GREMLIN Database
EMRY - Probable multidrug resistance protein EmrY
UniProt: P52600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13283
Length: 512 (418)
Sequences: 41590 (29721)
Seq/√Len: 1453.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_T108_V5.2721.00
94_S182_G4.0951.00
101_S176_L3.7351.00
92_F119_M3.6221.00
99_M112_F3.6021.00
354_W371_P3.2161.00
216_G249_L3.2141.00
107_D111_F3.1611.00
394_L402_A2.8211.00
105_N108_V2.7381.00
212_L255_W2.6711.00
65_A114_V2.6241.00
82_E133_R2.6101.00
50_A106_L2.5211.00
306_N309_W2.5091.00
16_L139_K2.4741.00
61_S114_V2.4631.00
87_L190_L2.4531.00
208_P255_W2.4291.00
282_T413_S2.3661.00
267_S398_K2.3281.00
100_C112_F2.3161.00
324_I377_F2.3051.00
320_M373_F2.3041.00
223_M242_T2.2941.00
51_S54_E2.1701.00
96_S115_V2.1621.00
187_T191_T2.1391.00
215_L248_S2.1361.00
169_F173_W2.1031.00
69_A118_L2.0951.00
139_K142_F2.0591.00
286_L417_G2.0581.00
24_S150_T2.0261.00
54_E106_L2.0071.00
395_P398_K2.0051.00
96_S119_M1.9901.00
220_L245_S1.9811.00
96_S112_F1.9561.00
265_D398_K1.9451.00
89_S122_P1.9261.00
73_T122_P1.9251.00
250_I254_I1.8891.00
98_L102_L1.8731.00
43_T46_G1.8671.00
135_Y143_A1.8571.00
108_V112_F1.8491.00
290_G421_T1.8451.00
87_L186_L1.8441.00
83_L87_L1.8401.00
98_L179_V1.8401.00
103_S108_V1.8221.00
106_L110_I1.8161.00
239_I243_V1.8021.00
136_P139_K1.7891.00
366_T370_L1.7761.00
165_I173_W1.7751.00
40_A166_C1.7671.00
300_Q310_A1.7621.00
305_Y313_A1.7581.00
20_T135_Y1.7481.00
330_R334_K1.7191.00
351_C375_Q1.7101.00
167_D308_I1.6771.00
100_C109_L1.6691.00
58_V109_L1.6561.00
227_G232_W1.6521.00
50_A54_E1.6351.00
61_S110_I1.6281.00
347_M378_A1.6191.00
189_C193_L1.6051.00
219_G241_L1.5831.00
289_S414_G1.5821.00
305_Y309_W1.5801.00
170_S173_W1.5791.00
28_F154_A1.5671.00
91_T186_L1.5671.00
40_A174_I1.5581.00
78_Q400_A1.5571.00
103_S112_F1.5541.00
45_S55_G1.5471.00
298_L303_M1.5351.00
17_W21_I1.5341.00
77_A126_L1.5301.00
226_K230_L1.5121.00
206_N209_G1.5101.00
19_V134_N1.5101.00
26_A86_F1.5081.00
309_W312_L1.5041.00
68_I214_V1.4891.00
255_W259_S1.4891.00
173_W180_P1.4591.00
351_C378_A1.4401.00
219_G248_S1.4371.00
137_P140_R1.4271.00
364_D367_G1.4271.00
240_I244_V1.4171.00
216_G245_S1.4141.00
164_Y168_N1.4141.00
88_L92_F1.4111.00
344_S381_C1.4101.00
25_L185_V1.4021.00
254_I258_T1.4001.00
99_M108_V1.3981.00
339_L342_T1.3971.00
76_L85_L1.3821.00
87_L189_C1.3771.00
36_I174_I1.3771.00
188_L192_L1.3751.00
351_C371_P1.3711.00
94_S179_V1.3701.00
222_I226_K1.3681.00
167_D306_N1.3601.00
275_T279_V1.3511.00
212_L248_S1.3381.00
365_F369_I1.3361.00
216_G248_S1.3351.00
107_D110_I1.3281.00
278_I409_F1.3281.00
272_R276_I1.3121.00
69_A121_G1.3101.00
