GREMLIN Database
FLIK - Flagellar hook-length control protein
UniProt: P52614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20268
Length: 375 (360)
Sequences: 930 (873)
Seq/√Len: 46.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_S293_V5.9251.00
231_L244_L4.5811.00
285_Q319_N3.2831.00
240_W293_V3.1211.00
280_N303_V3.0411.00
264_H270_E2.9901.00
233_A261_L2.7761.00
29_F33_L2.7431.00
295_A303_V2.6581.00
303_V306_T2.5681.00
264_H267_D2.5641.00
247_H303_V2.5431.00
288_S294_R2.5371.00
317_Q374_F2.5201.00
261_L274_S2.4721.00
280_N284_I2.4541.00
286_M301_L2.4261.00
261_L307_Q2.3571.00
331_A334_Q2.3481.00
247_H250_L2.3131.00
311_S374_F2.2431.00
302_P315_L2.2351.00
251_F264_H2.2201.00
257_Q371_V2.1971.00
249_S252_T2.1781.00
273_I286_M2.1521.00
313_I316_G2.1261.00
241_Q293_V2.0841.00
233_A243_S2.0731.00
315_L318_S2.0721.00
303_V307_Q2.0641.00
252_T288_S2.0170.99
92_Q98_L1.9940.99
284_I317_Q1.9900.99
247_H280_N1.9820.99
240_W288_S1.9760.99
286_M320_I1.9210.99
255_G307_Q1.9140.99
311_S373_I1.9050.99
250_L280_N1.9040.99
267_D270_E1.8860.99
293_V322_G1.8850.99
267_D272_Q1.8510.99
247_H307_Q1.8490.99
299_A302_P1.8440.99
282_A300_A1.8440.99
272_Q318_S1.8070.99
256_Q261_L1.7740.98
272_Q281_Q1.7660.98
284_I293_V1.7610.98
271_V293_V1.7580.98
314_Q317_Q1.7540.98
288_S371_V1.7260.98
240_W322_G1.7250.98
285_Q370_G1.7170.98
187_L191_V1.7080.98
274_S311_S1.6920.98
261_L311_S1.6920.98
257_Q264_H1.6770.98
293_V299_A1.6530.98
270_E293_V1.6410.97
233_A237_S1.6360.97
288_S322_G1.6150.97
259_A281_Q1.6060.97
275_L318_S1.5990.97
260_E287_V1.5820.97
293_V319_N1.5670.97
280_N305_R1.5640.97
246_Q264_H1.5410.96
286_M319_N1.5400.96
257_Q267_D1.5380.96
281_Q298_E1.5240.96
133_A136_A1.5200.96
245_S315_L1.5050.96
240_W270_E1.5000.96
282_A315_L1.4840.95
231_L270_E1.4780.95
284_I373_I1.4750.95
270_E289_P1.4640.95
250_L273_I1.4560.95
240_W279_D1.4480.95
262_R267_D1.4210.94
241_Q262_R1.4190.94
270_E285_Q1.4190.94
294_R322_G1.4100.94
243_S275_L1.4080.94
258_S293_V1.4040.94
265_P269_G1.4000.94
284_I295_A1.3990.94
47_A52_V1.3960.94
292_H295_A1.3940.93
261_L373_I1.3940.93
240_W257_Q1.3830.93
246_Q255_G1.3710.93
298_E302_P1.3640.93
260_E282_A1.3520.92
290_H293_V1.3500.92
293_V296_A1.3450.92
240_W296_A1.3360.92
240_W246_Q1.3320.92
295_A311_S1.3320.92
240_W259_A1.3300.92
240_W271_V1.3260.92
240_W249_S1.3230.92
266_Q292_H1.3200.91
267_D284_I1.3190.91
314_Q318_S1.3180.91
271_V288_S1.3140.91
274_S308_L1.3060.91
290_H307_Q1.2970.91
247_H300_A1.2900.90
253_R289_P1.2750.90
255_G283_Q1.2720.90
235_L270_E1.2720.90
284_I303_V1.2700.90
270_E310_E1.2630.90
254_Q261_L1.2600.89
243_S262_R1.2480.89
262_R272_Q1.2440.89
270_E273_I1.2400.89
289_P294_R1.2380.89
249_S270_E1.2370.89
250_L292_H1.2350.88
240_W315_L1.2310.88
303_V318_S1.2280.88
274_S374_F1.2260.88
233_A264_H1.2260.88
26_A33_L1.2170.88
233_A275_L1.2030.87
280_N306_T1.2010.87
248_I256_Q1.1990.87
293_V300_A1.1950.87
