GREMLIN Database
FLII - Flagellum-specific ATP synthase
UniProt: P52612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20266
Length: 457 (408)
Sequences: 7959 (2819)
Seq/√Len: 139.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_D126_K7.6951.00
174_R266_H4.9351.00
207_G253_A4.5001.00
354_S367_D4.3011.00
41_A79_L3.7491.00
165_P366_I3.4311.00
391_F428_L3.2591.00
50_A96_A2.9881.00
119_R129_D2.8851.00
52_C79_L2.8581.00
67_S79_L2.8441.00
106_S109_Q2.8301.00
441_D444_A2.8251.00
114_P265_Q2.6591.00
53_V64_E2.5651.00
254_T326_Y2.5321.00
157_H174_R2.5261.00
46_L69_V2.4831.00
172_V325_F2.4721.00
205_V257_A2.4631.00
109_Q139_T2.3681.00
52_C94_V2.3451.00
257_A322_I2.3351.00
226_A230_A2.3191.00
380_I385_Y2.3161.00
121_L256_I2.3151.00
382_E386_A2.2761.00
115_A137_T2.2711.00
164_R440_A2.2691.00
399_Q402_R2.2501.00
190_V436_I2.2411.00
390_T393_Q2.2051.00
40_E76_R2.1731.00
53_V95_Y2.1261.00
414_S417_M2.0941.00
235_I256_I2.0911.00
217_K221_E2.0611.00
335_Q352_V2.0391.00
357_L362_H2.0321.00
33_R40_E2.0111.00
41_A94_V2.0081.00
425_W429_E2.0031.00
140_G144_T1.9741.00
227_E230_A1.9571.00
390_T420_K1.9391.00
47_P50_A1.9251.00
169_L391_F1.9121.00
183_G186_V1.8951.00
31_L88_V1.8911.00
258_E311_R1.8821.00
54_I67_S1.8511.00
32_T42_T1.8261.00
168_A445_S1.8261.00
28_Y93_R1.7991.00
405_V422_I1.7881.00
168_A431_Y1.7821.00
220_I234_V1.7691.00
362_H433_Q1.7601.00
172_V351_I1.7591.00
413_G417_M1.7481.00
402_R406_S1.7471.00
140_G259_D1.7311.00
140_G255_R1.7121.00
160_D167_N1.7101.00
233_V256_I1.7051.00
362_H429_E1.6961.00
221_E224_L1.6711.00
360_A429_E1.6501.00
361_G389_R1.6451.00
221_E225_G1.6371.00
27_R96_A1.6351.00
119_R131_L1.6241.00
328_V343_A1.6171.00
131_L224_L1.6091.00
50_A105_Q1.6091.00
203_V233_V1.5821.00
203_V265_Q1.5731.00
381_S384_H1.5581.00
166_I351_I1.5401.00
53_V66_E1.5301.00
121_L235_I1.5181.00
266_H321_S1.5051.00
171_T376_M1.5031.00
41_A44_L1.4991.00
205_V256_I1.4921.00
114_P259_D1.4791.00
119_R132_P1.4781.00
127_P132_P1.4651.00
179_G347_L1.4651.00
110_L256_I1.4641.00
203_V260_F1.4611.00
387_R450_E1.4511.00
108_K142_L1.4481.00
166_I195_M1.4441.00
314_N317_S1.4431.00
435_G438_E1.4401.00
55_E93_R1.4401.00
423_A426_P1.4361.00
178_M325_F1.4251.00
207_G271_M1.4221.00
114_P263_R1.4171.00
376_M388_V1.4051.00
116_L256_I1.4041.00
241_V245_L1.4001.00
360_A402_R1.3621.00
115_A135_D1.3571.00
55_E95_Y1.3531.00
65_V83_E1.3511.00
222_N378_A1.3461.00
111_P139_T1.3461.00
209_I249_G1.3451.00
250_A308_L1.3441.00
259_D263_R1.3411.00
55_E64_E1.3411.00
52_C67_S1.3041.00
337_D340_A1.3011.00
420_K424_L1.2931.00
119_R127_P1.2911.00
