GREMLIN Database
YFJV - Putative arsenical pump membrane protein (Fragment)
UniProt: P52137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13208
Length: 338 (280)
Sequences: 7484 (5226)
Seq/√Len: 312.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_S83_Q3.5441.00
64_I74_A3.5231.00
123_P126_A3.4521.00
307_T310_Y3.3741.00
310_Y313_R3.3111.00
130_L134_R3.0531.00
212_E216_G2.8831.00
181_G185_R2.8401.00
49_V295_W2.7841.00
286_P296_L2.7121.00
46_L310_Y2.7001.00
137_W141_L2.6841.00
179_N182_K2.6171.00
132_T136_G2.5721.00
147_F150_L2.5531.00
131_A134_R2.4491.00
95_A322_V2.4281.00
143_L147_F2.3151.00
122_T125_S2.2621.00
101_I105_L2.2271.00
41_S45_T2.2181.00
82_A86_S2.2081.00
140_L144_L2.1451.00
231_F327_L2.0331.00
62_P92_D2.0311.00
309_G313_R2.0161.00
144_L147_F2.0021.00
142_L146_G1.9581.00
144_L164_G1.9571.00
134_R137_W1.9411.00
141_L148_F1.9071.00
203_Y207_N1.8981.00
133_F136_G1.8811.00
83_Q86_S1.8721.00
140_L148_F1.8561.00
242_S284_I1.8291.00
213_Y217_V1.8091.00
320_V324_F1.8011.00
72_V254_A1.8001.00
59_A96_I1.7821.00
235_F327_L1.7401.00
250_V278_C1.7281.00
146_G150_L1.7161.00
328_A332_W1.6311.00
105_L108_R1.6011.00
235_F323_L1.5911.00
238_A323_L1.5821.00
139_V147_F1.5711.00
102_M321_P1.5631.00
112_P115_Y1.5581.00
129_D134_R1.5551.00
134_R138_I1.5541.00
139_V143_L1.5541.00
98_A325_V1.5181.00
213_Y216_G1.5041.00
315_G319_T1.4991.00
263_T267_K1.4821.00
124_A127_I1.4771.00
86_S90_S1.4701.00
98_A321_P1.4611.00
131_A135_A1.4521.00
65_V81_F1.4471.00
138_I142_L1.4381.00
63_L66_S1.4311.00
135_A139_V1.4291.00
107_F314_T1.4221.00
60_S67_N1.4131.00
144_L148_F1.3881.00
53_G295_W1.3801.00
157_V161_A1.3731.00
132_T135_A1.3691.00
73_S275_V1.3671.00
101_I104_Y1.3611.00
122_T126_A1.3571.00
284_I319_T1.3411.00
239_F243_V1.3391.00
140_L147_F1.3071.00
217_V220_L1.2951.00
61_L92_D1.2881.00
136_G147_F1.2801.00
241_S288_G1.2801.00
147_F151_E1.2761.00
144_L149_F1.2751.00
111_I115_Y1.2721.00
61_L280_L1.2661.00
111_I114_T1.2651.00
216_G219_N1.2591.00
166_A170_V1.2501.00
107_F110_V1.2471.00
133_F137_W1.2421.00
238_A319_T1.2421.00
138_I141_L1.2371.00
156_L159_A1.2361.00
69_V250_V1.2351.00
316_I320_V1.2351.00
137_W148_F1.2291.00
99_T318_M1.2241.00
180_T184_L1.2181.00
129_D132_T1.2181.00
69_V247_M1.2081.00
62_P89_I1.2041.00
85_A89_I1.2011.00
225_G228_A1.1951.00
227_W331_A1.1891.00
234_G277_G1.1871.00
58_T99_T1.1851.00
88_M276_I1.1841.00
235_F239_F1.1721.00
312_F316_I1.1641.00
91_V329_A1.1621.00
72_V251_L1.1401.00
136_G140_L1.1231.00
145_V148_F1.1181.00
49_V52_A1.1051.00
141_L147_F1.0991.00
141_L145_V1.0961.00
124_A128_K1.0901.00
195_S247_M1.0881.00
136_G139_V1.0831.00
181_G184_L1.0831.00
217_V221_L1.0831.00
83_Q268_E1.0781.00
137_W147_F1.0771.00
227_W328_A1.0761.00
168_L172_A1.0741.00
104_Y109_R1.0681.00
234_G273_A1.0631.00
94_A325_V1.0521.00
237_T278_C1.0521.00
209_G212_E1.0481.00
273_A277_G1.0451.00
134_R144_L1.0431.00
134_R148_F1.0371.00
146_G149_F1.0271.00
47_A103_L1.0241.00
46_L50_M1.0171.00
161_A164_G1.0161.00
264_G267_K1.0101.00
127_I134_R1.0001.00
158_S161_A0.9991.00
