GREMLIN Database
RSTA - Transcriptional regulatory protein RstA
UniProt: P52108 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13190
Length: 239 (204)
Sequences: 68454 (48210)
Seq/√Len: 3375.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_G30_V3.7011.00
14_G32_P3.1451.00
18_A30_V3.0481.00
7_V37_A2.7211.00
35_D57_G2.5971.00
38_E66_D2.5161.00
33_R57_G2.4611.00
29_T46_P2.4541.00
34_G58_K2.4091.00
58_K66_D2.3641.00
42_L70_K2.3441.00
18_A22_A2.1251.00
3_T29_T2.1231.00
20_Y105_P2.0391.00
3_T27_Q2.0361.00
24_H109_L1.9921.00
31_E40_T1.9611.00
87_H107_V1.9401.00
165_A168_E1.9331.00
200_R203_D1.9191.00
32_P36_Q1.8261.00
54_M81_L1.8151.00
33_R36_Q1.8071.00
51_L63_I1.7961.00
77_L90_A1.7731.00
64_C75_I1.7601.00
84_D104_P1.7511.00
68_R96_C1.7091.00
143_T156_A1.7031.00
183_R203_D1.6411.00
29_T40_T1.6371.00
5_V31_E1.6361.00
172_E189_N1.6041.00
171_W175_T1.5891.00
77_L95_A1.5851.00
21_L112_L1.5821.00
58_K62_T1.5781.00
66_D70_K1.5651.00
59_D62_T1.5561.00
34_G63_I1.5291.00
205_A208_R1.5001.00
166_D212_K1.4961.00
81_L86_N1.4941.00
40_T44_E1.4881.00
66_D69_A1.4671.00
181_M189_N1.4581.00
97_D111_R1.4561.00
40_T43_R1.4421.00
29_T44_E1.4371.00
49_V73_G1.4311.00
76_V115_H1.4311.00
35_D58_K1.4111.00
48_L112_L1.4031.00
41_I67_L1.3931.00
182_D185_A1.3861.00
38_E63_I1.3831.00
62_T65_R1.3801.00
64_C77_L1.3591.00
11_A32_P1.3451.00
140_H145_T1.3251.00
53_I77_L1.3051.00
51_L64_C1.2921.00
8_E14_G1.2791.00
65_R93_M1.2741.00
39_E43_R1.2691.00
7_V55_L1.2631.00
96_C118_Q1.2611.00
53_I61_M1.2561.00
152_V159_E1.2471.00
26_M113_R1.2401.00
9_D52_D1.2371.00
147_D150_N1.2321.00
40_T46_P1.2221.00
138_A145_T1.2181.00
38_E58_K1.2181.00
92_E113_R1.2091.00
36_Q39_E1.2071.00
83_S86_N1.1901.00
5_V46_P1.1701.00
35_D39_E1.1691.00
145_T154_T1.1661.00
172_E181_M1.1641.00
31_E37_A1.1581.00
25_D113_R1.1571.00
36_Q40_T1.1531.00
61_M89_L1.1431.00
216_N220_P1.1281.00
172_E176_H1.1241.00
5_V37_A1.1161.00
185_A189_N1.1121.00
48_L116_L1.1121.00
84_D88_I1.1101.00
3_T44_E1.1101.00
61_M90_A1.1061.00
24_H113_R1.1001.00
204_V207_S1.0931.00
109_L113_R1.0861.00
146_I174_A1.0811.00
184_D199_D1.0651.00
148_P171_W1.0331.00
167_F171_W1.0311.00
85_M89_L1.0281.00
61_M93_M1.0241.00
4_I26_M1.0201.00
107_V110_A1.0141.00
65_R89_L1.0081.00
89_L93_M1.0061.00
96_C115_H1.0051.00
5_V40_T0.9961.00
137_K149_I0.9881.00
110_A114_L0.9811.00
172_E186_L0.9781.00
17_I78_L0.9771.00
31_E36_Q0.9761.00
115_H118_Q0.9741.00
7_V49_V0.9741.00
37_A41_I0.9631.00
216_N219_E0.9571.00
18_A28_V0.9551.00
51_L75_I0.9541.00
41_I71_W0.9531.00
6_F17_I0.9491.00
140_H143_T0.9481.00
181_M185_A0.9471.00
88_I92_E0.9451.00
168_E171_W0.9441.00
38_E42_L0.9381.00
87_H100_L0.9281.00
200_R204_V0.9261.00
37_A63_I0.9251.00
53_I59_D0.9201.00
5_V41_I0.9201.00
7_V31_E0.9131.00
154_T159_E0.9091.00
146_I167_F0.9081.00
201_S205_A0.9051.00
206_I210_R0.9051.00
64_C93_M0.9051.00
12_E16_L0.9031.00
138_A147_D0.9021.00
164_T168_E0.8981.00
62_T66_D0.8941.00
49_V67_L0.8941.00
163_S212_K0.8931.00
15_S30_V0.8841.00
11_A15_S0.8831.00
26_M109_L0.8791.00
39_E42_L0.8691.00
91_L111_R0.8631.00
82_D100_L0.8581.00
6_F28_V0.8571.00
200_R207_S0.8571.00
19_A23_K0.8551.00
64_C95_A0.8501.00
11_A14_G0.8501.00
88_I106_A0.8431.00
55_L63_I0.8321.00
17_I108_L0.8261.00
45_N71_W0.8221.00
151_R168_E0.8221.00
215_D221_Y0.8211.00
