GREMLIN Database
YFJQ - UPF0380 protein YfjQ
UniProt: P52132 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13203
Length: 273 (264)
Sequences: 237 (124)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_D147_S5.1240.99
183_L224_I3.8180.96
22_R55_D3.7910.96
22_R58_Q3.4540.93
184_A205_L3.2600.90
45_Y107_H3.0040.86
182_A263_V2.9150.84
79_E85_L2.8260.82
14_I67_A2.6560.78
45_Y106_S2.4450.72
77_R108_D2.4390.72
191_R247_A2.3480.69
22_R26_F2.2980.67
185_K201_E2.2760.66
55_D59_R2.1530.62
48_I112_S2.0820.59
114_Q131_G2.0710.58
56_S77_R2.0640.58
32_V253_G2.0220.56
82_K252_D2.0090.56
137_V207_P1.9850.55
183_L247_A1.9490.54
182_A268_L1.9420.53
97_Q171_Q1.9350.53
171_Q179_V1.9330.53
228_L242_R1.9060.52
54_L87_L1.8970.52
180_Q223_R1.8810.51
191_R248_V1.8470.49
236_R240_G1.7980.48
162_R199_V1.7920.47
16_R197_Q1.7920.47
122_A131_G1.7640.46
257_L260_A1.7110.44
135_G139_V1.7010.44
183_L264_M1.6950.43
156_V230_K1.6480.42
191_R194_E1.6430.41
29_V117_P1.6390.41
38_H41_R1.6370.41
62_F149_V1.6300.41
53_L110_T1.6300.41
84_M122_A1.5900.39
48_I216_D1.5850.39
8_F131_G1.5600.38
211_Q223_R1.5520.38
214_S244_H1.5440.38
25_L89_R1.5400.37
19_P92_Q1.4910.36
110_T244_H1.4880.36
204_I241_G1.4820.35
139_V230_K1.4770.35
29_V134_F1.4650.35
172_S206_S1.4540.34
204_I207_P1.4390.34
84_M91_G1.4160.33
35_E204_I1.4080.33
53_L190_Y1.4060.33
24_E32_V1.4040.33
98_V254_D1.3860.32
70_T184_A1.3790.32
48_I161_E1.3420.30
170_M265_A1.3410.30
128_L154_Y1.3390.30
56_S59_R1.3380.30
220_T224_I1.3380.30
106_S138_R1.3320.30
97_Q179_V1.3180.30
142_K148_Q1.3130.29
14_I25_L1.3110.29
188_L192_F1.3100.29
28_V72_V1.2990.29
185_K267_T1.2980.29
25_L67_A1.2970.29
128_L255_V1.2970.29
6_S9_G1.2890.29
86_R100_E1.2770.28
6_S207_P1.2720.28
47_Y140_P1.2710.28
81_T150_I1.2620.28
156_V248_V1.2560.28
161_E165_E1.2450.27
18_R24_E1.2420.27
74_D85_L1.2410.27
98_V122_A1.2400.27
101_I133_S1.2360.27
123_V224_I1.2340.27
32_V85_L1.2320.27
47_Y107_H1.2290.27
134_F148_Q1.2210.26
65_F112_S1.2170.26
59_R249_R1.2140.26
150_I154_Y1.2140.26
7_R207_P1.2110.26
115_M153_A1.2010.26
114_Q138_R1.1900.25
16_R25_L1.1870.25
227_N230_K1.1820.25
103_L113_Y1.1760.25
160_F188_L1.1680.25
82_K149_V1.1670.25
46_T142_K1.1650.25
34_S37_K1.1530.24
215_N219_T1.1460.24
70_T259_R1.1420.24
245_T264_M1.1410.24
183_L265_A1.1330.24
19_P89_R1.1270.24
191_R195_D1.1260.24
94_T194_E1.1080.23
70_T205_L1.1000.23
119_M191_R1.1000.23
34_S132_E1.0870.22
163_V248_V1.0870.22
101_I120_F1.0860.22
114_Q122_A1.0810.22
80_H249_R1.0740.22
143_G149_V1.0730.22
8_F255_V1.0630.22
12_N254_D1.0580.22
32_V197_Q1.0530.22
228_L247_A1.0530.22
156_V252_D1.0490.21
216_D219_T1.0450.21
103_L127_G1.0380.21
80_H167_R1.0350.21
8_F114_Q1.0340.21
70_T80_H1.0330.21
65_F131_G1.0330.21
87_L122_A1.0320.21
77_R204_I1.0300.21
9_G195_D1.0290.21
8_F122_A1.0230.21