267_V322_I1.2891.00
208_L216_V1.2841.00
225_G228_G1.2841.00
254_T312_A1.2821.00
275_T279_M1.2791.00
31_L92_A1.2771.00
340_A352_V1.2701.00
122_D241_V1.2691.00
430_G433_Q1.2591.00
46_L77_L1.2581.00
397_S400_R1.2561.00
389_R392_K1.2531.00
281_Q304_K1.2531.00
151_Q318_G1.2521.00
30_R93_R1.2491.00
309_V346_I1.2481.00
155_I173_G1.2381.00
305_L343_A1.2261.00
32_T76_R1.2261.00
377_T385_Y1.2211.00
381_S442_W1.2191.00
46_L52_C1.2181.00
170_L351_I1.2161.00
444_A448_G1.2151.00
140_G262_D1.2141.00
385_Y389_R1.2071.00
53_V104_L1.2061.00
224_L229_R1.2041.00
115_A136_T1.2021.00
56_R65_V1.1991.00
161_T172_V1.1951.00
106_S139_T1.1931.00
178_M349_G1.1911.00
117_L203_V1.1891.00
393_Q417_M1.1861.00
138_E263_R1.1841.00
190_V437_F1.1771.00
34_A88_V1.1761.00
356_R359_E1.1721.00
30_R42_T1.1710.99
136_T139_T1.1680.99
111_P136_T1.1650.99
427_Q430_G1.1650.99
110_L252_Y1.1630.99
66_E126_K1.1610.99
264_G319_G1.1610.99
375_A379_L1.1470.99
390_T394_L1.1420.99
415_D419_D1.1360.99
163_V166_I1.1290.99
153_T156_E1.1220.99
367_D370_A1.1130.99
309_V343_A1.1060.99
254_T322_I1.1050.99
172_V323_T1.1020.99
42_T76_R1.1020.99
285_A293_A1.1000.99
120_V220_I1.0960.99
274_L343_A1.0940.99
412_K423_A1.0890.99
96_A105_Q1.0890.99
362_H432_L1.0890.99
117_L233_V1.0840.99
163_V191_L1.0800.99
380_I388_V1.0770.99
85_V88_V1.0760.99
213_G238_P1.0730.99
89_L92_A1.0660.99
131_L134_P1.0630.99
39_L67_S1.0530.99
251_A281_Q1.0500.99
370_A399_Q1.0460.99
207_G269_L1.0450.99
196_A232_S1.0430.99
55_E92_A1.0390.99
160_D442_W1.0340.99
40_E73_N1.0320.99
158_V379_L1.0290.99
202_D266_H1.0240.99
196_A270_I1.0170.99
41_A52_C1.0170.99
144_T262_D1.0150.99
83_E245_L1.0130.99
333_D336_Q1.0070.98
423_A427_Q0.9990.98
172_V178_M0.9940.98
123_G252_Y0.9920.98
357_L433_Q0.9810.98
359_E370_A0.9790.98
182_A186_V0.9780.98
81_P85_V0.9760.98
113_G116_L0.9750.98
123_G245_L0.9730.98
376_M380_I0.9620.98
263_R267_V0.9610.98
209_I271_M0.9600.98
333_D355_R0.9500.98
212_R215_E0.9490.98
305_L346_I0.9490.98
330_T337_D0.9480.98
73_N78_F0.9410.98
261_R267_V0.9400.98
183_G355_R0.9330.97
129_D132_P0.9310.97
119_R134_P0.9290.97
330_T340_A0.9280.97
121_L134_P0.9250.97
440_A448_G0.9250.97
228_G232_S0.9230.97
161_T325_F0.9210.97
51_T66_E0.9200.97
401_N405_V0.9190.97
384_H442_W0.9170.97
171_T442_W0.9170.97
153_T314_N0.9160.97
233_V260_F0.9130.97
183_G341_D0.9120.97
274_L309_V0.9080.97
384_H446_L0.9080.97
254_T269_L0.9080.97
251_A304_K0.9040.97
211_E215_E0.9020.97
152_R384_H0.9010.97
141_A144_T0.9000.97
305_L342_S0.8950.97
116_L233_V0.8920.97
123_G128_L0.8920.97
166_I170_L0.8920.97
410_Y413_G0.8910.97
56_R64_E0.8910.97
