FLIK - ECOLI - GREMLIN Contacts

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FLIK - Flagellar hook-length control protein

UniProt:	P52614	Sequences: MIRLAPLITADVDTTTLPGGKASDAAQDFLALLSEALAGETTTDKAAPQLLVATDKPTTKGEPLISDIVSDAQQANLLIPVDETPPVINDEQSTSTPLTTAQTMALAAVADKNTTKDEKADDLNEDVTASLSALFAMLPGFDNTPKVTDAPSTVLPTEKPTLFTKLTSEQLTTAQPDDAPGTPAQPLTPLVAEAQSKAEVISTPSPVTAAASPLITPHQTQPLPTVAAPVLSAPLGSHEWQQSLSQHISLFTRQGQQSAELRLHPQDLGEVQISLKVDDNQAQIQMVSPHQHVRAALEAALPVLRTQLAESGIQLGQSNISGESFSGQQQAASQQQQSQRTANHEPLAGEDDDTLPVPVSLQGRVTGNSGVDIFA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG20268
Length:	375 (360)
Sequences:	930 (873)
Seq/√Len:	46.0

ECOLI - FLIK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
288_S	293_V	5.925	1.00
231_L	244_L	4.581	1.00
285_Q	319_N	3.283	1.00
240_W	293_V	3.121	1.00
280_N	303_V	3.041	1.00
264_H	270_E	2.990	1.00
233_A	261_L	2.776	1.00
29_F	33_L	2.743	1.00
295_A	303_V	2.658	1.00
303_V	306_T	2.568	1.00
264_H	267_D	2.564	1.00
247_H	303_V	2.543	1.00
288_S	294_R	2.537	1.00
317_Q	374_F	2.520	1.00
261_L	274_S	2.472	1.00
280_N	284_I	2.454	1.00
286_M	301_L	2.426	1.00
261_L	307_Q	2.357	1.00
331_A	334_Q	2.348	1.00
247_H	250_L	2.313	1.00
311_S	374_F	2.243	1.00
302_P	315_L	2.235	1.00
251_F	264_H	2.220	1.00
257_Q	371_V	2.197	1.00
249_S	252_T	2.178	1.00
273_I	286_M	2.152	1.00
313_I	316_G	2.126	1.00
241_Q	293_V	2.084	1.00
233_A	243_S	2.073	1.00
315_L	318_S	2.072	1.00
303_V	307_Q	2.064	1.00
252_T	288_S	2.017	0.99
92_Q	98_L	1.994	0.99
284_I	317_Q	1.990	0.99
247_H	280_N	1.982	0.99
240_W	288_S	1.976	0.99
286_M	320_I	1.921	0.99
255_G	307_Q	1.914	0.99
311_S	373_I	1.905	0.99
250_L	280_N	1.904	0.99
267_D	270_E	1.886	0.99
293_V	322_G	1.885	0.99
267_D	272_Q	1.851	0.99
247_H	307_Q	1.849	0.99
299_A	302_P	1.844	0.99
282_A	300_A	1.844	0.99
272_Q	318_S	1.807	0.99
256_Q	261_L	1.774	0.98
272_Q	281_Q	1.766	0.98
284_I	293_V	1.761	0.98
271_V	293_V	1.758	0.98
314_Q	317_Q	1.754	0.98
288_S	371_V	1.726	0.98
240_W	322_G	1.725	0.98
285_Q	370_G	1.717	0.98
187_L	191_V	1.708	0.98
274_S	311_S	1.692	0.98
261_L	311_S	1.692	0.98
257_Q	264_H	1.677	0.98
293_V	299_A	1.653	0.98
270_E	293_V	1.641	0.97
233_A	237_S	1.636	0.97
288_S	322_G	1.615	0.97
259_A	281_Q	1.606	0.97
275_L	318_S	1.599	0.97
260_E	287_V	1.582	0.97
293_V	319_N	1.567	0.97
