GREMLIN Database
SGCB - Putative phosphotransferase enzyme IIB component SgcB
UniProt: P58035 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14343
Length: 92 (89)
Sequences: 459 (316)
Seq/√Len: 33.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_Q88_A3.9511.00
18_I56_S3.3071.00
22_L54_V3.1591.00
72_A82_L2.9301.00
19_A35_T2.8371.00
29_Q87_K2.5381.00
6_V22_L2.5331.00
81_A85_Q2.1400.99
38_C42_E1.8730.97
25_F83_K1.8710.97
2_K90_L1.8470.97
4_I26_L1.8370.96
3_K34_T1.8320.96
80_D84_Q1.7800.96
23_Q27_T1.7450.95
4_I33_A1.7130.95
73_L83_K1.6860.94
25_F73_L1.6000.93
52_L90_L1.5610.92
68_L89_L1.5500.91
10_T39_C1.4910.90
47_C65_I1.4610.89
18_I74_L1.3820.86
25_F29_Q1.3410.84
38_C43_I1.3310.83
85_Q88_A1.3070.82
16_T37_Q1.2820.81
78_N81_A1.2510.79
26_L33_A1.2490.79
40_L57_M1.2140.77
10_T23_Q1.2100.77
5_L39_C1.2010.76
83_K87_K1.1860.76
82_L85_Q1.1830.75
7_A50_M1.1760.75
48_N64_G1.1760.75
39_C42_E1.1560.74
26_L71_A1.1470.73
10_T57_M1.1050.70
72_A78_N1.0670.67
23_Q77_I1.0460.66
68_L82_L1.0160.64
19_A23_Q0.9760.60
2_K57_M0.9580.59
44_P61_S0.9410.58
11_G75_T0.9400.58
52_L86_I0.9360.57
11_G40_L0.9220.56
43_I53_I0.9190.56
77_I80_D0.9110.55
10_T40_L0.9090.55
27_T33_A0.9010.54
20_H23_Q0.8980.54
22_L86_I0.8970.54
3_K36_A0.8960.54
21_K70_G0.8920.54
20_H74_L0.8690.52
37_Q56_S0.8670.51
10_T41_N0.8650.51
5_L50_M0.8580.51
17_M70_G0.8520.50
68_L86_I0.8470.50
25_F87_K0.8290.48
21_K54_V0.8290.48
29_Q83_K0.7910.45
18_I57_M0.7760.44
55_T59_T0.7740.44
22_L35_T0.7700.43
12_M16_T0.7700.43
81_A88_A0.7610.43
38_C53_I0.7550.42
79_D84_Q0.7500.42
42_E69_N0.7430.41
71_A74_L0.7340.40
3_K9_G0.7200.39
69_N72_A0.7030.38
59_T67_T0.6950.37
55_T60_N0.6950.37
70_G78_N0.6930.37
54_V86_I0.6760.36
7_A42_E0.6760.36
30_G48_N0.6730.36
57_M60_N0.6690.35
71_A78_N0.6620.35
3_K46_N0.6540.34
10_T18_I0.6530.34
6_V9_G0.6470.34
30_G84_Q0.6460.34
79_D83_K0.6390.33
24_E79_D0.6330.33
41_N71_A0.6230.32
72_A75_T0.6170.31
3_K6_V0.6140.31
7_A38_C0.6130.31
40_L55_T0.6110.31
40_L61_S0.6090.31
16_T53_I0.6060.31
4_I90_L0.6050.31
81_A89_L0.6030.30
11_G74_L0.6030.30
28_E75_T0.5980.30
11_G39_C0.5900.30
37_Q42_E0.5890.29
32_S84_Q0.5890.29
22_L27_T0.5840.29
26_L54_V0.5820.29
10_T37_Q0.5810.29
43_I64_G0.5810.29
41_N56_S0.5780.29
5_L53_I0.5750.28
64_G89_L0.5730.28
24_E81_A0.5700.28
43_I52_L0.5690.28
81_A84_Q0.5680.28
36_A46_N0.5660.28
22_L26_L0.5560.27
54_V70_G0.5510.27
27_T44_P0.5480.27
25_F28_E0.5450.26
7_A65_I0.5250.25
60_N64_G0.5220.25
9_G39_C0.5220.25
39_C46_N0.5220.25
53_I74_L0.5180.25
24_E32_S0.5150.25
11_G59_T0.5100.24
25_F79_D0.5090.24
54_V78_N0.5080.24
29_Q84_Q0.5080.24
4_I62_D0.5070.24
50_M65_I0.5030.24
12_M78_N0.5020.24
3_K32_S0.5010.24
62_D69_N0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tvmA 1 1 99.8 0.453 Contact Map
3nbmA 1 0.9674 99.8 0.474 Contact Map
4mgeA 3 0.9674 99.7 0.498 Contact Map
1e2bA 1 0.9783 99.7 0.501 Contact Map
2l2qA 1 0.9674 99.7 0.511 Contact Map
1vkrA 1 0.9674 99.6 0.529 Contact Map
3czcA 1 0.9565 99.6 0.549 Contact Map
2kyrA 1 1 99.5 0.584 Contact Map
4tn5A 2 0.9891 99.4 0.591 Contact Map
2m1zA 1 0.9891 99.4 0.601 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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