GREMLIN Database
6PGL - 6-phosphogluconolactonase
UniProt: P52697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13231
Length: 331 (253)
Sequences: 9898 (7937)
Seq/√Len: 499.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_H99_G3.4691.00
81_P98_V3.3941.00
40_P53_G3.0431.00
51_Y89_T2.9421.00
97_F134_I2.9301.00
52_V63_Y2.8431.00
100_S103_A2.8261.00
51_Y96_V2.8251.00
131_S145_A2.8241.00
144_P154_F2.7871.00
34_V52_V2.7671.00
98_V109_T2.6131.00
97_F108_V2.6111.00
174_E193_V2.5721.00
54_V57_E2.5281.00
60_V98_V2.5271.00
193_V203_W2.4421.00
291_A302_Y2.4381.00
180_H194_N2.3951.00
51_Y62_A2.2681.00
290_I301_V2.2181.00
279_G292_A2.1541.00
192_C202_V2.0881.00
274_E291_A2.0441.00
246_C256_F2.0131.00
97_F142_W1.9341.00
143_V183_F1.9051.00
64_R67_P1.8861.00
107_S116_P1.8591.00
233_D247_D1.8551.00
257_S260_E1.8311.00
106_V144_P1.8261.00
135_S183_F1.8041.00
88_S133_N1.7971.00
42_V88_S1.7871.00
99_G129_C1.7781.00
87_I98_V1.7401.00
44_S48_R1.7241.00
201_D214_C1.6951.00
110_R113_D1.6681.00
192_C236_I1.6461.00
107_S119_V1.6441.00
81_P100_S1.6271.00
133_N182_V1.5691.00
227_D246_C1.5381.00
174_E178_P1.5201.00
90_D134_I1.5091.00
44_S89_T1.4991.00
143_V181_M1.4961.00
54_V61_L1.4851.00
245_A255_V1.4751.00
283_D286_G1.4711.00
195_E199_S1.4691.00
53_G84_P1.4591.00
52_V61_L1.4521.00
159_D162_L1.4211.00
204_E207_D1.4121.00
295_K298_H1.4041.00
143_V153_L1.3971.00
109_T116_P1.3791.00
43_V50_L1.3781.00
50_L65_I1.3751.00
136_P183_F1.3681.00
61_L77_E1.3651.00
53_G58_F1.3621.00
59_R77_E1.3621.00
89_T96_V1.3551.00
61_L74_F1.3471.00
194_N231_A1.3471.00
100_S105_N1.3401.00
85_T102_N1.3241.00
267_K270_F1.3191.00
97_F132_A1.3131.00
145_A178_P1.3031.00
291_A300_S1.2971.00
174_E195_E1.2761.00
123_V144_P1.2651.00
44_S49_Y1.2521.00
201_D217_T1.2461.00
283_D287_K1.2451.00
151_I193_V1.2391.00
81_P103_A1.2351.00
42_V87_I1.2241.00
143_V190_A1.2141.00
195_E198_S1.2131.00
48_R64_R1.2091.00
74_F77_E1.1911.00
247_D277_P1.1881.00
42_V89_T1.1851.00
214_C217_T1.1851.00
51_Y87_I1.1791.00
184_H236_I1.1751.00
133_N181_M1.1691.00
116_P119_V1.1631.00
174_E197_N1.1621.00
254_T270_F1.1341.00
100_S104_G1.1331.00
237_T282_V1.1291.00
41_M50_L1.1271.00
233_D279_G1.1271.00
212_I215_V1.1231.00
274_E293_G1.1211.00
238_P282_V1.1131.00
44_S47_K1.1131.00
146_L149_D1.1121.00
200_V246_C1.1111.00
99_G132_A1.1111.00
288_Y301_V1.1071.00
245_A282_V1.1021.00
83_S102_N1.0991.00
90_D94_Q1.0891.00
63_Y74_F1.0881.00
80_L109_T1.0811.00
130_H147_K1.0771.00
250_A254_T1.0701.00
43_V65_I1.0691.00
54_V58_F1.0671.00
98_V107_S1.0611.00
87_I96_V1.0601.00
146_L150_R1.0591.00
303_E306_G1.0561.00
62_A78_S1.0541.00
182_V235_H1.0421.00
182_V234_I1.0401.00
88_S132_A1.0331.00
88_S134_I1.0281.00
122_V154_F1.0271.00