236_S240_I1.3101.00
349_A353_Y1.3091.00
262_P265_D1.3061.00
141_T333_N1.2951.00
76_L80_I1.2911.00
309_W313_A1.2871.00
219_G244_V1.2761.00
330_R333_N1.2761.00
366_T369_I1.2761.00
18_C192_L1.2731.00
77_A82_E1.2711.00
94_S186_L1.2691.00
97_S178_N1.2621.00
428_R432_H1.2601.00
207_L211_T1.2571.00
81_G84_R1.2561.00
75_R79_R1.2491.00
22_A185_V1.2421.00
223_M245_S1.2381.00
95_L99_M1.2371.00
370_L373_F1.2371.00
428_R431_L1.2371.00
329_G333_N1.2331.00
84_R88_L1.2241.00
317_I376_G1.2191.00
62_F120_A1.2171.00
284_A382_F1.2151.00
22_A188_L1.2081.00
204_K261_N1.2071.00
104_T107_D1.1931.00
132_L140_R1.1891.00
22_A192_L1.1871.00
274_F278_I1.1831.00
299_L368_I1.1811.00
259_S262_P1.1781.00
92_F96_S1.1751.00
65_A117_G1.1661.00
244_V248_S1.1611.00
346_L350_V1.1601.00
226_K229_D1.1531.00
33_D36_I1.1511.00
43_T47_F1.1491.00
164_Y308_I1.1461.00
277_G390_S1.1431.00
253_V257_S1.1421.00
84_R195_G1.1371.00
245_S249_L1.1361.00
100_C175_F1.1351.00
215_L219_G1.1331.00
264_L267_S1.1321.00
87_L91_T1.1311.00
269_F275_T1.1301.00
57_W61_S1.1281.00
31_M151_V1.1251.00
353_Y356_S1.1221.00
94_S183_I1.1211.00
257_S267_S1.1201.00
348_Y378_A1.1171.00
186_L190_L1.1151.00
223_M238_I1.1071.00
327_L330_R1.1071.00
179_V183_I1.0951.00
16_L135_Y1.0861.00
254_I257_S1.0831.00
331_Y335_I1.0711.00
183_I187_T1.0711.00
212_L251_S1.0681.00
26_A90_V1.0671.00
267_S270_K1.0651.00
353_Y357_V1.0561.00
161_L164_Y1.0551.00
271_S275_T1.0511.00
132_L399_F1.0491.00
354_W357_V1.0461.00
165_I177_I1.0441.00
367_G371_P1.0431.00
328_I381_C1.0411.00
209_G255_W1.0381.00
224_L227_G1.0381.00
102_L176_L1.0311.00
390_S406_S1.0261.00
111_F115_V1.0211.00
108_V111_F1.0191.00
65_A69_A1.0181.00
339_L343_F1.0101.00
24_S146_L1.0091.00
41_I55_G1.0081.00
99_M102_L1.0031.00
252_L256_E1.0031.00
34_S63_G1.0021.00
180_P184_I1.0021.00
86_F130_L0.9991.00
351_C374_F0.9981.00
83_L190_L0.9981.00
370_L374_F0.9961.00
367_G370_L0.9951.00
47_F171_W0.9911.00
230_L237_T0.9891.00
168_N308_I0.9861.00
320_M324_I0.9831.00
253_V266_L0.9811.00
281_I406_S0.9761.00
263_I267_S0.9751.00
326_P330_R0.9741.00
86_F189_C0.9741.00
131_L147_W0.9711.00
295_M372_Q0.9691.00
14_G18_C0.9661.00
210_L214_V0.9631.00
313_A369_I0.9591.00
223_M241_L0.9581.00
138_E142_F0.9561.00
88_L91_T0.9521.00
59_I293_V0.9521.00
282_T409_F0.9471.00
343_F346_L0.9471.00
72_V210_L0.9471.00
228_R231_D0.9451.00
191_T194_K0.9431.00
67_A415_S0.9401.00
323_L326_P0.9391.00
265_D401_N0.9391.00
104_T172_G0.9371.00
165_I169_F0.9371.00
226_K231_D0.9371.00
172_G176_L0.9361.00
346_L349_A0.9351.00
417_G420_L0.9341.00
278_I405_M0.9291.00
230_L235_S0.9281.00
344_S378_A0.9271.00
237_T240_I0.9241.00
173_W176_L0.9221.00
