6PGL - ECOLI - GREMLIN Contacts

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6PGL - 6-phosphogluconolactonase

UniProt:	P52697	Sequences: MKQTVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSKEGFQPTETQPRGFNVDHSGKYLIAAGQKSHHISVYEIVGEQGLLHEKGRYAVGQGPMWVVVNAH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13231
Length:	331 (253)
Sequences:	9898 (7937)
Seq/√Len:	499.0

ECOLI - 6PGL YNCE TOLB BAMB
BACSU - YWHL YWHK 6PGL YXAL YVRE YUXL
HALSA - Q9HHP3 Q9HS46
SULSO - Q97VC7 Q97UH7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
86_H	99_G	3.469	1.00
81_P	98_V	3.394	1.00
40_P	53_G	3.043	1.00
51_Y	89_T	2.942	1.00
97_F	134_I	2.930	1.00
52_V	63_Y	2.843	1.00
100_S	103_A	2.826	1.00
51_Y	96_V	2.825	1.00
131_S	145_A	2.824	1.00
144_P	154_F	2.787	1.00
34_V	52_V	2.767	1.00
98_V	109_T	2.613	1.00
97_F	108_V	2.611	1.00
174_E	193_V	2.572	1.00
54_V	57_E	2.528	1.00
60_V	98_V	2.527	1.00
193_V	203_W	2.442	1.00
291_A	302_Y	2.438	1.00
180_H	194_N	2.395	1.00
51_Y	62_A	2.268	1.00
290_I	301_V	2.218	1.00
279_G	292_A	2.154	1.00
192_C	202_V	2.088	1.00
274_E	291_A	2.044	1.00
246_C	256_F	2.013	1.00
97_F	142_W	1.934	1.00
143_V	183_F	1.905	1.00
64_R	67_P	1.886	1.00
107_S	116_P	1.859	1.00
233_D	247_D	1.855	1.00
257_S	260_E	1.831	1.00
106_V	144_P	1.826	1.00
135_S	183_F	1.804	1.00
88_S	133_N	1.797	1.00
42_V	88_S	1.787	1.00
99_G	129_C	1.778	1.00
87_I	98_V	1.740	1.00
44_S	48_R	1.724	1.00
201_D	214_C	1.695	1.00
110_R	113_D	1.668	1.00
192_C	236_I	1.646	1.00
107_S	119_V	1.644	1.00
81_P	100_S	1.627	1.00
133_N	182_V	1.569	1.00
227_D	246_C	1.538	1.00
174_E	178_P	1.520	1.00
90_D	134_I	1.509	1.00
44_S	89_T	1.499	1.00
143_V	181_M	1.496	1.00
54_V	61_L	1.485	1.00
245_A	255_V	1.475	1.00
283_D	286_G	1.471	1.00
195_E	199_S	1.469	1.00
53_G	84_P	1.459	1.00
52_V	61_L	1.452	1.00
159_D	162_L	1.421	1.00
204_E	207_D	1.412	1.00
295_K	298_H	1.404	1.00
143_V	153_L	1.397	1.00
109_T	116_P	1.379	1.00
43_V	50_L	1.378	1.00
50_L	65_I	1.375	1.00
136_P	183_F	1.368	1.00
61_L	77_E	1.365	1.00
53_G	58_F	1.362	1.00
59_R	77_E	1.362	1.00
89_T	96_V	1.355	1.00
61_L	74_F	1.347	1.00
194_N	231_A	1.347	1.00
100_S	105_N	1.340	1.00
85_T	102_N	1.324	1.00
267_K	270_F	1.319	1.00
97_F	132_A	1.313	1.00
145_A	178_P	1.303	1.00
291_A	300_S	1.297	1.00
174_E	195_E	1.276	1.00
123_V	144_P	1.265	1.00
44_S	49_Y	1.252	1.00
201_D	217_T	1.246	1.00
283_D	287_K	1.245	1.00
151_I	193_V	1.239	1.00
81_P	103_A	1.235	1.00
42_V	87_I	1.224	1.00
