GREMLIN Database
PRP2 - Serine/threonine-protein phosphatase 2
UniProt: P55799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13102
Length: 218 (187)
Sequences: 4241 (3152)
Seq/√Len: 230.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_E61_D5.5761.00
204_T213_S3.4251.00
31_Q65_L2.9741.00
27_Y61_D2.9561.00
27_Y31_Q2.9211.00
45_L72_T2.8521.00
28_Q58_E2.7761.00
75_K80_A2.5001.00
48_S66_L2.4311.00
27_Y65_L2.3741.00
72_T127_I2.3701.00
19_V138_I2.2831.00
47_I138_I2.2311.00
23_I62_V2.2131.00
49_V138_I2.1961.00
30_L48_S2.1711.00
128_E181_D2.0791.00
87_E121_H2.0411.00
37_L214_F1.9871.00
80_A84_E1.9861.00
33_R214_F1.9481.00
100_D104_D1.9171.00
182_Y200_I1.8941.00
185_F201_Y1.8881.00
67_N116_L1.8551.00
18_W37_L1.8131.00
26_E207_P1.7881.00
64_R116_L1.7761.00
185_F199_Q1.7391.00
184_I202_I1.7161.00
18_W216_K1.6941.00
39_F44_D1.6561.00
26_E29_L1.6461.00
200_I215_Y1.6401.00
23_I30_L1.6381.00
67_N119_K1.6111.00
67_N115_D1.5311.00
52_N62_V1.5021.00
47_I127_I1.4711.00
52_N73_S1.4701.00
19_V184_I1.4691.00
73_S123_L1.4321.00
94_W99_G1.4281.00
129_I134_I1.4261.00
53_I79_E1.4131.00
126_I137_A1.4081.00
34_L65_L1.4061.00
202_I215_Y1.3991.00
30_L62_V1.3941.00
30_L65_L1.3841.00
60_L64_R1.3621.00
52_N66_L1.3561.00
136_Y182_Y1.3311.00
119_K123_L1.3281.00
63_L120_F1.3261.00
48_S71_F1.3061.00
106_N116_L1.3051.00
48_S73_S1.3021.00
29_L206_S1.2911.00
157_S163_V1.2741.00
139_A183_F1.2731.00
49_V74_V1.2501.00
80_A160_L1.2401.00
184_I215_Y1.2351.00
16_H216_K1.2291.00
16_H44_D1.2171.00
144_P158_E1.1951.00
26_E206_S1.1851.00
189_M207_P1.1651.00
19_V136_Y1.1641.00
128_E137_A1.1621.00
75_K83_L1.1421.00
52_N74_V1.1341.00
94_W98_G1.1301.00
45_L70_W1.1171.00
17_I129_I1.1121.00
86_F117_L1.1031.00
124_P127_I1.0961.00
117_L121_H1.0911.00
102_F106_N1.0731.00
17_I45_L1.0701.00
34_L48_S1.0611.00
102_F105_L1.0541.00
54_D98_G1.0431.00
60_L105_L1.0371.00
159_L163_V1.0351.00
75_K160_L1.0341.00
135_K181_D1.0101.00
75_K123_L0.9941.00
46_L71_F0.9921.00
29_L209_S0.9811.00
75_K156_E0.9801.00
32_S35_H0.9801.00
129_I138_I0.9681.00
63_L116_L0.9671.00
21_G204_T0.9611.00
125_H156_E0.9521.00
27_Y58_E0.9391.00
136_Y184_I0.9381.00
160_L163_V0.9361.00
81_M161_W0.9321.00
54_D78_H0.9321.00
79_E83_L0.9281.00
53_I63_L0.9251.00
137_A183_F0.9201.00
64_R115_D0.9201.00
128_E134_I0.9191.00
118_L122_H0.9171.00
81_M97_S0.9131.00
25_G59_S0.9121.00
49_V202_I0.9111.00
21_G202_I0.9060.99
189_M201_Y0.9010.99
93_M97_S0.8990.99
48_S52_N0.8990.99
66_L73_S0.8960.99
27_Y62_V0.8950.99
179_G198_N0.8950.99
142_D162_P0.8890.99
189_M208_N0.8870.99
21_G48_S0.8870.99
66_L71_F0.8860.99
149_L154_I0.8850.99
18_W39_F0.8770.99
158_E162_P0.8730.99
184_I200_I0.8720.99
65_L68_Q0.8670.99
83_L120_F0.8650.99
137_A181_D0.8460.99
157_S160_L0.8460.99
98_G102_F0.8450.99
41_P44_D0.8440.99
83_L121_H0.8390.99
149_L152_K0.8350.99
164_D173_E0.8230.99
21_G213_S0.8190.99
17_I138_I0.8170.99
23_I48_S0.8160.99
136_Y200_I0.8070.99
144_P147_E0.8020.99
163_V188_M0.7900.99
177_I180_A0.7840.99
73_S124_P0.7800.98
53_I82_A0.7780.98
32_S36_Q0.7760.98
190_F201_Y0.7750.98
193_I213_S0.7720.98
