GREMLIN Database
CSIE - Stationary phase-inducible protein CsiE
UniProt: P54901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13418
Length: 426 (388)
Sequences: 3420 (2984)
Seq/√Len: 151.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_V162_Q4.9651.00
289_A316_D4.3091.00
42_V47_A4.1631.00
23_T39_L3.6551.00
356_E360_R3.6171.00
16_R50_D3.6141.00
64_L78_G3.4261.00
285_P320_G3.3951.00
63_Q82_N3.3121.00
248_L301_A2.9001.00
139_R190_E2.8981.00
307_E313_H2.8921.00
55_G68_T2.7661.00
80_V84_R2.7181.00
246_R252_R2.6811.00
244_H305_G2.6221.00
394_T397_L2.6141.00
256_E332_Q2.5921.00
239_K260_C2.5901.00
64_L76_V2.5111.00
62_H89_H2.4861.00
79_T82_N2.3901.00
67_T77_E2.3821.00
42_V46_I2.3411.00
408_D415_Q2.3141.00
340_Q367_L2.3101.00
42_V50_D2.2941.00
300_R316_D2.2431.00
342_I372_M2.2421.00
341_I390_I2.2391.00
256_E329_W2.1981.00
240_R309_E2.1591.00
289_A296_V2.1441.00
345_T348_D2.1101.00
84_R207_E2.0871.00
299_T323_A2.0791.00
415_Q418_Q2.0551.00
196_Q202_P2.0321.00
411_L416_Q2.0111.00
266_H318_E2.0091.00
340_Q368_N2.0021.00
245_F298_T1.9841.00
36_F47_A1.9741.00
84_R162_Q1.9541.00
353_A356_E1.9261.00
283_T317_E1.8631.00
343_L359_L1.8271.00
245_F326_F1.8171.00
363_T420_R1.8061.00
282_N320_G1.8011.00
273_R318_E1.7981.00
135_L194_H1.7941.00
17_R53_E1.7671.00
400_F403_P1.7591.00
78_G83_Q1.7501.00
17_R54_T1.7381.00
249_G298_T1.7321.00
411_L419_I1.7211.00
189_Q208_P1.7201.00
21_L54_T1.6891.00
69_G72_G1.6821.00
137_S144_F1.6711.00
295_L323_A1.6511.00
303_L319_S1.6501.00
270_A274_S1.5981.00
246_R256_E1.5951.00
266_H321_L1.5871.00
342_I386_A1.5771.00
34_A44_D1.5741.00
259_L329_W1.5671.00
295_L299_T1.5651.00
295_L327_G1.5571.00
348_D351_R1.5541.00
345_T352_E1.5451.00
57_E86_C1.5271.00
30_T75_R1.5231.00
67_T75_R1.5111.00
55_G66_L1.5011.00
259_L263_L1.4861.00
161_L165_A1.4821.00
348_D352_E1.4821.00
303_L322_V1.4791.00
253_F326_F1.4721.00
54_T66_L1.4571.00
188_A191_I1.4471.00
242_V260_C1.4301.00
180_E205_P1.4211.00
78_G84_R1.4191.00
44_D48_S1.4161.00
32_T35_T1.4131.00
362_L420_R1.4091.00
390_I405_I1.3911.00
17_R50_D1.3881.00
282_N321_L1.3861.00
37_S47_A1.3681.00
65_T77_E1.3641.00
391_A395_M1.3631.00
373_S376_A1.3541.00
391_A404_L1.3501.00
403_P422_M1.3421.00
405_I415_Q1.3381.00
122_N125_D1.3331.00
390_I407_T1.3331.00
204_P207_E1.3301.00
245_F299_T1.3301.00
241_L299_T1.3231.00
287_E291_L1.3221.00
12_S15_Q1.3201.00
386_A402_P1.3051.00
118_G121_R1.3041.00
281_D317_E1.3001.00
299_T302_A1.2951.00
