GREMLIN Database
YGCE - Uncharacterized sugar kinase YgcE
UniProt: P55138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13033
Length: 492 (437)
Sequences: 12496 (8542)
Seq/√Len: 408.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_E171_R4.2091.00
22_D26_N3.4941.00
18_V60_A3.3951.00
151_D154_S2.9261.00
358_K362_D2.9131.00
398_P441_I2.8611.00
33_G59_F2.7991.00
358_K454_N2.7191.00
389_Q393_D2.7071.00
333_M345_I2.6901.00
307_V344_W2.6891.00
150_V177_V2.6891.00
374_H400_R2.6721.00
33_G63_D2.6611.00
39_H99_P2.6471.00
424_P428_T2.6471.00
425_D428_T2.6221.00
31_G63_D2.6021.00
179_M182_T2.5751.00
136_E176_D2.5691.00
385_D438_D2.4781.00
54_W132_R2.4641.00
20_M64_L2.4161.00
92_A120_A2.4061.00
51_D132_R2.3881.00
151_D158_S2.3571.00
164_M171_R2.3391.00
156_A171_R2.2781.00
121_Y137_F2.2401.00
358_K451_D2.2111.00
207_T212_V2.1781.00
19_V409_S2.1751.00
159_E165_D2.1511.00
9_I57_L2.1501.00
4_K76_V2.1241.00
130_T206_T2.1231.00
15_S32_K2.0621.00
188_T191_A2.0441.00
312_N344_W2.0241.00
114_H118_D2.0151.00
443_I446_N2.0121.00
273_T349_I2.0081.00
42_D45_T1.9781.00
63_D67_Q1.9661.00
6_I417_A1.9361.00
403_A435_R1.9201.00
316_T333_M1.9011.00
396_N447_A1.8981.00
341_D344_W1.8981.00
306_C343_A1.8981.00
7_I61_G1.8971.00
36_Q52_D1.8921.00
51_D95_T1.8691.00
377_I388_M1.8641.00
315_M457_I1.8581.00
296_P299_L1.8511.00
7_I18_V1.8511.00
11_G16_T1.8501.00
189_P199_A1.8331.00
134_T203_V1.8301.00
454_N459_K1.8071.00
5_Y28_V1.8061.00
299_L302_K1.7831.00
277_L349_I1.7691.00
204_V419_G1.7671.00
400_R439_I1.7581.00
233_I269_K1.7531.00
178_Q182_T1.7451.00
221_D431_D1.6991.00
94_G131_H1.6931.00
91_K95_T1.6891.00
398_P439_I1.6821.00
393_D446_N1.6631.00
303_K343_A1.6631.00
138_K178_Q1.6621.00
183_V186_H1.6461.00
5_Y20_M1.6441.00
303_K306_C1.6401.00
224_T374_H1.6381.00
113_E117_P1.6271.00
393_D443_I1.6261.00
4_K74_D1.6141.00
447_A451_D1.6041.00
295_S299_L1.5961.00
183_V204_V1.5961.00
111_P114_H1.5941.00
88_A125_F1.5831.00
89_L173_M1.5601.00
275_S279_D1.5601.00
153_K242_L1.5541.00
355_L453_M1.5321.00
110_R114_H1.5241.00
330_R337_D1.5111.00
362_D459_K1.5041.00
460_D464_H1.5021.00
316_T320_W1.4951.00
403_A437_K1.4951.00
6_I422_L1.4811.00
31_G64_L1.4671.00
23_L422_L1.4581.00
31_G60_A1.4561.00
170_P173_M1.4441.00
302_K306_C1.4421.00
54_W58_C1.4381.00
49_P52_D1.4381.00
198_P201_L1.4351.00
445_S448_K1.4331.00
130_T184_L1.4281.00
417_A423_Y1.4191.00
64_L68_F1.4141.00
386_L390_I1.3951.00
65_M72_K1.3881.00
385_D401_R1.3861.00
301_N305_S1.3821.00
77_G416_T1.3821.00
304_A386_L1.3811.00
303_K342_Y1.3761.00
300_L346_Y1.3711.00
20_M68_F1.3671.00
128_Y132_R1.3671.00
9_I61_G1.3671.00
29_C64_L1.3621.00
29_C67_Q1.3581.00
134_T185_G1.3581.00
347_R351_E1.3581.00
39_H52_D1.3551.00
229_L391_F1.3511.00