246_C254_T1.0241.00
41_M52_V1.0231.00
81_P107_S1.0221.00
64_R72_L1.0181.00
80_L107_S1.0151.00
45_P93_G1.0121.00
36_G57_E1.0101.00
192_C234_I1.0091.00
199_S217_T1.0051.00
254_T267_K1.0021.00
235_H281_N1.0011.00
81_P84_P1.0001.00
282_V289_L0.9971.00
90_D97_F0.9971.00
203_W214_C0.9941.00
237_T240_G0.9911.00
135_S138_N0.9911.00
292_A297_H0.9861.00
259_S262_G0.9821.00
86_H132_A0.9811.00
183_F205_L0.9751.00
288_Y292_A0.9691.00
127_D147_K0.9671.00
53_G87_I0.9641.00
176_A195_E0.9621.00
247_D280_F0.9621.00
148_Q152_C0.9591.00
184_H192_C0.9471.00
91_H134_I0.9451.00
54_V59_R0.9311.00
193_V201_D0.9301.00
281_N290_I0.9281.00
60_V87_I0.9261.00
184_H187_E0.9201.00
28_L31_V0.9201.00
293_G302_Y0.9151.00
64_R73_T0.9061.00
253_I291_A0.9031.00
86_H131_S0.9021.00
120_V123_V0.9001.00
39_Q56_P0.9001.00
283_D290_I0.8991.00
91_H138_N0.8931.00
67_P72_L0.8881.00
227_D250_A0.8821.00
34_V54_V0.8741.00
182_V236_I0.8731.00
185_P236_I0.8651.00
128_G147_K0.8591.00
129_C144_P0.8581.00
192_C244_Y0.8541.00
57_E61_L0.8521.00
160_G163_V0.8501.00
283_D288_Y0.8471.00
194_N198_S0.8471.00
177_G196_L0.8441.00
90_D95_F0.8421.00
134_I142_W0.8411.00
274_E277_P0.8391.00
179_R196_L0.8351.00
106_V132_A0.8341.00
136_P187_E0.8341.00
144_P152_C0.8271.00
174_E203_W0.8271.00
40_P86_H0.8241.00
84_P98_V0.8211.00
239_D242_H0.8181.00
215_V218_L0.8161.00
131_S181_M0.8151.00
235_H245_A0.8131.00
155_T159_D0.8101.00
90_D93_G0.8091.00
81_P109_T0.8021.00
247_D251_S0.7971.00
274_E300_S0.7941.00
288_Y303_E0.7941.00
235_H280_F0.7931.00
144_P148_Q0.7921.00
37_Q56_P0.7921.00
184_H188_Q0.7811.00
189_Y202_V0.7801.00
95_F108_V0.7781.00
205_L212_I0.7751.00
142_W156_V0.7721.00
49_Y75_A0.7711.00
189_Y204_E0.7681.00
154_F162_L0.7671.00
34_V38_V0.7661.00
65_I72_L0.7651.00
145_A151_I0.7591.00
38_V52_V0.7581.00
108_V156_V0.7471.00
194_N234_I0.7421.00
135_S139_R0.7411.00
89_T111_L0.7411.00
130_H179_R0.7391.00
252_L270_F0.7391.00
59_R79_A0.7341.00
278_R294_Q0.7341.00
133_N183_F0.7331.00
44_S51_Y0.7321.00
98_V103_A0.7291.00
253_I280_F0.7281.00
64_R75_A0.7271.00
185_P240_G0.7271.00
270_F273_T0.7241.00
53_G98_V0.7211.00
280_F289_L0.7161.00
248_R252_L0.7161.00
176_A197_N0.7141.00
237_T241_R0.7001.00
123_V129_C0.7001.00
88_S97_F0.6981.00
34_V63_Y0.6901.00
267_K271_Q0.6871.00
181_M193_V0.6841.00
105_N119_V0.6831.00
119_V122_V0.6831.00
235_H282_V0.6811.00
40_P87_I0.6811.00
278_R292_A0.6801.00
161_H164_A0.6691.00
100_S107_S0.6681.00
49_Y62_A0.6671.00
280_F291_A0.6671.00
293_G298_H0.6651.00
145_A181_M0.6641.00
108_V120_V0.6621.00
48_R66_A0.6581.00
291_A295_K0.6571.00
80_L98_V0.6571.00
39_Q85_T0.6541.00
195_E201_D0.6541.00
27_T30_Q0.6511.00
113_D116_P0.6511.00
39_Q58_F0.6471.00
256_F267_K0.6451.00
237_T245_A0.6451.00