280_N	305_R	1.564	0.97
246_Q	264_H	1.541	0.96
286_M	319_N	1.540	0.96
257_Q	267_D	1.538	0.96
281_Q	298_E	1.524	0.96
133_A	136_A	1.520	0.96
245_S	315_L	1.505	0.96
240_W	270_E	1.500	0.96
282_A	315_L	1.484	0.95
231_L	270_E	1.478	0.95
284_I	373_I	1.475	0.95
270_E	289_P	1.464	0.95
250_L	273_I	1.456	0.95
240_W	279_D	1.448	0.95
262_R	267_D	1.421	0.94
241_Q	262_R	1.419	0.94
270_E	285_Q	1.419	0.94
294_R	322_G	1.410	0.94
243_S	275_L	1.408	0.94
258_S	293_V	1.404	0.94
265_P	269_G	1.400	0.94
284_I	295_A	1.399	0.94
47_A	52_V	1.396	0.94
292_H	295_A	1.394	0.93
261_L	373_I	1.394	0.93
240_W	257_Q	1.383	0.93
246_Q	255_G	1.371	0.93
298_E	302_P	1.364	0.93
260_E	282_A	1.352	0.92
290_H	293_V	1.350	0.92
293_V	296_A	1.345	0.92
240_W	296_A	1.336	0.92
240_W	246_Q	1.332	0.92
295_A	311_S	1.332	0.92
240_W	259_A	1.330	0.92
240_W	271_V	1.326	0.92
240_W	249_S	1.323	0.92
266_Q	292_H	1.320	0.91
267_D	284_I	1.319	0.91
314_Q	318_S	1.318	0.91
271_V	288_S	1.314	0.91
274_S	308_L	1.306	0.91
290_H	307_Q	1.297	0.91
247_H	300_A	1.290	0.90
253_R	289_P	1.275	0.90
255_G	283_Q	1.272	0.90
235_L	270_E	1.272	0.90
284_I	303_V	1.270	0.90
270_E	310_E	1.263	0.90
254_Q	261_L	1.260	0.89
243_S	262_R	1.248	0.89
262_R	272_Q	1.244	0.89
270_E	273_I	1.240	0.89
289_P	294_R	1.238	0.89
249_S	270_E	1.237	0.89
250_L	292_H	1.235	0.88
240_W	315_L	1.231	0.88
303_V	318_S	1.228	0.88
274_S	374_F	1.226	0.88
233_A	264_H	1.226	0.88
26_A	33_L	1.217	0.88
233_A	275_L	1.203	0.87
280_N	306_T	1.201	0.87
248_I	256_Q	1.199	0.87
293_V	300_A	1.195	0.87
235_L	240_W	1.192	0.87
236_G	261_L	1.184	0.86
298_E	312_G	1.183	0.86
244_L	302_P	1.181	0.86
250_L	272_Q	1.167	0.85
241_Q	253_R	1.164	0.85
283_Q	313_I	1.162	0.85
308_L	370_G	1.158	0.85
302_P	318_S	1.158	0.85
290_H	300_A	1.151	0.85
250_L	306_T	1.148	0.84
235_L	293_V	1.139	0.84
300_A	311_S	1.136	0.84
231_L	240_W	1.132	0.84
300_A	315_L	1.117	0.83
280_N	317_Q	1.115	0.83
277_V	313_I	1.115	0.83
240_W	321_S	1.112	0.83
314_Q	322_G	1.110	0.82
51_L	54_T	1.108	0.82
253_R	264_H	1.104	0.82
259_A	321_S	1.089	0.81
264_H	303_V	1.079	0.81
260_E	298_E	1.075	0.80
99_T	109_V	1.072	0.80
246_Q	290_H	1.072	0.80
32_L	37_L	1.071	0.80
260_E	293_V	1.069	0.80
77_L	84_T	1.066	0.80
307_Q	374_F	1.060	0.79
275_L	370_G	1.052	0.79
261_L	267_D	1.049	0.79
311_S	317_Q	1.044	0.78
249_S	293_V	1.043	0.78