241_S246_N0.9971.00
134_R147_F0.9941.00
178_I182_K0.9931.00
118_S122_T0.9931.00
257_I274_N0.9891.00
246_N288_G0.9881.00
41_S110_V0.9841.00
164_G168_L0.9801.00
116_X119_L0.9791.00
111_I116_X0.9691.00
89_I93_A0.9691.00
129_D133_F0.9681.00
54_F99_T0.9651.00
114_T117_V0.9651.00
51_A55_I0.9561.00
143_L146_G0.9521.00
128_K134_R0.9521.00
129_D135_A0.9521.00
130_L133_F0.9511.00
64_I71_I0.9461.00
53_G292_T0.9361.00
134_R141_L0.9341.00
130_L135_A0.9281.00
183_V187_A0.9231.00
139_V142_L0.9221.00
273_A330_L0.9221.00
317_V320_V0.9191.00
258_D261_T0.9171.00
236_L240_L0.9171.00
97_A101_I0.9151.00
148_F151_E0.9131.00
49_V306_I0.9101.00
167_V171_V0.9051.00
61_L88_M0.9041.00
263_T266_V0.9041.00
216_G220_L0.9041.00
195_S282_P0.9031.00
152_P156_L0.9031.00
137_W140_L0.8991.00
93_A97_A0.8981.00
64_I85_A0.8961.00
191_I297_H0.8941.00
292_T295_W0.8921.00
233_T237_T0.8881.00
157_V160_I0.8841.00
158_S164_G0.8761.00
91_V325_V0.8751.00
102_M106_F0.8721.00
146_G151_E0.8721.00
305_T309_G0.8701.00
328_A331_A0.8681.00
134_R145_V0.8601.00
124_A130_L0.8581.00
246_N282_P0.8511.00
55_I59_A0.8511.00
149_F153_Q0.8481.00
237_T277_G0.8481.00
67_N289_S0.8471.00
241_S282_P0.8471.00
289_S292_T0.8411.00
169_F173_K0.8401.00
104_Y108_R0.8391.00
255_L258_D0.8371.00
82_A85_A0.8351.00
68_L247_M0.8351.00
46_L107_F0.8341.00
247_M290_L0.8311.00
133_F144_L0.8241.00
135_A138_I0.8231.00
91_V95_A0.8231.00
50_M54_F0.8221.00
158_S165_A0.8151.00
136_G146_G0.8151.00
311_Y315_G0.8141.00
94_A329_A0.8121.00
155_I160_I0.8071.00
129_D137_W0.8051.00
224_K229_A0.8001.00
69_V279_D0.8001.00
194_F198_M0.7991.00
59_A63_L0.7941.00
206_R212_E0.7931.00
105_L109_R0.7921.00
178_I181_G0.7901.00
95_A280_L0.7901.00
319_T323_L0.7871.00
286_P293_L0.7841.00
88_M275_V0.7841.00
242_S288_G0.7801.00
157_V165_A0.7760.99
226_L230_T0.7760.99
161_A168_L0.7750.99
237_T242_S0.7690.99
61_L279_D0.7690.99
137_W144_L0.7660.99
112_P118_S0.7630.99
264_G268_E0.7580.99
258_D262_A0.7580.99
282_P288_G0.7580.99
59_A66_S0.7550.99
143_L148_F0.7530.99
262_A267_K0.7530.99
318_M322_V0.7520.99
266_V269_A0.7500.99
130_L148_F0.7470.99
69_V289_S0.7460.99
145_V149_F0.7450.99
203_Y206_R0.7440.99
58_T92_D0.7430.99
230_T273_A0.7400.99
57_D291_A0.7370.99
160_I164_G0.7360.99
237_T274_N0.7350.99
76_F254_A0.7330.99
237_T253_G0.7330.99
182_K185_R0.7320.99
324_F328_A0.7290.99
50_M314_T0.7270.99
242_S319_T0.7270.99
188_P191_I0.7220.99
91_V276_I0.7220.99
237_T241_S0.7210.99
205_L211_T0.7200.99
254_A275_V0.7160.99
249_T253_G0.7110.99
130_L137_W0.7070.99
234_G326_T0.7070.99
247_M250_V0.7060.99
208_A255_L0.7060.99
49_V53_G0.7050.99
60_S297_H0.6990.99
60_S66_S0.6990.99
165_A172_A0.6970.99
70_N279_D0.6960.99
134_R142_L0.6880.99
54_F283_K0.6880.99
76_F258_D0.6870.99
114_T118_S0.6870.99
141_L144_L0.6820.99
316_I319_T0.6800.99
88_M272_Y0.6780.99
41_S46_L0.6750.99
113_A119_L0.6730.99
157_V172_A0.6720.99
136_G150_L0.6710.99
254_A271_I0.6710.99
258_D271_I0.6700.99
69_V291_A0.6680.98
68_L292_T0.6660.98
254_A257_I0.6660.98
238_A322_V0.6630.98
218_L236_L0.6620.98
283_K292_T0.6610.98