140_P148_Q1.0220.21
139_V183_L1.0180.21
145_V205_L1.0140.21
89_R157_L1.0060.20
87_L250_G1.0030.20
128_L242_R1.0020.20
36_D80_H0.9960.20
158_G162_R0.9940.20
54_L81_T0.9920.20
41_R109_G0.9860.20
51_I235_G0.9830.20
37_K222_Q0.9790.20
182_A247_A0.9790.20
196_H234_S0.9770.20
152_G198_P0.9710.19
53_L89_R0.9600.19
132_E259_R0.9450.19
87_L157_L0.9440.19
24_E148_Q0.9390.19
65_F115_M0.9380.19
41_R62_F0.9340.18
202_S205_L0.9320.18
84_M174_L0.9310.18
170_M269_L0.9300.18
31_S251_I0.9270.18
72_V77_R0.9270.18
81_T248_V0.9260.18
135_G230_K0.9250.18
117_P135_G0.9180.18
101_I157_L0.9170.18
178_P224_I0.9170.18
7_R194_E0.9150.18
63_Q172_S0.9140.18
21_T165_E0.9110.18
233_L245_T0.9100.18
22_R36_D0.9090.18
9_G85_L0.9080.18
180_Q220_T0.9040.18
238_A247_A0.9010.18
84_M123_V0.8990.18
8_F68_C0.8980.18
185_K189_T0.8910.17
32_V89_R0.8890.17
82_K143_G0.8890.17
95_G133_S0.8880.17
215_N248_V0.8800.17
182_A267_T0.8800.17
66_F89_R0.8800.17
165_E172_S0.8740.17
226_E231_G0.8730.17
183_L234_S0.8700.17
210_W213_E0.8680.17
109_G117_P0.8630.17
100_E113_Y0.8600.17
26_F33_F0.8590.17
18_R21_T0.8420.16
21_T254_D0.8410.16
58_Q97_Q0.8410.16
47_Y192_F0.8400.16
41_R47_Y0.8390.16
53_L264_M0.8370.16
198_P236_R0.8370.16
51_I158_G0.8350.16
250_G253_G0.8350.16
10_A13_L0.8290.16
35_E265_A0.8270.16
84_M161_E0.8250.16
52_S55_D0.8230.16
67_A190_Y0.8210.16
171_Q201_E0.8200.16
26_F36_D0.8160.16
25_L90_E0.8130.16
29_V66_F0.8120.16
21_T24_E0.8090.16
109_G113_Y0.8090.16
56_S155_E0.8050.16
116_L125_Q0.8030.16
58_Q192_F0.8030.16
48_I149_V0.8020.16
145_V193_G0.7980.15
117_P190_Y0.7980.15
85_L137_V0.7950.15
36_D238_A0.7940.15
76_R85_L0.7930.15
138_R142_K0.7910.15
25_L253_G0.7870.15
129_V205_L0.7850.15
37_K46_T0.7850.15
72_V201_E0.7850.15
173_L193_G0.7830.15
47_Y160_F0.7820.15
155_E190_Y0.7820.15
159_I162_R0.7820.15
58_Q193_G0.7810.15
9_G202_S0.7800.15
11_A229_I0.7790.15
115_M122_A0.7780.15
179_V182_A0.7770.15
67_A191_R0.7770.15
212_D218_W0.7760.15
180_Q215_N0.7730.15
9_G12_N0.7730.15
6_S173_L0.7700.15
24_E129_V0.7700.15
107_H127_G0.7700.15
46_T137_V0.7700.15
72_V130_C0.7690.15
105_N124_C0.7650.15
105_N126_N0.7650.15
99_P110_T0.7610.15
14_I199_V0.7610.15
59_R85_L0.7590.15
204_I228_L0.7560.15
221_Y265_A0.7540.15
90_E222_Q0.7490.14
87_L101_I0.7470.14
182_A191_R0.7470.14
145_V152_G0.7470.14
173_L182_A0.7460.14
184_A268_L0.7430.14
214_S230_K0.7370.14
26_F168_D0.7370.14
67_A136_E0.7360.14
202_S213_E0.7320.14
205_L256_K0.7280.14
190_Y254_D0.7250.14
57_L86_R0.7250.14
163_V266_E0.7210.14
9_G14_I0.7200.14
208_R227_N0.7140.14
154_Y242_R0.7100.14
112_S170_M0.7090.14
202_S239_K0.7090.14
65_F68_C0.7060.14
213_E244_H0.7010.14
220_T267_T0.7000.13
37_K47_Y0.6970.13
18_R148_Q0.6950.13
176_P179_V0.6950.13
91_G256_K0.6930.13
64_P100_E0.6920.13
71_R216_D0.6910.13
25_L29_V0.6900.13
49_P69_Q0.6900.13