391_A406_Y1.2911.00
234_L238_I1.2901.00
140_L190_E1.2861.00
370_K386_A1.2811.00
263_L322_V1.2741.00
304_A307_E1.2741.00
338_E367_L1.2681.00
64_L83_Q1.2581.00
320_G323_A1.2561.00
13_A53_E1.2441.00
133_V153_C1.2421.00
243_N247_E1.2411.00
297_R300_R1.2401.00
51_I55_G1.2361.00
21_L58_I1.2281.00
33_M44_D1.2241.00
282_N317_E1.2231.00
132_L136_C1.2191.00
340_Q370_K1.2181.00
32_T44_D1.2151.00
238_I260_C1.2111.00
318_E321_L1.2111.00
266_H325_I1.2081.00
151_F155_Y1.2061.00
241_L302_A1.1941.00
362_L416_Q1.1711.00
347_N351_R1.1691.00
253_F329_W1.1661.00
82_N85_L1.1621.00
128_N198_R1.1481.00
299_T303_L1.1421.00
25_F86_C1.1371.00
417_E420_R1.1321.00
34_A38_E1.1321.00
185_F189_Q1.1291.00
23_T36_F1.1241.00
340_Q385_G1.1010.99
189_Q205_P1.1010.99
84_R158_Y1.1010.99
188_A212_A1.1000.99
331_M358_Q1.0990.99
19_Q40_N1.0980.99
274_S315_S1.0940.99
182_C185_F1.0940.99
188_A192_G1.0920.99
121_R125_D1.0890.99
325_I328_A1.0890.99
242_V259_L1.0830.99
129_L157_Q1.0820.99
252_R256_E1.0780.99
296_V323_A1.0700.99
355_I411_L1.0690.99
241_L326_F1.0690.99
130_Q149_I1.0650.99
80_V207_E1.0630.99
21_L90_W1.0630.99
363_T416_Q1.0630.99
58_I64_L1.0610.99
155_Y214_L1.0590.99
270_A314_L1.0560.99
270_A273_R1.0530.99
125_D128_N1.0530.99
260_C264_Y1.0450.99
296_V300_R1.0440.99
296_V320_G1.0410.99
134_N149_I1.0410.99
417_E421_K1.0380.99
188_A215_F1.0350.99
288_F320_G1.0300.99
414_H418_Q1.0290.99
88_F155_Y1.0280.99
300_R319_S1.0250.99
19_Q23_T1.0240.99
40_N47_A1.0150.99
396_P406_Y1.0110.99
145_E219_R1.0090.99
243_N254_Y1.0080.99
230_R264_Y1.0050.99
351_R354_Q1.0030.99
125_D129_L1.0030.99
405_I422_M1.0030.99
84_R159_C1.0020.99
358_Q411_L1.0000.99
130_Q150_H0.9990.99
30_T73_S0.9960.99
249_G253_F0.9960.99
241_L305_G0.9920.99
185_F208_P0.9870.99
295_L330_L0.9850.99
53_E56_R0.9820.99
317_E320_G0.9810.99
357_Q361_E0.9770.99
377_F400_F0.9750.99
19_Q39_L0.9720.99
88_F158_Y0.9710.99
238_I242_V0.9650.98
407_T411_L0.9650.98
32_T73_S0.9640.98
121_R157_Q0.9600.98
296_V316_D0.9600.98
405_I419_I0.9600.98
136_C191_I0.9580.98
295_L326_F0.9580.98
269_Q273_R0.9570.98
161_L164_H0.9570.98
244_H247_E0.9550.98
271_L312_V0.9510.98
238_I267_L0.9490.98
285_P317_E0.9480.98
176_R209_L0.9470.98
64_L86_C0.9450.98
32_T48_S0.9440.98
343_L356_E0.9430.98
163_H207_E0.9380.98
232_R236_Q0.9380.98
242_V326_F0.9370.98
45_D48_S0.9330.98
345_T351_R0.9310.98
273_R280_I0.9280.98
155_Y159_C0.9270.98
184_E212_A0.9260.98
283_T320_G0.9250.98
341_I366_P0.9220.98
33_M37_S0.9220.98
