GREMLIN Database
DLHH - Putative carboxymethylenebutenolidase
UniProt: P56262 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14321
Length: 271 (215)
Sequences: 34281 (24235)
Seq/√Len: 1652.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_M165_A3.5111.00
157_A166_A3.4731.00
92_Y123_D3.3841.00
34_S41_N2.7271.00
130_W134_N2.5711.00
202_G232_P2.4351.00
213_E230_V2.3301.00
82_E259_L2.2641.00
36_P41_N2.2011.00
137_D140_R2.1761.00
216_R226_A2.1651.00
168_A171_G2.1651.00
229_I257_R2.1591.00
62_V124_L2.1551.00
227_E257_R2.1441.00
153_T166_A2.1021.00
49_P85_L2.0401.00
128_A163_L2.0081.00
58_V136_G1.9841.00
56_L85_L1.9781.00
142_M262_F1.9671.00
44_A87_I1.9471.00
167_V258_M1.9431.00
58_V131_A1.9431.00
84_Y263_K1.9181.00
231_Y257_R1.9081.00
143_I153_T1.8601.00
33_T44_A1.8261.00
31_G48_R1.8051.00
78_R82_E1.7641.00
58_V85_L1.7641.00
46_H85_L1.7441.00
48_R85_L1.7061.00
154_W168_A1.6751.00
202_G230_V1.6681.00
209_Q230_V1.6561.00
82_E263_K1.6321.00
188_I191_D1.6221.00
87_I131_A1.5881.00
253_D257_R1.5851.00
167_V262_F1.5791.00
256_Q260_E1.5791.00
130_W133_R1.5331.00
59_V84_Y1.5241.00
64_E147_C1.5221.00
146_F170_Y1.5171.00
227_E264_Q1.5111.00
125_D129_S1.5001.00
85_L136_G1.4901.00
216_R228_I1.4861.00
217_Q221_A1.4771.00
49_P56_L1.4751.00
87_I127_V1.4611.00
203_Q233_D1.4081.00
46_H87_I1.4001.00
35_I127_V1.3981.00
125_D160_N1.3931.00
216_R220_R1.3871.00
202_G233_D1.3731.00
213_E217_Q1.3691.00
231_Y253_D1.3571.00
219_L224_A1.3451.00
165_A265_Y1.3211.00
143_I156_Y1.3191.00
47_A88_A1.3121.00
59_V144_T1.3061.00
124_L156_Y1.2771.00
200_Y212_V1.2511.00
257_R260_E1.2451.00
58_V87_I1.2281.00
128_A141_L1.2001.00
140_R164_K1.1931.00
198_G216_R1.1771.00
146_F169_W1.1731.00
61_V76_C1.1711.00
77_R81_L1.1641.00
200_Y209_Q1.1571.00
122_A159_H1.1541.00
199_L229_I1.1471.00
168_A198_G1.1441.00
167_V197_L1.1441.00
61_V144_T1.1421.00
166_A196_I1.1391.00
35_I44_A1.1391.00
32_F43_P1.1351.00
44_A127_V1.1301.00
117_D120_V1.1281.00
213_E228_I1.1281.00
214_T217_Q1.1221.00
129_S133_R1.1201.00
196_I219_L1.1201.00
220_R226_A1.1181.00
225_K265_Y1.1071.00
154_W215_M1.1041.00
198_G212_V1.0901.00
209_Q213_E1.0881.00
89_P127_V1.0831.00
218_A222_A1.0831.00
129_S162_Q1.0781.00
76_C88_A1.0771.00
34_S43_P1.0741.00
169_W258_M1.0711.00
121_L155_L1.0691.00
184_Q187_D1.0681.00
197_L229_I1.0651.00
231_Y234_A1.0641.00
125_D159_H1.0621.00
218_A221_A1.0541.00
129_S160_N1.0431.00
60_I128_A1.0331.00
73_R77_R1.0311.00
126_H129_S1.0211.00
52_S56_L1.0171.00
144_T167_V1.0151.00
261_W265_Y1.0131.00
31_G134_N1.0031.00
199_L231_Y0.9961.00
55_P137_D0.9891.00
165_A261_W0.9881.00
33_T130_W0.9871.00
29_V48_R0.9871.00
125_D156_Y0.9841.00
37_S40_D0.9811.00
252_E256_Q0.9751.00
65_I148_W0.9731.00
63_Q91_L0.9631.00
60_I127_V0.9521.00
259_L263_K0.9501.00
62_V91_L0.9481.00
200_Y230_V0.9471.00
170_Y238_F0.9401.00
139_H164_K0.9321.00
62_V143_I0.9281.00
78_R81_L0.9261.00
61_V86_A0.9191.00
59_V79_L0.9181.00
57_P137_D0.9171.00
200_Y228_I0.9141.00
155_L159_H0.9091.00
115_V118_S0.9061.00
165_A262_F0.9051.00
57_P140_R0.9041.00
76_C80_A0.8991.00
154_W196_I0.8981.00
143_I166_A0.8921.00
52_S55_P0.8921.00
62_V89_P0.8911.00
198_G215_M0.8841.00
124_L152_I0.8771.00
181_S187_D0.8771.00
38_Q92_Y0.8721.00
219_L226_A0.8611.00
43_P90_E0.8611.00
118_S122_A0.8501.00
186_V189_A0.8491.00
166_A194_A0.8471.00
144_T169_W0.8431.00
254_G258_M0.8431.00
78_R255_W0.8311.00
32_F45_Y0.8301.00
197_L261_W0.8251.00
58_V141_L0.8231.00
45_Y69_H0.8191.00
157_A194_A0.8181.00
154_W171_G0.8151.00
199_L254_G0.8131.00
150_G171_G0.8051.00