143_V	190_A	1.214	1.00
195_E	198_S	1.213	1.00
48_R	64_R	1.209	1.00
74_F	77_E	1.191	1.00
247_D	277_P	1.188	1.00
42_V	89_T	1.185	1.00
214_C	217_T	1.185	1.00
51_Y	87_I	1.179	1.00
184_H	236_I	1.175	1.00
133_N	181_M	1.169	1.00
116_P	119_V	1.163	1.00
174_E	197_N	1.162	1.00
254_T	270_F	1.134	1.00
100_S	104_G	1.133	1.00
237_T	282_V	1.129	1.00
41_M	50_L	1.127	1.00
233_D	279_G	1.127	1.00
212_I	215_V	1.123	1.00
274_E	293_G	1.121	1.00
238_P	282_V	1.113	1.00
44_S	47_K	1.113	1.00
146_L	149_D	1.112	1.00
200_V	246_C	1.111	1.00
99_G	132_A	1.111	1.00
288_Y	301_V	1.107	1.00
245_A	282_V	1.102	1.00
83_S	102_N	1.099	1.00
90_D	94_Q	1.089	1.00
63_Y	74_F	1.088	1.00
80_L	109_T	1.081	1.00
130_H	147_K	1.077	1.00
250_A	254_T	1.070	1.00
43_V	65_I	1.069	1.00
54_V	58_F	1.067	1.00
98_V	107_S	1.061	1.00
87_I	96_V	1.060	1.00
146_L	150_R	1.059	1.00
303_E	306_G	1.056	1.00
62_A	78_S	1.054	1.00
182_V	235_H	1.042	1.00
182_V	234_I	1.040	1.00
88_S	132_A	1.033	1.00
88_S	134_I	1.028	1.00
122_V	154_F	1.027	1.00
246_C	254_T	1.024	1.00
41_M	52_V	1.023	1.00
81_P	107_S	1.022	1.00
64_R	72_L	1.018	1.00
80_L	107_S	1.015	1.00
45_P	93_G	1.012	1.00
36_G	57_E	1.010	1.00
192_C	234_I	1.009	1.00
199_S	217_T	1.005	1.00
254_T	267_K	1.002	1.00
235_H	281_N	1.001	1.00
81_P	84_P	1.000	1.00
282_V	289_L	0.997	1.00
90_D	97_F	0.997	1.00
203_W	214_C	0.994	1.00
237_T	240_G	0.991	1.00
135_S	138_N	0.991	1.00
292_A	297_H	0.986	1.00
259_S	262_G	0.982	1.00
86_H	132_A	0.981	1.00
183_F	205_L	0.975	1.00
288_Y	292_A	0.969	1.00
127_D	147_K	0.967	1.00
53_G	87_I	0.964	1.00
176_A	195_E	0.962	1.00
247_D	280_F	0.962	1.00
148_Q	152_C	0.959	1.00
184_H	192_C	0.947	1.00
91_H	134_I	0.945	1.00
54_V	59_R	0.931	1.00
193_V	201_D	0.930	1.00
281_N	290_I	0.928	1.00
60_V	87_I	0.926	1.00
184_H	187_E	0.920	1.00
28_L	31_V	0.920	1.00
293_G	302_Y	0.915	1.00
64_R	73_T	0.906	1.00
253_I	291_A	0.903	1.00
86_H	131_S	0.902	1.00
120_V	123_V	0.900	1.00
39_Q	56_P	0.900	1.00
283_D	290_I	0.899	1.00
91_H	138_N	0.893	1.00
67_P	72_L	0.888	1.00
227_D	250_A	0.882	1.00
34_V	54_V	0.874	1.00
182_V	236_I	0.873	1.00
185_P	236_I	0.865	1.00
128_G	147_K	0.859	1.00
129_C	144_P	0.858	1.00
192_C	244_Y	0.854	1.00
57_E	61_L	0.852	1.00
160_G	163_V	0.850	1.00
283_D	288_Y	0.847	1.00
194_N	198_S	0.847	1.00
177_G	196_L	0.844	1.00
90_D	95_F	0.842	1.00
134_I	142_W	0.841	1.00
274_E	277_P	0.839	1.00
179_R	196_L	0.835	1.00
106_V	132_A	0.834	1.00
136_P	187_E	0.834	1.00
144_P	152_C	0.827	1.00