90_V185_V0.9211.00
338_R342_T0.9181.00
211_T215_L0.9181.00
359_F364_D0.9181.00
84_R87_L0.9171.00
50_A55_G0.9151.00
37_S58_V0.9101.00
97_S116_Q0.9101.00
127_S147_W0.9091.00
299_L313_A0.9091.00
64_V415_S0.9051.00
36_I162_G0.9031.00
261_N264_L0.9021.00
274_F402_A0.9011.00
111_F114_V0.9001.00
237_T241_L0.8971.00
54_E107_D0.8961.00
82_E195_G0.8951.00
61_S65_A0.8951.00
251_S254_I0.8901.00
14_G17_W0.8891.00
29_M182_G0.8851.00
336_D339_L0.8831.00
424_L428_R0.8801.00
47_F172_G0.8791.00
343_F347_M0.8771.00
78_Q401_N0.8721.00
142_F330_R0.8711.00
271_S398_K0.8701.00
180_P183_I0.8681.00
205_M210_L0.8671.00
300_Q307_A0.8661.00
273_N393_G0.8641.00
340_L343_F0.8621.00
363_I367_G0.8601.00
312_L316_P0.8571.00
249_L253_V0.8561.00
271_S393_G0.8561.00
316_P320_M0.8501.00
209_G259_S0.8481.00
324_I327_L0.8461.00
102_L112_F0.8461.00
324_I328_I0.8451.00
352_Y375_Q0.8441.00
197_E200_T0.8421.00
342_T346_L0.8421.00
23_L127_S0.8421.00
163_G307_A0.8411.00
227_G230_L0.8411.00
271_S395_P0.8391.00
74_G78_Q0.8381.00
429_E433_H0.8371.00
274_F390_S0.8371.00
133_R399_F0.8361.00
44_I109_L0.8351.00
195_G198_T0.8321.00
313_A365_F0.8301.00
80_I85_L0.8281.00
299_L305_Y0.8271.00
272_R275_T0.8241.00
246_V250_I0.8241.00
344_S382_F0.8231.00
354_W367_G0.8221.00
317_I375_Q0.8201.00
90_V186_L0.8201.00
345_F382_F0.8201.00
255_W258_T0.8191.00
101_S172_G0.8181.00
45_S52_T0.8171.00
324_I380_A0.8161.00
332_G385_P0.8131.00
89_S119_M0.8121.00
331_Y340_L0.8111.00
142_F333_N0.8111.00
83_L195_G0.8051.00
58_V106_L0.8041.00
18_C21_I0.8041.00
94_S98_L0.8041.00
240_I243_V0.8031.00
198_T201_S0.8011.00
320_M377_F0.7991.00
98_L176_L0.7991.00
149_M153_I0.7951.00
15_T18_C0.7941.00
82_E129_S0.7941.00
140_R392_S0.7931.00
33_D178_N0.7901.00
299_L303_M0.7891.00
230_L233_F0.7861.00
216_G219_G0.7841.00
66_N411_T0.7831.00
27_T151_V0.7821.00
420_L423_T0.7801.00
91_T95_L0.7791.00
423_T427_R0.7781.00
257_S266_L0.7761.00
78_Q82_E0.7761.00
158_G162_G0.7711.00
242_T246_V0.7691.00
40_A44_I0.7681.00
313_A316_P0.7661.00
387_T406_S0.7651.00
73_T89_S0.7651.00
85_L122_P0.7651.00
166_C174_I0.7611.00
187_T190_L0.7571.00
208_P211_T0.7561.00
15_T194_K0.7561.00
359_F363_I0.7541.00
360_M363_I0.7531.00
208_P212_L0.7531.00
319_I323_L0.7481.00
26_A123_L0.7451.00
238_I241_L0.7451.00
17_W135_Y0.7441.00
22_A189_C0.7421.00
188_L191_T0.7421.00
214_V218_G0.7421.00
93_F182_G0.7361.00
388_T392_S0.7351.00
141_T329_G0.7341.00
32_L178_N0.7321.00
247_I251_S0.7291.00
104_T112_F0.7281.00
200_T203_V0.7281.00
80_I84_R0.7281.00
41_I59_I0.7271.00
176_L180_P0.7271.00
17_W143_A0.7241.00
250_I253_V0.7241.00
280_S345_F0.7241.00
60_T225_D0.7231.00
141_T145_A0.7231.00