119_Q122_A0.8041.00
170_Y237_A0.8021.00
67_G151_R0.8021.00
184_Q188_I0.8011.00
195_P225_K0.7991.00
253_D256_Q0.7961.00
47_A86_A0.7951.00
29_V50_K0.7941.00
61_V72_I0.7941.00
202_G209_Q0.7921.00
132_S164_K0.7881.00
195_P265_Y0.7871.00
260_E264_Q0.7871.00
122_A126_H0.7851.00
214_T218_A0.7851.00
41_N98_P0.7831.00
37_S126_H0.7811.00
132_S162_Q0.7721.00
190_T218_A0.7701.00
53_D56_L0.7691.00
51_Q56_L0.7671.00
38_Q122_A0.7641.00
167_V199_L0.7601.00
150_G168_A0.7601.00
132_S135_G0.7581.00
210_E213_E0.7461.00
120_V152_I0.7441.00
187_D190_T0.7411.00
59_V142_M0.7391.00
229_I253_D0.7391.00
137_D164_K0.7361.00
142_M164_K0.7311.00
79_L144_T0.7301.00
200_Y207_I0.7281.00
30_A47_A0.7261.00
47_A80_A0.7251.00
84_Y262_F0.7221.00
82_E256_Q0.7221.00
170_Y201_G0.7221.00
30_A45_Y0.7201.00
143_I163_L0.7181.00
59_V262_F0.7101.00
129_S132_S0.7071.00
158_A192_L0.7071.00
91_L148_W0.7031.00
132_S138_V0.7021.00
170_Y239_N0.7011.00
151_R155_L0.6941.00
100_D103_D0.6891.00
158_A188_I0.6871.00
128_A132_S0.6851.00
80_A86_A0.6841.00
33_T46_H0.6841.00
153_T157_A0.6831.00
60_I163_L0.6821.00
79_L258_M0.6821.00
171_G200_Y0.6801.00
223_N226_A0.6791.00
35_I126_H0.6721.00
69_H90_E0.6701.00
260_E263_K0.6671.00
142_M265_Y0.6661.00
153_T168_A0.6651.00
61_V88_A0.6641.00
78_R259_L0.6641.00
170_Y204_D0.6641.00
190_T222_A0.6631.00
62_V152_I0.6611.00
44_A130_W0.6591.00
63_Q94_R0.6561.00
155_L158_A0.6541.00
84_Y142_M0.6521.00
166_A215_M0.6501.00
180_N183_K0.6491.00
132_S141_L0.6451.00
169_W199_L0.6441.00
62_V153_T0.6371.00
179_L182_P0.6341.00
144_T258_M0.6291.00
78_R252_E0.6291.00
27_A81_L0.6291.00
212_V216_R0.6251.00
183_K186_V0.6231.00
59_V86_A0.6231.00
57_P84_Y0.6221.00
84_Y259_L0.6211.00
65_I91_L0.6191.00
37_S42_M0.6121.00
48_R56_L0.6111.00
217_Q220_R0.6091.00
60_I87_I0.6091.00
80_A85_L0.6081.00
197_L227_E0.6031.00
125_D163_L0.6011.00
251_A254_G0.6011.00
99_N103_D0.5991.00
197_L257_R0.5971.00
185_P188_I0.5961.00
44_A89_P0.5951.00
125_D128_A0.5911.00
212_V228_I0.5881.00
213_E216_R0.5871.00
40_D98_P0.5861.00
51_Q54_G0.5851.00
211_S214_T0.5831.00
94_R97_D0.5831.00
154_W166_A0.5811.00
132_S136_G0.5781.00
169_W254_G0.5741.00
47_A77_R0.5731.00
122_A125_D0.5731.00
37_S122_A0.5721.00
209_Q228_I0.5711.00
196_I224_A0.5711.00
198_G226_A0.5711.00
57_P139_H0.5631.00
118_S159_H0.5621.00
121_L125_D0.5601.00
76_C86_A0.5591.00
164_K195_P0.5561.00
148_W152_I0.5491.00
255_W258_M0.5481.00
189_A192_L0.5481.00
89_P124_L0.5481.00
205_N235_G0.5471.00
196_I215_M0.5441.00
33_T87_I0.5391.00
72_I146_F0.5391.00
43_P97_D0.5381.00
144_T168_A0.5341.00
91_L94_R0.5341.00
47_A73_R0.5331.00
210_E214_T0.5311.00
61_V146_F0.5311.00
121_L152_I0.5301.00
47_A76_C0.5301.00
147_C236_H0.5301.00
63_Q147_C0.5251.00
128_A156_Y0.5241.00
159_H188_I0.5241.00
208_P211_S0.5231.00
227_E230_V0.5231.00
205_N209_Q0.5221.00
58_V142_M0.5211.00
131_A134_N0.5201.00
258_M262_F0.5201.00
45_Y73_R0.5191.00
189_A222_A0.5161.00
166_A171_G0.5131.00
49_P80_A0.5121.00
79_L259_L0.5111.00
181_S184_Q0.5101.00
158_A215_M0.5061.00
144_T262_F0.5041.00
157_A196_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f67A 1 0.8856 100 0.334 Contact Map
1xfdA 2 0.9373 100 0.351 Contact Map
4wjlA 2 0.9336 100 0.351 Contact Map
2ecfA 2 0.9336 100 0.364 Contact Map
2z3zA 2 0.8967 100 0.365 Contact Map
4a5sA 2 0.9483 100 0.366 Contact Map
4q1vA 2 0.9188 100 0.368 Contact Map
4zv9A 1 0.8672 100 0.369 Contact Map
4hxfB 4 0.9557 100 0.371 Contact Map
1z68A 2 0.9299 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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