PRP2 - ECOLI - GREMLIN Contacts

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PRP2 - Serine/threonine-protein phosphatase 2

UniProt:	P55799	Sequences: MPSTRYQKINAHHYRHIWVVGDIHGEYQLLQSRLHQLSFFPKIDLLISVGDNIDRGPESLDVLRLLNQPWFTSVKGNHEAMALEAFETGDGNMWLASGGDWFFDLNDSEQQEAIDLLLKFHHLPHIIEITNDNIKYAIAHADYPGSEYLFGKEIAESELLWPVDRVQKSLNGELQQINGADYFIFGHMMFDNIQTFANQIYIDTGSPNSGRLSFYKIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13102
Length:	218 (187)
Sequences:	4241 (3152)
Seq/√Len:	230.5

ECOLI - PRP2 PRP1 APAH
BACSU - PRPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_E	61_D	5.576	1.00
204_T	213_S	3.425	1.00
31_Q	65_L	2.974	1.00
27_Y	61_D	2.956	1.00
27_Y	31_Q	2.921	1.00
45_L	72_T	2.852	1.00
28_Q	58_E	2.776	1.00
75_K	80_A	2.500	1.00
48_S	66_L	2.431	1.00
27_Y	65_L	2.374	1.00
72_T	127_I	2.370	1.00
19_V	138_I	2.283	1.00
47_I	138_I	2.231	1.00
23_I	62_V	2.213	1.00
49_V	138_I	2.196	1.00
30_L	48_S	2.171	1.00
128_E	181_D	2.079	1.00
87_E	121_H	2.041	1.00
37_L	214_F	1.987	1.00
80_A	84_E	1.986	1.00
33_R	214_F	1.948	1.00
100_D	104_D	1.917	1.00
182_Y	200_I	1.894	1.00
185_F	201_Y	1.888	1.00
67_N	116_L	1.855	1.00
18_W	37_L	1.813	1.00
26_E	207_P	1.788	1.00
64_R	116_L	1.776	1.00
185_F	199_Q	1.739	1.00
184_I	202_I	1.716	1.00
18_W	216_K	1.694	1.00
39_F	44_D	1.656	1.00
26_E	29_L	1.646	1.00
200_I	215_Y	1.640	1.00
23_I	30_L	1.638	1.00
67_N	119_K	1.611	1.00
67_N	115_D	1.531	1.00
52_N	62_V	1.502	1.00
47_I	127_I	1.471	1.00
52_N	73_S	1.470	1.00
19_V	184_I	1.469	1.00
73_S	123_L	1.432	1.00
94_W	99_G	1.428	1.00
129_I	134_I	1.426	1.00
53_I	79_E	1.413	1.00
126_I	137_A	1.408	1.00
34_L	65_L	1.406	1.00
202_I	215_Y	1.399	1.00
30_L	62_V	1.394	1.00
30_L	65_L	1.384	1.00
60_L	64_R	1.362	1.00
52_N	66_L	1.356	1.00
136_Y	182_Y	1.331	1.00
119_K	123_L	1.328	1.00
63_L	120_F	1.326	1.00
48_S	71_F	1.306	1.00
106_N	116_L	1.305	1.00
48_S	73_S	1.302	1.00
29_L	206_S	1.291	1.00
157_S	163_V	1.274	1.00
139_A	183_F	1.273	1.00
49_V	74_V	1.250	1.00
80_A	160_L	1.240	1.00
184_I	215_Y	1.235	1.00
16_H	216_K	1.229	1.00
16_H	44_D	1.217	1.00
144_P	158_E	1.195	1.00
26_E	206_S	1.185	1.00
189_M	207_P	1.165	1.00
19_V	136_Y	1.164	1.00
128_E	137_A	1.162	1.00
75_K	83_L	1.142	1.00
52_N	74_V	1.134	1.00
94_W	98_G	1.130	1.00
45_L	70_W	1.117	1.00
17_I	129_I	1.112	1.00
86_F	117_L	1.103	1.00
124_P	127_I	1.096	1.00
117_L	121_H	1.091	1.00
102_F	106_N	1.073	1.00
17_I	45_L	1.070	1.00
34_L	48_S	1.061	1.00
102_F	105_L	1.054	1.00
54_D	98_G	1.043	1.00
