GREMLIN Database
YGCG - UPF0603 protein YgcG
UniProt: P55140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13035
Length: 290 (252)
Sequences: 2135 (1926)
Seq/√Len: 121.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_K141_K5.6381.00
80_F281_S5.1821.00
134_F142_G4.3321.00
47_K148_N3.8171.00
33_T63_I3.7561.00
123_G127_R3.6241.00
96_I130_M3.5531.00
40_E140_A3.4561.00
34_S41_K3.3081.00
47_K144_E2.9031.00
37_N40_E2.8021.00
62_L79_V2.7861.00
117_V122_A2.7231.00
106_R287_S2.6901.00
94_I117_V2.4891.00
118_T122_A2.4111.00
80_F95_L2.3661.00
85_L95_L2.3551.00
133_A145_L2.2951.00
73_E106_R2.2271.00
118_T121_L2.2161.00
130_M146_A2.2161.00
133_A138_K2.1321.00
94_I150_L2.1261.00
54_N155_T2.1241.00
35_S100_W2.0831.00
109_V113_L2.0781.00
37_N140_A2.0171.00
48_L147_I1.9711.00
76_A97_V1.9521.00
51_I151_N1.9521.00
111_Y282_G1.8961.00
99_A102_D1.8941.00
60_A85_L1.8911.00
105_V131_I1.8841.00
117_V153_Q1.8761.00
126_I288_G1.7891.00
28_Q52_F1.7411.00
96_I143_L1.7141.00
98_V143_L1.6881.00
22_V79_V1.6121.00
72_I106_R1.6051.00
77_T108_Q1.5761.00
71_T74_Q1.5721.00
50_S54_N1.5601.00
105_V126_I1.5551.00
23_P83_W1.5451.00
43_E144_E1.5411.00
70_E78_R1.5391.00
87_D90_R1.5321.00
16_A19_P1.5171.00
133_A141_K1.5021.00
35_S63_I1.4861.00
129_N149_A1.4751.00
67_T102_D1.4721.00
72_I97_V1.4691.00
122_A286_A1.4491.00
77_T80_F1.4311.00
264_G267_G1.4181.00
28_Q49_E1.4121.00
56_Q92_D1.4051.00
109_V119_D1.3891.00
105_V130_M1.3881.00
72_I287_S1.3861.00
117_V150_L1.3631.00
87_D92_D1.3551.00
61_V143_L1.3411.00
44_L140_A1.3311.00
116_K157_Q1.3181.00
141_K145_L1.3071.00
188_F192_W1.3031.00
51_I59_I1.2941.00
115_E157_Q1.2911.00
84_R276_G1.2841.00
63_I67_T1.2771.00
264_G269_S1.2701.00
107_I150_L1.2701.00
73_E108_Q1.2631.00
133_A136_Q1.2611.00
126_I130_M1.2520.99
58_Q87_D1.2430.99
131_I135_K1.2400.99
27_Q45_T1.2400.99
77_T281_S1.2320.99
182_W186_V1.2090.99
179_A183_V1.1990.99
190_P194_F1.1980.99
67_T99_A1.1880.99
247_C250_Q1.1860.99
111_Y114_E1.1700.99
100_W139_L1.1550.99
187_M194_F1.1480.99
51_I57_V1.1370.99
181_F185_A1.1330.99
114_E282_G1.1330.99
121_L153_Q1.1190.99
73_E287_S1.1160.99
77_T81_D1.1140.99
67_T72_I1.1040.99
78_R82_N1.0960.99
36_L143_L1.0760.98
108_Q287_S1.0740.98
74_Q77_T1.0670.98
140_A144_E1.0520.98
187_M191_F1.0360.98
81_D91_N1.0210.98
75_Y97_V1.0210.98
267_G270_D1.0110.98
271_S277_G0.9990.97
144_E148_N0.9990.97
269_S272_G0.9900.97
29_V44_L0.9900.97
191_F195_H0.9880.97
259_H263_S0.9860.97
22_V70_E0.9800.97
96_I105_V0.9790.97
265_S268_G0.9790.97
262_N265_S0.9750.97
44_L47_K0.9690.97
227_S231_F0.9580.97
266_A271_S0.9580.97
153_Q156_S0.9560.97
41_K45_T0.9530.97
79_V83_W0.9530.97
74_Q78_R0.9500.97
49_E52_F0.9500.97
194_F198_S0.9470.96