273_I	307_Q	1.042	0.78
247_H	262_R	1.040	0.78
292_H	309_A	1.039	0.78
39_G	47_A	1.038	0.78
257_Q	290_H	1.036	0.78
236_G	240_W	1.035	0.78
259_A	275_L	1.028	0.77
294_R	298_E	1.024	0.77
272_Q	317_Q	1.016	0.76
256_Q	299_A	1.011	0.76
289_P	295_A	1.009	0.76
49_Q	59_T	1.008	0.76
252_T	266_Q	1.003	0.75
243_S	278_D	0.992	0.75
264_H	292_H	0.991	0.75
231_L	292_H	0.988	0.74
285_Q	309_A	0.988	0.74
250_L	307_Q	0.985	0.74
265_P	304_L	0.983	0.74
269_G	304_L	0.983	0.74
48_P	52_V	0.981	0.74
246_Q	280_N	0.979	0.74
267_D	310_E	0.974	0.73
264_H	299_A	0.969	0.73
294_R	321_S	0.964	0.73
273_I	285_Q	0.964	0.73
274_S	297_L	0.963	0.72
81_V	85_P	0.961	0.72
21_K	25_A	0.956	0.72
284_I	307_Q	0.956	0.72
245_S	249_S	0.948	0.71
239_E	250_L	0.947	0.71
272_Q	303_V	0.945	0.71
292_H	370_G	0.940	0.71
264_H	295_A	0.939	0.71
244_L	300_A	0.934	0.70
252_T	282_A	0.933	0.70
251_F	315_L	0.931	0.70
270_E	373_I	0.930	0.70
358_P	362_Q	0.929	0.70
91_E	103_T	0.928	0.70
274_S	321_S	0.926	0.69
280_N	315_L	0.925	0.69
250_L	370_G	0.924	0.69
223_L	228_A	0.923	0.69
317_Q	321_S	0.921	0.69
241_Q	299_A	0.919	0.69
277_V	374_F	0.912	0.68
252_T	290_H	0.909	0.68
297_L	364_R	0.909	0.68
250_L	369_S	0.907	0.68
252_T	287_V	0.905	0.68
288_S	292_H	0.904	0.68
31_A	59_T	0.904	0.68
250_L	270_E	0.904	0.68
242_Q	290_H	0.903	0.67
251_F	372_D	0.902	0.67
16_T	22_A	0.897	0.67
250_L	259_A	0.893	0.67
92_Q	96_T	0.892	0.67
186_P	195_Q	0.892	0.67
301_L	318_S	0.891	0.66
92_Q	95_S	0.888	0.66
236_G	243_S	0.887	0.66
262_R	283_Q	0.883	0.66
256_Q	284_I	0.882	0.66
94_T	97_P	0.880	0.65
274_S	368_N	0.878	0.65
247_H	295_A	0.877	0.65
233_A	236_G	0.875	0.65
297_L	319_N	0.875	0.65
70_S	80_P	0.871	0.65
268_L	300_A	0.870	0.65
240_W	264_H	0.870	0.65
32_L	276_K	0.868	0.64
283_Q	317_Q	0.864	0.64
246_Q	310_E	0.862	0.64
262_R	266_Q	0.855	0.63
274_S	373_I	0.854	0.63
255_G	264_H	0.854	0.63
260_E	292_H	0.852	0.63
251_F	307_Q	0.849	0.63
288_S	319_N	0.848	0.63
266_Q	324_S	0.846	0.62
274_S	296_A	0.845	0.62
135_F	139_P	0.841	0.62
244_L	259_A	0.838	0.62
233_A	318_S	0.838	0.62
56_K	60_K	0.838	0.62
256_Q	259_A	0.838	0.62
16_T	50_L	0.836	0.61
93_S	97_P	0.836	0.61
272_Q	291_Q	0.836	0.61
322_G	371_V	0.835	0.61
364_R	369_S	0.835	0.61
367_G	372_D	0.825	0.60
258_S	308_L	0.821	0.60
267_D	317_Q	0.820	0.60
241_Q	264_H	0.816	0.60