219_G245_S0.7231.00
69_A72_V0.7231.00
156_I318_G0.7191.00
30_Q123_L0.7141.00
223_M227_G0.7131.00
32_L36_I0.7101.00
352_Y356_S0.7101.00
43_T166_C0.7091.00
176_L179_V0.7071.00
361_P364_D0.7071.00
369_I373_F0.7061.00
381_C385_P0.7051.00
203_V261_N0.7051.00
131_L143_A0.7051.00
44_I47_F0.7021.00
28_F157_C0.7001.00
324_I381_C0.7001.00
222_I241_L0.6991.00
264_L405_M0.6961.00
20_T143_A0.6961.00
132_L144_L0.6961.00
345_F349_A0.6951.00
270_K275_T0.6931.00
227_G233_F0.6921.00
305_Y365_F0.6911.00
359_F362_T0.6901.00
308_I312_L0.6881.00
228_R232_W0.6871.00
130_L193_L0.6841.00
294_L422_M0.6841.00
278_I406_S0.6811.00
331_Y334_K0.6801.00
96_S99_M0.6781.00
26_A185_V0.6771.00
226_K233_F0.6771.00
151_V155_P0.6761.00
350_V354_W0.6751.00
68_I218_G0.6731.00
196_R199_E0.6721.00
144_L388_T0.6721.00
297_Q301_E0.6711.00
69_A73_T0.6701.00
343_F381_C0.6701.00
100_C103_S0.6681.00
96_S116_Q0.6681.00
190_L194_K0.6681.00
112_F115_V0.6681.00
97_S179_V0.6661.00
152_I321_P0.6651.00
422_M426_G0.6641.00
332_G336_D0.6641.00
236_S239_I0.6621.00
423_T426_G0.6621.00
273_N277_G0.6611.00
129_S400_A0.6611.00
243_V247_I0.6541.00
251_S255_W0.6531.00
391_F399_F0.6531.00
204_K208_P0.6511.00
215_L218_G0.6491.00
413_S417_G0.6481.00
316_P369_I0.6471.00
85_L88_L0.6471.00
167_D307_A0.6461.00
145_A149_M0.6451.00
335_I339_L0.6421.00
298_L302_T0.6411.00
19_V22_A0.6411.00
46_G49_G0.6391.00
342_T345_F0.6391.00
235_S239_I0.6381.00
153_I157_C0.6371.00
221_Q415_S0.6361.00
93_F119_M0.6361.00
219_G223_M0.6351.00
407_N410_R0.6351.00
262_P266_L0.6341.00
100_C116_Q0.6341.00
181_M184_I0.6341.00
335_I340_L0.6331.00
163_G311_G0.6311.00
195_G199_E0.6301.00
48_L106_L0.6281.00
266_L270_K0.6281.00
33_D113_R0.6281.00
33_D93_F0.6271.00
216_G253_V0.6231.00
342_T349_A0.6231.00
128_Q147_W0.6231.00
273_N276_I0.6211.00
317_I372_Q0.6201.00
130_L134_N0.6201.00
144_L148_S0.6191.00
248_S251_S0.6171.00
233_F237_T0.6171.00
217_V408_F0.6161.00
74_G404_S0.6151.00
391_F403_S0.6141.00
65_A118_L0.6141.00
142_F146_L0.6121.00
157_C160_I0.6121.00
288_Y379_V0.6121.00
178_N182_G0.6121.00
350_V353_Y0.6121.00
233_F236_S0.6091.00
327_L331_Y0.6091.00
70_I407_N0.6091.00
293_V418_T0.6091.00
44_I48_L0.6081.00
233_F239_I0.6071.00
165_I174_I0.6061.00
275_T278_I0.6021.00
67_A412_L0.6011.00
347_M377_F0.6001.00
99_M115_V0.6001.00
31_M154_A0.5991.00
55_G58_V0.5991.00
347_M374_F0.5991.00
71_P213_L0.5961.00
132_L391_F0.5961.00
44_I55_G0.5961.00
77_A129_S0.5941.00
246_V249_L0.5941.00
217_V412_L0.5931.00
42_P46_G0.5901.00
32_L158_G0.5901.00
160_I315_A0.5901.00
154_A158_G0.5901.00
355_R359_F0.5891.00
103_S109_L0.5881.00
280_S386_L0.5871.00
230_L238_I0.5871.00