51_D55_A1.3411.00
385_D440_F1.3351.00
354_A390_I1.3301.00
92_A121_Y1.3271.00
225_A372_A1.3201.00
90_L123_T1.3161.00
186_H200_G1.3151.00
71_N74_D1.3001.00
84_R208_S1.2991.00
314_L340_M1.2941.00
109_T113_E1.2881.00
223_E373_K1.2871.00
240_K257_P1.2851.00
354_A394_V1.2841.00
374_H398_P1.2821.00
227_I391_F1.2811.00
178_Q184_L1.2801.00
354_A391_F1.2781.00
16_T57_L1.2711.00
141_I155_W1.2661.00
336_F340_M1.2631.00
21_Y27_V1.2571.00
401_R440_F1.2511.00
299_L303_K1.2261.00
86_C100_L1.2261.00
388_M440_F1.2201.00
266_G356_T1.2171.00
448_K452_A1.2171.00
396_N451_D1.2171.00
29_C68_F1.2161.00
222_D240_K1.2151.00
207_T415_N1.2111.00
302_K305_S1.2061.00
164_M174_L1.2061.00
183_V202_P1.1991.00
414_I433_M1.1981.00
301_N385_D1.1941.00
316_T349_I1.1921.00
136_E178_Q1.1881.00
16_T56_S1.1831.00
390_I394_V1.1821.00
359_N459_K1.1821.00
118_D166_K1.1811.00
446_N449_R1.1771.00
130_T138_K1.1761.00
221_D224_T1.1711.00
59_F63_D1.1701.00
358_K395_F1.1701.00
9_I18_V1.1681.00
55_A59_F1.1651.00
57_L129_L1.1651.00
47_E99_P1.1651.00
383_N405_N1.1621.00
160_D165_D1.1551.00
94_G137_F1.1361.00
183_V419_G1.1281.00
334_I461_L1.1171.00
123_T137_F1.1111.00
457_I460_D1.1101.00
362_D366_N1.1081.00
5_Y74_D1.1071.00
268_R273_T1.1011.00
113_E116_N1.1001.00
21_Y413_A1.0981.00
110_R113_E1.0961.00
49_P99_P1.0931.00
36_Q39_H1.0921.00
80_L130_T1.0911.00
298_D301_N1.0911.00
53_L125_F1.0901.00
281_L345_I1.0901.00
65_M68_F1.0821.00
301_N384_S1.0811.00
4_K23_L1.0791.00
20_M70_G1.0741.00
164_M169_I1.0731.00
141_I177_V1.0721.00
77_G420_L1.0701.00
141_I150_V1.0681.00
221_D427_A1.0641.00
225_A237_M1.0641.00
50_D88_A1.0611.00
268_R271_M1.0611.00
63_D66_S1.0571.00
31_G67_Q1.0551.00
6_I420_L1.0551.00
376_I400_R1.0521.00
240_K259_T1.0501.00
138_K184_L1.0411.00
131_H137_F1.0341.00
353_V381_G1.0311.00
224_T376_I1.0301.00
114_H117_P1.0291.00
78_I201_L1.0291.00
57_L61_G1.0281.00
361_Y395_F1.0241.00
307_V311_C1.0201.00
423_Y429_A1.0161.00
70_G74_D1.0091.00
273_T316_T1.0081.00
443_I447_A1.0021.00
46_A104_Q1.0001.00
331_G336_F0.9981.00
226_V378_T0.9941.00
355_L394_V0.9921.00
414_I429_A0.9921.00
5_Y70_G0.9901.00
323_N326_E0.9881.00
89_L122_V0.9871.00
77_G204_V0.9851.00
221_D373_K0.9851.00
362_D454_N0.9821.00
366_N397_L0.9811.00
340_M344_W0.9801.00
326_E329_K0.9771.00
150_V154_S0.9761.00
381_G387_F0.9761.00
35_L56_S0.9761.00
436_V439_I0.9751.00
305_S386_L0.9731.00
303_K346_Y0.9721.00
418_V429_A0.9691.00
85_C146_G0.9651.00
6_I77_G0.9651.00
81_G408_A0.9611.00
444_E447_A0.9601.00
316_T348_S0.9601.00
62_H66_S0.9591.00
7_I20_M0.9571.00
37_P48_H0.9571.00
18_V64_L0.9521.00
155_W179_M0.9511.00
358_K394_V0.9491.00
21_Y410_L0.9371.00
396_N449_R0.9371.00
186_H202_P0.9301.00
52_D55_A0.9281.00
204_V420_L0.9281.00
374_H439_I0.9231.00