174_E	203_W	0.827	1.00
40_P	86_H	0.824	1.00
84_P	98_V	0.821	1.00
239_D	242_H	0.818	1.00
215_V	218_L	0.816	1.00
131_S	181_M	0.815	1.00
235_H	245_A	0.813	1.00
155_T	159_D	0.810	1.00
90_D	93_G	0.809	1.00
81_P	109_T	0.802	1.00
247_D	251_S	0.797	1.00
274_E	300_S	0.794	1.00
288_Y	303_E	0.794	1.00
235_H	280_F	0.793	1.00
144_P	148_Q	0.792	1.00
37_Q	56_P	0.792	1.00
184_H	188_Q	0.781	1.00
189_Y	202_V	0.780	1.00
95_F	108_V	0.778	1.00
205_L	212_I	0.775	1.00
142_W	156_V	0.772	1.00
49_Y	75_A	0.771	1.00
189_Y	204_E	0.768	1.00
154_F	162_L	0.767	1.00
34_V	38_V	0.766	1.00
65_I	72_L	0.765	1.00
145_A	151_I	0.759	1.00
38_V	52_V	0.758	1.00
108_V	156_V	0.747	1.00
194_N	234_I	0.742	1.00
135_S	139_R	0.741	1.00
89_T	111_L	0.741	1.00
130_H	179_R	0.739	1.00
252_L	270_F	0.739	1.00
59_R	79_A	0.734	1.00
278_R	294_Q	0.734	1.00
133_N	183_F	0.733	1.00
44_S	51_Y	0.732	1.00
98_V	103_A	0.729	1.00
253_I	280_F	0.728	1.00
64_R	75_A	0.727	1.00
185_P	240_G	0.727	1.00
270_F	273_T	0.724	1.00
53_G	98_V	0.721	1.00
280_F	289_L	0.716	1.00
248_R	252_L	0.716	1.00
176_A	197_N	0.714	1.00
237_T	241_R	0.700	1.00
123_V	129_C	0.700	1.00
88_S	97_F	0.698	1.00
34_V	63_Y	0.690	1.00
267_K	271_Q	0.687	1.00
181_M	193_V	0.684	1.00
105_N	119_V	0.683	1.00
119_V	122_V	0.683	1.00
235_H	282_V	0.681	1.00
40_P	87_I	0.681	1.00
278_R	292_A	0.680	1.00
161_H	164_A	0.669	1.00
100_S	107_S	0.668	1.00
49_Y	62_A	0.667	1.00
280_F	291_A	0.667	1.00
293_G	298_H	0.665	1.00
145_A	181_M	0.664	1.00
108_V	120_V	0.662	1.00
48_R	66_A	0.658	1.00
291_A	295_K	0.657	1.00
80_L	98_V	0.657	1.00
39_Q	85_T	0.654	1.00
195_E	201_D	0.654	1.00
27_T	30_Q	0.651	1.00
113_D	116_P	0.651	1.00
39_Q	58_F	0.647	1.00
256_F	267_K	0.645	1.00
237_T	245_A	0.645	1.00
178_P	195_E	0.642	1.00
34_V	61_L	0.641	1.00
45_P	89_T	0.641	1.00
67_P	73_T	0.641	1.00
197_N	201_D	0.640	1.00
106_V	129_C	0.632	1.00
182_V	192_C	0.629	1.00
52_V	57_E	0.628	1.00
204_E	215_V	0.627	1.00
227_D	248_R	0.627	1.00
244_Y	248_R	0.626	1.00
103_A	107_S	0.623	1.00
118_G	160_G	0.621	1.00
293_G	300_S	0.620	1.00
62_A	65_I	0.619	1.00
248_R	254_T	0.619	1.00
275_T	293_G	0.617	1.00
42_V	51_Y	0.615	1.00
127_D	146_L	0.615	1.00
60_V	96_V	0.615	1.00
275_T	294_Q	0.614	1.00
279_G	282_V	0.613	1.00
241_R	257_S	0.613	1.00
94_Q	112_E	0.612	1.00
60_V	84_P	0.612	1.00
137_D	140_T	0.611	0.99
123_V	146_L	0.611	0.99
145_A	193_V	0.611	0.99
204_E	213_E	0.609	0.99
234_I	246_C	0.607	0.99
245_A	280_F	0.606	0.99
288_Y	291_A	0.605	0.99
