GREMLIN Database
HSLJ - Heat shock protein HslJ
UniProt: P52644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13181
Length: 140 (125)
Sequences: 1602 (1344)
Seq/√Len: 120.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_S87_A5.8441.00
67_C93_C4.3471.00
72_G86_L3.5091.00
69_R91_M3.4071.00
66_M106_S3.2541.00
66_M102_D3.1691.00
64_G70_F3.0421.00
88_M106_S2.5581.00
56_F74_G2.5171.00
66_M88_M2.4951.00
34_R53_E2.1711.00
62_I86_L2.1601.00
37_L133_Y2.1191.00
102_D106_S1.9941.00
53_E70_F1.9861.00
37_L105_I1.9491.00
34_R55_S1.9281.00
62_I83_A1.8851.00
103_N107_E1.5781.00
65_S69_R1.5691.00
114_Q125_A1.5561.00
36_V51_P1.4871.00
69_R90_R1.4631.00
112_G124_L1.4511.00
68_N89_T1.4061.00
76_L81_L1.4031.00
126_T129_Q1.3791.00
116_D125_A1.3501.00
70_F105_I1.3361.00
107_E111_E1.3321.00
66_M105_I1.3081.00
64_G105_I1.3061.00
61_M73_E1.3041.00
62_I72_G1.3041.00
41_N129_Q1.2881.00
38_E121_Q1.2851.00
126_T130_T1.2741.00
57_G63_S1.2741.00
66_M70_F1.2661.00
116_D123_T1.2400.99
73_E84_K1.2170.99
95_N99_N1.2120.99
69_R87_A1.1970.99
62_I70_F1.1850.99
53_E105_I1.1820.99
108_M133_Y1.1680.99
64_G106_S1.1550.99
33_H37_L1.1230.99
40_V105_I1.0960.99
113_A126_T1.0910.99
56_F83_A1.0830.98
52_P101_L1.0460.98
39_S44_P1.0450.98
56_F62_I1.0350.98
52_P65_S1.0350.98
37_L40_V1.0290.98
100_E104_T1.0130.98
46_T49_K1.0080.98
37_L131_L0.9950.97
44_P47_S0.9900.97
117_L122_L0.9610.97
60_M74_G0.9600.97
118_T121_Q0.9380.96
40_V108_M0.9370.96
75_K84_K0.9360.96
30_L33_H0.9260.96
10_L14_M0.9220.96
116_D126_T0.9000.95
61_M71_S0.9000.95
38_E134_K0.9000.95
81_L115_V0.8970.95
71_S88_M0.8820.95
76_L115_V0.8800.95
72_G87_A0.8500.93
101_L104_T0.8490.93
42_G45_V0.8400.93
83_A112_G0.8360.93
49_K91_M0.8330.93
12_L20_N0.8240.92
33_H117_L0.8160.92
107_E110_K0.8160.92
55_S63_S0.8140.92
86_L109_L0.8100.92
63_S69_R0.8070.92
69_R92_M0.8040.91
85_G90_R0.8020.91
7_F10_L0.8000.91
7_F11_S0.7940.91
39_S42_G0.7890.91
35_F102_D0.7850.90
66_M99_N0.7820.90
89_T92_M0.7820.90
126_T132_T0.7800.90
96_P99_N0.7770.90
35_F115_V0.7760.90
71_S91_M0.7610.89
52_P70_F0.7530.89
81_L112_G0.7440.88
82_T113_A0.7210.86
11_S15_A0.7200.86
90_R103_N0.7190.86
125_A131_L0.7150.86
70_F91_M0.7060.85
87_A90_R0.7060.85
83_A110_K0.7040.85
54_I62_I0.7020.85
10_L15_A0.6950.84
46_T101_L0.6900.84
40_V104_T0.6870.84
92_M99_N0.6860.83
41_N44_P0.6840.83
35_F122_L0.6840.83
32_H56_F0.6800.83
65_S102_D0.6790.83
7_F14_M0.6790.83
70_F106_S0.6750.82
33_H55_S0.6740.82
91_M94_A0.6710.82
41_N47_S0.6650.82
87_A92_M0.6630.81
95_N100_E0.6610.81
40_V133_Y0.6570.81
68_N102_D0.6520.80
34_R51_P0.6520.80
8_V15_A0.6460.80
18_V22_K0.6420.79
63_S71_S0.6330.78
34_R44_P0.6320.78
7_F13_L0.6290.78
52_P56_F0.6240.77
31_Q59_K0.6220.77
11_S26_T0.6210.77
71_S75_K0.6200.77
125_A129_Q0.6200.77
56_F108_M0.6190.77
94_A99_N0.6170.77
16_G21_D0.6150.76
73_E120_N0.6080.75
108_M113_A0.6070.75
10_L13_L0.6050.75
9_A13_L0.6030.75
96_P100_E0.5980.74
66_M91_M0.5900.73
127_A130_T0.5880.73
6_A18_V0.5880.73
65_S91_M0.5820.72
103_N106_S0.5790.72
54_I70_F0.5790.72
30_L117_L0.5780.72
86_L110_K0.5720.71
47_S51_P0.5690.71
115_V125_A0.5620.70
16_G24_A0.5620.70
9_A18_V0.5600.69
74_G81_L0.5590.69
126_T131_L0.5530.68
6_A13_L0.5530.68
37_L121_Q0.5450.67
102_D105_I0.5400.67
118_T123_T0.5350.66
27_P33_H0.5340.66
104_T108_M0.5330.66
42_G107_E0.5310.65
92_M95_N0.5310.65
99_N102_D0.5290.65
24_A28_E0.5290.65
52_P86_L0.5280.65
90_R94_A0.5270.65
52_P105_I0.5230.64
87_A94_A0.5230.64
84_K95_N0.5210.64
79_G114_Q0.5200.64
54_I112_G0.5180.63
52_P64_G0.5160.63
43_K104_T0.5130.63
8_V11_S0.5120.63
75_K88_M0.5100.62
80_E114_Q0.5100.62
29_Q33_H0.5080.62
70_F101_L0.5080.62
47_S96_P0.5070.62
122_L134_K0.5060.62
19_S116_D0.5050.62
12_L21_D0.5050.62
105_I133_Y0.5040.61
75_K82_T0.5030.61
43_K46_T0.5020.61
80_E116_D0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ktsA 1 0.8286 100 0.253 Contact Map
2la7A 1 0.9286 99.9 0.359 Contact Map
4zgfA 1 0.7929 95.6 0.828 Contact Map
4l3rA 2 0.8 92.2 0.853 Contact Map
4qflA 1 0.6643 86 0.87 Contact Map
1sluA 2 0.7786 78.9 0.88 Contact Map
3zbiC 1 0.1929 70.1 0.888 Contact Map
2y6tE 2 0.85 68.9 0.889 Contact Map
4qrlA 1 0.6857 60.4 0.895 Contact Map
4peuA 1 0.7714 47.4 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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