73_S119_K0.7700.98
64_R105_L0.7690.98
158_E161_W0.7670.98
134_I181_D0.7670.98
129_I136_Y0.7650.98
23_I66_L0.7620.98
125_H160_L0.7600.98
205_G208_N0.7590.98
192_N211_R0.7540.98
101_W105_L0.7530.98
40_F43_I0.7480.98
72_T129_I0.7460.98
190_F193_I0.7420.98
189_M205_G0.7420.98
64_R67_N0.7410.98
47_I72_T0.7410.98
157_S161_W0.7380.98
24_H207_P0.7370.98
75_K125_H0.7330.98
31_Q35_H0.7280.98
61_D64_R0.7270.98
63_L67_N0.7260.98
120_F123_L0.7240.98
182_Y198_N0.7230.98
111_Q114_I0.7210.97
94_W97_S0.7170.97
47_I129_I0.7140.97
31_Q61_D0.7120.97
18_W214_F0.7100.97
158_E163_V0.7100.97
114_I118_L0.7090.97
99_G102_F0.7000.97
34_L39_F0.6980.97
17_I47_I0.6970.97
164_D167_Q0.6960.97
18_W44_D0.6960.97
39_F46_L0.6960.97
195_T200_I0.6930.97
206_S212_L0.6890.97
34_L46_L0.6870.97
72_T123_L0.6790.96
95_L99_G0.6770.96
74_V138_I0.6730.96
45_L69_P0.6730.96
92_N95_L0.6700.96
51_D78_H0.6620.96
62_V65_L0.6540.96
129_I135_K0.6540.96
72_T124_P0.6530.96
94_W102_F0.6500.95
127_I138_I0.6480.95
59_S102_F0.6460.95
20_V48_S0.6420.95
18_W40_F0.6410.95
82_A120_F0.6370.95
82_A94_W0.6360.95
35_H121_H0.6350.95
159_L162_P0.6340.95
79_E120_F0.6330.95
20_V214_F0.6320.95
104_D108_S0.6270.94
207_P210_G0.6140.94
33_R37_L0.6110.94
19_V49_V0.6090.94
152_K156_E0.6080.93
156_E160_L0.6080.93
74_V127_I0.6060.93
51_D77_N0.6000.93
20_V33_R0.5900.92
64_R68_Q0.5890.92
116_L119_K0.5870.92
142_D183_F0.5870.92
115_D118_L0.5850.92
40_F44_D0.5800.92
190_F194_Q0.5800.92
24_H49_V0.5770.92
95_L98_G0.5770.92
162_P166_V0.5740.91
61_D65_L0.5690.91
65_L71_F0.5690.91
45_L129_I0.5670.91
93_M96_A0.5670.91
20_V46_L0.5650.91
98_G101_W0.5650.91
174_L179_G0.5640.91
53_I59_S0.5630.91
82_A102_F0.5620.91
37_L44_D0.5620.91
44_D216_K0.5620.91
143_Y179_G0.5610.90
29_L32_S0.5530.90
20_V212_L0.5530.90
152_K155_A0.5500.90
147_E154_I0.5500.90
28_Q32_S0.5490.90
79_E99_G0.5480.89
48_S214_F0.5460.89
177_I181_D0.5450.89
185_F190_F0.5440.89
101_W104_D0.5430.89
63_L106_N0.5430.89
162_P167_Q0.5400.89
143_Y159_L0.5400.89
54_D188_M0.5390.89
72_T75_K0.5390.89
190_F205_G0.5390.89
20_V30_L0.5350.88
104_D107_D0.5320.88
195_T215_Y0.5280.88
52_N123_L0.5270.88
76_G79_E0.5260.87
30_L71_F0.5220.87
126_I159_L0.5190.87
19_V200_I0.5190.87
98_G103_F0.5170.87
157_S162_P0.5160.86
59_S62_V0.5150.86
126_I143_Y0.5150.86
83_L87_E0.5140.86
194_Q197_A0.5130.86
60_L116_L0.5130.86
93_M99_G0.5100.86
105_L108_S0.5090.86
137_A143_Y0.5090.86
82_A117_L0.5090.86
145_G149_L0.5090.86
83_L117_L0.5070.85
176_Q198_N0.5050.85
206_S209_S0.5030.85
38_S69_P0.5020.85
35_H115_D0.5010.85
81_M84_E0.5010.85
26_E57_P0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjcA 1 0.8945 100 0.375 Contact Map
2dfjA 2 0.8945 100 0.398 Contact Map
4j6oA 1 0.9679 100 0.42 Contact Map
1g5bA 4 0.9908 100 0.43 Contact Map
2z72A 1 0.9771 100 0.459 Contact Map
3icfA 2 0.9358 100 0.524 Contact Map
4i5lC 1 0.9358 100 0.534 Contact Map
3h63A 1 0.9266 100 0.542 Contact Map
4il1A 1 0.9312 100 0.544 Contact Map
1fjmA 1 0.9312 100 0.547 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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