60_L	105_L	1.037	1.00
159_L	163_V	1.035	1.00
75_K	160_L	1.034	1.00
135_K	181_D	1.010	1.00
75_K	123_L	0.994	1.00
46_L	71_F	0.992	1.00
29_L	209_S	0.981	1.00
75_K	156_E	0.980	1.00
32_S	35_H	0.980	1.00
129_I	138_I	0.968	1.00
63_L	116_L	0.967	1.00
21_G	204_T	0.961	1.00
125_H	156_E	0.952	1.00
27_Y	58_E	0.939	1.00
136_Y	184_I	0.938	1.00
160_L	163_V	0.936	1.00
81_M	161_W	0.932	1.00
54_D	78_H	0.932	1.00
79_E	83_L	0.928	1.00
53_I	63_L	0.925	1.00
137_A	183_F	0.920	1.00
64_R	115_D	0.920	1.00
128_E	134_I	0.919	1.00
118_L	122_H	0.917	1.00
81_M	97_S	0.913	1.00
25_G	59_S	0.912	1.00
49_V	202_I	0.911	1.00
21_G	202_I	0.906	0.99
189_M	201_Y	0.901	0.99
93_M	97_S	0.899	0.99
48_S	52_N	0.899	0.99
66_L	73_S	0.896	0.99
27_Y	62_V	0.895	0.99
179_G	198_N	0.895	0.99
142_D	162_P	0.889	0.99
189_M	208_N	0.887	0.99
21_G	48_S	0.887	0.99
66_L	71_F	0.886	0.99
149_L	154_I	0.885	0.99
18_W	39_F	0.877	0.99
158_E	162_P	0.873	0.99
184_I	200_I	0.872	0.99
65_L	68_Q	0.867	0.99
83_L	120_F	0.865	0.99
137_A	181_D	0.846	0.99
157_S	160_L	0.846	0.99
98_G	102_F	0.845	0.99
41_P	44_D	0.844	0.99
83_L	121_H	0.839	0.99
149_L	152_K	0.835	0.99
164_D	173_E	0.823	0.99
21_G	213_S	0.819	0.99
17_I	138_I	0.817	0.99
23_I	48_S	0.816	0.99
136_Y	200_I	0.807	0.99
144_P	147_E	0.802	0.99
163_V	188_M	0.790	0.99
177_I	180_A	0.784	0.99
73_S	124_P	0.780	0.98
53_I	82_A	0.778	0.98
32_S	36_Q	0.776	0.98
190_F	201_Y	0.775	0.98
193_I	213_S	0.772	0.98
73_S	119_K	0.770	0.98
64_R	105_L	0.769	0.98
158_E	161_W	0.767	0.98
134_I	181_D	0.767	0.98
129_I	136_Y	0.765	0.98
23_I	66_L	0.762	0.98
125_H	160_L	0.760	0.98
205_G	208_N	0.759	0.98
192_N	211_R	0.754	0.98
101_W	105_L	0.753	0.98
40_F	43_I	0.748	0.98
72_T	129_I	0.746	0.98
190_F	193_I	0.742	0.98
189_M	205_G	0.742	0.98
64_R	67_N	0.741	0.98
47_I	72_T	0.741	0.98
157_S	161_W	0.738	0.98
24_H	207_P	0.737	0.98
75_K	125_H	0.733	0.98
31_Q	35_H	0.728	0.98
61_D	64_R	0.727	0.98
63_L	67_N	0.726	0.98
120_F	123_L	0.724	0.98
182_Y	198_N	0.723	0.98
111_Q	114_I	0.721	0.97
94_W	97_S	0.717	0.97
47_I	129_I	0.714	0.97
31_Q	61_D	0.712	0.97
18_W	214_F	0.710	0.97
158_E	163_V	0.710	0.97
114_I	118_L	0.709	0.97
99_G	102_F	0.700	0.97
34_L	39_F	0.698	0.97
17_I	47_I	0.697	0.97
164_D	167_Q	0.696	0.97
18_W	44_D	0.696	0.97
39_F	46_L	0.696	0.97
195_T	200_I	0.693	0.97
206_S	212_L	0.689	0.97
34_L	46_L	0.687	0.97
72_T	123_L	0.679	0.96
95_L	99_G	0.677	0.96
74_V	138_I	0.673	0.96
45_L	69_P	0.673	0.96
92_N	95_L	0.670	0.96
51_D	78_H	0.662	0.96
