GREMLIN Database
INSB4 - Insertion element IS1 4 protein InsB
UniProt: P57998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40002
Length: 167 (133)
Sequences: 188 (147)
Seq/√Len: 12.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E65_R3.4540.99
134_Q144_L3.1570.97
65_R124_R3.0820.97
137_A144_L2.9110.96
135_H160_Y2.6400.93
49_Y88_S2.5630.91
149_S152_L2.5180.91
48_G153_H2.4060.89
98_W110_L2.3520.87
58_W62_A2.1800.83
134_Q137_A2.1240.81
49_Y85_R1.8950.73
134_Q145_S1.7870.68
127_R131_N1.7630.67
46_Q59_L1.7580.67
57_R154_D1.7560.67
61_Y129_N1.7170.65
63_Y128_Y1.6620.62
58_W86_L1.6410.61
127_R130_L1.6270.61
43_M100_T1.6180.60
74_V82_T1.6170.60
80_M108_S1.5920.59
49_Y66_L1.5840.58
157_I161_L1.5550.57
68_K128_Y1.5290.56
130_L144_L1.5140.55
128_Y134_Q1.4890.54
139_L144_L1.4780.53
48_G127_R1.4780.53
140_G146_F1.4680.53
122_T138_R1.4670.52
125_I139_L1.4550.52
83_L109_R1.4280.50
49_Y60_F1.3600.47
65_R159_H1.3510.46
80_M84_G1.3500.46
42_E124_R1.3480.46
105_L118_S1.3440.46
130_L140_G1.3330.46
50_V153_H1.3300.45
63_Y68_K1.3140.45
130_L134_Q1.2790.43
42_E122_T1.2760.43
58_W143_S1.2740.43
125_I159_H1.2570.42
61_Y155_K1.2050.39
47_W164_K1.1750.38
64_D146_F1.1670.37
64_D145_S1.1600.37
101_D126_E1.1600.37
74_V150_V1.1530.37
131_N135_H1.1390.36
39_V49_Y1.1300.35
44_D138_R1.1290.35
61_Y115_H1.1280.35
50_V147_S1.1230.35
130_L137_A1.1190.35
59_L158_G1.1060.34
63_Y67_R1.1020.34
84_G117_I1.0820.33
106_Y126_E1.0800.33
72_A86_L1.0720.33
42_E119_K1.0700.33
47_W122_T1.0670.33
47_W146_F1.0640.32
139_L157_I1.0640.32
97_I116_V1.0620.32
67_R92_P1.0550.32
57_R150_V1.0360.31
131_N160_Y1.0310.31
59_L93_F1.0230.31
47_W86_L1.0140.30
134_Q140_G0.9930.29
128_Y144_L0.9860.29
33_P36_D0.9820.29
137_A145_S0.9800.29
70_V143_S0.9730.28
89_L93_F0.9700.28
126_E133_R0.9700.28
136_L149_S0.9580.28
51_G81_A0.9560.28
128_Y136_L0.9490.27
43_M161_L0.9350.27
63_Y100_T0.9310.27
50_V117_I0.9310.27
87_M162_N0.9310.27
146_F153_H0.9240.26
80_M104_P0.9220.26
63_Y82_T0.9150.26
80_M145_S0.9130.26
135_H153_H0.9040.26
63_Y124_R0.8910.25
93_F123_Q0.8840.25
43_M120_R0.8770.25
88_S100_T0.8740.24
46_Q132_L0.8570.24
91_S96_V0.8450.23
74_V86_L0.8090.22
45_E53_K0.8090.22
67_R128_Y0.8040.22
66_L161_L0.8010.22
34_G37_V0.7990.22
95_V130_L0.7930.22
63_Y165_H0.7850.21
93_F158_G0.7820.21
90_L156_V0.7810.21
137_A140_G0.7730.21
40_C121_Y0.7640.21
43_M152_L0.7630.20
51_G71_V0.7550.20
152_L156_V0.7530.20
67_R165_H0.7520.20
92_P108_S0.7500.20
77_E82_T0.7480.20
82_T157_I0.7470.20
42_E103_W0.7290.19
62_A147_S0.7280.19
149_S156_V0.7260.19
71_V85_R0.7200.19
56_Q89_L0.7180.19
50_V57_R0.7150.19
54_S85_R0.6990.18
123_Q127_R0.6970.18
37_V125_I0.6850.18
56_Q117_I0.6830.18
73_H159_H0.6820.18
84_G108_S0.6800.18
61_Y125_I0.6800.18
101_D106_Y0.6800.18
57_R110_L0.6710.18
158_G163_I0.6700.18
147_S153_H0.6700.18
106_Y143_S0.6700.18
121_Y142_K0.6680.17
50_V103_W0.6660.17
138_R147_S0.6660.17
92_P125_I0.6580.17
46_Q123_Q0.6550.17
68_K130_L0.6510.17
57_R70_V0.6500.17
110_L154_D0.6460.17
38_I73_H0.6430.17
42_E45_E0.6410.17
52_A64_D0.6390.17
160_Y164_K0.6350.17
101_D138_R0.6350.17
62_A70_V0.6320.16
68_K124_R0.6320.16
48_G131_N0.6220.16
54_S99_M0.6220.16
77_E81_A0.6190.16
53_K106_Y0.6160.16
131_N164_K0.6130.16
134_Q139_L0.6120.16
59_L75_F0.6100.16
99_M151_E0.6030.16
38_I102_G0.6020.16
51_G151_E0.6020.16
59_L90_L0.5970.15
99_M136_L0.5960.15
83_L165_H0.5940.15
41_A165_H0.5930.15
90_L137_A0.5910.15
70_V76_G0.5900.15
98_W150_V0.5860.15
124_R132_L0.5820.15
87_M110_L0.5810.15
40_C65_R0.5810.15
86_L142_K0.5780.15
60_F133_R0.5760.15
75_F78_R0.5740.15
132_L136_L0.5700.15
49_Y74_V0.5690.15
51_G107_E0.5680.15
52_A98_W0.5680.15
59_L157_I0.5660.15
85_R105_L0.5650.15
44_D53_K0.5600.14
58_W105_L0.5590.14
63_Y164_K0.5570.14
99_M110_L0.5560.14
79_T87_M0.5490.14
54_S88_S0.5480.14
125_I153_H0.5440.14
70_V131_N0.5400.14
77_E91_S0.5390.14
71_V78_R0.5340.14
106_Y127_R0.5330.14
123_Q158_G0.5280.14
62_A138_R0.5220.14
86_L117_I0.5120.13
98_W105_L0.5120.13
115_H132_L0.5070.13
68_K164_K0.5060.13
151_E155_K0.5040.13
48_G122_T0.5020.13
68_K134_Q0.5010.13
128_Y165_H0.5010.13
160_Y163_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.982 97.8 0.864 Contact Map
1bcoA 1 0.8024 97.5 0.872 Contact Map
4fw1A 2 0.8024 97.4 0.872 Contact Map
3l3uA 2 0.7066 97.4 0.874 Contact Map
1cxqA 2 0.7665 97.2 0.877 Contact Map
4mq3A 1 0.7006 97.2 0.878 Contact Map
4cf8A 2 0.7066 97.1 0.88 Contact Map
1c6vA 4 0.6647 96.9 0.882 Contact Map
4pa1A 2 0.7066 96.6 0.887 Contact Map
1ex4A 5 0.7006 96.6 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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