GREMLIN Database
LDHD - D-lactate dehydrogenase
UniProt: P52643 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13186
Length: 329 (287)
Sequences: 18894 (13087)
Seq/√Len: 772.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_N219_A4.4451.00
217_E245_E3.2391.00
239_D242_A3.1081.00
147_A163_L2.7371.00
248_K287_C2.5271.00
146_T169_R2.5221.00
207_L236_A2.4651.00
46_E70_K2.4211.00
192_P222_Q2.3431.00
146_T171_L2.2791.00
225_N251_K2.2621.00
148_G194_L2.2021.00
195_F219_A2.1821.00
171_L197_E2.0981.00
152_T172_A2.0661.00
196_S222_Q2.0651.00
213_H261_E2.0491.00
110_I163_L2.0381.00
190_D193_T2.0341.00
124_Y128_R2.0291.00
58_R89_E1.9921.00
317_N322_E1.9491.00
119_R122_R1.9191.00
148_G198_S1.9131.00
221_E251_K1.9021.00
158_A161_R1.8971.00
117_N200_V1.8941.00
245_E249_N1.8901.00
71_Y95_V1.8521.00
111_G120_I1.8311.00
215_L220_F1.8221.00
169_R187_E1.8111.00
44_G68_G1.8071.00
58_R62_E1.8001.00
227_V252_I1.7901.00
248_K283_R1.7891.00
229_I238_I1.7771.00
113_M200_V1.7481.00
228_M254_S1.7451.00
213_H239_D1.7361.00
110_I166_F1.7281.00
244_I287_C1.7121.00
192_P219_A1.6941.00
86_A89_E1.6431.00
287_C290_V1.6331.00
217_E221_E1.6291.00
149_V156_G1.6221.00
220_F246_A1.6161.00
147_A168_M1.6091.00
115_T121_H1.6051.00
112_M256_G1.6051.00
193_T197_E1.5991.00
35_T59_P1.5941.00
199_D224_K1.5811.00
108_H297_A1.5651.00
209_P212_Y1.5561.00
145_K302_E1.5511.00
62_E90_L1.5441.00
34_L37_K1.5141.00
243_A255_L1.5131.00
116_L254_S1.5111.00
240_S261_E1.5051.00
218_A222_Q1.5041.00
140_F145_K1.5041.00
35_T57_S1.4851.00
171_L189_V1.4851.00
28_E45_C1.4751.00
215_L219_A1.4741.00
195_F215_L1.4701.00
207_L212_Y1.4701.00
103_E143_Y1.4601.00
163_L168_M1.4541.00
316_S320_K1.4521.00
141_T306_S1.4401.00
223_M227_V1.4341.00
159_M204_H1.4291.00
107_E162_I1.4281.00
203_L237_L1.4171.00
244_I248_K1.4131.00
109_A159_M1.4121.00
228_M253_G1.4071.00
169_R197_E1.4031.00
217_E242_A1.3981.00
158_A162_I1.3821.00
204_H232_T1.3811.00
46_E68_G1.3691.00
219_A222_Q1.3691.00
87_A94_V1.3671.00
61_L90_L1.3571.00
125_Q128_R1.3461.00
149_V202_S1.3431.00
317_N325_P1.3301.00
212_Y236_A1.3251.00
47_A71_Y1.3071.00
103_E158_A1.2981.00
205_C237_L1.2921.00
42_A64_L1.2891.00
233_S237_L1.2851.00
313_Q317_N1.2841.00
39_A63_E1.2691.00
203_L229_I1.2571.00
187_E197_E1.2411.00
194_L198_S1.2401.00
57_S60_V1.2391.00
309_Q313_Q1.2381.00
126_R131_N1.2301.00
58_R86_A1.2191.00
108_H112_M1.2171.00
125_Q129_D1.2091.00
260_Y292_F1.2041.00
149_V160_L1.2031.00
109_A232_T1.1931.00
150_I205_C1.1911.00
114_M166_F1.1831.00
85_D89_E1.1801.00
192_P218_A1.1771.00
116_L228_M1.1771.00
159_M202_S1.1721.00
150_I215_L1.1711.00
161_R167_G1.1611.00
101_D298_F1.1601.00
318_L324_C1.1471.00
61_L87_A1.1471.00
150_I214_L1.1431.00
116_L256_G1.1421.00
152_T157_V1.1411.00
224_K227_V1.1371.00
74_L82_V1.1341.00
218_A221_E1.1341.00
202_S232_T1.1301.00
111_G114_M1.1271.00
71_Y318_L1.1261.00
121_H124_Y1.1221.00
106_A162_I1.1171.00
86_A90_L1.1161.00
130_A286_A1.1111.00
116_L291_L1.1041.00
200_V228_M1.1041.00
214_L237_L1.1001.00
82_V87_A1.1001.00
171_L198_S1.0971.00
265_D282_R1.0961.00
220_F229_I1.0881.00