27_T	31_V	0.604	0.99
276_Q	294_Q	0.603	0.99
149_D	176_A	0.600	0.99
258_V	261_D	0.598	0.99
48_R	51_Y	0.593	0.99
62_A	89_T	0.590	0.99
300_S	303_E	0.590	0.99
207_D	212_I	0.587	0.99
56_P	83_S	0.586	0.99
216_Q	220_M	0.585	0.99
85_T	100_S	0.582	0.99
236_I	243_L	0.581	0.99
237_T	242_H	0.580	0.99
195_E	203_W	0.575	0.99
135_S	140_T	0.569	0.99
282_V	304_I	0.569	0.99
186_N	189_Y	0.567	0.99
129_C	132_A	0.566	0.99
200_V	243_L	0.565	0.99
49_Y	64_R	0.565	0.99
49_Y	89_T	0.563	0.99
212_I	220_M	0.563	0.99
200_V	234_I	0.562	0.99
257_S	266_S	0.562	0.99
28_L	32_V	0.561	0.99
73_T	76_A	0.559	0.99
297_H	300_S	0.558	0.99
183_F	190_A	0.557	0.99
139_R	157_S	0.556	0.99
152_C	170_V	0.556	0.99
39_Q	83_S	0.553	0.99
229_R	250_A	0.553	0.99
122_V	152_C	0.552	0.99
147_K	177_G	0.551	0.99
212_I	216_Q	0.551	0.99
212_I	218_L	0.549	0.99
75_A	78_S	0.548	0.99
114_G	117_V	0.547	0.99
276_Q	293_G	0.547	0.99
227_D	231_A	0.544	0.99
160_G	164_A	0.544	0.99
123_V	154_F	0.544	0.99
266_S	270_F	0.544	0.99
216_Q	260_E	0.543	0.99
110_R	117_V	0.542	0.99
85_T	103_A	0.537	0.99
127_D	148_Q	0.537	0.99
243_L	246_C	0.534	0.99
277_P	291_A	0.534	0.99
46_D	93_G	0.532	0.99
269_G	272_P	0.531	0.99
102_N	128_G	0.531	0.99
99_G	106_V	0.531	0.99
284_H	288_Y	0.530	0.99
229_R	249_T	0.529	0.99
246_C	250_A	0.528	0.99
135_S	141_L	0.526	0.99
111_L	114_G	0.525	0.98
115_L	118_G	0.525	0.98
97_F	106_V	0.525	0.98
116_P	121_D	0.524	0.98
123_V	142_W	0.522	0.98
273_T	300_S	0.521	0.98
72_L	76_A	0.520	0.98
245_A	289_L	0.516	0.98
151_I	181_M	0.515	0.98
189_Y	192_C	0.514	0.98
146_L	154_F	0.513	0.98
149_D	177_G	0.513	0.98
112_E	115_L	0.513	0.98
202_V	216_Q	0.512	0.98
298_H	301_V	0.512	0.98
110_R	114_G	0.511	0.98
267_K	272_P	0.510	0.98
274_E	295_K	0.508	0.98
255_V	271_Q	0.508	0.98
105_N	121_D	0.506	0.98
268_E	271_Q	0.504	0.98
173_V	203_W	0.504	0.98
291_A	294_Q	0.503	0.98
240_G	244_Y	0.501	0.98
255_V	282_V	0.500	0.98
179_R	195_E	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vyhC	1	0.8127	100	0.149	Contact Map
3ow8A	3	0.8248	100	0.187	Contact Map
1gotB	1	0.8278	100	0.205	Contact Map
4wjuA	1	0.8308	100	0.209	Contact Map
3w15A	1	0.8399	100	0.209	Contact Map
4lg9A	1	0.8036	100	0.21	Contact Map
3sfzA	1	0.8187	100	0.211	Contact Map
3j60g	1	0.8761	100	0.212	Contact Map
3fm0A	1	0.864	100	0.214	Contact Map
3dm0A	1	0.8248	100	0.214	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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