417_A422_L0.9201.00
135_G188_T0.9181.00
22_D28_V0.9181.00
139_D144_Y0.9111.00
297_E300_L0.9101.00
235_L361_Y0.9101.00
95_T132_R0.9051.00
304_A307_V0.8981.00
347_R386_L0.8961.00
157_W174_L0.8951.00
233_I357_L0.8941.00
127_G139_D0.8931.00
375_V395_F0.8911.00
33_G60_A0.8901.00
97_A120_A0.8901.00
336_F345_I0.8891.00
395_F398_P0.8871.00
79_G204_V0.8871.00
20_M75_I0.8861.00
11_G129_L0.8821.00
76_V420_L0.8751.00
58_C62_H0.8751.00
138_K176_D0.8731.00
80_L129_L0.8721.00
65_M75_I0.8701.00
30_E406_G0.8681.00
7_I75_I0.8681.00
124_S147_Q0.8671.00
87_R122_V0.8631.00
156_A176_D0.8621.00
282_G342_Y0.8541.00
153_K244_K0.8521.00
141_I179_M0.8461.00
76_V422_L0.8451.00
355_L454_N0.8441.00
444_E449_R0.8441.00
144_Y157_W0.8431.00
41_P45_T0.8421.00
333_M349_I0.8421.00
89_L97_A0.8411.00
90_L94_G0.8361.00
418_V426_Y0.8361.00
186_H199_A0.8341.00
307_V312_N0.8341.00
298_D302_K0.8331.00
350_L390_I0.8291.00
310_G313_G0.8281.00
234_A265_Y0.8271.00
277_L346_Y0.8261.00
213_E378_T0.8231.00
158_S163_V0.8221.00
73_E198_P0.8211.00
276_W279_D0.8211.00
189_P200_G0.8181.00
156_A159_E0.8161.00
52_D56_S0.8151.00
304_A347_R0.8141.00
80_L133_L0.8131.00
225_A375_V0.8131.00
84_R143_N0.8131.00
382_S405_N0.8111.00
318_L321_L0.8101.00
444_E448_K0.8091.00
187_I201_L0.8091.00
400_R436_V0.8091.00
91_K97_A0.8001.00
142_A207_T0.7991.00
75_I201_L0.7991.00
237_M364_M0.7961.00
153_K241_A0.7941.00
47_E107_R0.7931.00
178_Q205_C0.7931.00
210_K234_A0.7921.00
33_G56_S0.7911.00
329_K332_I0.7911.00
428_T432_N0.7911.00
34_L275_S0.7891.00
58_C191_A0.7851.00
217_A378_T0.7831.00
40_T46_A0.7821.00
27_V30_E0.7811.00
84_R263_E0.7801.00
72_K75_I0.7771.00
101_I107_R0.7771.00
269_K353_V0.7751.00
354_A387_F0.7751.00
213_E408_A0.7741.00
460_D463_K0.7731.00
313_G453_M0.7701.00
103_W232_Y0.7681.00
139_D175_F0.7651.00
8_G79_G0.7651.00
307_V310_G0.7641.00
452_A457_I0.7611.00
11_G57_L0.7611.00
88_A100_L0.7581.00
377_I391_F0.7571.00
242_L251_P0.7571.00
150_V155_W0.7571.00
305_S385_D0.7541.00
238_N259_T0.7541.00
126_S206_T0.7511.00
139_D177_V0.7511.00
377_I401_R0.7491.00
61_G65_M0.7491.00
91_K120_A0.7481.00
448_K453_M0.7471.00
350_L384_S0.7471.00
113_E328_Y0.7471.00
278_R297_E0.7451.00
90_L137_F0.7431.00
187_I198_P0.7431.00
423_Y432_N0.7421.00
227_I357_L0.7421.00
382_S388_M0.7421.00
227_I233_I0.7401.00
13_S102_S0.7381.00
217_A226_V0.7381.00
315_M334_I0.7361.00
325_W329_K0.7361.00
19_V27_V0.7341.00
94_G120_A0.7341.00
307_V343_A0.7321.00
34_L278_R0.7301.00
275_S297_E0.7271.00
284_S300_L0.7271.00
358_K459_K0.7231.00
359_N454_N0.7231.00
255_S258_Q0.7141.00
277_L345_I0.7141.00
389_Q443_I0.7141.00
21_Y404_I0.7131.00
77_G202_P0.7131.00
151_D156_A0.7131.00
377_I399_A0.7111.00
363_N367_E0.7101.00
50_D99_P0.7081.00
197_F200_G0.7061.00
308_P311_C0.7061.00
