GREMLIN Database
PTHC - Glucitol/sorbitol permease IIC component
UniProt: P56579 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10969
Length: 187 (173)
Sequences: 190 (105)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_T107_C3.9210.97
148_L152_V3.8690.97
75_G87_L3.7830.96
20_G33_L3.7100.96
73_C151_L3.5190.94
3_E6_T2.8850.85
73_C147_L2.8370.84
18_K21_E2.5540.77
100_Y104_S2.1240.62
78_V113_L2.0970.61
40_I44_L2.0640.60
45_I128_I1.9470.55
26_M34_L1.9470.55
22_V31_L1.9450.55
106_S110_M1.9330.55
13_I80_C1.8580.52
9_A116_H1.8430.51
44_L58_Q1.8260.51
5_I77_F1.8040.50
23_F31_L1.7720.48
105_Y157_R1.7620.48
20_G162_D1.7160.46
5_I8_G1.6990.45
97_P165_T1.6980.45
8_G11_W1.6570.44
17_Q125_Y1.6410.43
11_W61_A1.6410.43
26_M31_L1.6090.42
85_L104_S1.6060.42
125_Y139_L1.5970.41
24_T27_V1.5950.41
25_G152_V1.5830.41
27_V31_L1.5650.40
152_V170_K1.5550.40
66_S70_L1.5380.39
15_L95_Y1.5220.38
26_M80_C1.5170.38
81_N85_L1.5120.38
21_E25_G1.5120.38
105_Y153_T1.5100.38
85_L105_Y1.4920.37
98_S162_D1.4790.37
170_K173_G1.4380.35
20_G34_L1.4230.35
19_G112_G1.4060.34
101_A109_S1.3670.32
17_Q152_V1.3660.32
110_M117_I1.3650.32
125_Y140_G1.3620.32
76_T84_T1.3600.32
34_L80_C1.3070.30
53_I133_T1.2990.30
22_V47_F1.2950.30
47_F54_E1.2640.29
44_L48_I1.2450.28
100_Y103_A1.2290.28
66_S166_A1.2230.28
132_L145_S1.2120.27
5_I125_Y1.2040.27
101_A111_N1.1980.27
75_G137_L1.1810.26
80_C165_T1.1670.26
67_R95_Y1.1570.25
140_G144_V1.1490.25
31_L145_S1.1470.25
15_L146_Y1.1400.25
26_M137_L1.1320.25
51_H124_V1.1310.25
65_V89_R1.1210.24
155_F159_W1.1130.24
153_T157_R1.1090.24
103_A107_C1.0930.23
138_P141_P1.0880.23
67_R118_N1.0670.23
20_G52_R1.0600.23
13_I18_K1.0340.22
84_T107_C1.0300.22
18_K50_Q1.0260.22
56_F60_C1.0250.22
79_F84_T1.0250.22
57_A63_N1.0130.21
17_Q144_V1.0040.21
42_N77_F1.0030.21
77_F116_H1.0030.21
39_V109_S0.9960.21
63_N71_L0.9950.21
43_A149_V0.9930.21
76_T110_M0.9920.21
40_I166_A0.9920.21
39_V98_S0.9880.21
6_T9_A0.9830.20
64_P159_W0.9810.20
21_E28_T0.9750.20
55_R59_R0.9700.20
128_I144_V0.9680.20
10_E20_G0.9640.20
75_G113_L0.9620.20
38_L120_G0.9550.20
57_A71_L0.9550.20
86_S103_A0.9490.20
79_F87_L0.9380.19
26_M35_I0.9340.19
17_Q33_L0.9340.19
75_G99_Y0.9300.19
18_K134_T0.9280.19
101_A154_N0.9190.19
14_G91_M0.9180.19
4_T8_G0.9160.19
10_E132_L0.8960.18
5_I78_V0.8950.18
31_L130_S0.8910.18
76_T106_S0.8840.18
105_Y110_M0.8830.18
132_L135_L0.8830.18
10_E138_P0.8770.18
6_T20_G0.8770.18
60_C64_P0.8730.18
55_R58_Q0.8680.17
35_I126_L0.8650.17
67_R106_S0.8640.17
7_H11_W0.8560.17
94_K166_A0.8520.17
126_L129_A0.8500.17
48_I128_I0.8480.17
59_R102_A0.8460.17
53_I124_V0.8440.17
35_I73_C0.8400.17
6_T141_P0.8380.17
46_N75_G0.8170.16
18_K74_I0.8130.16
109_S168_F0.8090.16
95_Y102_A0.8060.16
80_C98_S0.8060.16
45_I91_M0.8050.16
95_Y166_A0.7990.16
77_F110_M0.7930.16
94_K122_L0.7890.16