183_G333_D0.8900.97
205_V233_V0.8890.97
138_E259_D0.8820.96
202_D265_Q0.8810.96
420_K423_A0.8780.96
84_E87_G0.8770.96
279_M331_E0.8720.96
165_P432_L0.8700.96
303_A306_P0.8680.96
159_L199_T0.8650.96
54_I92_A0.8630.96
312_A324_A0.8610.96
161_T167_N0.8610.96
116_L121_L0.8600.96
270_I327_T0.8580.96
397_S417_M0.8530.96
72_F77_L0.8530.96
151_Q317_S0.8520.96
209_I250_A0.8510.96
72_F90_P0.8510.96
253_A269_L0.8500.96
387_R446_L0.8420.95
196_A206_V0.8420.95
349_G374_R0.8410.95
356_R399_Q0.8410.95
168_A449_L0.8410.95
157_H266_H0.8400.95
335_Q370_A0.8380.95
268_L325_F0.8380.95
408_G419_D0.8360.95
248_Q252_Y0.8350.95
218_D378_A0.8330.95
273_S327_T0.8310.95
192_L219_F0.8310.95
228_G231_R0.8300.95
376_M384_H0.8280.95
51_T104_L0.8270.95
114_P260_F0.8260.95
31_L39_L0.8260.95
192_L270_I0.8230.95
246_R283_E0.8230.95
28_Y95_Y0.8230.95
204_I207_G0.8220.95
259_D262_D0.8190.95
397_S401_N0.8180.95
126_K133_S0.8160.95
243_P246_R0.8160.95
335_Q340_A0.8100.94
38_V288_I0.8090.94
440_A446_L0.8070.94
83_E242_S0.8040.94
108_K248_Q0.8020.94
440_A445_S0.8010.94
393_Q433_Q0.8010.94
377_T392_K0.8010.94
34_A142_L0.8000.94
220_I224_L0.8000.94
291_P299_P0.7990.94
243_P247_M0.7980.94
205_V235_I0.7980.94
148_N151_Q0.7970.94
50_A104_L0.7970.94
247_M284_I0.7940.94
277_Y308_L0.7940.94
442_W446_L0.7930.94
50_A107_G0.7910.94
398_F425_W0.7910.94
160_D194_M0.7880.94
279_M297_Y0.7880.94
35_T407_V0.7870.93
68_E82_L0.7850.93
406_S415_D0.7820.93
160_D449_L0.7810.93
334_D341_D0.7810.93
352_V370_A0.7800.93
158_V171_T0.7790.93
203_V267_V0.7730.93
123_G241_V0.7720.93
196_A204_I0.7710.93
171_T380_I0.7650.92
169_L388_V0.7550.92
354_S370_A0.7550.92
183_G334_D0.7540.92
145_P307_A0.7520.92
109_Q141_A0.7520.92
211_E276_R0.7500.92
153_T319_G0.7480.92
83_E126_K0.7480.92
237_A241_V0.7470.92
167_N445_S0.7450.91
173_G375_A0.7440.91
200_R266_H0.7420.91
142_L252_Y0.7420.91
269_L312_A0.7420.91
181_F340_A0.7410.91
68_E248_Q0.7400.91
387_R449_L0.7390.91
174_R321_S0.7330.91
380_I384_H0.7290.91
279_M342_S0.7290.91
119_R128_L0.7270.90
153_T317_S0.7220.90
352_V355_R0.7180.90
278_A305_L0.7180.90
403_D409_A0.7160.90
212_R276_R0.7150.90
413_G419_D0.7150.90
166_I191_L0.7150.90
393_Q397_S0.7150.90
424_L427_Q0.7140.90
395_L428_L0.7110.89
205_V253_A0.7110.89
419_D423_A0.7110.89
108_K167_N0.7110.89
443_E447_Q0.7090.89
386_A389_R0.7080.89
332_G337_D0.7070.89
161_T166_I0.7040.89
81_P84_E0.7030.89
277_Y304_K0.7010.89
230_A233_V0.7010.89
155_I375_A0.7010.89
261_R322_I0.7000.89
301_V304_K0.6970.89
199_T268_L0.6960.88
178_M351_I0.6950.88
202_D231_R0.6950.88
112_L255_R0.6950.88
41_A67_S0.6940.88