240_W	250_L	0.816	0.60
253_R	278_D	0.810	0.59
252_T	307_Q	0.805	0.59
264_H	310_E	0.805	0.59
282_A	289_P	0.803	0.58
281_Q	318_S	0.803	0.58
101_A	106_L	0.802	0.58
264_H	284_I	0.802	0.58
162_L	166_L	0.799	0.58
312_G	372_D	0.796	0.58
157_T	174_A	0.795	0.58
335_Q	340_R	0.794	0.57
270_E	314_Q	0.793	0.57
96_T	99_T	0.791	0.57
272_Q	277_V	0.791	0.57
303_V	310_E	0.791	0.57
267_D	271_V	0.791	0.57
310_E	322_G	0.787	0.57
281_Q	285_Q	0.787	0.57
367_G	370_G	0.786	0.57
154_V	175_Q	0.784	0.57
274_S	319_N	0.784	0.57
284_I	288_S	0.784	0.57
62_E	187_L	0.782	0.56
282_A	307_Q	0.781	0.56
243_S	371_V	0.781	0.56
248_I	271_V	0.777	0.56
253_R	307_Q	0.777	0.56
245_S	248_I	0.773	0.55
246_Q	249_S	0.772	0.55
77_L	92_Q	0.770	0.55
167_T	189_P	0.770	0.55
272_Q	280_N	0.770	0.55
259_A	369_S	0.768	0.55
242_Q	255_G	0.767	0.55
272_Q	282_A	0.767	0.55
298_E	301_L	0.766	0.55
231_L	264_H	0.766	0.55
267_D	283_Q	0.763	0.54
291_Q	295_A	0.762	0.54
262_R	318_S	0.759	0.54
233_A	273_I	0.757	0.54
52_V	56_K	0.756	0.54
363_G	367_G	0.755	0.54
247_H	274_S	0.755	0.54
257_Q	309_A	0.753	0.53
256_Q	319_N	0.752	0.53
240_W	243_S	0.752	0.53
338_S	345_E	0.749	0.53
178_D	182_T	0.744	0.53
271_V	318_S	0.740	0.52
322_G	374_F	0.740	0.52
259_A	374_F	0.737	0.52
96_T	107_A	0.737	0.52
297_L	300_A	0.733	0.52
241_Q	372_D	0.732	0.51
240_W	319_N	0.731	0.51
289_P	293_V	0.730	0.51
229_P	288_S	0.730	0.51
253_R	283_Q	0.728	0.51
272_Q	306_T	0.727	0.51
262_R	276_K	0.726	0.51
245_S	250_L	0.724	0.51
258_S	371_V	0.723	0.51
309_A	317_Q	0.721	0.50
160_P	169_E	0.719	0.50
243_S	272_Q	0.718	0.50
254_Q	311_S	0.718	0.50
265_P	268_L	0.717	0.50
278_D	281_Q	0.716	0.50
247_H	284_I	0.716	0.50
300_A	323_E	0.715	0.50
83_E	112_K	0.714	0.50
251_F	266_Q	0.710	0.49
244_L	316_G	0.709	0.49
262_R	292_H	0.708	0.49
251_F	303_V	0.707	0.49
358_P	361_L	0.706	0.49
244_L	297_L	0.706	0.49
261_L	305_R	0.703	0.49
267_D	274_S	0.703	0.49
231_L	234_P	0.702	0.48
196_S	212_S	0.702	0.48
292_H	324_S	0.699	0.48
138_L	144_T	0.698	0.48
255_G	289_P	0.696	0.48
252_T	271_V	0.695	0.48
258_S	267_D	0.694	0.48
185_Q	190_L	0.691	0.47
266_Q	280_N	0.690	0.47
283_Q	309_A	0.689	0.47
310_E	318_S	0.688	0.47
254_Q	287_V	0.688	0.47
271_V	297_L	0.686	0.47
256_Q	311_S	0.686	0.47
251_F	288_S	0.686	0.47
306_T	374_F	0.685	0.47
290_H	302_P	0.685	0.47
271_V	286_M	0.682	0.47