62_V	65_L	0.654	0.96
129_I	135_K	0.654	0.96
72_T	124_P	0.653	0.96
94_W	102_F	0.650	0.95
127_I	138_I	0.648	0.95
59_S	102_F	0.646	0.95
20_V	48_S	0.642	0.95
18_W	40_F	0.641	0.95
82_A	120_F	0.637	0.95
82_A	94_W	0.636	0.95
35_H	121_H	0.635	0.95
159_L	162_P	0.634	0.95
79_E	120_F	0.633	0.95
20_V	214_F	0.632	0.95
104_D	108_S	0.627	0.94
207_P	210_G	0.614	0.94
33_R	37_L	0.611	0.94
19_V	49_V	0.609	0.94
152_K	156_E	0.608	0.93
156_E	160_L	0.608	0.93
74_V	127_I	0.606	0.93
51_D	77_N	0.600	0.93
20_V	33_R	0.590	0.92
64_R	68_Q	0.589	0.92
116_L	119_K	0.587	0.92
142_D	183_F	0.587	0.92
115_D	118_L	0.585	0.92
40_F	44_D	0.580	0.92
190_F	194_Q	0.580	0.92
24_H	49_V	0.577	0.92
95_L	98_G	0.577	0.92
162_P	166_V	0.574	0.91
61_D	65_L	0.569	0.91
65_L	71_F	0.569	0.91
45_L	129_I	0.567	0.91
93_M	96_A	0.567	0.91
20_V	46_L	0.565	0.91
98_G	101_W	0.565	0.91
174_L	179_G	0.564	0.91
53_I	59_S	0.563	0.91
82_A	102_F	0.562	0.91
37_L	44_D	0.562	0.91
44_D	216_K	0.562	0.91
143_Y	179_G	0.561	0.90
29_L	32_S	0.553	0.90
20_V	212_L	0.553	0.90
152_K	155_A	0.550	0.90
147_E	154_I	0.550	0.90
28_Q	32_S	0.549	0.90
79_E	99_G	0.548	0.89
48_S	214_F	0.546	0.89
177_I	181_D	0.545	0.89
185_F	190_F	0.544	0.89
101_W	104_D	0.543	0.89
63_L	106_N	0.543	0.89
162_P	167_Q	0.540	0.89
143_Y	159_L	0.540	0.89
54_D	188_M	0.539	0.89
72_T	75_K	0.539	0.89
190_F	205_G	0.539	0.89
20_V	30_L	0.535	0.88
104_D	107_D	0.532	0.88
195_T	215_Y	0.528	0.88
52_N	123_L	0.527	0.88
76_G	79_E	0.526	0.87
30_L	71_F	0.522	0.87
126_I	159_L	0.519	0.87
19_V	200_I	0.519	0.87
98_G	103_F	0.517	0.87
157_S	162_P	0.516	0.86
59_S	62_V	0.515	0.86
126_I	143_Y	0.515	0.86
83_L	87_E	0.514	0.86
194_Q	197_A	0.513	0.86
60_L	116_L	0.513	0.86
93_M	99_G	0.510	0.86
105_L	108_S	0.509	0.86
137_A	143_Y	0.509	0.86
82_A	117_L	0.509	0.86
145_G	149_L	0.509	0.86
83_L	117_L	0.507	0.85
176_Q	198_N	0.505	0.85
206_S	209_S	0.503	0.85
38_S	69_P	0.502	0.85
35_H	115_D	0.501	0.85
81_M	84_E	0.501	0.85
26_E	57_P	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qjcA	1	0.8945	100	0.375	Contact Map
2dfjA	2	0.8945	100	0.398	Contact Map
4j6oA	1	0.9679	100	0.42	Contact Map
1g5bA	4	0.9908	100	0.43	Contact Map
2z72A	1	0.9771	100	0.459	Contact Map
3icfA	2	0.9358	100	0.524	Contact Map
4i5lC	1	0.9358	100	0.534	Contact Map
3h63A	1	0.9266	100	0.542	Contact Map
4il1A	1	0.9312	100	0.544	Contact Map
1fjmA	1	0.9312	100	0.547	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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