51_L77_L0.8201.00
199_D203_D0.8201.00
50_L78_L0.8151.00
50_L108_L0.8141.00
84_D87_H0.8081.00
215_D224_K0.8061.00
89_L92_E0.8051.00
207_S211_K0.8011.00
53_I81_L0.7991.00
107_V111_R0.7981.00
15_S18_A0.7921.00
63_I67_L0.7921.00
85_M106_A0.7871.00
3_T46_P0.7841.00
53_I86_N0.7791.00
208_R211_K0.7771.00
49_V75_I0.7691.00
54_M80_S0.7661.00
175_T189_N0.7641.00
74_P96_C0.7621.00
105_P109_L0.7601.00
114_L119_N0.7541.00
34_G38_E0.7531.00
58_K63_I0.7501.00
76_V97_D0.7481.00
184_D188_K0.7471.00
41_I73_G0.7461.00
65_R69_A0.7421.00
76_V111_R0.7351.00
86_N89_L0.7321.00
183_R199_D0.7211.00
172_E175_T0.7131.00
6_F18_A0.7111.00
41_I46_P0.7091.00
78_L103_T0.7091.00
114_L117_R0.7051.00
38_E41_I0.7051.00
42_L71_W0.6991.00
154_T157_N0.6991.00
84_D106_A0.6971.00
21_L26_M0.6921.00
214_L220_P0.6921.00
175_T181_M0.6911.00
103_T108_L0.6901.00
72_S121_Q0.6891.00
6_F30_V0.6891.00
3_T47_D0.6881.00
15_S19_A0.6851.00
34_G57_G0.6821.00
139_L148_P0.6811.00
8_E55_L0.6811.00
13_V103_T0.6801.00
92_E110_A0.6781.00
16_L20_Y0.6761.00
7_V63_I0.6751.00
90_A95_A0.6741.00
104_P107_V0.6741.00
204_V208_R0.6691.00
41_I49_V0.6681.00
173_L206_I0.6621.00
20_Y109_L0.6621.00
214_L221_Y0.6591.00
210_R215_D0.6561.00
151_R167_F0.6551.00
143_T155_L0.6521.00
14_G18_A0.6511.00
22_A28_V0.6491.00
185_A188_K0.6491.00
4_I48_L0.6471.00
144_L155_L0.6441.00
87_H104_P0.6431.00
22_A27_Q0.6431.00
116_L119_N0.6421.00
197_G202_V0.6321.00
74_P116_L0.6311.00
4_I21_L0.6291.00
106_A110_A0.6201.00
165_A205_A0.6181.00
119_N123_T0.6161.00
10_D13_V0.6151.00
53_I90_A0.6141.00
42_L66_D0.6131.00
10_D80_S0.6111.00
143_T147_D0.6091.00
147_D152_V0.6091.00
26_M116_L0.6011.00
170_L221_Y0.6011.00
68_R73_G0.6001.00
38_E70_K0.6001.00
72_S122_A0.5921.00
79_T87_H0.5901.00
155_L216_N0.5871.00
50_L112_L0.5861.00
52_D101_K0.5831.00
214_L218_A0.5831.00
170_L209_L0.5831.00
139_L174_A0.5831.00
148_P175_T0.5831.00
155_L158_T0.5811.00
146_I171_W0.5811.00
203_D206_I0.5761.00
4_I112_L0.5691.00
34_G55_L0.5651.00
172_E190_L0.5631.00
137_K148_P0.5621.00
9_D79_T0.5621.00
103_T107_V0.5601.00
139_L143_T0.5551.00
137_K141_F0.5541.00
219_E222_R0.5531.00
36_Q57_G0.5511.00
61_M86_N0.5511.00
155_L214_L0.5481.00
146_I153_V0.5471.00
168_E172_E0.5451.00
51_L55_L0.5431.00
155_L215_D0.5431.00
50_L76_V0.5431.00
206_I218_A0.5431.00
141_F174_A0.5421.00
169_L173_L0.5411.00
64_C68_R0.5401.00
20_Y24_H0.5381.00
67_L71_W0.5361.00
139_L142_G0.5341.00
82_D102_T0.5321.00
166_D208_R0.5311.00
48_L115_H0.5311.00
111_R115_H0.5311.00
41_I63_I0.5291.00
67_L75_I0.5291.00
68_R74_P0.5201.00
16_L19_A0.5181.00
198_L201_S0.5171.00
144_L153_V0.5151.00
88_I91_L0.5141.00
141_F145_T0.5121.00
79_T101_K0.5121.00
6_F14_G0.5101.00
97_D114_L0.5101.00
33_R55_L0.5071.00
110_A113_R0.5071.00
67_L73_G0.5071.00
68_R71_W0.5041.00
187_L196_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gwrA 1 0.9289 100 0.208 Contact Map
2oqrA 2 0.9456 100 0.22 Contact Map
4kfcA 2 0.9372 100 0.221 Contact Map
4b09A 2 0.8912 100 0.225 Contact Map
3r0jA 2 0.9163 100 0.23 Contact Map
1ys7A 2 0.9414 100 0.23 Contact Map
1kgsA 1 0.9121 100 0.253 Contact Map
1p2fA 1 0.8996 100 0.267 Contact Map
3q9sA 1 0.8787 100 0.275 Contact Map
2hqrA 2 0.9121 100 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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