257_Q	322_G	0.682	0.47
339_Q	343_N	0.681	0.46
264_H	317_Q	0.680	0.46
245_S	251_F	0.678	0.46
316_G	319_N	0.678	0.46
119_K	134_L	0.677	0.46
243_S	293_V	0.676	0.46
235_L	273_I	0.676	0.46
323_E	374_F	0.673	0.46
308_L	318_S	0.672	0.46
255_G	278_D	0.672	0.46
220_T	224_P	0.671	0.45
246_Q	257_Q	0.670	0.45
281_Q	322_G	0.670	0.45
168_S	171_L	0.668	0.45
273_I	317_Q	0.668	0.45
251_F	285_Q	0.667	0.45
65_I	70_S	0.666	0.45
260_E	272_Q	0.665	0.45
245_S	252_T	0.665	0.45
112_K	117_D	0.664	0.45
247_H	308_L	0.662	0.45
113_N	123_L	0.660	0.44
143_N	202_S	0.659	0.44
241_Q	270_E	0.659	0.44
365_V	373_I	0.656	0.44
239_E	314_Q	0.654	0.44
266_Q	303_V	0.653	0.44
287_V	290_H	0.650	0.43
240_W	275_L	0.647	0.43
88_I	99_T	0.644	0.43
261_L	264_H	0.643	0.43
260_E	264_H	0.642	0.43
274_S	279_D	0.642	0.43
78_L	82_D	0.641	0.43
233_A	240_W	0.640	0.42
275_L	372_D	0.640	0.42
16_T	20_G	0.640	0.42
257_Q	310_E	0.638	0.42
266_Q	276_K	0.637	0.42
85_P	117_D	0.636	0.42
243_S	314_Q	0.635	0.42
206_P	216_T	0.632	0.42
101_A	212_S	0.632	0.42
332_A	337_Q	0.632	0.42
261_L	301_L	0.631	0.42
273_I	323_E	0.630	0.41
245_S	270_E	0.629	0.41
284_I	316_G	0.628	0.41
264_H	371_V	0.628	0.41
284_I	370_G	0.626	0.41
242_Q	245_S	0.626	0.41
181_G	185_Q	0.625	0.41
250_L	314_Q	0.622	0.41
298_E	316_G	0.620	0.41
242_Q	272_Q	0.620	0.41
244_L	264_H	0.618	0.40
278_D	318_S	0.618	0.40
244_L	299_A	0.617	0.40
80_P	84_T	0.616	0.40
32_L	286_M	0.615	0.40
119_K	124_N	0.614	0.40
317_Q	373_I	0.612	0.40
287_V	307_Q	0.610	0.40
252_T	260_E	0.609	0.39
244_L	262_R	0.609	0.39
281_Q	305_R	0.608	0.39
288_S	321_S	0.607	0.39
270_E	318_S	0.607	0.39
276_K	294_R	0.606	0.39
274_S	286_M	0.606	0.39
223_L	356_P	0.606	0.39
152_S	163_F	0.602	0.39
254_Q	307_Q	0.602	0.39
234_P	239_E	0.601	0.39
262_R	274_S	0.601	0.39
235_L	241_Q	0.600	0.39
245_S	367_G	0.597	0.38
254_Q	284_I	0.596	0.38
273_I	318_S	0.595	0.38
255_G	285_Q	0.593	0.38
253_R	266_Q	0.593	0.38
201_I	207_V	0.593	0.38
111_D	147_V	0.590	0.38
154_V	214_L	0.588	0.38
258_S	289_P	0.587	0.37
272_Q	275_L	0.585	0.37
50_L	61_G	0.584	0.37
247_H	374_F	0.583	0.37
275_L	314_Q	0.583	0.37
229_P	314_Q	0.582	0.37
290_H	323_E	0.582	0.37
235_L	239_E	0.580	0.37
242_Q	247_H	0.580	0.37
249_S	257_Q	0.580	0.37
259_A	278_D	0.579	0.37
53_A	145_P	0.579	0.37
63_P	66_S	0.578	0.37
259_A	272_Q	0.578	0.37