265_V268_E0.6610.98
53_G283_K0.6600.98
128_K132_T0.6580.98
178_I183_V0.6580.98
184_L187_A0.6560.98
143_L164_G0.6520.98
246_N289_S0.6520.98
113_A116_X0.6460.98
108_R112_P0.6450.98
144_L150_L0.6450.98
168_L178_I0.6420.98
142_L151_E0.6420.98
89_I92_D0.6410.98
245_N248_P0.6410.98
156_L160_I0.6400.98
245_N282_P0.6380.98
40_F45_T0.6350.98
65_V68_L0.6340.98
288_G319_T0.6340.98
115_Y118_S0.6320.98
140_L143_L0.6320.98
57_D289_S0.6320.98
233_T274_N0.6310.98
289_S293_L0.6290.98
95_A325_V0.6260.98
250_V254_A0.6190.98
285_T288_G0.6180.98
326_T330_L0.6160.97
127_I133_F0.6140.97
92_D330_L0.6130.97
315_G318_M0.6120.97
55_I96_I0.6110.97
169_F172_A0.6080.97
46_L306_I0.6080.97
52_A55_I0.6080.97
309_G312_F0.6050.97
167_V172_A0.6040.97
123_P127_I0.6030.97
286_P312_F0.6010.97
81_F85_A0.6010.97
83_Q87_V0.6000.97
214_L217_V0.5980.97
75_D78_G0.5970.97
57_D283_K0.5940.97
275_V279_D0.5930.97
128_K131_A0.5920.97
57_D292_T0.5920.97
197_G251_L0.5910.97
125_S128_K0.5900.97
69_V195_S0.5890.97
66_S195_S0.5880.97
233_T257_I0.5870.97
254_A258_D0.5860.97
184_L190_Q0.5850.97
57_D279_D0.5850.97
280_L322_V0.5830.96
102_M317_V0.5830.96
244_M249_T0.5810.96
320_V323_L0.5800.96
139_V150_L0.5720.96
138_I145_V0.5690.96
88_M199_Y0.5690.96
189_W196_L0.5690.96
77_F271_I0.5690.96
100_L104_Y0.5650.96
92_D97_A0.5650.96
319_T322_V0.5640.96
131_A148_F0.5640.96
158_S170_V0.5630.96
67_N291_A0.5620.96
90_S329_A0.5590.96
164_G173_K0.5580.95
238_A277_G0.5570.95
53_G311_Y0.5550.95
149_F152_P0.5550.95
120_L123_P0.5540.95
136_G148_F0.5540.95
312_F315_G0.5520.95
116_X120_L0.5510.95
74_A78_G0.5500.95
313_R316_I0.5500.95
247_M289_S0.5470.95
230_T330_L0.5470.95
234_G242_S0.5470.95
307_T313_R0.5440.95
54_F318_M0.5430.95
182_K186_G0.5420.95
60_S63_L0.5410.95
62_P96_I0.5400.95
234_G327_L0.5390.95
65_V85_A0.5390.95
240_L249_T0.5360.94
134_R140_L0.5330.94
72_V247_M0.5330.94
275_V292_T0.5320.94
191_I247_M0.5310.94
238_A242_S0.5310.94
215_S256_S0.5300.94
141_L150_L0.5290.94
67_N279_D0.5280.94
98_A102_M0.5270.94
49_V305_T0.5250.94
158_S168_L0.5250.94
195_S199_Y0.5220.94
196_L200_I0.5210.94
68_L282_P0.5200.93
282_P289_S0.5180.93
276_I326_T0.5180.93
286_P311_Y0.5180.93
164_G167_V0.5170.93
265_V270_M0.5170.93
180_T183_V0.5150.93
202_V211_T0.5150.93
113_A117_V0.5150.93
198_M285_T0.5110.93
120_L128_K0.5110.93
222_A229_A0.5100.93
306_I310_Y0.5100.93
106_F109_R0.5080.93
283_K322_V0.5080.93
206_R211_T0.5060.93
194_F197_G0.5050.92
158_S172_A0.5040.92
69_V290_L0.5020.92
164_G172_A0.5020.92
225_G232_G0.5010.92
96_I100_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.9172 100 0.416 Contact Map
4r1iA 2 0.9822 99.9 0.628 Contact Map
4r0cA 3 0.9645 99.8 0.684 Contact Map
1ldfA 3 0.3254 32.3 0.949 Contact Map
3qnqA 2 0.3609 21.7 0.953 Contact Map
4nefA 4 0.3669 14.3 0.956 Contact Map
3c02A 3 0.3314 12.4 0.957 Contact Map
3d9sA 3 0.3402 9.7 0.959 Contact Map
3qe7A 2 0.2663 9.7 0.959 Contact Map
2b6oA 6 0.3432 8.8 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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