GREMLIN Database
PRP1 - Serine/threonine-protein phosphatase 1
UniProt: P55798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14026
Length: 218 (192)
Sequences: 4225 (3183)
Seq/√Len: 229.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_Q63_R5.8181.00
204_T213_T3.5341.00
33_R67_L3.0501.00
29_L63_R3.0041.00
29_L33_R2.9781.00
30_E60_Q2.9721.00
47_L74_C2.8551.00
50_S68_L2.5761.00
77_R82_Q2.4931.00
74_C129_L2.4731.00
29_L67_L2.4251.00
21_L140_I2.3621.00
49_I140_I2.2831.00
25_I64_C2.2731.00
32_L50_S2.2301.00
51_V140_I2.1811.00
130_E181_D2.1361.00
39_C214_L2.1241.00
89_A123_Q2.1091.00
69_E118_A2.0141.00
35_K214_L1.9361.00
102_D106_A1.9341.00
82_Q86_D1.9321.00
182_H200_H1.8971.00
20_W39_C1.8851.00
185_F201_Y1.8821.00
66_Q118_A1.8311.00
69_E121_K1.8231.00
28_C207_V1.8161.00
25_I32_L1.7791.00
185_F199_L1.7751.00
184_W202_I1.7411.00
41_F46_D1.7001.00
200_H215_V1.6851.00
28_C31_Q1.6811.00
20_W216_Q1.6531.00
54_V64_C1.6391.00
116_K120_E1.6321.00
49_I129_L1.6141.00
69_E117_T1.6111.00
128_I139_V1.5311.00
21_L184_W1.4941.00
202_I215_V1.4901.00
32_L67_L1.4861.00
54_V75_A1.4691.00
55_I81_E1.4651.00
75_A125_L1.4311.00
36_L67_L1.4241.00
54_V68_L1.4171.00
138_H182_H1.3621.00
32_L64_C1.3601.00
65_L122_C1.3371.00
141_A183_F1.3231.00
50_S73_V1.3191.00
62_L66_Q1.3171.00
121_K125_L1.3111.00
18_H46_D1.3071.00
50_S75_A1.2761.00
31_Q206_A1.2741.00
56_D100_G1.2611.00
184_W215_V1.2581.00
51_V76_V1.2561.00
164_S168_L1.2391.00
82_Q162_L1.2271.00
189_P207_V1.2151.00
18_H216_Q1.1971.00
77_R162_L1.1841.00
62_L107_L1.1651.00
28_C206_A1.1621.00
21_L138_H1.1601.00
96_W101_G1.1481.00
130_E139_V1.1301.00
126_P129_L1.1211.00
88_L119_L1.1201.00
54_V76_V1.1121.00
158_L173_K1.1121.00
19_I47_L1.1111.00
77_R85_M1.1011.00
161_V165_R1.0821.00
47_L72_W1.0811.00
150_Y155_D1.0641.00
36_L50_S1.0601.00
119_L123_Q1.0541.00
65_L118_A1.0531.00
165_R188_T1.0401.00
190_L193_R1.0301.00
77_R125_L1.0291.00
83_M99_N1.0291.00
48_L73_V1.0181.00
23_G204_T0.9841.00
77_R158_L0.9841.00
139_V183_F0.9711.00
137_K181_D0.9691.00
29_L60_Q0.9621.00
81_E85_M0.9601.00
34_R37_W0.9581.00
164_S167_R0.9561.00
146_P160_Q0.9541.00
31_Q209_G0.9541.00
68_L73_V0.9511.00
56_D80_H0.9481.00
51_V202_I0.9451.00
130_E136_G0.9371.00
85_M122_C0.9341.00
23_G50_S0.9291.00
55_I65_L0.9291.00
66_Q69_E0.9261.00
19_I140_I0.9231.00
120_E124_H0.9201.00
96_W100_G0.9171.00
205_G208_F0.9161.00
189_P208_F0.9131.00
50_S54_V0.9111.00
23_G202_I0.9010.99
68_L75_A0.9000.99
138_H184_W0.8990.99
67_L70_Q0.8950.99
95_L99_N0.8950.99
66_Q117_T0.8920.99
25_I50_S0.8920.99
29_L64_C0.8880.99
184_W200_H0.8820.99
20_W41_F0.8810.99
84_A96_W0.8740.99
34_R38_H0.8680.99
166_S169_G0.8650.99
136_G181_D0.8490.99
23_G213_T0.8460.99
146_P149_V0.8440.99
160_Q164_S0.8410.99
163_W168_L0.8400.99
83_M163_W0.8330.99
164_S169_G0.8220.99
165_R168_L0.8150.99
138_H200_H0.8100.99
103_W107_L0.8090.99
55_I84_A0.8080.99
63_R66_Q0.8060.99
192_H211_E0.8050.99
41_F48_L0.7990.99
85_M123_Q0.7980.99
167_R170_E0.7960.99
159_H162_L0.7950.99
101_G104_F0.7890.99
177_I180_A0.7870.99
189_P201_Y0.7850.99
154_K157_D0.7780.98
66_Q107_L0.7750.98
42_D45_R0.7740.98
163_W167_R0.7730.98
65_L69_E0.7680.98