271_S275_S0.9450.96
30_T60_A0.9340.96
177_Y181_F0.9320.96
40_E43_E0.9310.96
107_I125_I0.9190.96
258_Y262_N0.9190.96
254_S258_Y0.9180.96
42_K46_H0.9140.96
86_G93_G0.9100.96
183_V186_V0.9070.95
59_I150_L0.9060.95
36_L63_I0.9040.95
25_L52_F0.9000.95
63_I143_L0.8970.95
66_T69_D0.8950.95
40_E44_L0.8930.95
64_V99_A0.8920.95
45_T49_E0.8860.95
33_T100_W0.8860.95
47_K151_N0.8820.95
109_V114_E0.8820.95
10_F13_S0.8810.95
32_L63_I0.8810.95
66_T99_A0.8650.94
145_L148_N0.8600.94
36_L40_E0.8570.94
49_E53_N0.8510.94
195_H199_N0.8510.94
40_E144_E0.8480.94
255_G258_Y0.8450.93
91_N112_G0.8370.93
228_I231_F0.8330.93
77_T95_L0.8280.93
176_Y180_I0.8210.92
25_L28_Q0.8190.92
38_S42_K0.8180.92
265_S270_D0.8130.92
250_Q254_S0.8120.92
272_G275_S0.8090.92
96_I146_A0.8050.92
107_I126_I0.8040.92
131_I146_A0.8030.92
194_F197_G0.8020.92
114_E119_D0.8010.91
17_A20_T0.8000.91
264_G268_G0.8000.91
266_A270_D0.7990.91
261_D266_A0.7990.91
191_F194_F0.7960.91
154_L157_Q0.7930.91
33_T67_T0.7900.91
266_A269_S0.7890.91
36_L140_A0.7880.91
76_A108_Q0.7880.91
261_D265_S0.7880.91
125_I146_A0.7840.91
25_L83_W0.7810.90
46_H50_S0.7780.90
267_G273_G0.7760.90
263_S266_A0.7730.90
40_E138_K0.7630.89
256_R259_H0.7630.89
67_T75_Y0.7600.89
92_D158_H0.7590.89
59_I151_N0.7530.89
94_I113_L0.7510.89
124_D128_S0.7510.89
180_I184_F0.7500.89
263_S267_G0.7490.89
125_I150_L0.7440.88
35_S98_V0.7420.88
192_W196_Q0.7420.88
275_S280_S0.7400.88
267_G272_G0.7390.88
110_G114_E0.7380.88
261_D264_G0.7380.88
257_S260_S0.7310.87
122_A287_S0.7300.87
210_I213_I0.7300.87
178_F182_W0.7300.87
258_Y261_D0.7290.87
258_Y263_S0.7280.87
44_L61_V0.7270.87
259_H264_G0.7150.86
127_R131_I0.7150.86
76_A281_S0.7130.86
59_I94_I0.7080.86
50_S53_N0.7060.85
120_A124_D0.7050.85
113_L154_L0.6990.85
278_G286_A0.6980.85
99_A103_R0.6970.85
25_L30_T0.6930.84
76_A80_F0.6920.84
264_G270_D0.6910.84
40_E143_L0.6900.84
94_I97_V0.6890.84
127_R288_G0.6880.84
254_S257_S0.6850.84
56_Q87_D0.6830.83
179_A185_A0.6820.83
171_S174_D0.6820.83
126_I131_I0.6820.83
189_F193_F0.6820.83
63_I100_W0.6800.83
157_Q160_Y0.6790.83
117_V146_A0.6790.83
78_R81_D0.6770.83
105_V146_A0.6760.83
105_V142_G0.6760.83
247_C251_K0.6750.83
104_T131_I0.6750.83
77_T106_R0.6740.83
22_V75_Y0.6710.82
134_F139_L0.6680.82
80_F280_S0.6660.82
55_T154_L0.6650.82
43_E47_K0.6600.81
109_V118_T0.6600.81
95_L108_Q0.6600.81
63_I139_L0.6600.81
149_A152_N0.6590.81
28_Q48_L0.6570.81
124_D157_Q0.6550.81
175_H179_A0.6530.81
98_V134_F0.6510.80
178_F196_Q0.6500.80
269_S274_F0.6470.80
72_I76_A0.6400.79
38_S41_K0.6400.79
272_G277_G0.6400.79
6_L13_S0.6400.79
200_F204_C0.6370.79
65_P101_S0.6350.79
278_G284_G0.6310.78
72_I99_A0.6300.78
254_S259_H0.6290.78
44_L144_E0.6280.78