245_F249_G0.9220.98
185_F212_A0.9160.98
288_F323_A0.9140.98
78_G162_Q0.9130.98
21_L76_V0.9110.98
23_T40_N0.9090.98
83_Q162_Q0.9070.98
266_H273_R0.9060.98
238_I264_Y0.9050.98
303_L314_L0.9010.98
305_G309_E0.8980.98
24_L66_L0.8930.97
364_L367_L0.8930.97
62_H86_C0.8930.97
346_G395_M0.8910.97
192_G208_P0.8890.97
400_F404_L0.8810.97
388_L419_I0.8800.97
16_R46_I0.8800.97
413_T417_E0.8760.97
258_G332_Q0.8750.97
48_S68_T0.8720.97
340_Q387_A0.8720.97
163_H203_V0.8670.97
355_I407_T0.8660.97
133_V137_S0.8660.97
38_E41_G0.8660.97
180_E185_F0.8600.97
137_S140_L0.8580.97
86_C90_W0.8570.97
149_I153_C0.8570.97
163_H204_P0.8540.97
158_Y162_Q0.8540.97
347_N352_E0.8510.97
244_H248_L0.8460.96
285_P289_A0.8430.96
17_R57_E0.8420.96
389_I402_P0.8410.96
44_D73_S0.8410.96
62_H82_N0.8360.96
151_F214_L0.8350.96
185_F188_A0.8350.96
128_N132_L0.8330.96
355_I416_Q0.8310.96
331_M334_N0.8280.96
193_R196_Q0.8250.96
146_S375_K0.8250.96
240_R243_N0.8240.96
302_A305_G0.8240.96
352_E371_H0.8210.96
355_I394_T0.8200.96
78_G82_N0.8190.96
48_S70_Y0.8190.96
145_E148_D0.8190.96
411_L415_Q0.8120.96
238_I241_L0.8120.96
389_I400_F0.8090.95
246_R249_G0.8080.95
162_Q207_E0.8070.95
212_A216_S0.8070.95
416_Q420_R0.8060.95
22_L90_W0.7980.95
156_L211_M0.7970.95
235_R264_Y0.7960.95
176_R206_D0.7950.95
159_C163_H0.7950.95
169_P210_F0.7940.95
345_T350_E0.7930.95
271_L275_L0.7920.95
32_T72_G0.7900.95
235_R260_C0.7890.95
211_M214_L0.7840.95
343_L390_I0.7830.95
298_T302_A0.7830.95
179_A212_A0.7820.95
13_A50_D0.7820.95
399_L403_P0.7810.95
257_Q261_D0.7760.94
372_M380_T0.7730.94
68_T74_Y0.7700.94
408_D412_T0.7630.94
253_F256_E0.7620.94
49_L52_S0.7590.94
389_I404_L0.7590.94
280_I317_E0.7590.94
70_Y73_S0.7580.94
230_R233_Q0.7580.94
267_L270_A0.7580.94
267_L285_P0.7570.94
321_L325_I0.7570.94
347_N350_E0.7550.93
132_L194_H0.7550.93
309_E312_V0.7540.93
350_E354_Q0.7510.93
358_Q410_T0.7460.93
46_I50_D0.7450.93
299_T326_F0.7450.93
262_Q328_A0.7430.93
259_L332_Q0.7420.93
25_F87_L0.7410.93
217_M269_Q0.7410.93
136_C187_V0.7370.93
174_L177_R0.7330.92
20_I54_T0.7320.92
214_L217_M0.7320.92
343_L352_E0.7320.92
234_L264_Y0.7300.92
84_R169_P0.7300.92
189_Q193_R0.7290.92
54_T58_I0.7290.92
258_G262_Q0.7280.92
273_R320_G0.7280.92
350_E353_A0.7250.92
346_G374_V0.7220.92
270_A315_S0.7220.92
166_G170_Q0.7220.92
244_H302_A0.7210.92
206_D209_L0.7200.92
322_V325_I0.7200.92
38_E44_D0.7190.92
48_S51_I0.7130.91
48_S74_Y0.7110.91
148_D155_Y0.7090.91
307_E314_L0.7080.91