178_P195_E0.6421.00
34_V61_L0.6411.00
45_P89_T0.6411.00
67_P73_T0.6411.00
197_N201_D0.6401.00
106_V129_C0.6321.00
182_V192_C0.6291.00
52_V57_E0.6281.00
204_E215_V0.6271.00
227_D248_R0.6271.00
244_Y248_R0.6261.00
103_A107_S0.6231.00
118_G160_G0.6211.00
293_G300_S0.6201.00
62_A65_I0.6191.00
248_R254_T0.6191.00
275_T293_G0.6171.00
42_V51_Y0.6151.00
127_D146_L0.6151.00
60_V96_V0.6151.00
275_T294_Q0.6141.00
279_G282_V0.6131.00
241_R257_S0.6131.00
94_Q112_E0.6121.00
60_V84_P0.6121.00
137_D140_T0.6110.99
123_V146_L0.6110.99
145_A193_V0.6110.99
204_E213_E0.6090.99
234_I246_C0.6070.99
245_A280_F0.6060.99
288_Y291_A0.6050.99
27_T31_V0.6040.99
276_Q294_Q0.6030.99
149_D176_A0.6000.99
258_V261_D0.5980.99
48_R51_Y0.5930.99
62_A89_T0.5900.99
300_S303_E0.5900.99
207_D212_I0.5870.99
56_P83_S0.5860.99
216_Q220_M0.5850.99
85_T100_S0.5820.99
236_I243_L0.5810.99
237_T242_H0.5800.99
195_E203_W0.5750.99
135_S140_T0.5690.99
282_V304_I0.5690.99
186_N189_Y0.5670.99
129_C132_A0.5660.99
200_V243_L0.5650.99
49_Y64_R0.5650.99
49_Y89_T0.5630.99
212_I220_M0.5630.99
200_V234_I0.5620.99
257_S266_S0.5620.99
28_L32_V0.5610.99
73_T76_A0.5590.99
297_H300_S0.5580.99
183_F190_A0.5570.99
139_R157_S0.5560.99
152_C170_V0.5560.99
39_Q83_S0.5530.99
229_R250_A0.5530.99
122_V152_C0.5520.99
147_K177_G0.5510.99
212_I216_Q0.5510.99
212_I218_L0.5490.99
75_A78_S0.5480.99
114_G117_V0.5470.99
276_Q293_G0.5470.99
227_D231_A0.5440.99
160_G164_A0.5440.99
123_V154_F0.5440.99
266_S270_F0.5440.99
216_Q260_E0.5430.99
110_R117_V0.5420.99
85_T103_A0.5370.99
127_D148_Q0.5370.99
243_L246_C0.5340.99
277_P291_A0.5340.99
46_D93_G0.5320.99
269_G272_P0.5310.99
102_N128_G0.5310.99
99_G106_V0.5310.99
284_H288_Y0.5300.99
229_R249_T0.5290.99
246_C250_A0.5280.99
135_S141_L0.5260.99
111_L114_G0.5250.98
115_L118_G0.5250.98
97_F106_V0.5250.98
116_P121_D0.5240.98
123_V142_W0.5220.98
273_T300_S0.5210.98
72_L76_A0.5200.98
245_A289_L0.5160.98
151_I181_M0.5150.98
189_Y192_C0.5140.98
146_L154_F0.5130.98
149_D177_G0.5130.98
112_E115_L0.5130.98
202_V216_Q0.5120.98
298_H301_V0.5120.98
110_R114_G0.5110.98
267_K272_P0.5100.98
274_E295_K0.5080.98
255_V271_Q0.5080.98
105_N121_D0.5060.98
268_E271_Q0.5040.98
173_V203_W0.5040.98
291_A294_Q0.5030.98
240_G244_Y0.5010.98
255_V282_V0.5000.98
179_R195_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.8127 100 0.149 Contact Map
3ow8A 3 0.8248 100 0.187 Contact Map
1gotB 1 0.8278 100 0.205 Contact Map
4wjuA 1 0.8308 100 0.209 Contact Map
3w15A 1 0.8399 100 0.209 Contact Map
4lg9A 1 0.8036 100 0.21 Contact Map
3sfzA 1 0.8187 100 0.211 Contact Map
3j60g 1 0.8761 100 0.212 Contact Map
3fm0A 1 0.864 100 0.214 Contact Map
3dm0A 1 0.8248 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.