16_T35_L0.7061.00
90_L121_Y0.7051.00
35_L48_H0.7031.00
218_G434_V0.7021.00
316_T352_S0.7011.00
141_I256_I0.6971.00
82_S143_N0.6961.00
57_L60_A0.6951.00
301_N304_A0.6951.00
245_D249_Y0.6951.00
51_D96_P0.6921.00
266_G269_K0.6921.00
459_K463_K0.6901.00
441_I444_E0.6891.00
351_E390_I0.6881.00
65_M70_G0.6881.00
6_I76_V0.6861.00
197_F201_L0.6861.00
313_G351_E0.6851.00
375_V399_A0.6841.00
304_A346_Y0.6841.00
128_Y131_H0.6841.00
78_I187_I0.6831.00
373_K397_L0.6811.00
209_D231_T0.6811.00
115_T167_F0.6811.00
305_S389_Q0.6811.00
155_W258_Q0.6811.00
446_N451_D0.6801.00
165_D170_P0.6801.00
274_V301_N0.6791.00
219_L224_T0.6771.00
239_G243_P0.6740.99
55_A58_C0.6740.99
375_V397_L0.6730.99
418_V425_D0.6720.99
163_V167_F0.6690.99
121_Y173_M0.6680.99
317_V332_I0.6680.99
11_G56_S0.6670.99
160_D166_K0.6670.99
165_D171_R0.6660.99
130_T134_T0.6650.99
51_D128_Y0.6640.99
47_E98_A0.6630.99
90_L128_Y0.6610.99
89_L98_A0.6600.99
180_P206_T0.6600.99
187_I197_F0.6570.99
312_N340_M0.6570.99
417_A421_G0.6570.99
313_G347_R0.6570.99
265_Y269_K0.6560.99
184_L205_C0.6550.99
126_S143_N0.6550.99
389_Q440_F0.6540.99
449_R453_M0.6540.99
374_H397_L0.6540.99
398_P442_P0.6530.99
23_L76_V0.6530.99
51_D99_P0.6520.99
401_R437_K0.6510.99
21_Y409_S0.6510.99
448_K451_D0.6490.99
58_C132_R0.6480.99
227_I375_V0.6460.99
199_A202_P0.6460.99
83_I103_W0.6450.99
186_H189_P0.6450.99
433_M436_V0.6430.99
453_M457_I0.6420.99
191_A200_G0.6400.99
311_C347_R0.6390.99
121_Y131_H0.6370.99
323_N327_P0.6370.99
61_G64_L0.6370.99
427_A431_D0.6360.99
372_A397_L0.6350.99
247_V367_E0.6340.99
264_G360_N0.6340.99
414_I418_V0.6330.99
183_V420_L0.6310.99
208_S211_P0.6280.99
94_G121_Y0.6270.99
224_T373_K0.6260.99
388_M401_R0.6230.99
59_F62_H0.6220.99
233_I391_F0.6220.99
312_N339_S0.6220.99
142_A180_P0.6210.99
82_S125_F0.6180.99
301_N386_L0.6170.99
149_P174_L0.6170.99
90_L131_H0.6140.99
120_A172_H0.6130.99
165_D168_N0.6120.99
310_G344_W0.6120.99
396_N444_E0.6120.99
127_G137_F0.6090.99
30_E67_Q0.6070.99
58_C61_G0.6050.99
214_A236_M0.6050.99
347_R390_I0.6040.99
78_I203_V0.6020.99
69_A72_K0.6010.99
54_W191_A0.6010.99
27_V404_I0.6000.99
277_L281_L0.5990.99
90_L120_A0.5990.99
188_T200_G0.5980.99
180_P207_T0.5970.99
311_C315_M0.5960.99
141_I255_S0.5960.99
423_Y433_M0.5950.99
385_D389_Q0.5950.99
382_S401_R0.5920.99
24_E432_N0.5910.99
229_L377_I0.5910.99
235_L360_N0.5900.99
75_I197_F0.5890.99
50_D100_L0.5880.99
297_E301_N0.5880.99
389_Q392_A0.5870.99
119_V163_V0.5870.99
23_L417_A0.5860.99
86_C102_S0.5840.99
123_T131_H0.5840.99
51_D54_W0.5810.98
216_G407_C0.5800.98
351_E355_L0.5800.98
210_K228_S0.5800.98
317_V462_T0.5770.98
318_L352_S0.5760.98
88_A96_P0.5750.98
124_S143_N0.5750.98
307_V347_R0.5750.98
384_S387_F0.5740.98
6_I23_L0.5740.98