192_G196_Q0.7070.91
80_V83_Q0.7030.91
16_R42_V0.7030.91
185_F205_P0.7020.91
160_L164_H0.6990.91
142_K150_H0.6980.91
398_P401_S0.6930.90
282_N292_Y0.6930.90
155_Y158_Y0.6920.90
360_R413_T0.6910.90
30_T72_G0.6910.90
157_Q161_L0.6890.90
237_S241_L0.6850.90
137_S375_K0.6850.90
168_T204_P0.6840.90
285_P316_D0.6820.90
273_R314_L0.6810.89
273_R276_F0.6780.89
132_L135_L0.6770.89
300_R304_A0.6720.89
348_D354_Q0.6720.89
236_Q309_E0.6710.89
270_A318_E0.6700.89
196_Q208_P0.6670.88
358_Q416_Q0.6640.88
14_P18_C0.6630.88
125_D164_H0.6610.88
339_K388_L0.6590.88
306_F314_L0.6580.88
51_I74_Y0.6570.88
345_T349_S0.6560.88
288_F319_S0.6560.88
274_S318_E0.6530.87
185_F209_L0.6530.87
272_N324_V0.6510.87
365_L420_R0.6500.87
359_L390_I0.6490.87
262_Q353_A0.6490.87
360_R364_L0.6460.87
409_L415_Q0.6460.87
43_D49_L0.6460.87
48_S52_S0.6440.87
352_E356_E0.6430.87
182_C212_A0.6420.87
418_Q421_K0.6410.86
120_A126_D0.6410.86
329_W332_Q0.6410.86
121_R124_Y0.6360.86
92_R96_R0.6310.86
27_P59_L0.6300.85
348_D395_M0.6300.85
301_A304_A0.6290.85
79_T378_L0.6290.85
265_T269_Q0.6270.85
180_E209_L0.6270.85
59_L65_T0.6250.85
307_E310_Y0.6240.85
171_F176_R0.6220.85
325_I350_E0.6220.85
130_Q134_N0.6200.85
12_S18_C0.6190.84
255_D333_E0.6190.84
241_L303_L0.6190.84
340_Q369_I0.6190.84
358_Q362_L0.6180.84
293_P297_R0.6180.84
45_D49_L0.6160.84
282_N289_A0.6160.84
37_S44_D0.6150.84
91_L96_R0.6150.84
44_D68_T0.6130.84
360_R368_N0.6130.84
207_E210_F0.6130.84
186_Q189_Q0.6120.84
386_A390_I0.6110.84
187_V191_I0.6100.84
292_Y320_G0.6100.84
339_K403_P0.6090.84
341_I388_L0.6080.83
204_P214_L0.6080.83
48_S69_G0.6060.83
280_I321_L0.6050.83
283_T321_L0.6040.83
407_T419_I0.6040.83
33_M51_I0.6030.83
80_V166_G0.6000.83
79_T83_Q0.6000.83
119_I126_D0.5990.83
266_H269_Q0.5990.83
150_H153_C0.5980.82
20_I50_D0.5980.82
66_L315_S0.5970.82
271_L310_Y0.5970.82
33_M47_A0.5940.82
47_A50_D0.5940.82
345_T355_I0.5940.82
256_E331_M0.5920.82
325_I332_Q0.5920.82
218_L270_A0.5910.82
273_R277_A0.5910.82
289_A320_G0.5900.82
31_A338_E0.5890.81
26_Q83_Q0.5890.81
144_F148_D0.5880.81
227_A232_R0.5880.81
15_Q18_C0.5820.81
73_S354_Q0.5810.81
125_D161_L0.5810.81
244_H308_S0.5810.81
289_A293_P0.5800.80
188_A208_P0.5800.80
299_T322_V0.5790.80
273_R282_N0.5790.80
126_D129_L0.5790.80
213_L216_S0.5760.80
192_G201_Q0.5750.80
68_T390_I0.5700.79
51_I54_T0.5700.79
16_R19_Q0.5690.79
17_R40_N0.5680.79
196_Q203_V0.5640.79
252_R255_D0.5640.79
80_V163_H0.5640.79
174_L385_G0.5630.78