235_L240_W1.1920.87
236_G261_L1.1840.86
298_E312_G1.1830.86
244_L302_P1.1810.86
250_L272_Q1.1670.85
241_Q253_R1.1640.85
283_Q313_I1.1620.85
308_L370_G1.1580.85
302_P318_S1.1580.85
290_H300_A1.1510.85
250_L306_T1.1480.84
235_L293_V1.1390.84
300_A311_S1.1360.84
231_L240_W1.1320.84
300_A315_L1.1170.83
280_N317_Q1.1150.83
277_V313_I1.1150.83
240_W321_S1.1120.83
314_Q322_G1.1100.82
51_L54_T1.1080.82
253_R264_H1.1040.82
259_A321_S1.0890.81
264_H303_V1.0790.81
260_E298_E1.0750.80
99_T109_V1.0720.80
246_Q290_H1.0720.80
32_L37_L1.0710.80
260_E293_V1.0690.80
77_L84_T1.0660.80
307_Q374_F1.0600.79
275_L370_G1.0520.79
261_L267_D1.0490.79
311_S317_Q1.0440.78
249_S293_V1.0430.78
273_I307_Q1.0420.78
247_H262_R1.0400.78
292_H309_A1.0390.78
39_G47_A1.0380.78
257_Q290_H1.0360.78
236_G240_W1.0350.78
259_A275_L1.0280.77
294_R298_E1.0240.77
272_Q317_Q1.0160.76
256_Q299_A1.0110.76
289_P295_A1.0090.76
49_Q59_T1.0080.76
252_T266_Q1.0030.75
243_S278_D0.9920.75
264_H292_H0.9910.75
231_L292_H0.9880.74
285_Q309_A0.9880.74
250_L307_Q0.9850.74
265_P304_L0.9830.74
269_G304_L0.9830.74
48_P52_V0.9810.74
246_Q280_N0.9790.74
267_D310_E0.9740.73
264_H299_A0.9690.73
294_R321_S0.9640.73
273_I285_Q0.9640.73
274_S297_L0.9630.72
81_V85_P0.9610.72
21_K25_A0.9560.72
284_I307_Q0.9560.72
245_S249_S0.9480.71
239_E250_L0.9470.71
272_Q303_V0.9450.71
292_H370_G0.9400.71
264_H295_A0.9390.71
244_L300_A0.9340.70
252_T282_A0.9330.70
251_F315_L0.9310.70
270_E373_I0.9300.70
358_P362_Q0.9290.70
91_E103_T0.9280.70
274_S321_S0.9260.69
280_N315_L0.9250.69
250_L370_G0.9240.69
223_L228_A0.9230.69
317_Q321_S0.9210.69
241_Q299_A0.9190.69
277_V374_F0.9120.68
252_T290_H0.9090.68
297_L364_R0.9090.68
250_L369_S0.9070.68
252_T287_V0.9050.68
288_S292_H0.9040.68
31_A59_T0.9040.68
250_L270_E0.9040.68
242_Q290_H0.9030.67
251_F372_D0.9020.67
16_T22_A0.8970.67
250_L259_A0.8930.67
92_Q96_T0.8920.67
186_P195_Q0.8920.67
301_L318_S0.8910.66
92_Q95_S0.8880.66
236_G243_S0.8870.66
262_R283_Q0.8830.66
256_Q284_I0.8820.66
94_T97_P0.8800.65
274_S368_N0.8780.65
247_H295_A0.8770.65
233_A236_G0.8750.65
297_L319_N0.8750.65
70_S80_P0.8710.65
268_L300_A0.8700.65
240_W264_H0.8700.65
32_L276_K0.8680.64
283_Q317_Q0.8640.64
246_Q310_E0.8620.64
262_R266_Q0.8550.63
274_S373_I0.8540.63
255_G264_H0.8540.63
260_E292_H0.8520.63
251_F307_Q0.8490.63
288_S319_N0.8480.63
266_Q324_S0.8460.62
274_S296_A0.8450.62
135_F139_P0.8410.62
244_L259_A0.8380.62
233_A318_S0.8380.62
56_K60_K0.8380.62
256_Q259_A0.8380.62
16_T50_L0.8360.61
93_S97_P0.8360.61
272_Q291_Q0.8360.61
322_G371_V0.8350.61
364_R369_S0.8350.61
367_G372_D0.8250.60
258_S308_L0.8210.60
267_D317_Q0.8200.60
241_Q264_H0.8160.60
240_W250_L0.8160.60
253_R278_D0.8100.59
252_T307_Q0.8050.59
264_H310_E0.8050.59
282_A289_P0.8030.58
281_Q318_S0.8030.58
101_A106_L0.8020.58
264_H284_I0.8020.58
162_L166_L0.7990.58
312_G372_D0.7960.58
157_T174_A0.7950.58