290_E300_S0.6930.88
314_N321_S0.6930.88
247_M281_Q0.6930.88
297_Y334_D0.6910.88
267_V283_E0.6850.88
403_D406_S0.6850.88
341_D344_R0.6850.88
162_G191_L0.6840.88
294_T342_S0.6830.88
264_G318_G0.6820.87
412_K422_I0.6820.87
50_A108_K0.6820.87
171_T384_H0.6810.87
196_A231_R0.6810.87
216_V236_A0.6750.87
367_D399_Q0.6730.87
183_G296_G0.6730.87
384_H388_V0.6730.87
43_G46_L0.6720.87
402_R429_E0.6710.87
386_A390_T0.6690.86
237_A246_R0.6680.86
395_L399_Q0.6650.86
383_Q450_E0.6640.86
394_L420_K0.6620.86
38_V78_F0.6610.86
133_S136_T0.6610.86
124_S127_P0.6590.86
129_D134_P0.6590.86
287_A291_P0.6560.85
398_F402_R0.6560.85
197_R202_D0.6550.85
119_R133_S0.6510.85
411_A414_S0.6510.85
271_M308_L0.6500.85
412_K415_D0.6500.85
82_L245_L0.6500.85
173_G374_R0.6500.85
203_V231_R0.6500.85
77_L94_V0.6470.85
134_P137_T0.6470.85
195_M268_L0.6460.84
170_L372_I0.6460.84
154_P378_A0.6460.84
128_L236_A0.6440.84
127_P131_L0.6440.84
375_A380_I0.6440.84
184_S346_I0.6430.84
128_L241_V0.6430.84
383_Q387_R0.6410.84
184_S344_R0.6390.84
71_G78_F0.6390.84
93_R96_A0.6370.84
291_P303_A0.6370.84
138_E141_A0.6370.84
121_L124_S0.6360.84
382_E435_G0.6360.84
57_Q89_L0.6320.83
256_I260_F0.6320.83
72_F78_F0.6310.83
251_A277_Y0.6290.83
204_I232_S0.6290.83
168_A171_T0.6280.83
440_A444_A0.6280.83
249_G253_A0.6280.83
413_G416_P0.6260.83
163_V194_M0.6260.83
258_E261_R0.6180.82
64_E95_Y0.6170.82
104_L107_G0.6170.82
431_Y448_G0.6170.82
65_V87_G0.6160.82
132_P136_T0.6140.81
50_A167_N0.6130.81
107_G141_A0.6130.81
187_G272_D0.6120.81
252_Y255_R0.6110.81
56_R92_A0.6110.81
394_L428_L0.6100.81
435_G439_R0.6070.81
68_E108_K0.6070.81
278_A339_I0.6050.80
221_E226_A0.6040.80
122_D128_L0.6030.80
290_E313_G0.6020.80
225_G229_R0.6010.80
51_T108_K0.6010.80
246_R250_A0.6000.80
336_Q343_A0.5970.80
180_L325_F0.5960.79
173_G379_L0.5950.79
426_P429_E0.5940.79
115_A138_E0.5930.79
369_E395_L0.5930.79
345_A372_I0.5890.79
437_F448_G0.5890.79
226_A234_V0.5860.78
255_R259_D0.5840.78
254_T271_M0.5840.78
111_P137_T0.5830.78
206_V216_V0.5820.78
156_E319_G0.5800.78
417_M426_P0.5790.77
65_V81_P0.5780.77
184_S279_M0.5780.77
39_L54_I0.5770.77
151_Q314_N0.5720.77
46_L96_A0.5710.77
188_K272_D0.5710.77
167_N198_Y0.5710.77
444_A447_Q0.5700.76
356_R400_R0.5690.76
445_S448_G0.5680.76
285_A300_S0.5680.76
128_L133_S0.5670.76
35_T38_V0.5670.76
139_T420_K0.5660.76
143_I307_A0.5640.76
114_P139_T0.5640.76
277_Y281_Q0.5630.76
266_H314_N0.5630.76
422_I426_P0.5620.75
164_R448_G0.5610.75
88_V92_A0.5610.75
160_D200_R0.5610.75
52_C77_L0.5600.75
246_R249_G0.5600.75
197_R437_F0.5600.75
131_L229_R0.5590.75
117_L265_Q0.5590.75