107_H112_S0.6890.13
145_V151_E0.6870.13
45_Y138_R0.6830.13
93_I233_L0.6810.13
167_R268_L0.6790.13
12_N241_G0.6750.13
125_Q184_A0.6730.13
37_K110_T0.6690.13
172_S177_P0.6620.13
92_Q223_R0.6600.13
16_R67_A0.6560.13
258_N261_L0.6550.13
70_T74_D0.6510.13
12_N159_I0.6500.13
26_F77_R0.6460.13
114_Q120_F0.6440.12
68_C131_G0.6430.12
80_H110_T0.6320.12
192_F198_P0.6300.12
27_R202_S0.6300.12
248_V257_L0.6280.12
7_R76_R0.6260.12
243_T268_L0.6240.12
173_L263_V0.6240.12
28_V71_R0.6230.12
37_K253_G0.6230.12
43_E177_P0.6220.12
29_V230_K0.6210.12
67_A119_M0.6200.12
158_G199_V0.6190.12
7_R96_K0.6170.12
125_Q133_S0.6150.12
57_L69_Q0.6080.12
55_D194_E0.6080.12
10_A166_K0.6060.12
32_V129_V0.6050.12
128_L138_R0.6050.12
7_R140_P0.5990.12
81_T260_A0.5960.12
62_F157_L0.5960.12
77_R81_T0.5960.12
104_L129_V0.5950.12
88_R111_S0.5940.12
23_E257_L0.5920.12
105_N231_G0.5910.12
124_C231_G0.5910.12
126_N231_G0.5910.12
53_L253_G0.5900.12
157_L218_W0.5880.12
234_S244_H0.5870.12
29_V33_F0.5860.12
44_R108_D0.5860.12
8_F102_I0.5850.11
16_R117_P0.5850.11
33_F137_V0.5850.11
113_Y145_V0.5840.11
144_D154_Y0.5840.11
20_L24_E0.5830.11
224_I264_M0.5820.11
101_I149_V0.5820.11
60_E152_G0.5800.11
162_R206_S0.5780.11
36_D195_D0.5760.11
34_S117_P0.5750.11
12_N247_A0.5740.11
128_L180_Q0.5740.11
63_Q90_E0.5720.11
47_Y115_M0.5680.11
36_D77_R0.5640.11
13_L55_D0.5640.11
203_Q233_L0.5640.11
37_K224_I0.5630.11
48_I62_F0.5630.11
214_S243_T0.5630.11
9_G222_Q0.5580.11
65_F160_F0.5570.11
62_F143_G0.5550.11
181_Q195_D0.5550.11
48_I136_E0.5550.11
87_L198_P0.5530.11
70_T145_V0.5530.11
60_E69_Q0.5520.11
9_G247_A0.5460.11
237_N240_G0.5440.11
112_S164_E0.5430.11
227_N266_E0.5390.11
131_G170_M0.5370.11
146_V199_V0.5360.11
63_Q196_H0.5330.11
69_Q227_N0.5320.11
34_S140_P0.5320.11
21_T154_Y0.5320.11
163_V171_Q0.5310.11
70_T167_R0.5310.11
97_Q119_M0.5310.11
179_V197_Q0.5290.11
89_R136_E0.5280.11
160_F170_M0.5260.11
26_F55_D0.5250.11
222_Q247_A0.5250.11
100_E127_G0.5240.11
40_S62_F0.5220.10
62_F150_I0.5210.10
162_R165_E0.5200.10
29_V159_I0.5190.10
23_E193_G0.5170.10
147_S150_I0.5150.10
91_G243_T0.5150.10
77_R176_P0.5150.10
91_G163_V0.5120.10
7_R247_A0.5090.10
32_V174_L0.5080.10
106_S223_R0.5080.10
12_N16_R0.5070.10
57_L246_R0.5030.10
72_V78_R0.5030.10
219_T249_R0.5010.10
68_C93_I0.5000.10
65_F122_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pdiA 1 0.5348 30.4 0.974 Contact Map
3aekA 1 0.5495 22.6 0.976 Contact Map
3u7qA 1 0.5714 22 0.976 Contact Map
3sgiA 1 0 19.1 0.977 Contact Map
2fhoA 1 0.1612 15.4 0.978 Contact Map
3slrA 2 0.6081 15.3 0.978 Contact Map
4wesB 2 0.6007 13.3 0.978 Contact Map
3u7qB 2 0.6117 10.5 0.979 Contact Map
4a0eA 1 0.3663 9.2 0.98 Contact Map
1uokA 1 0.6227 8.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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