190_L201_Y0.7680.98
96_W99_N0.7620.98
26_H207_V0.7600.98
20_W46_D0.7600.98
27_G61_S0.7600.98
166_S170_E0.7590.98
43_P46_D0.7530.98
49_I74_C0.7490.98
33_R37_W0.7440.98
104_F107_L0.7440.98
144_D164_S0.7420.98
179_G198_N0.7400.98
160_Q165_R0.7380.98
97_L100_G0.7380.98
139_V181_D0.7350.98
25_I68_L0.7340.98
75_A121_K0.7330.98
160_Q163_W0.7320.98
33_R63_R0.7320.98
20_W214_L0.7300.98
207_V210_G0.7270.98
36_L48_L0.7250.98
127_F162_L0.7240.98
75_A126_P0.7230.98
182_H198_N0.7110.97
165_R173_K0.7090.97
149_V156_V0.7080.97
195_D200_H0.7070.97
20_W42_D0.7020.97
189_P205_G0.7010.97
193_R213_T0.6990.97
153_Q156_V0.6900.97
164_S170_E0.6870.97
115_A118_A0.6860.97
206_A212_L0.6820.96
158_L162_L0.6730.96
129_L140_I0.6690.96
66_Q109_D0.6670.96
22_S214_L0.6660.96
77_R127_F0.6640.96
19_I49_I0.6630.96
37_W123_Q0.6610.96
53_D80_H0.6590.96
47_L71_H0.6590.96
39_C46_D0.6560.96
160_Q167_R0.6520.95
100_G104_F0.6470.95
76_V140_I0.6440.95
74_C125_L0.6420.95
163_W169_G0.6400.95
122_C125_L0.6390.95
26_H51_V0.6370.95
128_I145_Y0.6350.95
47_L135_T0.6340.95
22_S50_S0.6310.95
74_C126_P0.6260.94
163_W166_S0.6250.94
161_V164_S0.6230.94
36_L41_F0.6230.94
194_V197_G0.6210.94
66_Q114_Q0.6210.94
19_I135_T0.6200.94
84_A122_C0.6180.94
90_S93_M0.6170.94
32_L68_L0.6150.94
22_S35_K0.6140.94
21_L51_V0.6130.94
159_H163_W0.6050.93
53_D79_N0.6020.93
57_R163_W0.6020.93
174_G179_G0.5980.93
30_E34_R0.5980.93
32_L73_V0.5970.93
164_S171_R0.5950.93
61_S104_F0.5910.92
63_R67_L0.5870.92
109_D112_Q0.5870.92
66_Q70_Q0.5850.92
157_D160_Q0.5820.92
91_Q95_L0.5730.91
162_L168_L0.5700.91
31_Q34_R0.5690.91
84_A104_F0.5680.91
118_A122_C0.5650.91
35_K39_C0.5650.91
127_F158_L0.5640.91
46_D216_Q0.5640.91
135_T140_I0.5630.91
110_N114_Q0.5600.90
64_C67_L0.5600.90
81_E122_C0.5590.90
56_D104_F0.5580.90
37_W117_T0.5570.90
54_V125_L0.5570.90
144_D183_F0.5560.90
177_I181_D0.5550.90
50_S214_L0.5550.90
85_M119_L0.5530.90
67_L73_V0.5520.90
22_S48_L0.5450.89
168_L172_Q0.5390.89
193_R204_T0.5380.88
150_Y156_V0.5360.88
108_A111_Q0.5360.88
84_A114_Q0.5360.88
185_F190_L0.5340.88
21_L200_H0.5330.88
185_F194_V0.5320.88
55_I61_S0.5320.88
69_E73_V0.5320.88
76_V129_L0.5300.88
99_N105_I0.5290.88
192_H204_T0.5260.87
42_D46_D0.5260.87
40_R71_H0.5240.87
56_D188_T0.5230.87
167_R171_R0.5230.87
194_V199_L0.5220.87
28_C59_P0.5220.87
160_Q169_G0.5200.87
57_R80_H0.5200.87
206_A209_G0.5180.87
62_L118_A0.5150.86
130_E135_T0.5150.86
56_D189_P0.5140.86
169_G172_Q0.5130.86
165_R170_E0.5120.86
21_L215_V0.5120.86
22_S32_L0.5110.86
37_W40_R0.5110.86
167_R172_Q0.5090.86
83_M86_D0.5050.85
111_Q114_Q0.5050.85
117_T120_E0.5050.85
27_G57_R0.5030.85
28_C58_G0.5000.85
98_M102_D0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjcA 1 0.8761 100 0.363 Contact Map
2dfjA 2 0.8761 100 0.392 Contact Map
4j6oA 1 0.9358 100 0.412 Contact Map
1g5bA 4 0.9817 100 0.434 Contact Map
2z72A 1 0.9679 100 0.458 Contact Map
3icfA 2 0.9266 100 0.52 Contact Map
3h63A 1 0.9358 100 0.538 Contact Map
4i5lC 1 0.9266 100 0.544 Contact Map
4il1A 1 0.9312 100 0.552 Contact Map
1fjmA 1 0.9312 100 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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