335_Q340_R0.7940.57
270_E314_Q0.7930.57
96_T99_T0.7910.57
272_Q277_V0.7910.57
303_V310_E0.7910.57
267_D271_V0.7910.57
310_E322_G0.7870.57
281_Q285_Q0.7870.57
367_G370_G0.7860.57
154_V175_Q0.7840.57
274_S319_N0.7840.57
284_I288_S0.7840.57
62_E187_L0.7820.56
282_A307_Q0.7810.56
243_S371_V0.7810.56
248_I271_V0.7770.56
253_R307_Q0.7770.56
245_S248_I0.7730.55
246_Q249_S0.7720.55
77_L92_Q0.7700.55
167_T189_P0.7700.55
272_Q280_N0.7700.55
259_A369_S0.7680.55
242_Q255_G0.7670.55
272_Q282_A0.7670.55
298_E301_L0.7660.55
231_L264_H0.7660.55
267_D283_Q0.7630.54
291_Q295_A0.7620.54
262_R318_S0.7590.54
233_A273_I0.7570.54
52_V56_K0.7560.54
363_G367_G0.7550.54
247_H274_S0.7550.54
257_Q309_A0.7530.53
256_Q319_N0.7520.53
240_W243_S0.7520.53
338_S345_E0.7490.53
178_D182_T0.7440.53
271_V318_S0.7400.52
322_G374_F0.7400.52
259_A374_F0.7370.52
96_T107_A0.7370.52
297_L300_A0.7330.52
241_Q372_D0.7320.51
240_W319_N0.7310.51
289_P293_V0.7300.51
229_P288_S0.7300.51
253_R283_Q0.7280.51
272_Q306_T0.7270.51
262_R276_K0.7260.51
245_S250_L0.7240.51
258_S371_V0.7230.51
309_A317_Q0.7210.50
160_P169_E0.7190.50
243_S272_Q0.7180.50
254_Q311_S0.7180.50
265_P268_L0.7170.50
278_D281_Q0.7160.50
247_H284_I0.7160.50
300_A323_E0.7150.50
83_E112_K0.7140.50
251_F266_Q0.7100.49
244_L316_G0.7090.49
262_R292_H0.7080.49
251_F303_V0.7070.49
358_P361_L0.7060.49
244_L297_L0.7060.49
261_L305_R0.7030.49
267_D274_S0.7030.49
231_L234_P0.7020.48
196_S212_S0.7020.48
292_H324_S0.6990.48
138_L144_T0.6980.48
255_G289_P0.6960.48
252_T271_V0.6950.48
258_S267_D0.6940.48
185_Q190_L0.6910.47
266_Q280_N0.6900.47
283_Q309_A0.6890.47
310_E318_S0.6880.47
254_Q287_V0.6880.47
271_V297_L0.6860.47
256_Q311_S0.6860.47
251_F288_S0.6860.47
306_T374_F0.6850.47
290_H302_P0.6850.47
271_V286_M0.6820.47
257_Q322_G0.6820.47
339_Q343_N0.6810.46
264_H317_Q0.6800.46
245_S251_F0.6780.46
316_G319_N0.6780.46
119_K134_L0.6770.46
243_S293_V0.6760.46
235_L273_I0.6760.46
323_E374_F0.6730.46
308_L318_S0.6720.46
255_G278_D0.6720.46
220_T224_P0.6710.45
246_Q257_Q0.6700.45
281_Q322_G0.6700.45
168_S171_L0.6680.45
273_I317_Q0.6680.45
251_F285_Q0.6670.45
65_I70_S0.6660.45
260_E272_Q0.6650.45
245_S252_T0.6650.45
112_K117_D0.6640.45
247_H308_L0.6620.45
113_N123_L0.6600.44
143_N202_S0.6590.44
241_Q270_E0.6590.44
365_V373_I0.6560.44
239_E314_Q0.6540.44
266_Q303_V0.6530.44
287_V290_H0.6500.43
240_W275_L0.6470.43
88_I99_T0.6440.43
261_L264_H0.6430.43
260_E264_H0.6420.43
274_S279_D0.6420.43
78_L82_D0.6410.43
233_A240_W0.6400.42
275_L372_D0.6400.42
16_T20_G0.6400.42
257_Q310_E0.6380.42
266_Q276_K0.6370.42
85_P117_D0.6360.42
243_S314_Q0.6350.42
206_P216_T0.6320.42
101_A212_S0.6320.42
332_A337_Q0.6320.42
261_L301_L0.6310.42
273_I323_E0.6300.41
245_S270_E0.6290.41
284_I316_G0.6280.41
264_H371_V0.6280.41
284_I370_G0.6260.41
242_Q245_S0.6260.41
181_G185_Q0.6250.41
250_L314_Q0.6220.41
298_E316_G0.6200.41
242_Q272_Q0.6200.41