147_L151_L0.7830.16
41_M78_V0.7690.15
57_A135_L0.7690.15
65_V148_L0.7670.15
125_Y132_L0.7650.15
35_I77_F0.7580.15
39_V101_A0.7560.15
24_T151_L0.7550.15
54_E128_I0.7550.15
56_F171_K0.7510.15
85_L99_Y0.7480.15
39_V162_D0.7460.15
76_T105_Y0.7380.15
109_S162_D0.7290.14
17_Q119_P0.7270.14
65_V70_L0.7240.14
149_V153_T0.7230.14
6_T66_S0.7230.14
47_F144_V0.7220.14
125_Y144_V0.7070.14
18_K28_T0.7070.14
14_G18_K0.7040.14
132_L137_L0.7010.14
101_A162_D0.6990.14
109_S164_T0.6970.14
159_W163_L0.6950.14
20_G119_P0.6920.14
35_I144_V0.6910.14
38_L103_A0.6860.14
42_N45_I0.6720.13
87_L117_I0.6710.13
101_A104_S0.6710.13
50_Q124_V0.6690.13
132_L141_P0.6680.13
170_K174_I0.6680.13
36_S60_C0.6670.13
54_E92_P0.6660.13
164_T168_F0.6640.13
47_F125_Y0.6630.13
17_Q160_V0.6600.13
50_Q122_L0.6600.13
47_F151_L0.6590.13
76_T153_T0.6580.13
111_N117_I0.6580.13
101_A105_Y0.6570.13
24_T28_T0.6560.13
98_S164_T0.6520.13
8_G141_P0.6500.13
54_E73_C0.6480.13
92_P95_Y0.6460.13
105_Y154_N0.6450.13
85_L101_A0.6430.13
17_Q156_F0.6420.13
34_L157_R0.6410.13
156_F160_V0.6400.13
69_L110_M0.6370.13
3_E7_H0.6360.13
23_F74_I0.6360.13
8_G175_Q0.6330.13
109_S154_N0.6320.13
92_P173_G0.6310.13
138_P155_F0.6300.13
57_A87_L0.6290.13
144_V175_Q0.6270.12
137_L145_S0.6270.12
156_F167_I0.6260.12
15_L62_G0.6260.12
94_K113_L0.6250.12
8_G31_L0.6240.12
22_V169_E0.6230.12
98_S109_S0.6210.12
168_F171_K0.6210.12
87_L168_F0.6210.12
6_T17_Q0.6170.12
55_R152_V0.6170.12
33_L67_R0.6130.12
25_G73_C0.6130.12
104_S117_I0.6080.12
8_G145_S0.6050.12
6_T11_W0.5990.12
11_W60_C0.5990.12
5_I24_T0.5960.12
25_G151_L0.5950.12
78_V116_H0.5920.12
20_G130_S0.5920.12
41_M116_H0.5910.12
5_I33_L0.5900.12
71_L87_L0.5880.12
63_N103_A0.5830.12
22_V145_S0.5820.12
148_L151_L0.5760.12
35_I157_R0.5750.12
38_L41_M0.5740.12
47_F134_T0.5720.12
77_F119_P0.5650.11
41_M168_F0.5640.11
21_E134_T0.5600.11
70_L113_L0.5600.11
71_L146_Y0.5560.11
66_S84_T0.5550.11
13_I33_L0.5540.11
61_A71_L0.5530.11
84_T103_A0.5480.11
6_T91_M0.5480.11
35_I78_V0.5480.11
5_I26_M0.5470.11
149_V160_V0.5460.11
5_I91_M0.5440.11
113_L140_G0.5380.11
6_T102_A0.5380.11
94_K103_A0.5380.11
111_N122_L0.5340.11
84_T122_L0.5200.11
41_M92_P0.5180.11
125_Y130_S0.5180.11
8_G61_A0.5110.11
56_F71_L0.5110.11
117_I153_T0.5110.11
110_M153_T0.5080.11
36_S54_E0.5070.10
33_L36_S0.5060.10
76_T154_N0.5010.10
42_N89_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7273 14.1 0.969 Contact Map
4pd6A 3 0.8128 12.1 0.97 Contact Map
2kv5A 1 0.1765 7.3 0.973 Contact Map
4gqzA 2 0.2888 6 0.974 Contact Map
1lf6A 1 0.3422 5.1 0.975 Contact Map
3qrxB 2 0.107 3.6 0.977 Contact Map
3e9vA 1 0.5348 3.1 0.977 Contact Map
4b19A 1 0.1604 2.9 0.978 Contact Map
3mw9A 5 0.4973 2.5 0.978 Contact Map
3tx3A 2 0.5882 2.4 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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