218_D222_N0.5580.75
247_M252_Y0.5580.75
410_Y419_D0.5570.75
283_E299_P0.5560.75
180_L351_I0.5550.74
108_K252_Y0.5550.74
66_E69_V0.5540.74
185_G283_E0.5530.74
182_A194_M0.5530.74
123_G127_P0.5530.74
125_G205_V0.5530.74
247_M304_K0.5520.74
204_I270_I0.5520.74
67_S81_P0.5520.74
190_V193_G0.5500.74
126_K139_T0.5490.74
124_S407_V0.5490.74
193_G236_A0.5490.74
332_G341_D0.5470.73
117_L229_R0.5460.73
401_N406_S0.5460.73
110_L113_G0.5460.73
195_M325_F0.5450.73
54_I57_Q0.5450.73
254_T257_A0.5440.73
56_R85_V0.5440.73
261_R266_H0.5440.73
250_A271_M0.5440.73
127_P134_P0.5430.73
223_I228_G0.5420.73
242_S246_R0.5410.73
114_P233_V0.5390.72
242_S245_L0.5390.72
160_D445_S0.5380.72
65_V242_S0.5380.72
133_S137_T0.5380.72
88_V94_V0.5380.72
153_T318_G0.5370.72
136_T259_D0.5370.72
224_L232_S0.5350.72
285_A299_P0.5340.72
409_A413_G0.5340.72
161_T312_A0.5330.72
115_A134_P0.5320.71
83_E87_G0.5310.71
108_K124_S0.5310.71
181_F347_L0.5310.71
180_L353_L0.5310.71
92_A95_Y0.5300.71
243_P250_A0.5290.71
57_Q64_E0.5280.71
163_V436_I0.5280.71
119_R130_G0.5280.71
247_M251_A0.5280.71
81_P88_V0.5270.71
404_L407_V0.5270.71
31_L34_A0.5270.71
282_R339_I0.5270.71
438_E442_W0.5260.71
140_G263_R0.5260.71
91_G94_V0.5240.70
80_M284_I0.5230.70
158_V375_A0.5230.70
331_E336_Q0.5230.70
117_L127_P0.5220.70
377_T436_I0.5220.70
197_R220_I0.5210.70
210_G328_V0.5200.70
219_F224_L0.5200.70
158_V442_W0.5200.70
42_T75_Q0.5190.70
208_L211_E0.5170.69
345_A350_H0.5170.69
68_E71_G0.5160.69
81_P87_G0.5160.69
152_R396_S0.5160.69
355_R359_E0.5160.69
170_L366_I0.5140.69
147_F317_S0.5140.69
237_A245_L0.5130.69
46_L51_T0.5130.69
51_T107_G0.5120.69
161_T181_F0.5120.69
57_Q93_R0.5110.68
398_F429_E0.5100.68
171_T372_I0.5090.68
176_Q374_R0.5080.68
44_L96_A0.5080.68
391_F449_L0.5060.68
27_R45_Q0.5060.68
186_V355_R0.5060.68
184_S345_A0.5050.67
216_V238_P0.5050.67
247_M250_A0.5050.67
222_N255_R0.5040.67
78_F288_I0.5040.67
226_A270_I0.5030.67
376_M385_Y0.5030.67
27_R30_R0.5030.67
120_V128_L0.5030.67
105_Q108_K0.5020.67
283_E297_Y0.5000.67
54_I64_E0.5000.67
135_D138_E0.5000.67
159_L172_V0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oaaA 2 0.9125 100 0.098 Contact Map
2qe7A 1 0.9059 100 0.1 Contact Map
1fx0A 1 0.9125 100 0.117 Contact Map
2r9vA 1 0.93 100 0.125 Contact Map
3vr4D 1 0.919 100 0.127 Contact Map
2ck3A 1 0.9125 100 0.127 Contact Map
2c61A 2 0.8731 100 0.127 Contact Map
3gqbB 1 0.9212 100 0.13 Contact Map
3j9tA 1 0.9081 100 0.137 Contact Map
3mfyA 1 0.7505 100 0.139 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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