138_E141_T0.5861.00
226_K238_I0.5851.00
205_M209_G0.5831.00
223_M226_K0.5831.00
37_S44_I0.5811.00
312_L315_A0.5801.00
209_G256_E0.5801.00
204_K207_L0.5761.00
135_Y139_K0.5751.00
23_L130_L0.5741.00
215_L244_V0.5731.00
274_F394_L0.5731.00
348_Y351_C0.5731.00
227_G231_D0.5721.00
412_L416_V0.5721.00
235_S240_I0.5711.00
207_L210_L0.5701.00
242_T245_S0.5701.00
128_Q144_L0.5691.00
213_L217_V0.5691.00
360_M364_D0.5671.00
396_D399_F0.5661.00
336_D340_L0.5601.00
38_N59_I0.5601.00
142_F145_A0.5591.00
63_G415_S0.5581.00
162_G166_C0.5571.00
173_W177_I0.5561.00
210_L263_I0.5561.00
327_L377_F0.5551.00
351_C354_W0.5551.00
289_S292_I0.5531.00
83_L194_K0.5511.00
82_E196_R0.5511.00
295_M299_L0.5511.00
82_E130_L0.5501.00
62_F66_N0.5501.00
67_A411_T0.5491.00
74_G126_L0.5491.00
48_L171_W0.5491.00
227_G238_I0.5481.00
419_S423_T0.5481.00
28_F150_T0.5481.00
45_S50_A0.5471.00
282_T416_V0.5461.00
279_V283_C0.5441.00
68_I210_L0.5431.00
30_Q120_A0.5431.00
377_F381_C0.5421.00
405_M409_F0.5411.00
281_I386_L0.5411.00
281_I410_R0.5391.00
262_P267_S0.5391.00
187_T192_L0.5391.00
23_L134_N0.5371.00
45_S51_S0.5361.00
134_N194_K0.5361.00
244_V251_S0.5331.00
166_C307_A0.5331.00
306_N310_A0.5331.00
398_K401_N0.5331.00
208_P259_S0.5311.00
332_G388_T0.5301.00
21_I25_L0.5291.00
74_G400_A0.5271.00
291_A352_Y0.5261.00
354_W370_L0.5251.00
273_N389_I0.5231.00
29_M181_M0.5231.00
235_S238_I0.5231.00
17_W139_K0.5221.00
90_V182_G0.5221.00
245_S248_S0.5211.00
92_F115_V0.5211.00
261_N265_D0.5211.00
359_F371_P0.5211.00
101_S179_V0.5201.00
206_N255_W0.5191.00
213_L263_I0.5191.00
328_I331_Y0.5171.00
373_F377_F0.5161.00
128_Q403_S0.5151.00
225_D228_R0.5141.00
357_V367_G0.5131.00
390_S393_G0.5131.00
17_W142_F0.5121.00
284_A288_Y0.5121.00
133_R196_R0.5111.00
164_Y312_L0.5101.00
245_S250_I0.5101.00
199_E202_P0.5101.00
285_Y410_R0.5091.00
66_N120_A0.5091.00
222_I230_L0.5081.00
152_I325_S0.5081.00
138_E333_N0.5081.00
75_R261_N0.5071.00
96_S103_S0.5061.00
102_L108_V0.5051.00
15_T192_L0.5051.00
229_D232_W0.5041.00
216_G220_L0.5041.00
341_V385_P0.5041.00
63_G414_G0.5041.00
348_Y352_Y0.5041.00
232_W235_S0.5031.00
252_L264_L0.5011.00
96_S100_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8027 100 0.4 Contact Map
4j05A 3 0.7207 100 0.418 Contact Map
4pypA 1 0.8125 100 0.439 Contact Map
3wdoA 1 0.7695 100 0.44 Contact Map
2gfpA 2 0.7305 100 0.448 Contact Map
3o7qA 1 0.75 100 0.449 Contact Map
4gc0A 1 0.8359 100 0.468 Contact Map
4zw9A 1 0.8516 100 0.471 Contact Map
4ldsA 2 0.8008 100 0.472 Contact Map
4xnjA 1 0.8496 100 0.476 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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