201_I223_M1.0871.00
62_E86_A1.0811.00
146_T197_E1.0711.00
191_L219_A1.0701.00
226_G251_K1.0611.00
241_Q283_R1.0571.00
37_K40_K1.0521.00
248_K286_A1.0511.00
150_I201_I1.0431.00
73_A314_N1.0411.00
240_S262_N1.0381.00
103_E162_I1.0361.00
108_H293_T1.0351.00
247_L290_V1.0331.00
313_Q325_P1.0301.00
35_T39_A1.0201.00
216_N242_A1.0191.00
113_M147_A1.0151.00
174_D178_S1.0131.00
85_D88_K1.0101.00
177_P188_Y1.0041.00
164_K185_G1.0021.00
175_P210_E0.9981.00
113_M163_L0.9961.00
93_K324_C0.9851.00
191_L195_F0.9811.00
189_V194_L0.9701.00
189_V193_T0.9661.00
150_I191_L0.9651.00
112_M291_L0.9621.00
244_I283_R0.9601.00
108_H256_G0.9601.00
161_R164_K0.9591.00
246_A251_K0.9521.00
240_S282_R0.9501.00
28_E41_T0.9451.00
305_T309_Q0.9451.00
47_A315_L0.9451.00
73_A311_T0.9441.00
206_P211_N0.9431.00
84_L88_K0.9401.00
73_A95_V0.9371.00
74_L81_N0.9241.00
157_V178_S0.9221.00
110_I162_I0.9211.00
189_V197_E0.9171.00
61_L72_I0.9121.00
172_A186_V0.9101.00
215_L229_I0.9051.00
104_A141_T0.9041.00
216_N239_D0.9031.00
83_D86_A0.9021.00
198_S201_I0.8991.00
205_C214_L0.8941.00
117_N140_F0.8931.00
220_F251_K0.8921.00
82_V94_V0.8911.00
240_S284_L0.8881.00
246_A252_I0.8871.00
40_K43_N0.8771.00
159_M163_L0.8731.00
150_I203_L0.8731.00
125_Q288_H0.8681.00
115_T120_I0.8631.00
117_N145_K0.8601.00
147_A202_S0.8561.00
115_T291_L0.8541.00
143_Y167_G0.8491.00
39_A60_V0.8481.00
203_L215_L0.8421.00
141_T300_T0.8421.00
262_N279_D0.8421.00
110_I159_M0.8411.00
76_C81_N0.8391.00
314_N317_N0.8381.00
149_V159_M0.8381.00
102_P158_A0.8291.00
220_F223_M0.8231.00
117_N228_M0.8211.00
105_V297_A0.8161.00
59_P62_E0.8161.00
179_A182_L0.8161.00
254_S291_L0.8151.00
43_N63_E0.8081.00
172_A188_Y0.8071.00
47_A319_E0.8061.00
243_A252_I0.8051.00
238_I243_A0.8051.00
121_H125_Q0.8051.00
142_M168_M0.8041.00
226_G253_G0.8041.00
241_Q245_E0.8021.00
245_E248_K0.8021.00
140_F302_E0.7971.00
195_F201_I0.7921.00
49_C311_T0.7881.00
71_Y315_L0.7881.00
201_I227_V0.7811.00
152_T160_L0.7741.00
37_K41_T0.7731.00
103_E107_E0.7641.00
48_V56_G0.7641.00
241_Q261_E0.7591.00
111_G115_T0.7571.00
168_M200_V0.7551.00
207_L211_N0.7521.00
192_P196_S0.7491.00
255_L290_V0.7461.00
102_P154_K0.7451.00
262_N265_D0.7431.00
160_L170_L0.7421.00
110_I113_M0.7421.00
109_A204_H0.7421.00
103_E141_T0.7411.00
140_F301_A0.7381.00
72_I87_A0.7361.00
107_E118_R0.7331.00
257_M290_V0.7331.00
247_L289_N0.7331.00
221_E249_N0.7241.00
109_A202_S0.7221.00
195_F222_Q0.7211.00
42_A48_V0.7211.00
226_G252_I0.7161.00
123_A296_Q0.7131.00
260_Y265_D0.7131.00
25_F316_S0.7111.00
146_T198_S0.7111.00
117_N121_H0.7081.00
173_F191_L0.7081.00
44_G65_K0.7081.00
99_A154_K0.7051.00
306_S309_Q0.7031.00
181_A188_Y0.7011.00
238_I255_L0.7001.00
104_A303_A0.6991.00
191_L214_L0.6991.00
58_R83_D0.6981.00
193_T196_S0.6961.00
127_T285_S0.6961.00
162_I166_F0.6941.00
143_Y306_S0.6901.00
217_E251_K0.6891.00
79_F84_L0.6881.00
113_M159_M0.6881.00
97_V310_T0.6871.00
140_F226_G0.6871.00
174_D177_P0.6861.00
182_L185_G0.6801.00
113_M142_M0.6781.00
228_M256_G0.6781.00
109_A112_M0.6771.00
97_V307_I0.6741.00
58_R90_L0.6741.00
39_A59_P0.6721.00
203_L233_S0.6671.00