418_Q422_M0.5620.78
18_C93_R0.5610.78
339_K343_L0.5600.78
32_T74_Y0.5600.78
122_N202_P0.5590.78
124_Y157_Q0.5580.78
262_Q332_Q0.5580.78
22_L26_Q0.5570.78
35_T92_R0.5570.78
44_D350_E0.5570.78
380_T386_A0.5560.78
236_Q311_G0.5540.77
238_I311_G0.5530.77
233_Q309_E0.5520.77
216_S276_F0.5510.77
369_I372_M0.5510.77
234_L237_S0.5500.77
78_G86_C0.5480.77
48_S55_G0.5480.77
287_E290_R0.5480.77
64_L84_R0.5480.77
20_I383_P0.5470.77
246_R253_F0.5470.77
294_R297_R0.5450.76
235_R261_D0.5450.76
213_L217_M0.5450.76
54_T76_V0.5450.76
30_T267_L0.5450.76
148_D151_F0.5440.76
31_A39_L0.5440.76
314_L318_E0.5430.76
350_E410_T0.5420.76
326_F386_A0.5410.76
269_Q272_N0.5410.76
185_F355_I0.5410.76
85_L89_H0.5390.75
357_Q360_R0.5390.75
374_V395_M0.5380.75
363_T390_I0.5370.75
294_R298_T0.5370.75
270_A278_I0.5370.75
11_L15_Q0.5360.75
300_R303_L0.5360.75
24_L55_G0.5360.75
407_T415_Q0.5350.75
39_L194_H0.5340.75
247_E250_N0.5340.75
154_L363_T0.5340.75
120_A157_Q0.5330.75
373_S377_F0.5330.75
203_V211_M0.5310.74
315_S318_E0.5310.74
262_Q329_W0.5300.74
123_F164_H0.5300.74
288_F419_I0.5300.74
231_D384_R0.5270.74
217_M278_I0.5270.74
347_N359_L0.5260.74
240_R306_F0.5260.74
21_L24_L0.5260.74
28_G167_I0.5250.74
285_P288_F0.5250.74
259_L302_A0.5230.73
288_F317_E0.5220.73
292_Y327_G0.5220.73
301_A305_G0.5220.73
240_R308_S0.5210.73
19_Q42_V0.5210.73
354_Q358_Q0.5210.73
188_A195_W0.5200.73
414_H417_E0.5190.73
292_Y323_A0.5170.72
142_K149_I0.5160.72
356_E371_H0.5160.72
366_P369_I0.5150.72
245_F250_N0.5150.72
42_V375_K0.5130.72
196_Q199_A0.5110.72
11_L228_H0.5100.71
155_Y203_V0.5100.71
190_E193_R0.5100.71
364_L373_S0.5080.71
37_S98_C0.5070.71
90_W94_G0.5070.71
57_E62_H0.5070.71
129_L132_L0.5070.71
135_L224_L0.5060.71
328_A331_M0.5050.71
344_L397_L0.5050.71
270_A322_V0.5040.71
345_T354_Q0.5040.71
23_T27_P0.5040.71
207_E259_L0.5040.71
277_A282_N0.5030.70
154_L157_Q0.5020.70
136_C190_E0.5020.70
249_G302_A0.5000.70
60_R170_Q0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6iA 2 0.9178 100 0.245 Contact Map
3sqnA 2 0.9108 100 0.315 Contact Map
1h99A 2 0.5141 99.9 0.631 Contact Map
3ufeA 2 0.2512 99.2 0.798 Contact Map
3rioA 1 0.3944 99.2 0.799 Contact Map
3czcA 1 0.1995 99.1 0.808 Contact Map
1vkrA 1 0.2019 98.7 0.83 Contact Map
1tvmA 1 0.2512 98.6 0.838 Contact Map
2l2qA 1 0.2089 97.8 0.871 Contact Map
1e2bA 1 0.2066 97.5 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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