244_L264_H0.6180.40
278_D318_S0.6180.40
244_L299_A0.6170.40
80_P84_T0.6160.40
32_L286_M0.6150.40
119_K124_N0.6140.40
317_Q373_I0.6120.40
287_V307_Q0.6100.40
252_T260_E0.6090.39
244_L262_R0.6090.39
281_Q305_R0.6080.39
288_S321_S0.6070.39
270_E318_S0.6070.39
276_K294_R0.6060.39
274_S286_M0.6060.39
223_L356_P0.6060.39
152_S163_F0.6020.39
254_Q307_Q0.6020.39
234_P239_E0.6010.39
262_R274_S0.6010.39
235_L241_Q0.6000.39
245_S367_G0.5970.38
254_Q284_I0.5960.38
273_I318_S0.5950.38
255_G285_Q0.5930.38
253_R266_Q0.5930.38
201_I207_V0.5930.38
111_D147_V0.5900.38
154_V214_L0.5880.38
258_S289_P0.5870.37
272_Q275_L0.5850.37
50_L61_G0.5840.37
247_H374_F0.5830.37
275_L314_Q0.5830.37
229_P314_Q0.5820.37
290_H323_E0.5820.37
235_L239_E0.5800.37
242_Q247_H0.5800.37
249_S257_Q0.5800.37
259_A278_D0.5790.37
53_A145_P0.5790.37
63_P66_S0.5780.37
259_A272_Q0.5780.37
255_G303_V0.5780.37
301_L312_G0.5770.37
246_Q300_A0.5770.37
299_A374_F0.5750.36
240_W252_T0.5750.36
266_Q282_A0.5730.36
321_S370_G0.5720.36
161_T165_K0.5710.36
23_S27_Q0.5700.36
247_H283_Q0.5660.36
234_P266_Q0.5660.36
188_T193_E0.5660.36
292_H317_Q0.5650.35
25_A28_D0.5630.35
251_F313_I0.5620.35
246_Q279_D0.5620.35
240_W290_H0.5590.35
312_G315_L0.5540.34
280_N295_A0.5540.34
293_V374_F0.5530.34
115_T180_P0.5530.34
187_L190_L0.5530.34
112_K120_A0.5520.34
248_I287_V0.5490.34
242_Q274_S0.5480.34
277_V323_E0.5480.34
240_W317_Q0.5470.34
234_P294_R0.5460.34
257_Q315_L0.5450.34
272_Q371_V0.5440.34
259_A270_E0.5440.34
253_R285_Q0.5430.33
197_K213_P0.5420.33
162_L170_Q0.5410.33
212_S336_Q0.5410.33
245_S316_G0.5400.33
91_E96_T0.5390.33
255_G314_Q0.5390.33
302_P316_G0.5380.33
39_G63_P0.5380.33
241_Q266_Q0.5380.33
253_R257_Q0.5360.33
297_L310_E0.5340.33
262_R317_Q0.5330.33
254_Q364_R0.5320.33
264_H307_Q0.5320.33
115_T118_E0.5320.33
274_S322_G0.5310.32
86_P346_P0.5310.32
168_S173_T0.5310.32
303_V326_S0.5300.32
280_N374_F0.5290.32
101_A109_V0.5280.32
260_E283_Q0.5280.32
259_A311_S0.5260.32
272_Q290_H0.5250.32
246_Q251_F0.5250.32
364_R370_G0.5220.32
245_S288_S0.5220.32
73_Q83_E0.5200.31
237_S266_Q0.5190.31
245_S257_Q0.5190.31
284_I318_S0.5190.31
91_E122_D0.5170.31
182_T188_T0.5150.31
254_Q270_E0.5150.31
134_L138_L0.5140.31
231_L294_R0.5130.31
289_P309_A0.5110.31
251_F281_Q0.5100.31
281_Q314_Q0.5100.31
282_A323_E0.5090.31
80_P83_E0.5080.30
310_E323_E0.5060.30
275_L313_I0.5050.30
114_T165_K0.5040.30
370_G373_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rrlA 1 0.4507 100 0.537 Contact Map
3a2aA 2 0.088 14.7 0.954 Contact Map
2e0cA 2 0.2747 7.1 0.96 Contact Map
2kgsA 1 0.2613 3.8 0.965 Contact Map
2jmpA 1 0.2613 3.6 0.965 Contact Map
3vn0A 2 0.1307 3.4 0.966 Contact Map
3zbhA 2 0.2 3.4 0.966 Contact Map
3favB 1 0.1493 3.2 0.966 Contact Map
2mdvA 2 0.1013 3.1 0.966 Contact Map
2e0gA 1 0.28 2.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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