255_G	303_V	0.578	0.37
301_L	312_G	0.577	0.37
246_Q	300_A	0.577	0.37
299_A	374_F	0.575	0.36
240_W	252_T	0.575	0.36
266_Q	282_A	0.573	0.36
321_S	370_G	0.572	0.36
161_T	165_K	0.571	0.36
23_S	27_Q	0.570	0.36
247_H	283_Q	0.566	0.36
234_P	266_Q	0.566	0.36
188_T	193_E	0.566	0.36
292_H	317_Q	0.565	0.35
25_A	28_D	0.563	0.35
251_F	313_I	0.562	0.35
246_Q	279_D	0.562	0.35
240_W	290_H	0.559	0.35
312_G	315_L	0.554	0.34
280_N	295_A	0.554	0.34
293_V	374_F	0.553	0.34
115_T	180_P	0.553	0.34
187_L	190_L	0.553	0.34
112_K	120_A	0.552	0.34
248_I	287_V	0.549	0.34
242_Q	274_S	0.548	0.34
277_V	323_E	0.548	0.34
240_W	317_Q	0.547	0.34
234_P	294_R	0.546	0.34
257_Q	315_L	0.545	0.34
272_Q	371_V	0.544	0.34
259_A	270_E	0.544	0.34
253_R	285_Q	0.543	0.33
197_K	213_P	0.542	0.33
162_L	170_Q	0.541	0.33
212_S	336_Q	0.541	0.33
245_S	316_G	0.540	0.33
91_E	96_T	0.539	0.33
255_G	314_Q	0.539	0.33
302_P	316_G	0.538	0.33
39_G	63_P	0.538	0.33
241_Q	266_Q	0.538	0.33
253_R	257_Q	0.536	0.33
297_L	310_E	0.534	0.33
262_R	317_Q	0.533	0.33
254_Q	364_R	0.532	0.33
264_H	307_Q	0.532	0.33
115_T	118_E	0.532	0.33
274_S	322_G	0.531	0.32
86_P	346_P	0.531	0.32
168_S	173_T	0.531	0.32
303_V	326_S	0.530	0.32
280_N	374_F	0.529	0.32
101_A	109_V	0.528	0.32
260_E	283_Q	0.528	0.32
259_A	311_S	0.526	0.32
272_Q	290_H	0.525	0.32
246_Q	251_F	0.525	0.32
364_R	370_G	0.522	0.32
245_S	288_S	0.522	0.32
73_Q	83_E	0.520	0.31
237_S	266_Q	0.519	0.31
245_S	257_Q	0.519	0.31
284_I	318_S	0.519	0.31
91_E	122_D	0.517	0.31
182_T	188_T	0.515	0.31
254_Q	270_E	0.515	0.31
134_L	138_L	0.514	0.31
231_L	294_R	0.513	0.31
289_P	309_A	0.511	0.31
251_F	281_Q	0.510	0.31
281_Q	314_Q	0.510	0.31
282_A	323_E	0.509	0.31
80_P	83_E	0.508	0.30
310_E	323_E	0.506	0.30
275_L	313_I	0.505	0.30
114_T	165_K	0.504	0.30
370_G	373_I	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rrlA	1	0.4507	100	0.537	Contact Map
3a2aA	2	0.088	14.7	0.954	Contact Map
2e0cA	2	0.2747	7.1	0.96	Contact Map
2kgsA	1	0.2613	3.8	0.965	Contact Map
2jmpA	1	0.2613	3.6	0.965	Contact Map
3vn0A	2	0.1307	3.4	0.966	Contact Map
3zbhA	2	0.2	3.4	0.966	Contact Map
3favB	1	0.1493	3.2	0.966	Contact Map
2mdvA	2	0.1013	3.1	0.966	Contact Map
2e0gA	1	0.28	2.8	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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