274_V300_L0.5730.98
181_G419_G0.5730.98
32_K406_G0.5710.98
418_V423_Y0.5710.98
191_A197_F0.5700.98
415_N426_Y0.5690.98
84_R146_G0.5690.98
263_E267_I0.5670.98
236_M261_L0.5670.98
310_G347_R0.5660.98
96_P99_P0.5660.98
49_P55_A0.5660.98
320_W333_M0.5650.98
239_G262_Y0.5650.98
45_T101_I0.5640.98
418_V421_G0.5640.98
410_L414_I0.5630.98
248_A264_G0.5620.98
304_A350_L0.5610.98
41_P44_D0.5600.98
353_V387_F0.5600.98
142_A255_S0.5580.98
14_Q17_K0.5580.98
86_C125_F0.5570.98
26_N403_A0.5560.98
227_I235_L0.5560.98
308_P312_N0.5560.98
85_C232_Y0.5560.98
321_L338_S0.5550.98
451_D454_N0.5550.98
85_C103_W0.5540.98
48_H102_S0.5530.98
202_P420_L0.5520.98
187_I196_H0.5500.98
228_S378_T0.5500.98
215_L414_I0.5480.98
301_N350_L0.5480.98
136_E186_H0.5470.98
231_T380_G0.5470.98
5_Y73_E0.5450.98
226_V236_M0.5440.98
357_L391_F0.5440.98
153_K156_A0.5420.98
261_L265_Y0.5410.98
147_Q157_W0.5400.98
176_D182_T0.5400.98
83_I208_S0.5390.98
13_S103_W0.5370.97
135_G190_Q0.5360.97
252_I261_L0.5350.97
237_M372_A0.5350.97
228_S234_A0.5340.97
163_V166_K0.5340.97
313_G457_I0.5330.97
146_G208_S0.5330.97
330_R333_M0.5310.97
355_L358_K0.5310.97
46_A102_S0.5300.97
81_G412_A0.5300.97
6_I423_Y0.5300.97
315_M319_D0.5290.97
130_T205_C0.5290.97
85_C208_S0.5290.97
48_H83_I0.5280.97
242_L260_L0.5280.97
275_S278_R0.5270.97
53_L100_L0.5270.97
19_V410_L0.5260.97
169_I174_L0.5250.97
142_A211_P0.5250.97
148_W167_F0.5240.97
215_L426_Y0.5240.97
111_P115_T0.5240.97
392_A399_A0.5230.97
8_G409_S0.5200.97
311_C344_W0.5190.97
283_E342_Y0.5190.97
209_D380_G0.5190.97
228_S408_A0.5190.97
271_M275_S0.5180.97
356_T359_N0.5180.97
266_G360_N0.5170.97
280_M341_D0.5170.97
259_T426_Y0.5160.97
224_T431_D0.5160.97
229_L381_G0.5150.97
129_L133_L0.5150.97
277_L282_G0.5150.97
322_T326_E0.5150.97
265_Y322_T0.5140.97
227_I377_I0.5140.97
5_Y68_F0.5130.97
56_S59_F0.5120.97
68_F72_K0.5120.97
261_L269_K0.5120.97
235_L357_L0.5120.97
315_M355_L0.5090.97
316_T319_D0.5090.97
50_D125_F0.5080.96
181_G418_V0.5080.96
4_K422_L0.5070.96
303_K307_V0.5070.96
115_T119_V0.5070.96
83_I100_L0.5050.96
409_S412_A0.5050.96
313_G316_T0.5040.96
60_A64_L0.5030.96
155_W255_S0.5030.96
260_L263_E0.5030.96
300_L384_S0.5020.96
47_E101_I0.5020.96
317_V461_L0.5010.96
130_T203_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9187 100 0.181 Contact Map
3qdkA 2 0.9593 100 0.2 Contact Map
3ifrA 2 0.9146 100 0.202 Contact Map
3hz6A 1 0.9024 100 0.203 Contact Map
2itmA 2 0.8943 100 0.205 Contact Map
3wxlA 2 0.9167 100 0.222 Contact Map
3ezwA 3 0.9146 100 0.224 Contact Map
3l0qA 2 0.9411 100 0.225 Contact Map
3h3nX 3 0.9146 100 0.227 Contact Map
3g25A 3 0.9106 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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