423_M0.6171.00
61_A65_F0.6151.00
74_Y90_N0.6151.00
43_I240_V0.6131.00
411_M423_M0.6121.00
28_V242_S0.6111.00
32_P243_T0.6091.00
112_L132_V0.6091.00
260_S263_G0.6091.00
414_F421_T0.6081.00
20_S155_T0.6071.00
21_G155_T0.6071.00
114_Y117_P0.6071.00
49_T204_F0.6061.00
170_W174_R0.6061.00
134_W137_V0.6051.00
144_P213_A0.6031.00
387_Y390_V0.6021.00
6_D9_K0.6021.00
102_I353_V0.6001.00
422_A427_N0.5991.00
411_M424_Y0.5971.00
323_P326_G0.5971.00
57_S61_A0.5971.00
62_K66_L0.5941.00
143_G146_M0.5921.00
80_C375_L0.5921.00
58_M390_V0.5921.00
336_I339_L0.5921.00
63_M80_C0.5911.00
133_L335_T0.5911.00
73_S208_E0.5911.00
34_N351_G0.5901.00
57_S207_V0.5901.00
410_V416_T0.5891.00
351_G354_S0.5881.00
234_I237_V0.5871.00
420_I428_Y0.5861.00
224_V228_T0.5861.00
280_F284_A0.5851.00
74_Y86_G0.5851.00
114_Y279_S0.5841.00
132_V290_L0.5841.00
377_H381_G0.5841.00
216_V323_P0.5841.00
317_V320_A0.5831.00
313_I317_V0.5821.00
375_L379_H0.5771.00
105_V109_V0.5771.00
360_F364_P0.5771.00
48_V197_L0.5771.00
212_V296_L0.5771.00
297_A301_A0.5761.00
111_Y282_A0.5761.00
28_V31_L0.5761.00
420_I425_A0.5751.00
59_V394_A0.5741.00
146_M150_V0.5741.00
137_V294_T0.5741.00
266_A274_A0.5721.00
43_I47_L0.5721.00
168_F271_G0.5711.00
19_V23_I0.5711.00
203_S239_Y0.5701.00
104_M286_C0.5701.00
46_W243_T0.5691.00
148_T291_G0.5691.00
97_C293_W0.5671.00
49_T201_L0.5661.00
181_A186_G0.5661.00
181_A184_V0.5651.00
391_T405_S0.5651.00
34_N38_T0.5611.00
35_L200_T0.5601.00
147_I295_L0.5601.00
359_I402_V0.5591.00
73_S212_V0.5581.00
92_L363_V0.5571.00
29_F162_I0.5541.00
217_V224_V0.5541.00
168_F270_L0.5531.00
415_V424_Y0.5531.00
6_D70_P0.5521.00
72_G211_S0.5491.00
413_S428_Y0.5491.00
111_Y263_G0.5491.00
373_L391_T0.5481.00
55_G394_A0.5481.00
393_I397_Y0.5481.00
388_L391_T0.5451.00
45_G193_I0.5451.00
414_F420_I0.5441.00
266_A270_L0.5431.00
22_N209_S0.5431.00
115_F279_S0.5421.00
285_G288_G0.5421.00
152_A156_V0.5391.00
182_W185_S0.5381.00
350_F354_S0.5381.00
173_F249_M0.5371.00
220_P223_N0.5371.00
416_T421_T0.5331.00
28_V162_I0.5321.00
104_M107_I0.5321.00
245_A248_G0.5321.00
15_V213_A0.5311.00
398_C402_V0.5311.00
208_E365_Y0.5301.00
250_I254_A0.5291.00
299_Q323_P0.5291.00
126_T129_C0.5281.00
8_H218_K0.5271.00
98_W330_V0.5261.00
329_I333_L0.5251.00
411_M418_M0.5251.00
181_A185_S0.5251.00
107_I111_Y0.5241.00
234_I241_L0.5241.00
411_M427_N0.5221.00
361_T364_P0.5211.00
28_V32_P0.5201.00
261_P265_A0.5201.00
24_M29_F0.5181.00
89_T364_P0.5181.00
217_V227_A0.5171.00
173_F177_T0.5171.00
160_I163_V0.5171.00
10_V144_P0.5171.00
96_A360_F0.5171.00
56_L208_E0.5171.00
77_A86_G0.5161.00
35_L196_T0.5151.00
66_L375_L0.5151.00
277_I281_C0.5151.00
20_S23_I0.5141.00
385_P389_A0.5141.00
397_Y400_W0.5131.00
155_T158_A0.5121.00
193_I197_L0.5111.00
324_V327_L0.5111.00
250_I264_D0.5101.00
30_L33_A0.5091.00
131_V134_W0.5081.00
26_S104_M0.5071.00
144_P148_T0.5071.00
410_V422_A0.5061.00
205_I357_S0.5061.00
266_A269_A0.5061.00
54_L232_V0.5061.00
134_W328_I0.5061.00
102_I105_V0.5051.00
82_G86_G0.5051.00
210_A224_V0.5041.00
397_Y401_A0.5041.00
414_F429_N0.5021.00
222_R225_P0.5011.00
290_L293_W0.5011.00
263_G267_R0.5001.00
161_P277_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9506 100 0.218 Contact Map
3giaA 1 0.9528 100 0.33 Contact Map
4djkA 2 0.9056 100 0.361 Contact Map
2jlnA 1 0.8966 99.1 0.849 Contact Map
3dh4A 3 0.9393 98.9 0.855 Contact Map
2xq2A 2 0.9416 98.9 0.857 Contact Map
2a65A 2 0.9281 97.7 0.899 Contact Map
4xp4A 1 0.9483 97.6 0.901 Contact Map
4wgvA 2 0.8157 97.6 0.902 Contact Map
4us3A 1 0.8809 97.1 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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