243_A257_M0.6671.00
265_D285_S0.6661.00
146_T224_K0.6641.00
313_Q316_S0.6641.00
36_E40_K0.6581.00
148_G173_F0.6571.00
181_A185_G0.6571.00
74_L79_F0.6561.00
30_F33_L0.6521.00
265_D279_D0.6501.00
301_A305_T0.6481.00
73_A315_L0.6471.00
201_I224_K0.6461.00
145_K200_V0.6441.00
104_A107_E0.6401.00
212_Y261_E0.6391.00
312_L316_S0.6341.00
124_Y127_T0.6331.00
282_R286_A0.6321.00
245_E251_K0.6301.00
113_M230_V0.6291.00
106_A158_A0.6251.00
195_F223_M0.6231.00
104_A300_T0.6201.00
205_C233_S0.6181.00
80_N207_L0.6171.00
181_A186_V0.6171.00
59_P63_E0.6161.00
256_G291_L0.6151.00
108_H111_G0.6151.00
99_A310_T0.6151.00
248_K288_H0.6121.00
100_Y298_F0.6081.00
79_F96_R0.6071.00
147_A159_M0.6051.00
30_F41_T0.6051.00
157_V161_R0.6051.00
65_K69_V0.6021.00
73_A97_V0.6001.00
146_T199_D0.5971.00
285_S292_F0.5961.00
47_A73_A0.5951.00
208_T211_N0.5931.00
317_N323_T0.5921.00
281_F285_S0.5891.00
64_L69_V0.5881.00
217_E249_N0.5881.00
43_N65_K0.5871.00
103_E167_G0.5851.00
213_H216_N0.5841.00
171_L194_L0.5841.00
142_M166_F0.5821.00
99_A102_P0.5821.00
126_R129_D0.5811.00
108_H118_R0.5801.00
217_E246_A0.5791.00
61_L92_L0.5781.00
299_L304_L0.5781.00
65_K68_G0.5761.00
162_I165_G0.5751.00
164_K170_L0.5741.00
36_E59_P0.5741.00
112_M115_T0.5741.00
226_G249_N0.5731.00
124_Y292_F0.5731.00
70_K318_L0.5701.00
213_H236_A0.5691.00
279_D282_R0.5681.00
113_M202_S0.5651.00
123_A294_G0.5651.00
75_R307_I0.5641.00
145_K168_M0.5621.00
201_I215_L0.5591.00
117_N168_M0.5581.00
240_S244_I0.5581.00
236_A261_E0.5551.00
105_V109_A0.5531.00
317_N324_C0.5511.00
283_R287_C0.5501.00
36_E39_A0.5501.00
100_Y307_I0.5501.00
65_K90_L0.5501.00
112_M116_L0.5501.00
127_T260_Y0.5481.00
39_A64_L0.5451.00
152_T188_Y0.5451.00
23_F316_S0.5431.00
177_P181_A0.5431.00
56_G61_L0.5391.00
133_S136_G0.5381.00
248_K289_N0.5361.00
50_I56_G0.5331.00
246_A249_N0.5321.00
115_T124_Y0.5311.00
309_Q312_L0.5311.00
171_L187_E0.5301.00
234_R295_H0.5291.00
100_Y310_T0.5281.00
161_R165_G0.5281.00
121_H291_L0.5281.00
122_R126_R0.5261.00
247_L255_L0.5241.00
128_R286_A0.5231.00
71_Y93_K0.5221.00
24_G320_K0.5211.00
182_L188_Y0.5201.00
123_A137_L0.5201.00
205_C211_N0.5191.00
247_L287_C0.5181.00
127_T292_F0.5161.00
241_Q282_R0.5151.00
141_T302_E0.5141.00
180_A183_E0.5141.00
172_A181_A0.5111.00
24_G316_S0.5101.00
244_I290_V0.5101.00
126_R137_L0.5091.00
195_F214_L0.5081.00
191_L215_L0.5081.00
311_T314_N0.5071.00
152_T174_D0.5061.00
90_L93_K0.5061.00
97_V100_Y0.5041.00
110_I147_A0.5041.00
165_G168_M0.5041.00
175_P178_S0.5041.00
41_T44_G0.5021.00
201_I219_A0.5011.00
183_E186_V0.5011.00
160_L172_A0.5011.00
150_I194_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cujA 4 1 100 0.186 Contact Map
3wwzA 4 0.997 100 0.203 Contact Map
1xdwA 1 0.997 100 0.204 Contact Map
1dxyA 5 0.997 100 0.205 Contact Map
3wwyA 4 0.997 100 0.206 Contact Map
1ygyA 4 0.9453 100 0.207 Contact Map
1sc6A 4 0.9088 100 0.208 Contact Map
2g76A 2 0.9149 100 0.213 Contact Map
3k5pA 3 0.9453 100 0.215 Contact Map
2yq5A 4 0.9939 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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