253_A257_S0.6280.78
73_E77_T0.6270.78
108_Q281_S0.6230.78
146_A149_A0.6200.77
51_I154_L0.6180.77
56_Q90_R0.6170.77
182_W185_A0.6160.77
80_F110_G0.6160.77
77_T109_V0.6150.77
268_G273_G0.6140.76
59_I147_I0.6130.76
12_C19_P0.6120.76
186_V190_P0.6090.76
56_Q156_S0.6080.76
85_L276_G0.6080.76
80_F85_L0.6020.75
69_D102_D0.5970.74
29_V45_T0.5940.74
22_V78_R0.5920.74
44_L147_I0.5910.74
29_V48_L0.5900.74
122_A126_I0.5890.74
176_Y209_C0.5880.73
197_G202_R0.5860.73
133_A146_A0.5840.73
30_T79_V0.5830.73
26_Q30_T0.5820.73
272_G276_G0.5810.72
63_I98_V0.5800.72
126_I286_A0.5800.72
148_N151_N0.5790.72
108_Q122_A0.5770.72
270_D273_G0.5760.72
98_V131_I0.5750.72
52_F58_Q0.5750.72
36_L41_K0.5740.72
67_T104_T0.5740.72
260_S265_S0.5730.71
125_I149_A0.5720.71
13_S18_Q0.5710.71
207_G214_Y0.5680.71
60_A63_I0.5660.71
197_G201_C0.5640.70
207_G212_A0.5640.70
14_F17_A0.5620.70
209_C212_A0.5580.69
273_G276_G0.5570.69
21_I24_Q0.5540.69
251_K255_G0.5520.69
135_K146_A0.5520.69
209_C213_I0.5520.69
98_V130_M0.5510.69
126_I146_A0.5500.68
201_C207_G0.5480.68
190_P193_F0.5480.68
17_A41_K0.5460.68
22_V62_L0.5450.68
52_F87_D0.5430.67
177_Y182_W0.5430.67
46_H49_E0.5420.67
173_S177_Y0.5420.67
260_S264_G0.5410.67
261_D271_S0.5390.67
54_N128_S0.5380.67
189_F194_F0.5370.67
198_S201_C0.5340.66
28_Q58_Q0.5340.66
187_M195_H0.5330.66
207_G213_I0.5330.66
95_L281_S0.5320.66
205_K208_V0.5310.66
109_V282_G0.5300.66
65_P100_W0.5280.65
129_N145_L0.5280.65
35_S139_L0.5280.65
117_V154_L0.5270.65
13_S16_A0.5260.65
111_Y120_A0.5250.65
54_N159_Q0.5250.65
193_F196_Q0.5250.65
185_A189_F0.5240.65
28_Q45_T0.5240.65
201_C210_I0.5220.64
48_L52_F0.5220.64
33_T69_D0.5210.64
202_R208_V0.5200.64
157_Q162_T0.5200.64
111_Y280_S0.5190.64
8_F13_S0.5190.64
270_D274_F0.5180.64
62_L75_Y0.5180.64
190_P205_K0.5180.64
131_I288_G0.5160.64
201_C204_C0.5160.64
57_V113_L0.5160.64
57_V154_L0.5140.63
43_E46_H0.5120.63
263_S268_G0.5120.63
62_L95_L0.5110.63
112_G120_A0.5110.63
92_D159_Q0.5100.63
66_T102_D0.5090.62
58_Q86_G0.5090.62
72_I108_Q0.5080.62
178_F186_V0.5080.62
98_V105_V0.5060.62
251_K254_S0.5060.62
75_Y79_V0.5050.62
94_I118_T0.5050.62
6_L9_T0.5040.62
196_Q202_R0.5020.61
62_L97_V0.5020.61
14_F19_P0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kw7A 1 0.5414 100 0.57 Contact Map
3pvhA 1 0.5034 99.9 0.582 Contact Map
4oa3A 1 0.4862 99.9 0.59 Contact Map
2kptA 1 0.5103 99.9 0.599 Contact Map
2pk2A 3 0.5897 97 0.883 Contact Map
4kblA 2 0 91.8 0.914 Contact Map
4oe8C 1 0.1207 88.4 0.92 Contact Map
4fybB 1 0.3966 79.4 0.928 Contact Map
4ladB 1 0.1586 77.6 0.93 Contact Map
2nocA 1 0.3069 56.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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